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公开(公告)号：US07790747B2
公开(公告)日：2010-09-07
申请号：US11453221
申请日：2006-06-14
申请人： Yuanxi Zhou , Elyse Bourque , Yongbao Zhu , Jonathan Langille , Markus Metz , Wen Yang , Ernest J. McEachern , Curtis Harwig , Ian R. Baird , Tong-Shuang Li , Renato T. Skerlj
发明人： Yuanxi Zhou , Elyse Bourque , Yongbao Zhu , Jonathan Langille , Markus Metz , Wen Yang , Ernest J. McEachern , Curtis Harwig , Ian R. Baird , Tong-Shuang Li , Renato T. Skerlj
IPC分类号： A61K31/4545 , C07D409/14
CPC分类号： C07D413/14 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要： The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR5. These compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
摘要翻译： 本发明涉及趋化因子受体结合化合物，药物组合物及其用途。 更具体地，本发明涉及趋化因子受体活性的调节剂，优选CCR5的调节剂。 这些化合物表现出对人体免疫缺陷病毒（HIV）感染靶细胞的保护作用。
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公开(公告)号：US20090099205A1
公开(公告)日：2009-04-16
申请号：US11453221
申请日：2006-06-14
申请人： Yuanxi Zhou , Elyse Bourque , Yongbao Zhu , Jonathan Langille , Markus Metz , Wen Yang , Ernest J. McEachern , Curtis Harwig , Ian R. Baird , Tong-Shuang Li , Renato T. Skerlj
发明人： Yuanxi Zhou , Elyse Bourque , Yongbao Zhu , Jonathan Langille , Markus Metz , Wen Yang , Ernest J. McEachern , Curtis Harwig , Ian R. Baird , Tong-Shuang Li , Renato T. Skerlj
IPC分类号： A61K31/506 , C07D403/12 , A61K31/4545 , C07D409/14 , C12N5/06
CPC分类号： C07D413/14 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要： The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR5. These compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
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公开(公告)号：US07498346B2
公开(公告)日：2009-03-03
申请号：US11152589
申请日：2005-06-14
申请人： Yuanxi Zhou , Gary J. Bridger , Renato T. Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz
发明人： Yuanxi Zhou , Gary J. Bridger , Renato T. Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz
IPC分类号： A61K31/4453 , C07D211/58
CPC分类号： C07D417/14 , C07D401/12 , C07D401/14 , C07D413/14
摘要： The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR5. These compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
摘要翻译： 本发明涉及趋化因子受体结合化合物，药物组合物及其用途。 更具体地，本发明涉及趋化因子受体活性的调节剂，优选CCR5的调节剂。 这些化合物表现出对人体免疫缺陷病毒（HIV）感染靶细胞的保护作用。
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公开(公告)号：US07491735B2
公开(公告)日：2009-02-17
申请号：US11012002
申请日：2004-12-13
申请人： Yuanxi Zhou , Gary J. Bridger , Renato T. Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz , Maria R. Di Fluri , Siqiao Nan
发明人： Yuanxi Zhou , Gary J. Bridger , Renato T. Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz , Maria R. Di Fluri , Siqiao Nan
IPC分类号： A61K31/4468
CPC分类号： C07D401/14 , C07D401/12 , C07D413/14 , C07D417/14
摘要： The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR5. These compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
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公开(公告)号：US20070066624A1
公开(公告)日：2007-03-22
申请号：US11505669
申请日：2006-08-16
申请人： Yuanxi Zhou , Elyse Bourque , Yongbao Zhu , Ernest McEachern , Curtis Harwig , Renato Skerlj , Gary Bridger , Tong-Shuang Li , Markus Metz
发明人： Yuanxi Zhou , Elyse Bourque , Yongbao Zhu , Ernest McEachern , Curtis Harwig , Renato Skerlj , Gary Bridger , Tong-Shuang Li , Markus Metz
IPC分类号： A61K31/496 , A61K31/454 , C07D403/14 , C07D403/04
CPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D493/08
摘要： The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR4 or CCR5. In one aspect, these compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
摘要翻译： 本发明涉及趋化因子受体结合化合物，药物组合物及其用途。 更具体地，本发明涉及趋化因子受体活性的调节剂，优选CCR4或CCR5的调节剂。 一方面，这些化合物表现出针对人类免疫缺陷病毒（HIV）感染靶细胞的保护作用。
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公开(公告)号：US20050277670A1
公开(公告)日：2005-12-15
申请号：US11012002
申请日：2004-12-13
申请人： Yuanxi Zhou , Gary Bridger , Renato Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz , Maria Di Fluri , Siqiao Nan
发明人： Yuanxi Zhou , Gary Bridger , Renato Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz , Maria Di Fluri , Siqiao Nan
IPC分类号： A61K31/4545 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , C12N20060101 , C07D43/02
CPC分类号： C07D401/14 , C07D401/12 , C07D413/14 , C07D417/14
摘要： The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR5. These compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
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公开(公告)号：US20050277668A1
公开(公告)日：2005-12-15
申请号：US11152589
申请日：2005-06-14
申请人： Yuanxi Zhou , Gary Bridger , Renato Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz
发明人： Yuanxi Zhou , Gary Bridger , Renato Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz
IPC分类号： A61K31/4545 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , C12N20060101 , C07D41/14
CPC分类号： C07D417/14 , C07D401/12 , C07D401/14 , C07D413/14
摘要： The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR5. These compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
摘要翻译： 本发明涉及趋化因子受体结合化合物，药物组合物及其用途。 更具体地，本发明涉及趋化因子受体活性的调节剂，优选CCR5的调节剂。 这些化合物表现出对人体免疫缺陷病毒（HIV）感染靶细胞的保护作用。
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8.发明申请公开(公告)号：US20080167341A1
公开(公告)日：2008-07-10
申请号：US12036187
申请日：2008-02-22
申请人： Gary BRIDGER , Renato T. Skerlj , Al Kaller , Curtis Harwig , David Bogucki , Trevor R. Wilson , Jason B. Crawford , Ernest J. Mceachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Dennis Smith , Maria R. Di Fluri
发明人： Gary BRIDGER , Renato T. Skerlj , Al Kaller , Curtis Harwig , David Bogucki , Trevor R. Wilson , Jason B. Crawford , Ernest J. Mceachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Dennis Smith , Maria R. Di Fluri
IPC分类号： A61K31/4709 , A61P7/00
CPC分类号： A61K31/4184 , A61K31/415 , A61K31/436 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/495 , A61K31/497 , A61K31/4985 , A61K31/50 , A61K31/502 , A61K31/506 , A61K31/5377 , C07D235/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D471/04 , C07D471/06 , C07D491/04 , C07D491/052 , Y02A50/411
摘要： The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings. The compounds bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
摘要翻译： 本发明涉及由三个侧基包围的核心氮原子组成的杂环化合物，其中三个侧基中的两个优选为苯并咪唑基甲基和四氢喹啉基，第三侧基含有N并且任选地含有另外的环。 这些化合物与趋化因子受体结合，包括CXCR4和CCR5，并表现出针对人类免疫缺陷病毒（HIV）感染靶细胞的保护作用。
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公开(公告)号：US07354934B2
公开(公告)日：2008-04-08
申请号：US11301725
申请日：2005-12-13
申请人： Gary J. Bridger , Al Kaller , Curtis Harwig , Renato T. Skerlj , David Bogucki , Trevor R. Wilson , Jason B. Crawford , Ernest J. McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Dennis Smith , Maria R. Di Fluri
发明人： Gary J. Bridger , Al Kaller , Curtis Harwig , Renato T. Skerlj , David Bogucki , Trevor R. Wilson , Jason B. Crawford , Ernest J. McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Dennis Smith , Maria R. Di Fluri
IPC分类号： A61K31/4709 , C07D403/12
CPC分类号： C07D401/14 , C07D235/14 , C07D401/12 , C07D403/12 , C07D471/04 , C07D471/06 , C07D491/04
摘要： The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings. The compounds bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
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公开(公告)号：US20140296205A1
公开(公告)日：2014-10-02
申请号：US14129177
申请日：2012-06-27
申请人： Tong-Shuang Li , Ernest J. Mceachern , David J. Vocadlo , Yuanxi Zhou , Yongbao Zhu , Harold G. Selnick
发明人： Tong-Shuang Li , Ernest J. Mceachern , David J. Vocadlo , Yuanxi Zhou , Yongbao Zhu , Harold G. Selnick
IPC分类号： C07D513/04 , G01N33/50 , C12Q1/34
CPC分类号： C07D513/04 , C07H9/06 , C12Q1/34 , C12Q1/37 , G01N33/5038 , G01N2333/924 , G01N2500/04
摘要： The invention provides compounds with enhanced permeability for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
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