公开(公告)号：US08658991B2

公开(公告)日：2014-02-25

申请号：US13003688

申请日：2009-06-03

申请人： Yuehu Pu ,  Katsuhisa Yoshida ,  Yuichi Yamamoto ,  Hidenobu Sakamoto ,  Taizo Honda ,  Hisashi Harada ,  Takaaki Iwata

发明人： Yuehu Pu ,  Katsuhisa Yoshida ,  Yuichi Yamamoto ,  Hidenobu Sakamoto ,  Taizo Honda ,  Hisashi Harada ,  Takaaki Iwata

IPC分类号： A61N5/00

CPC分类号： A61N5/10 ,  A61N5/1043 ,  A61N2005/1087

摘要： In order to obtain a particle beam irradiation apparatus that enlarges the dose distribution of beam spots while suppressing a decrease of the maximum available range of a charged particle beam, the particle beam irradiation apparatus includes a particle beam acceleration means; particle beam transport means; scanning apparatus that includes first scanning means and second scanning means, and two-dimensionally scans the beam; and irradiation control means that controls the scanning apparatus so as to irradiate the beam onto a target region including a plurality of small regions. The irradiation control means controls the first scanning means so as to scan the beam over a small region serving as an irradiation subject among the plurality of the small regions, and controls the second scanning means so as to change the small region serving as the irradiation subject to be a different small region among the plurality of the small regions.

摘要翻译： 为了获得粒子束照射装置，其粒子束照射装置包括粒子束加速装置，粒子束照射装置在抑制带电粒子束的最大可用范围的减小的同时，扩大束斑的剂量分布， 粒子束传送装置; 扫描装置，其包括第一扫描装置和第二扫描装置，并二维地扫描光束; 以及照射控制装置，其控制扫描装置以将束照射到包括多个小区域的目标区域上。 照射控制装置控制第一扫描装置，以便在多个小区域中的用作照射对象的小区域上扫描光束，并且控制第二扫描装置以改变用作照射对象的小区域 成为多个小区域中的不同小区域。

公开(公告)号：US20110108737A1

公开(公告)日：2011-05-12

申请号：US13003688

申请日：2009-06-03

申请人： Yuehu Pu ,  Katsuhisa Yoshida ,  Yuichi Yamamoto ,  Hidenobu Sakamoto ,  Taizo Honda ,  Hisashi Harada ,  Takaaki Iwata

发明人： Yuehu Pu ,  Katsuhisa Yoshida ,  Yuichi Yamamoto ,  Hidenobu Sakamoto ,  Taizo Honda ,  Hisashi Harada ,  Takaaki Iwata

IPC分类号： H01J37/147

CPC分类号： A61N5/10 ,  A61N5/1043 ,  A61N2005/1087

摘要： In order to obtain a particle beam irradiation apparatus that enlarges the dose distribution of beam spots while suppressing a decrease of the maximum available range of a charged particle beam, the particle beam irradiation apparatus includes a particle beam acceleration means; particle beam transport means; scanning apparatus that includes first scanning means and second scanning means, and two-dimensionally scans the beam; and irradiation control means that controls the scanning apparatus so as to irradiate the beam onto a target region including a plurality of small regions. The irradiation control means controls the first scanning means so as to scan the beam over a small region serving as an irradiation subject among the plurality of the small regions, and controls the second scanning means so as to change the small region serving as the irradiation subject to be a different small region among the plurality of the small regions.

摘要翻译： 为了获得粒子束照射装置，其粒子束照射装置包括粒子束加速装置，粒子束照射装置在抑制带电粒子束的最大可用范围的减小的同时，扩大束斑的剂量分布， 粒子束传送装置; 扫描装置，其包括第一扫描装置和第二扫描装置，并二维地扫描光束; 以及照射控制装置，其控制扫描装置以将束照射到包括多个小区域的目标区域上。 照射控制装置控制第一扫描装置，以便在多个小区域中的用作照射对象的小区域上扫描光束，并且控制第二扫描装置以改变用作照射对象的小区域 成为多个小区域中的不同小区域。

公开(公告)号：US08314411B2

公开(公告)日：2012-11-20

申请号：US12738705

申请日：2009-04-24

申请人： Hisashi Harada ,  Takaaki Iwata ,  Taizo Honda ,  Yuehu Pu ,  Yuichi Yamamoto ,  Toshihiro Otani ,  Hidenobu Sakamoto

发明人： Hisashi Harada ,  Takaaki Iwata ,  Taizo Honda ,  Yuehu Pu ,  Yuichi Yamamoto ,  Toshihiro Otani ,  Hidenobu Sakamoto

IPC分类号： A61N5/10 ,  H01J37/256

CPC分类号： A61N5/1077 ,  A61N2005/1087 ,  A61N2005/1095

摘要： There is obtained a particle beam therapy system in which the beam size is reduced. There are provided an accelerator 14 that accelerates a charged particle beam; an irradiation apparatus that has a beam scanning apparatus 5a, 5b for performing scanning with the charged particle beam and irradiates the charged particle beam onto an irradiation subject; and a beam transport apparatus 15 that has a duct for ensuring a vacuum region or gas region that continues from the accelerator 14 to a beam outlet window 7 disposed at a more downstream position than the beam scanning apparatus 5a, 5b, and that transports the charged particle beam exiting from the accelerator 14 to the irradiation apparatus.

摘要翻译： 获得了粒径减小的粒子束治疗系统。 提供加速带电粒子束的加速器14; 具有用于利用带电粒子束进行扫描并将带电粒子束照射到照射对象上的光束扫描装置5a，5b的照射装置; 以及具有用于确保从加速器14延伸到设置在比光束扫描装置5a，5b的更下游位置处的光束出射窗口7的真空区域或气体区域的管道的光束传送装置15，并且传送带电 粒子束从加速器14离开到照射装置。

公开(公告)号：US20110260074A1

公开(公告)日：2011-10-27

申请号：US12864002

申请日：2010-01-28

申请人： Taizo Honda ,  Hisashi Harada ,  Yuehu Pu ,  Yuichi Yamamoto ,  Takaaki Iwata

发明人： Taizo Honda ,  Hisashi Harada ,  Yuehu Pu ,  Yuichi Yamamoto ,  Takaaki Iwata

IPC分类号： G21K1/08

CPC分类号： A61N5/1042 ,  A61N5/1043 ,  A61N5/1048 ,  A61N2005/1087

摘要： The objective of the present invention is to reduce the effect of the hysteresis of a scanning electromagnet so as to obtain a particle beam therapy system that realizes high-accuracy beam irradiation. There are included an irradiation management apparatus (32) that controls the scanning electromagnet (3), based on target irradiation position coordinates (Pi) of a charged particle beam (1b), and a position monitor (7) that measures measurement position coordinates (Ps) of the charged particle beam (1b). The irradiation management apparatus (32) has a command value creator (25) that outputs a control input (Io (Ir)) to the scanning electromagnet (3), based on the target irradiation position coordinates (Pi) and correction data (Ia) created on the basis of the measurement position coordinates (Ps), measured by the position monitor (7) in the preliminary irradiation in which the excitation pattern of the scanning electromagnet is the same as that of the main irradiation plan, and the target irradiation position coordinates (Pi).

摘要翻译： 本发明的目的是减少扫描电磁体的滞后效果，以获得实现高精度光束照射的粒子束治疗系统。 包括基于带电粒子束（1b）的目标照射位置坐标（Pi）来控制扫描电磁体（3）的照射管理装置（32）和测量位置坐标（ Ps）的带电粒子束（1b）。 照射管理装置（32）具有基于目标照射位置坐标（Pi）和校正数据（Ia）向扫描电磁体（3）输出控制输入（Io（Ir））的指令值生成器（25） 基于由扫描电磁体的激励图案与主照射平面的激励图案相同的预备照射中的位置监视器（7）测量的测量位置坐标（Ps）和目标照射位置 坐标（Pi）。

公开(公告)号：US20110218429A1

公开(公告)日：2011-09-08

申请号：US12738705

申请日：2009-04-24

申请人： Hisashi Harada ,  Takaaki Iwata ,  Taizo Honda ,  Yuehu Pu ,  Yuichi Yamamoto ,  Toshihiro Otani ,  Hidenobu Sakamoto

发明人： Hisashi Harada ,  Takaaki Iwata ,  Taizo Honda ,  Yuehu Pu ,  Yuichi Yamamoto ,  Toshihiro Otani ,  Hidenobu Sakamoto

IPC分类号： G03B42/02 ,  H01J3/26

CPC分类号： A61N5/1077 ,  A61N2005/1087 ,  A61N2005/1095

摘要： There is obtained a particle beam therapy system in which the beam size is reduced. There are provided an accelerator 14 that accelerates a charged particle beam; an irradiation apparatus that has a beam scanning apparatus 5a, 5b for performing scanning with the charged particle beam and irradiates the charged particle beam onto an irradiation subject ; and a beam transport apparatus 15 that has a duct for ensuring a vacuum region or gas region that continues from the accelerator 14 to a beam outlet window 7 disposed at a more downstream position than the beam scanning apparatus 5a, 5b, and that transports the charged particle beam exiting from the accelerator 14 to the irradiation apparatus.

摘要翻译： 获得了粒径减小的粒子束治疗系统。 提供加速带电粒子束的加速器14; 具有用于利用带电粒子束进行扫描并将带电粒子束照射到照射对象上的光束扫描装置5a，5b的照射装置; 以及具有用于确保从加速器14延伸到设置在比光束扫描装置5a，5b的更下游位置处的光束出射窗口7的真空区域或气体区域的管道的光束传送装置15，并且传送带电 粒子束从加速器14离开到照射装置。

公开(公告)号：US08405042B2

公开(公告)日：2013-03-26

申请号：US12864002

申请日：2010-01-28

申请人： Taizo Honda ,  Hisashi Harada ,  Yuehu Pu ,  Yuichi Yamamoto ,  Takaaki Iwata

发明人： Taizo Honda ,  Hisashi Harada ,  Yuehu Pu ,  Yuichi Yamamoto ,  Takaaki Iwata

IPC分类号： G21K1/08

CPC分类号： A61N5/1042 ,  A61N5/1043 ,  A61N5/1048 ,  A61N2005/1087

摘要： The objective of the present invention is to reduce the effect of the hysteresis of a scanning electromagnet so as to obtain a particle beam therapy system that realizes high-accuracy beam irradiation. There are included an irradiation management apparatus (32) that controls the scanning electromagnet (3), based on target irradiation position coordinates (Pi) of a charged particle beam (1b), and a position monitor (7) that measures measurement position coordinates (Ps) of the charged particle beam (1b). The irradiation management apparatus (32) has a command value creator (25) that outputs a control input (Io (Ir)) to the scanning electromagnet (3), based on the target irradiation position coordinates (Pi) and correction data (Ia) created on the basis of the measurement position coordinates (Ps), measured by the position monitor (7) in the preliminary irradiation in which the excitation pattern of the scanning electromagnet is the same as that of the main irradiation plan, and the target irradiation position coordinates (Pi).

摘要翻译： 本发明的目的是减少扫描电磁体的滞后效果，以获得实现高精度光束照射的粒子束治疗系统。 包括基于带电粒子束（1b）的目标照射位置坐标（Pi）来控制扫描电磁体（3）的照射管理装置（32）和测量位置坐标（ Ps）的带电粒子束（1b）。 照射管理装置（32）具有基于目标照射位置坐标（Pi）和校正数据（Ia）向扫描电磁体（3）输出控制输入（Io（Ir））的指令值生成器（25） 基于由扫描电磁体的激励图案与主照射平面的激励图案相同的预备照射中的位置监视器（7）测量的测量位置坐标（Ps）和目标照射位置 坐标（Pi）。

公开(公告)号：US20130320245A1

公开(公告)日：2013-12-05

申请号：US13985759

申请日：2011-04-25

申请人： Yuehu Pu ,  Taizo Honda ,  Takaaki Iwata

发明人： Yuehu Pu ,  Taizo Honda ,  Takaaki Iwata

IPC分类号： A61N5/10

CPC分类号： A61N5/1048 ,  A61N5/1042 ,  A61N2005/1087 ,  A61N2005/1095 ,  G21K1/10

摘要： There is provided a particle-beam energy changing apparatus that is capable of changing energy of a particle beam quickly and silently, in which a first energy changing unit and a second energy changing unit for changing energy of a particle beam passing therethrough by varying thicknesses of their attenuators attenuating the particle beam energy are arranged so that the particle beam passes through the first energy changing unit and the second energy changing unit; and the maximum attenuation amount by the first energy changing unit is set smaller than the maximum attenuation amount by the second energy changing unit.

摘要翻译： 提供了一种能够快速且静默地改变粒子束能量的粒子束能量改变装置，其中第一能量改变单元和第二能量改变单元用于通过改变粒子束的厚度来改变通过其的粒子束的能量 其衰减粒子束能量的衰减器被布置成使得粒子束通过第一能量改变单元和第二能量改变单元; 并且第一能量改变单元的最大衰减量被设定为小于第二能量变化单元的最大衰减量。

公开(公告)号：US08809815B2

公开(公告)日：2014-08-19

申请号：US13985759

申请日：2011-04-25

申请人： Yuehu Pu ,  Taizo Honda ,  Takaaki Iwata

发明人： Yuehu Pu ,  Taizo Honda ,  Takaaki Iwata

IPC分类号： A61N5/10 ,  G21K1/10

CPC分类号： A61N5/1048 ,  A61N5/1042 ,  A61N2005/1087 ,  A61N2005/1095 ,  G21K1/10

摘要： There is provided a particle-beam energy changing apparatus that is capable of changing energy of a particle beam quickly and silently, in which a first energy changing unit and a second energy changing unit for changing energy of a particle beam passing therethrough by varying thicknesses of their attenuators attenuating the particle beam energy are arranged so that the particle beam passes through the first energy changing unit and the second energy changing unit; and the maximum attenuation amount by the first energy changing unit is set smaller than the maximum attenuation amount by the second energy changing unit.

摘要翻译： 提供了一种能够快速且静默地改变粒子束能量的粒子束能量改变装置，其中第一能量改变单元和第二能量改变单元用于通过改变粒子束的厚度来改变通过其的粒子束的能量 其衰减粒子束能量的衰减器被布置成使得粒子束通过第一能量改变单元和第二能量改变单元; 并且第一能量改变单元的最大衰减量被设定为小于第二能量变化单元的最大衰减量。

公开(公告)号：US20140228615A1

公开(公告)日：2014-08-14

申请号：US14240650

申请日：2011-11-03

申请人： Masahiro Ikeda ,  Hisashi Harada ,  Kazushi Hanakawa ,  Toshihiro Otani ,  Tadashi Katayose ,  Taizo Honda ,  Yukiko Yamada ,  Yuehu Pu

发明人： Masahiro Ikeda ,  Hisashi Harada ,  Kazushi Hanakawa ,  Toshihiro Otani ,  Tadashi Katayose ,  Taizo Honda ,  Yukiko Yamada ,  Yuehu Pu

IPC分类号： A61N5/10

CPC分类号： A61N5/1081 ,  A61N5/1077 ,  A61N2005/1087 ,  A61N2005/1095

摘要： A particle beam irradiation apparatus according to the present invention is provided with a vacuum duct that forms a vacuum region through which the charged particle beam passes, a vacuum window through which the charged particle beam is launched from the vacuum region, a scanning electromagnet that scans the charged particle beam; a monitoring apparatus including a position monitor that detects the passing position of a charged particle beam and the beam size thereof, a low-scattering gas filling chamber including the monitoring apparatus, and an irradiation management apparatus that controls irradiation of the charged particle beam; the particle beam irradiation apparatus is characterized in that the low-scattering gas filling chamber is changeably disposed in such a manner that the beam-axis-direction positional relationship between the monitoring apparatus and the vacuum window is a desired one and in that the low-scattering gas filling chamber is filled with a low-scattering gas.

摘要翻译： 根据本发明的粒子束照射装置设置有真空管道，该真空管道形成带电粒子束通过的真空区域，从真空区域发射带电粒子束的真空窗口，扫描的扫描电磁体 带电粒子束; 监视装置，其包括检测带电粒子束的通过位置的位置监视器及其光束尺寸，包括监视装置的低散射气体填充室以及控制带电粒子束的照射的照射管理装置; 所述粒子束照射装置的特征在于，所述低散射气体充填室可变地设置成使得所述监视装置和所述真空窗口之间的射束轴向位置关系是期望的， 散射气体填充室填充有低散射气体。

公开(公告)号：US20140187847A1

公开(公告)日：2014-07-03

申请号：US14240197

申请日：2011-11-02

申请人： Masahiro Ikeda ,  Hisashi Harada ,  Kazushi Hanakawa ,  Toshihiro Otani ,  Tadashi Katayose ,  Taizo Honda ,  Yukiko Yamada ,  Yuehu Pu

发明人： Masahiro Ikeda ,  Hisashi Harada ,  Kazushi Hanakawa ,  Toshihiro Otani ,  Tadashi Katayose ,  Taizo Honda ,  Yukiko Yamada ,  Yuehu Pu

IPC分类号： A61N5/10

CPC分类号： A61N5/1077 ,  A61N5/1049 ,  A61N5/1069 ,  A61N2005/1087

摘要： A particle beam therapy system comprising a treatment table, a treatment table control unit and an irradiation control unit configured to output an instruction for controlling the treatment table control unit, an accelerator and a scanning electromagnet, wherein after the treatment table control unit controls the treatment table so as for a patient isocenter which is reference position of an affected area of a patient to move to a position of an irradiation isocenter which is set at a position which is closer to an irradiation nozzle than an equipment isocenter which is reference of positional relation of the irradiation nozzle and the treatment table, the irradiation control unit outputs an instruction for irradiating the patient with a particle beam.

摘要翻译： 一种粒子束治疗系统，包括治疗台，治疗台控制单元和照射控制单元，其被配置为输出用于控制治疗台控制单元的指令，加速器和扫描电磁体，其中在治疗台控制单元控制治疗 将患者的中心位置作为患者的受影响区域的基准位置移动到被设定在比作为位置关系的参照的设备等角点更靠近照射喷嘴的位置的照射等角点的位置 的照射喷嘴和处理台，照射控制单元输出用于对粒子束照射患者的指示。