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公开(公告)号：US07807382B2
公开(公告)日：2010-10-05
申请号：US12062630
申请日：2008-04-04
IPC分类号： G01N33/567 , G01N33/53
CPC分类号： C07K16/2851 , A61K47/6803 , A61K47/6849 , A61K2039/505 , C07K2317/14 , C07K2317/24 , C07K2317/56 , C07K2317/76 , C07K2319/30
摘要： The invention provides methods for inhibiting the interaction of endosialin with endosialin ligands. The inhibition is effectuated on the genetic level, by inhibiting endosialin gene expression, and on the protein level, by blocking the interaction of cell-surface expressed endosialin with ligands such as fibronectin and collagen. The invention provides methods for identifying inhibitors of the interaction of endosialin with endosialin ligands. Also provided are methods for inhibiting angiogenesis and neovascularization in vivo and in vitro.
摘要翻译： 本发明提供了抑制内皮素与内皮素配体相互作用的方法。 通过抑制内皮素基因表达和蛋白质水平，通过阻断细胞表面表达的内皮唾液酸与诸如纤连蛋白和胶原的配体的相互作用来实现抑制。 本发明提供鉴定抑制剂的方法，所述抑制剂与内皮素配体相关。 还提供了用于在体内和体外抑制血管生成和新生血管形成的方法。
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公开(公告)号：US08895000B2
公开(公告)日：2014-11-25
申请号：US12873667
申请日：2010-09-01
IPC分类号： A61K39/00 , A61K39/395 , C07K16/28
CPC分类号： C07K16/2851 , A61K47/6803 , A61K47/6849 , A61K2039/505 , C07K2317/14 , C07K2317/24 , C07K2317/56 , C07K2317/76 , C07K2319/30
摘要： The invention provides methods for inhibiting the interaction of endosialin with endosialin ligands. The inhibition is effectuated on the genetic level, by inhibiting endosialin gene expression, and on the protein level, by blocking the interaction of cell-surface expressed endosialin with ligands such as fibronectin and collagen. The invention provides methods for identifying inhibitors of the interaction of endosialin with endosialin ligands. Also provided are methods for inhibiting angiogenesis and neovascularization in vivo and in vitro.
摘要翻译： 本发明提供了抑制内皮素与内皮素配体相互作用的方法。 通过抑制内皮素基因表达和蛋白质水平，通过阻断细胞表面表达的内皮唾液酸与诸如纤连蛋白和胶原的配体的相互作用来实现抑制。 本发明提供鉴定抑制剂的方法，所述抑制剂与内皮素配体相关。 还提供了用于在体内和体外抑制血管生成和新生血管形成的方法。
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公开(公告)号：US20080248034A1
公开(公告)日：2008-10-09
申请号：US12062630
申请日：2008-04-04
IPC分类号： A61K39/395 , G01N33/50
CPC分类号： C07K16/2851 , A61K47/6803 , A61K47/6849 , A61K2039/505 , C07K2317/14 , C07K2317/24 , C07K2317/56 , C07K2317/76 , C07K2319/30
摘要： The invention provides methods for inhibiting the interaction of endosialin with endosialin ligands. The inhibition is effectuated on the genetic level, by inhibiting endosialin gene expression, and on the protein level, by blocking the interaction of cell-surface expressed endosialin with ligands such as fibronectin and collagen. The invention provides methods for identifying inhibitors of the interaction of endosialin with endosialin ligands. Also provided are methods for inhibiting angiogenesis and neovascularization in vivo and in vitro.
摘要翻译： 本发明提供了抑制内皮素与内皮素配体相互作用的方法。 通过抑制内皮素基因表达和蛋白质水平，通过阻断细胞表面表达的内皮唾液酸与诸如纤连蛋白和胶原的配体的相互作用来实现抑制。 本发明提供鉴定抑制剂的方法，所述抑制剂与内皮素配体相关。 还提供了用于在体内和体外抑制血管生成和新生血管形成的方法。
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公开(公告)号：US20110033455A1
公开(公告)日：2011-02-10
申请号：US12873667
申请日：2010-09-01
IPC分类号： A61K39/395 , C12N5/071 , A61P35/00
CPC分类号： C07K16/2851 , A61K47/6803 , A61K47/6849 , A61K2039/505 , C07K2317/14 , C07K2317/24 , C07K2317/56 , C07K2317/76 , C07K2319/30
摘要： The invention provides methods for inhibiting the interaction of endosialin with endosialin ligands. The inhibition is effectuated on the genetic level, by inhibiting endosialin gene expression, and on the protein level, by blocking the interaction of cell-surface expressed endosialin with ligands such as fibronectin and collagen. The invention provides methods for identifying inhibitors of the interaction of endosialin with endosialin ligands. Also provided are methods for inhibiting angiogenesis and neovascularization in vivo and in vitro.
摘要翻译： 本发明提供了抑制内皮素与内皮素配体相互作用的方法。 通过抑制内皮素基因表达和蛋白质水平，通过阻断细胞表面表达的内皮唾液酸与诸如纤连蛋白和胶原的配体的相互作用来实现抑制。 本发明提供鉴定抑制剂的方法，所述抑制剂与内皮素配体相关。 还提供了用于在体内和体外抑制血管生成和新生血管形成的方法。
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公开(公告)号：US08278065B2
公开(公告)日：2012-10-02
申请号：US12494631
申请日：2009-06-30
CPC分类号： C07K16/3084 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： Described herein are antibodies that specifically bind ganglioside GD2. Also described are nucleotides encoding such antibodies, cells expressing such antibodies, methods of use for such antibodies, and methods for using the antibodies to treat diseases associated with ganglioside GD2. In addition, tissue culture media supplements are described as are methods of use for the supplements. Described herein are albumin-ganglioside conjugates and corresponding methods for producing such conjugates. Methods of purifying or isolating antibodies are also described.
摘要翻译： 本文描述了特异性结合神经节苷脂GD2的抗体。 还描述了编码这种抗体的核苷酸，表达这种抗体的细胞，这种抗体的使用方法，以及使用该抗体治疗与神经节苷脂GD2相关的疾病的方法。 此外，组织培养基补充剂被描述为补充剂的使用方法。 本文描述的是白蛋白 - 神经节苷脂缀合物和用于产生这种缀合物的相应方法。 还描述了纯化或分离抗体的方法。
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公开(公告)号：US20100008851A1
公开(公告)日：2010-01-14
申请号：US12494631
申请日：2009-06-30
申请人： Nicholas C. Nicolaides , Philip M. Sass , Luigi Grasso , Wolfgang Ebel , Yuhong Zhou , Xun Zuo , Eric Routhier , Jun Yao
发明人： Nicholas C. Nicolaides , Philip M. Sass , Luigi Grasso , Wolfgang Ebel , Yuhong Zhou , Xun Zuo , Eric Routhier , Jun Yao
IPC分类号： A61K51/00 , C07K16/18 , C12N15/11 , A61K39/395 , C12N15/00 , C12N1/21 , C12N5/06 , C12P21/02 , A61K49/00
CPC分类号： C07K16/3084 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： Described herein are antibodies that specifically bind ganglioside GD2. Also described are nucleotides encoding such antibodies, cells expressing such antibodies, methods of use for such antibodies, and methods for using the antibodies to treat diseases associated with ganglioside GD2. In addition, tissue culture media supplements are described as are methods of use for the supplements. Described herein are albumin-ganglioside conjugates and corresponding methods for producing such conjugates. Methods of purifying or isolating antibodies are also described.
摘要翻译： 本文描述了特异性结合神经节苷脂GD2的抗体。 还描述了编码这种抗体的核苷酸，表达这种抗体的细胞，这种抗体的使用方法，以及使用该抗体治疗与神经节苷脂GD2相关的疾病的方法。 此外，组织培养基补充剂被描述为补充剂的使用方法。 本文描述的是白蛋白 - 神经节苷脂缀合物和用于产生这种缀合物的相应方法。 还描述了纯化或分离抗体的方法。
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公开(公告)号：US20130305396A1
公开(公告)日：2013-11-14
申请号：US13876232
申请日：2011-09-28
申请人： Luigi Grasso , Jian Min Lin , Yuhong Zhou , Brian E. Tomkowicz , Nicholas C. Nicolaides , Philip M. Sass
发明人： Luigi Grasso , Jian Min Lin , Yuhong Zhou , Brian E. Tomkowicz , Nicholas C. Nicolaides , Philip M. Sass
IPC分类号： A61K49/00
CPC分类号： A61K49/0008 , A01K67/0278 , A01K2217/072 , A01K2227/105 , A01K2267/0331 , A01K2267/0368 , A01K2267/0375 , C07K14/7056 , C07K14/70596 , G01N33/5088
摘要： Provided herein are rodents that express the human endosialin gene. In preferred embodiments, the rodent is a mouse. Preferably, the human endosialin gene is integrated into the native or endogenous endosialin gene locus. More preferably, the host rodent is null for the endogenous endosialin gene product. The human endosialin gene is preferably expressed in a similar development and disease response pattern as that of the native endosialin gene product in parental or wild type rodents. This feature makes these rodents useful for studying the effects of test agents to positively or negatively affect endosialin biology for therapeutic use. Use of human endosialin expressing rodents lacking native endosialin gene product (HUE rodents) is proposed as a strategy for developing agents that can positively or negatively affect the endosialin pathway and also serve as a screening tool to identify those agents that may be useful as human therapies.
摘要翻译： 本文提供表达人内皮唾液酸基因的啮齿动物。 在优选的实施方案中，啮齿动物是小鼠。 优选地，人内皮唾液酸蛋白基因整合到天然或内源性内唾液酸基因座。 更优选地，宿主啮齿动物对于内源性内唾液酸基因产物是无效的。 人内皮唾液酸蛋白基因优选以与亲本或野生型啮齿动物中的天然唾液酸内切酶基因产物相似的发育和疾病应答模式表达。 该特征使得这些啮齿动物可用于研究试验剂对用于治疗用途的唾液酸生物学的正面或负面影响的影响。 提出缺乏天然唾液酸内切酶基因产物（HUE啮齿类动物）的人类内皮糖蛋白表达啮齿动物的使用作为可以对内皮唾液酸途径有正面或负面影响的发育剂的策略，也可作为鉴定可用作人类治疗的药物的筛选工具 。
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公开(公告)号：US08507657B2
公开(公告)日：2013-08-13
申请号：US13593057
申请日：2012-08-23
CPC分类号： C07K16/3084 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： Described herein are antibodies that specifically bind ganglioside GD2. Also described are nucleotides encoding such antibodies, cells expressing such antibodies, methods of use for such antibodies, and methods for using the antibodies to treat diseases associated with ganglioside GD2. In addition, tissue culture media supplements are described as are methods of use for the supplements. Described herein are albumin-ganglioside conjugates and corresponding methods for producing such conjugates. Methods of purifying or isolating antibodies are also described.
摘要翻译： 本文描述了特异性结合神经节苷脂GD2的抗体。 还描述了编码这种抗体的核苷酸，表达这种抗体的细胞，这种抗体的使用方法，以及使用该抗体治疗与神经节苷脂GD2相关的疾病的方法。 此外，组织培养基补充剂被描述为补充剂的使用方法。 本文描述的是白蛋白 - 神经节苷脂缀合物和用于产生这种缀合物的相应方法。 还描述了纯化或分离抗体的方法。
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公开(公告)号：US20120328524A1
公开(公告)日：2012-12-27
申请号：US13593057
申请日：2012-08-23
CPC分类号： C07K16/3084 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： Described herein are antibodies that specifically bind ganglioside GD2. Also described are nucleotides encoding such antibodies, cells expressing such antibodies, methods of use for such antibodies, and methods for using the antibodies to treat diseases associated with ganglioside GD2. In addition, tissue culture media supplements are described as are methods of use for the supplements. Described herein are albumin-ganglioside conjugates and corresponding methods for producing such conjugates. Methods of purifying or isolating antibodies are also described.
摘要翻译： 本文描述了特异性结合神经节苷脂GD2的抗体。 还描述了编码这种抗体的核苷酸，表达这种抗体的细胞，这种抗体的使用方法，以及使用该抗体治疗与神经节苷脂GD2相关的疾病的方法。 此外，组织培养基补充剂被描述为补充剂的使用方法。 本文描述的是白蛋白 - 神经节苷脂缀合物和用于产生这种缀合物的相应方法。 还描述了纯化或分离抗体的方法。
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公开(公告)号：US08481703B2
公开(公告)日：2013-07-09
申请号：US13476656
申请日：2012-05-21
IPC分类号： C07H21/02
CPC分类号： C07K16/28 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/30 , C07K16/3069 , C07K2317/56 , C07K2317/732 , C07K2317/77
摘要： This invention relates to the use of monoclonal and polyclonal antibodies that specifically bind to and become internalized by mesothelin-positive cells and also induce an immune effector activity such as antibody dependent cellular cytotoxicity. The antibodies are useful in specific delivery of pharmacologic agents to mesothelin expressing cells as well as eliciting an immune-effector activity particularly on tumor cells and precursors. The invention is also related to cells expressing the monoclonal antibodies, polyclonal antibodies, antibody derivatives, such as human, humanized, and chimeric monoclonal antibodies, antibody fragments, mammalian cells expressing the monoclonal antibodies, derivatives and fragments, and methods of treating cancer using the antibodies, derivatives and fragments.
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