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公开(公告)号：US20070049787A1
公开(公告)日：2007-03-01
申请号：US11527097
申请日：2006-09-25
IPC分类号： A61N1/362
CPC分类号： A61B17/3421 , A61B2017/00243 , A61M1/1008 , A61M1/12 , A61M1/122 , A61M1/3659
摘要： The present invention provides an inflow cannula tip that is shaped to prevent suction with the ventricular wall and adapted to prevent platelet adhesion. In particular, the inlet portion of the cannula tip comprises two projections extending from the cylindrical body of the cannula tip with gaps between the projections. The projections may have beveled edges. The inlet portion of the cannula tip can accept blood flow from either the gaps in the side or from the bottom of the tip. Even if the edge of the cannula tip is close to or even touching ventricle wall, a suction condition will not result, as blood is allowed to flow through the gaps between the projections.
摘要翻译： 本发明提供一种流入套管末端，其形状适于防止与心室壁的吸引并适于防止血小板粘附。 特别地，套管尖端的入口部分包括从插管尖端的圆柱体延伸的两个突起，其中突出部之间具有间隙。 突起可以具有斜边。 套管尖端的入口部分可接受来自尖端的侧面或底部的间隙的血液流动。 即使插管尖端的边缘接近或甚至接触心室壁，由于允许血液流过突起之间的间隙，因此不会产生抽吸条件。
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公开(公告)号：US07156873B2
公开(公告)日：2007-01-02
申请号：US10655486
申请日：2003-09-03
CPC分类号： A61M1/122 , A61M1/101 , A61M1/1086 , A61M1/12
摘要： The present invention provides methods for detecting an abnormal condition of a blood pump system based on the power consumption of the pump actuator. By plotting differentiated power consumption of the pump actuator over time against the power consumption, a plot pattern is obtained. A change of the plot pattern area and/or a movement of the plot pattern will indicate a change in condition of the pump. A Heart Pump Area (HPA) index may be established which corresponds to the changing area of the plot pattern over time. A Heart Pump Position (HPP) index may be established which corresponds to the changing position of the plot pattern over time (e.g., corresponding to the distance the plot pattern has moved). By plotting the HPA index against the HPP index, changes in the condition of the pump can be monitored and any abnormal condition of the pump can be detected.
摘要翻译： 本发明提供了基于泵致动器的功率消耗来检测血液泵系统的异常状况的方法。 通过绘制泵致动器的不同功耗随着时间的推移消耗功率，可获得绘图模式。 曲线图区域的变化和/或曲线图的移动将指示泵状态的变化。 可以建立心脏泵面积（HPA）指数，其对应于随时间变化的情节区域的变化。 可以建立心泵位置（HPP）索引，其对应于随时间变化的情节图案的位置（例如，对应于绘图模式移动的距离）。 通过绘制HPA指数与HPP指数的关系，可以监测泵状态的变化，并检测出泵的任何异常情况。
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3.发明申请CRYOAGGREGATE FILTRATION FOR THE TREATMENT OF CARDIOMYOPATHY AND OTHER AUTOIMMUNE DISEASES 审中-公开用于治疗心脏病和其他自身免疫性疾病的血液滤过公开(公告)号：US20110197628A1
公开(公告)日：2011-08-18
申请号：US12864290
申请日：2009-01-26
IPC分类号： B01D9/02
CPC分类号： A61M1/3472 , A61M1/3482
摘要： Various embodiments of the present invention disclose processes and systems for the off-line in-vitro purification of plasma harvested from a patient. In an embodiment of a process, in a first step cellular components are capable of being eliminated by membrane plasma separation at temperatures sufficiently high to avoid formation of a cryoaggregates, and in a second step the resulting plasma solution is cooled to a temperature that allows the formation of cryoaggragated molecules, but no formation of a cryogel.
摘要翻译： 本发明的各种实施方案公开了从患者收获的血浆的离线体外纯化的方法和系统。 在方法的一个实施方案中，在第一步中，细胞组分能够通过在足够高的温度下通过膜血浆分离来消除，以避免形成低聚集体，并且在第二步骤中，将得到的血浆溶液冷却至允许 形成冷冻分子，但没有形成冷冻凝胶。
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4.发明授权公开(公告)号：US07284956B2
公开(公告)日：2007-10-23
申请号：US10291191
申请日：2002-11-08
IPC分类号： A61M1/12
CPC分类号： F04B49/06 , A61M1/101 , A61M1/1013 , A61M1/1086 , A61M1/122 , A61M1/127 , A61M2205/3334 , F04D15/0066 , Y10S415/90 , Y10S417/90
摘要： A control system for a continuous flow rotary blood pump is provided. A normal operating range of the blood pump is established. The normal operating range may comprise a normal pump flow range and a normal pressure head range. A target rotational speed of the pump is set in accordance with the normal operating range. A current operating condition of the blood pump is determined. The current operating condition may comprise a current pump flow, a current pressure head, and a current rotational speed of the pump. The current operating condition is compared with the normal operating range. An appropriate control algorithm is selected from a plurality of available control algorithms based on the comparison. The target rotational speed of the pump is adjusted using the selected control algorithm to maintain or recover the normal operating range.
摘要翻译： 提供了一种用于连续流动旋转血泵的控制系统。 建立血液泵的正常工作范围。 正常工作范围可以包括正常的泵流量范围和正常的压力范围。 泵的目标转速根据正常工作范围设定。 确定血液泵的当前运行状态。 当前的操作条件可以包括当前泵流量，当前压力头和泵的当前转速。 将当前运行状态与正常工作范围进行比较。 基于该比较，从多个可用的控制算法中选择适当的控制算法。 使用所选择的控制算法调整泵的目标转速，以维持或恢复正常工作范围。
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公开(公告)号：US06884210B2
公开(公告)日：2005-04-26
申请号：US10171094
申请日：2002-06-12
CPC分类号： A61M1/1017 , A61M1/101 , A61M1/1013 , A61M1/1036 , A61M1/122
摘要： It is an object of the present invention to realize a small and light blood pump that can control thrombosis and moreover, endure a prolonged use.A blood pump comprising an impeller, a casing having a suction inlet and a delivery outlet and rotatably encasing the impeller, a magnetic drive means for rotating the impeller by magnetically acting from outside of the casing on a magnet that the impeller includes, a magnetic attraction force adjustment means for adjusting the attraction force by said magnetic action, a control means for rotating speed of said magnetic drive means, and a pair of pivot bearings for supporting pivots at both ends of the impeller rotation shaft, wherein the distance between bearing faces of said both pivot bearings is set longer than the length of the rotation shaft of the impeller and the rotation speed of the impeller is controlled to a predetermined speed by said control means for rotating speed so as to levitate the impeller in the blood flow in the casing and to maintain out of contact between the pivots at both ends of the rotation shaft of the impeller and the bearing face of said both pivot bearing.
摘要翻译： 本发明的目的是实现能够控制血栓形成的小而轻的血液泵，并且延长使用寿命。 一种血泵，包括叶轮，具有吸入口和输出出口并且可旋转地包围叶轮的壳体;磁驱动装置，用于通过从壳体外部的磁力作用将叶轮旋转到叶轮包括的磁体上，磁吸引力 用于通过所述磁作用调节吸引力的力调节装置，用于使所述磁驱动装置转速的控制装置和用于在所述叶轮旋转轴的两端支撑枢轴的一对枢转轴承，其中， 所述两个枢转轴承设定得比叶轮的旋转轴的长度长，并且通过所述控制装置将叶轮的旋转速度控制到预定的速度，以使得在壳体中的血流中的叶轮悬浮 并且保持在叶轮的旋转轴的两端的枢轴与所述两个枢转轴的轴承面之间的接触 ng。
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公开(公告)号：US06817836B2
公开(公告)日：2004-11-16
申请号：US10241825
申请日：2002-09-10
IPC分类号： F04B4906
CPC分类号： F04B49/06 , A61M1/101 , A61M1/1036 , A61M1/1086 , A61M1/122 , A61M2205/3334 , F04D15/0066 , Y10S415/90
摘要： A control system for a continuous flow rotary blood pump is provided. A normal operating range of the blood pump is established. The normal operating range may comprise a normal pump flow range and a normal pressure head range. A target rotational speed of the pump is set in accordance with the normal operating range. A current operating condition of the blood pump is determined. The current operating condition may comprise a current pump flow, a current pressure head, and a current rotational speed of the pump. The current operating condition is compared with the normal operating range. An appropriate control algorithm is selected from a plurality of available control algorithms based on the comparison. The target rotational speed of the pump is adjusted using the selected control algorithm to maintain or recover the normal operating range.
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公开(公告)号：US5683231A
公开(公告)日：1997-11-04
申请号：US675014
申请日：1996-07-03
CPC分类号： A61M1/101 , A61M1/1036 , F04D13/026 , F04D13/027 , Y10S415/90
摘要： A blood pump used for heart-lung machines comprising an impeller, a casing having a suction inlet and a delivery outlet and rotatably encasing the impeller, a magnetic driver disposed outside the casing, and a magnetic attraction force adjuster. The impeller has a rotationally symmetric shape, such as a conical shape, is equipped with vanes having a pumping function on the side surface thereof and is also equipped with magnets, such as permanent magnets. The magnetic driver for rotating the impeller in cooperation with the magnets comprises a magnet assembly magnetically connected to the magnets and a rotation driver for rotating the magnet assembly. The magnetic attraction force adjuster adjusts the magnetic attraction force generated between the magnets and the magnet assembly by adjusting the gap between the magnets and the magnet assembly or by adjusting the exciting current of electromagnets when electromagnets are used for the magnet assembly. One of the pivot and pivot bearing for supporting the rotation shaft of the impeller is made of ceramics and the other is made of synthetic resin.
摘要翻译： 一种用于心肺机器的血泵，包括叶轮，具有吸入口和输出出口的壳体，并且可旋转地包围叶轮，设置在壳体外部的磁性驱动器和磁吸引力调节器。 叶轮具有诸如圆锥形的旋转对称形状，在其侧表面上装备有具有泵送功能的叶片，并且还配备有诸如永磁体的磁体。 用于与磁体协作旋转叶轮的磁驱动器包括磁力连接到磁体的磁体组件和用于旋转磁体组件的旋转驱动器。 磁力吸引力调节器通过调节磁体和磁体组件之间的间隙，或者当电磁铁用于磁体组件时，通过调节电磁体的励磁电流来调节磁体和磁体组件之间产生的磁吸引力。 用于支撑叶轮的旋转轴的枢轴和枢转轴承之一由陶瓷制成，另一个由合成树脂制成。
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公开(公告)号：US4402940A
公开(公告)日：1983-09-06
申请号：US418551
申请日：1982-09-17
申请人： Yukihiko Nose , Koji Kayashima , Akinori Sueoka , Yoshihiro Asanuma , Shigeru Shinagawa , James Smith , Andrej Werynski , Paul S. Malchesky
发明人： Yukihiko Nose , Koji Kayashima , Akinori Sueoka , Yoshihiro Asanuma , Shigeru Shinagawa , James Smith , Andrej Werynski , Paul S. Malchesky
CPC分类号： B01D69/08 , A61K35/16 , A61M1/3472 , A61M1/3482 , B01D69/02
摘要： This invention provides a method for treating blood plasma wherein a hollow fiber membrane which comprises at least a skin layer on one surface of the membrane and also a porous layer inside the membrane is employed. The skin layer of the membrane has micropores with average pore size of 50 to 450 A, and the membrane shows a water permeability of 80 ml/m.sup.2.hr.mmHg or more, and permeabilites for human blood plasma albumin of 85% or more and for human blood plasma immunoglobulin G(IgG) of 80% or more, and a rate of inhibition against human blood plasma immunoglobulin M(IgM) of 40% or more. Use of the above mentioned hollow fiber membrane, which makes it possible to selectively remove immune complex, rheumatoid factors, etc., without decrease in levels of immunological functions, brings excellent effects on therapy of autoimmune diseases.
摘要翻译： 本发明提供了一种治疗血浆的方法，其中采用在膜的一个表面上至少包含皮肤层以及膜内的多孔层的中空纤维膜。 膜的表层具有平均孔径为50〜450A的微孔，膜的透水性为80ml / m 2·hr·mmHg以上，透血性为85％以上的人血浆白蛋白， 对于80％以上的人血浆免疫球蛋白G（IgG），对人血浆免疫球蛋白M（IgM）的抑制率为40％以上。 使用上述中空纤维膜，这使得可以选择性地除去免疫复合物，类风湿因子等而不降低免疫功能水平，对自身免疫性疾病的治疗带来极好的效果。
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公开(公告)号：US4966709A
公开(公告)日：1990-10-30
申请号：US220919
申请日：1988-07-18
CPC分类号： A61M1/369 , A61M1/3472 , A61M1/3482 , B01D61/14 , B01D2313/22 , Y10S210/905 , Y10S210/908
摘要： A method for more selectively removing macromolecules from a plasma solution, whereby plasma containing the macromolecules to be removed is provided and heated to a temperature near or above normal body temperature but below the boiling point of the plasma solution. The heated plasma solution is filtered while at a temperature near or above normal body temperature but below its boiling point with a membrane filter to remove selectively macromolecules from the plasma solution. An apparatus for accomplishing the foregoing is also provided.
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10.发明授权Method and apparatus for on-line filtration removal of macromolecules from a physiological fluid 失效在线过滤从生理液体中除去大分子的方法和装置
公开(公告)号：US4350156A
公开(公告)日：1982-09-21
申请号：US154581
申请日：1980-05-29
申请人： Paul S. Malchesky , Yukihiko Nose
发明人： Paul S. Malchesky , Yukihiko Nose
IPC分类号： C07K1/14 , A61K35/14 , A61K38/16 , A61K39/00 , A61M1/34 , B01D61/16 , B01D61/20 , B01D61/22 , B01D61/58 , C07K14/76 , A61M5/00
CPC分类号： A61M1/3472 , A61M1/3482
摘要： An on-line filtration system for the removal of macromolecules greater than 70,000 mol. wt. from a physiological solution, such as blood, in the therapeutic treatment of various disease states. For blood, the plasma (which contains the macromolecules) is separated continuously from the blood using a first membrane filter with a membrane porosity of nominally 0.2 to 1.0 micron. The separated plasma is then continuously filtered in a physiological temperature state or a cooled state through a second membrane filter with a membrane porosity of nominally 0.01 to 0.2 micron, which retains the macromolecules. In the cooled state, separation of the macromolecules is effected more efficiently than could be done in the non-cooled state. The treated plasma (macromolecules removed) is then reunited with the blood flow coming from the first plasma filter and returned to the patient. The blood flow and filtration processes are generally continuous. Suitable agent(s) may be added to the separated plasma to promote formation of macromolecules.
摘要翻译： 用于去除大分子大于70,000mol的在线过滤系统。 重量 从生理解决方案，如血液，治疗各种疾病状态。 对于血液，使用膜孔隙率为0.2至1.0微米的第一膜过滤器，将血浆（其含有大分子）从血液连续分离。 然后将分离的等离子体在生理温度状态或冷却状态下通过具有标称为0.01至0.2微米的膜孔隙率的第二膜过滤器连续过滤，其保留大分子。 在冷却状态下，与非冷却状态相比，大分子的分离更有效。 然后将经处理的血浆（去除的大分子）与来自第一等离子体过滤器的血流重新团聚并返回给患者。 血流和过滤过程通常是连续的。 可以将合适的试剂加入到分离的等离子体中以促进大分子的形成。
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