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    Staphylococcal GTPase obg nucleotide sequence encoding Staphylococcal GTP-binding protein
    1.
    发明授权
    Staphylococcal GTPase obg nucleotide sequence encoding Staphylococcal GTP-binding protein 失效
    葡萄球菌GTP酶obg核苷酸序列编码葡萄球菌GTP结合蛋白

    公开(公告)号：US06706495B2

    公开(公告)日：2004-03-16

    申请号：US09792420

    申请日：2001-02-23

    申请人： Yueh-tyng Chien ,  Jason A. Thresher ,  C. Richard Wobbe ,  Judith M. Healy

    发明人： Yueh-tyng Chien ,  Jason A. Thresher ,  C. Richard Wobbe ,  Judith M. Healy

    IPC分类号： C12P2106

    CPC分类号： C12N9/14 ,  A61K38/00 ,  C07K14/31

    摘要： The present invention provides an isolated Staphylococcal GTPase obg gene and a Staphylococcal GTP-binding protein encoded thereby. A recombinant expression vector and an engineered host cell are also provided that include a polynucleotide encoding a Staphylococcal GTP-binding protein. The present invention further relates to a method of producing Staphylococcal GTP-binding protein and a method for high throughput screening to identify potential antimicrobial compounds useful against Staphylococcal bacterial strains.

    摘要翻译： 本发明提供了分离的葡萄球菌GTP酶obg基因和由其编码的葡萄球菌GTP结合蛋白。 还提供重组表达载体和工程化宿主细胞，其包括编码葡萄球菌GTP结合蛋白的多核苷酸。 本发明还涉及葡萄球菌GTP结合蛋白的生产方法和用于高通量筛选以识别可用于葡萄球菌菌株的抗微生物化合物的方法。

    Staphylococcus strains comprising an inducible gene encoding an RNA polymerase specificity factor
    4.
    发明授权
    Staphylococcus strains comprising an inducible gene encoding an RNA polymerase specificity factor 失效
    包含编码RNA聚合酶特异性因子的诱导型基因的葡萄球菌菌株

    公开(公告)号：US06451582B1

    公开(公告)日：2002-09-17

    申请号：US09501838

    申请日：2000-02-10

    申请人： Judith M. Healy ,  C. Richard Wobbe ,  Patricia Carroll ,  Jason Thresher

    发明人： Judith M. Healy ,  C. Richard Wobbe ,  Patricia Carroll ,  Jason Thresher

    IPC分类号： C12N120

    CPC分类号： C12N15/74 ,  C12N15/635 ,  C12Q1/18

    摘要： The present invention relates to a recombinant organism, and a bacterial strain such as Staphylococcus, and S. aureus, in particular. The organism has a regulatable gene for encoding an RNA polymerase specificity factor required for expression of at least one gene essential for growth of the organism. The regulatable gene is one which is responsive to an exogenous effector molecule, and may in particular be an inducer-responsive gene including an operator site, such as a lac operator, to which a repressor, such as a lacl-encoded repressor, is capable of binding. The regulatable gene may in particular be an IPTG responsive plaC allele.

    摘要翻译： 本发明特别涉及重组生物，特别涉及葡萄球菌，金黄色葡萄球菌等菌株。 生物体具有用于编码表达生物体生长所必需的至少一种基因所需的RNA聚合酶特异性因子的可调控基因。 可调节基因是对外源性效应分子有反应的基因，特别可能是诱导物反应性基因，其包括诸如lac操纵子的操纵位点，其中阻遏物如lacI编码的阻遏物能够 的约束力。 可调节基因特别可能是IPTG反应性plaC等位基因。