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1.
公开(公告)号:US5221757A
公开(公告)日:1993-06-22
申请号:US794980
申请日:1991-11-20
申请人: Yukihiro Ohashi , Mituo Suda , Shinji Yano , Akira Kawamata , Minehiro Okuda , Genji Imokawa
发明人: Yukihiro Ohashi , Mituo Suda , Shinji Yano , Akira Kawamata , Minehiro Okuda , Genji Imokawa
IPC分类号: A61K8/68 , A61Q19/00 , C07C233/18 , C07C235/08
CPC分类号: A61Q19/00 , A61K8/68 , C07C233/18 , C07C235/08
摘要: An amide derivative represented by the following general formula (II): ##STR1## (wherein R.sup.3 represents a straight-chain or branched, saturated or unsaturated hydrocarbon group carrying 10 to 40 carbon atoms; R.sup.4 represents a straight-chain or branched hydrocarbon group carrying 3 to 39 carbon atoms; and R.sup.5 represents a hydrogen atom, a straight-chain or branched, saturated or unsaturated hydrocarbon group carrying 10 to 40 carbon atoms or an acyl group); and a dermatologic preparation containing the same.
摘要翻译: 由以下通式(II)表示的酰胺衍生物:其中R 3表示直链或支链,饱和或不饱和的含有10〜40个碳原子的烃基; R4表示直链或支链的 含有3〜39个碳原子的烃基; R5表示氢原子,含有10〜40个碳原子的直链或支链,饱和或不饱和烃基或酰基)。 和含有其的皮肤病学制剂。
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2.
公开(公告)号:US5175321A
公开(公告)日:1992-12-29
申请号:US524864
申请日:1990-05-18
申请人: Yukihiro Ohashi , Mituo Suda , Shinji Yano , Akira Kawamata , Minehiro Okuda , Genji Imokawa
发明人: Yukihiro Ohashi , Mituo Suda , Shinji Yano , Akira Kawamata , Minehiro Okuda , Genji Imokawa
IPC分类号: A61K8/68 , A61Q19/00 , C07C233/18 , C07C235/08
CPC分类号: C07C233/18 , A61K8/68 , A61Q19/00 , C07C235/08 , Y10S514/844 , Y10S514/886
摘要: An amide derivative represented by the following general formula (I) or (II): ##STR1## (wherein R.sup.1 and R.sup.2 represent each a straight-chain or branched, saturated or unsaturated hydrocarbon group provided that one of them carries 26 to 39 carbon atoms while the other carries 9 to 39 carbon atoms); or ##STR2## (wherein R.sup.3 represents a straight-chain or branched, saturated or unsaturated hydrocarbon group carrying 10 to 40 carbon atoms; R.sup.4 represents a straight-chain or branched hydrocarbon group carrying 3 to 39 carbon atoms; and R.sup.5 represents a dydrogen atom, a straight-chain or branched, saturated or unsaturated hydrocarbon group carrying 10 to 40 carbon atoms or an acyl group);and a dermatologic preparation containing the same.
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3.
公开(公告)号:US5801258A
公开(公告)日:1998-09-01
申请号:US841788
申请日:1997-05-05
申请人: Yukihiro Ohashi , Akira Kawamata , Yukihiro Yada , Kazuhiko Higuchi , Kazue Tsukahara , Genji Imokawa
发明人: Yukihiro Ohashi , Akira Kawamata , Yukihiro Yada , Kazuhiko Higuchi , Kazue Tsukahara , Genji Imokawa
IPC分类号: A61K8/68 , A61Q19/00 , C07D317/24 , C07D317/30 , C07D317/18 , C07D317/28
CPC分类号: C07D317/30 , A61K8/68 , A61Q19/00 , C07D317/24
摘要: The amide derivative of the present invention is one represented by the following general formula (I) and the dermatologic preparation of the present invention is one containing said amide derivative. ##STR1## wherein R.sup.1 represents a straight-chain or branched, saturated or unsaturated hydrocarbon group carrying 10 to 40 carbon atoms; R.sup.2 represents a straight-chain or branched, saturated or unsaturated hydrocarbon group carrying 3 to 39 carbon atoms; R.sup.3 represents a group containing at least one group represented by the formula: ##STR2## wherein R.sup.4 and R.sup.5 each represents a hydrogen atom or a straight-chain or branched or cyclic, saturated or unsaturated hydrocarbon group, or R.sup.4 and R.sup.5 may form a hydrocarbon group together; and X represents ##STR3##
摘要翻译: 本发明的酰胺衍生物是由以下通式(I)表示的酰胺衍生物,本发明的皮肤病学制剂是含有含有10〜40个碳原子的酰胺衍生物 - 链或支链,饱和或不饱和烃基的化合物。 R2表示带有3至39个碳原子的直链或支链,饱和或不饱和的烃基; R3表示含有至少一个由下式表示的基团:其中R 4和R 5各自表示氢原子或直链或支链或环状,饱和或不饱和的烃基,或者R 4和R 5可以形成烃 团结在一起 而X代表
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4.
公开(公告)号:US5659052A
公开(公告)日:1997-08-19
申请号:US256344
申请日:1994-07-13
申请人: Yukihiro Ohashi , Akira Kawamata , Yukihiro Yada , Kazuhiko Higuchi , Kazue Tsukahara , Genji Imokawa
发明人: Yukihiro Ohashi , Akira Kawamata , Yukihiro Yada , Kazuhiko Higuchi , Kazue Tsukahara , Genji Imokawa
IPC分类号: A61K8/68 , A61Q19/00 , C07D317/24 , C07D317/30 , C07D317/18 , C07D317/28
CPC分类号: C07D317/30 , A61K8/68 , A61Q19/00 , C07D317/24
摘要: The amide derivative of the present invention is one represented by the following general formula (II) and the dermatologic preparation of the present invention is one containing said amide derivative. ##STR1## wherein R.sup.11 represents a straight-chain or branched hydrocarbon group carrying 10 to 40 carbon atoms; R.sup.12 represents a straight-chain or branched hydrocarbon group carrying 1 to 39 carbon atoms; R.sup.13 represents a hydrogen atom or a hydrocarbon group carrying 1 to 6 carbon atoms; and R.sup.14 represents a hydrogen atom or a hydrocarbon group having a straight-chain, branched or cyclic structure and carrying 1 to 40 carbon atoms which may contain an oxygen atom.
摘要翻译: PCT No.PCT / JP93 / 01676 Sec。 371日期:1994年7月13日 102(e)日期1994年7月13日PCT 1993年11月16日PCT公布。 公开号WO94 / 12490 日期1994年6月9日本发明的酰胺衍生物为下述通式(II)所示的酰胺衍生物,本发明的皮肤病学制剂为含有所述酰胺衍生物的皮肤病学制剂。 (II)其中R11表示含有10〜40个碳原子的直链或支链烃基; R12表示带有1〜39个碳原子的直链或支链烃基; R 13表示氢原子或含有1〜6个碳原子的烃基; R 14表示氢原子或具有直链,支链或环状结构且含有可含有氧原子的1〜40个碳原子的烃基。
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公开(公告)号:US5723497A
公开(公告)日:1998-03-03
申请号:US513872
申请日:1995-09-18
申请人: Yukihiro Ohashi , Yukihiro Yada , Yoshinori Takema , Taketoshi Fujimori , Akira Kawamata , Hiroyuki Ohsu , Kazuhiko Higuchi , Genji Imokawa , Hiroshi Kusuoku , Ayumi Ogawa , Tsutomu Fujimura
发明人: Yukihiro Ohashi , Yukihiro Yada , Yoshinori Takema , Taketoshi Fujimori , Akira Kawamata , Hiroyuki Ohsu , Kazuhiko Higuchi , Genji Imokawa , Hiroshi Kusuoku , Ayumi Ogawa , Tsutomu Fujimura
IPC分类号: A61K8/41 , A61K8/46 , A61K8/49 , A61K8/68 , A61K31/13 , A61Q17/04 , A61Q19/00 , A61Q19/08 , C07C215/08 , C07C215/10 , C07C215/12 , C07C217/28 , C07C219/06 , C07C229/12 , C07C229/24 , C07C233/18 , C07C235/10 , C07C237/06 , C07C323/25 , C07D295/088 , C07D311/58 , C07D311/72 , C07D317/22 , C07F7/08 , C07F9/09 , C07H15/04
CPC分类号: C07C323/25 , A61K8/41 , A61K8/46 , A61K8/49 , A61K8/68 , A61Q19/00 , A61Q19/08 , C07C215/08 , C07C215/10 , C07C215/12 , C07C217/28 , C07C219/06 , C07C229/12 , C07C229/24 , C07C233/18 , C07C235/10 , C07D295/088 , C07D311/58 , C07D311/72 , C07D317/22 , C07F7/0818 , C07F7/0847 , C07F7/0852 , C07F9/091 , C07H15/04 , A61Q17/04 , Y10S514/844 , Y10S514/845 , Y10S514/873
摘要: The present invention relates to an amine derivative represented by the following general formula (I) or (II): ##STR1## wherein R.sup.1 means a heteroatom-containing C.sub.1 -C.sub.40 hydrocarbon group which may have a ring structure, or the like; R.sup.2 -R.sup.5 each denote a C.sub.1 -C.sub.20 hydrocarbon group, hydrogen or the like; A.sup.1 represents ##STR2## or R.sup.15 --Z--.sup.16 --(CH.sub.2).sub.n --; B.sup.1 stands for hydrogen, a C.sub.1 -C.sub.10 hydrocarbon group, nitrogen or the like; C.sup.1 denotes hydrogen, a C.sub.1 -C.sub.10 hydrocarbon group, nitrogen, alcohol residue, phosphoric acid residue or the like; a dermatologic preparation containing the same; and a process for producing the amine derivative. This amine derivative has excellent effects of smoothing or removing wrinkles and improving keratinization.
摘要翻译: PCT No.PCT / JP94 / 00436 Sec。 371 1995年9月18日第 102(e)1995年9月18日PCT PCT 1994年3月17日PCT公布。 公开号WO94 / 21595 日期:1994年9月29日本发明涉及由以下通式(I)或(II)表示的胺衍生物:其中R 1表示含杂原子的C 1 -C 40烃 可以具有环结构的基团等; R2-R5各自表示C1-C20烃基,氢等; A1表示
或R15-Z-16-(CH2)n-; B1代表氢,C1-C10烃基,氮等; C1表示氢,C1-C10烃基,氮,醇残基,磷酸残基等; 含有该皮肤病的制剂; 和胺衍生物的制造方法。 该胺衍生物具有优异的平滑或去除皱纹和改善角质化的效果。 -
公开(公告)号:US5681864A
公开(公告)日:1997-10-28
申请号:US761144
申请日:1996-12-06
申请人: Yukihiro Ohashi , Taketoshi Fujimori , Minoru Nagai , Akira Kawamata , Yukihiro Yada , Kazuhiko Higuchi , Genji Imokawa , Yoshinori Takema , Yukiko Sakaino , Ayumi Ogawa , Tsutomu Fujimura
发明人: Yukihiro Ohashi , Taketoshi Fujimori , Minoru Nagai , Akira Kawamata , Yukihiro Yada , Kazuhiko Higuchi , Genji Imokawa , Yoshinori Takema , Yukiko Sakaino , Ayumi Ogawa , Tsutomu Fujimura
CPC分类号: A61Q19/00 , A61K8/41 , A61Q19/08 , A61Q17/04 , Y10S514/844 , Y10S514/845 , Y10S514/873
摘要: A composition for external skin care comprising an amine derivative represented by the following formula (1), ##STR1## wherein R.sup.1 is a linear, branched, or cyclic saturated or unsaturated hydrocarbon group having 4-40 carbon atoms, and R.sup.2, R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are individually a hydrogen atom or a hydrocarbon group having 1-10 carbon atoms, which may be substituted or unsubstituted by 1 or more hydroxy groups; or an acid addition salt thereof, in an amount from 0.0001 to less than 0.1% by weight; and a method of curing wrinkles and keratinization of the skin characterized by applying said amine derivative or its salt to the skin.
摘要翻译: 一种用于外部皮肤护理的组合物,其包含由下式(1)表示的胺衍生物,其中R1是具有4-40个碳原子的直链,支链或环状饱和或不饱和烃基,R2, R3,R4,R5和R6分别是氢原子或具有1-10个碳原子的烃基,其可以被1个或多个羟基取代或未取代; 或其酸加成盐,其量为0.0001至小于0.1重量%; 以及将皮肤上的所述胺衍生物或其盐施用于皮肤的皱纹和角质化的方法。
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公开(公告)号:US5552445A
公开(公告)日:1996-09-03
申请号:US211052
申请日:1994-03-23
申请人: Yukihiro Ohashi , Taketoshi Fujimori , Minoru Nagai , Akira Kawamata , Yukihiro Yada , Kazuhiko Higuchi , Genji Imokawa , Yoshinori Takema , Yukiko Sakaino , Ayumi Ogawa , Tsutomu Fujimura
发明人: Yukihiro Ohashi , Taketoshi Fujimori , Minoru Nagai , Akira Kawamata , Yukihiro Yada , Kazuhiko Higuchi , Genji Imokawa , Yoshinori Takema , Yukiko Sakaino , Ayumi Ogawa , Tsutomu Fujimura
CPC分类号: A61Q19/00 , A61K8/41 , A61Q19/08 , A61Q17/04 , Y10S514/844 , Y10S514/845 , Y10S514/873
摘要: A composition for external skin care comprising an amine derivative represented by the following formula (1), ##STR1## wherein R.sup.1 is a linear, branched, or cyclic saturated or unsaturated hydrocarbon group having 4-40 carbon atoms, and R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are individually a hydrogen atom or a hydrocarbon group having 1-10 carbon atoms, which may be substituted or unsubstituted by 1 or more hydroxy groups; or an acid addition salt thereof, in an amount from 0.0001 to less than 0.1% by weight; and a method of curing wrinkles and keratinization of the skin characterized by applying said amine derivative or its salt to the skin.
摘要翻译: PCT No.PCT / JP92 / 01210 Sec。 371日期1994年3月23日 102(e)1994年3月23日PCT PCT 1992年9月22日PCT公布。 出版物WO93 / 05763 日本1993年4月1日一种外用皮肤护理用组合物,其含有下述式(1)表示的胺衍生物,其中R1是具有4-40碳原子的直链,支链或环状的饱和或不饱和烃基 原子,R2,R3,R4,R5和R6分别是氢原子或具有1-10个碳原子的烃基,其可以被1个或多个羟基取代或未取代; 或其酸加成盐,其量为0.0001至小于0.1重量%; 以及将皮肤上的所述胺衍生物或其盐施用于皮肤的皱纹和角质化的方法。
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公开(公告)号:US5071971A
公开(公告)日:1991-12-10
申请号:US584739
申请日:1990-09-19
申请人: Shinji Yano , Akira Kawamata , Yoshihiro Minematsu , Shuichi Akazaki , Mitsuko Zama , Genji Imokawa , Naotake Takaishi , Tsuyoshi Ohtomo , Takashi Komori
发明人: Shinji Yano , Akira Kawamata , Yoshihiro Minematsu , Shuichi Akazaki , Mitsuko Zama , Genji Imokawa , Naotake Takaishi , Tsuyoshi Ohtomo , Takashi Komori
CPC分类号: A61K8/42 , A61K8/0212 , A61K8/68 , A61Q19/00 , C07H15/04 , A61Q1/02 , A61Q1/06 , A61Q19/10 , A61Q5/00 , A61Q5/006 , Y10S514/844 , Y10S514/846 , Y10S514/847 , Y10S514/969 , Y10S514/975
摘要: An external skin care preparation comprising a compound represented by the following general formula (I) or (II), or a salt thereof: ##STR1## wherein R.sup.1 means an aliphatic hydrocarbon group having 9-25 carbon atoms, A and B denote specific groups respectively, R.sup.6 and R.sup.7 are individually an aliphatic hydrocarbon group having 10-26 carbon atoms, and R.sup.8 denotes a group --CH.sub.2 CH.sub.2 OH, --CH.sub.2 COOH, or --COCH.sub.3.
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公开(公告)号:US5028416A
公开(公告)日:1991-07-02
申请号:US546276
申请日:1990-06-29
申请人: Shinji Yano , Akira Kawamata , Yoshihiro Minematsu , Shuichi Akazaki , Mitsuko Zama , Genji Imokawa , Naotake Takaishi , Tsuyoshi Ohtomo , Takashi Komori
发明人: Shinji Yano , Akira Kawamata , Yoshihiro Minematsu , Shuichi Akazaki , Mitsuko Zama , Genji Imokawa , Naotake Takaishi , Tsuyoshi Ohtomo , Takashi Komori
CPC分类号: A61K8/42 , A61K8/0212 , A61K8/68 , A61Q19/00 , C07H15/04 , A61Q1/02 , A61Q1/06 , A61Q19/10 , A61Q5/00 , A61Q5/006 , Y10S514/844 , Y10S514/846 , Y10S514/847 , Y10S514/969 , Y10S514/975
摘要: An external skin care preparation comprising a compound represented by the following general formula (I) or (II), or a salt thereof: ##STR1## wherein R.sup.1 means an aliphatic hydrocarbon group having 9-25 carbon atoms, A and B denote specific groups respectively, R.sup.6 and R.sup.7 are individually an aliphatic hydrocarbon group having 10-26 carbon atoms, and R.sup.8 denotes a group --CH.sub.2 CH.sub.2 OH, --CH.sub.2 COOH or --COCH.sub.3.
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公开(公告)号:US4985547A
公开(公告)日:1991-01-15
申请号:US163835
申请日:1988-03-03
申请人: Shinji Yano , Akira Kawamata , Yoshihiro Minematsu , Shuichi Akazaki , Mitsuko Zama , Genji Imokawa , Naotake Takaishi , Tsuyoshi Ohtomo , Takashi Komori
发明人: Shinji Yano , Akira Kawamata , Yoshihiro Minematsu , Shuichi Akazaki , Mitsuko Zama , Genji Imokawa , Naotake Takaishi , Tsuyoshi Ohtomo , Takashi Komori
CPC分类号: A61K8/42 , A61K8/0212 , A61K8/68 , A61Q19/00 , C07H15/04 , A61Q1/02 , A61Q1/06 , A61Q19/10 , A61Q5/00 , A61Q5/006 , Y10S514/844 , Y10S514/846 , Y10S514/847 , Y10S514/969 , Y10S514/975
摘要: An external skin care preparation comprising a compound represented by the following general formula (I) or (II), or a salt thereof: ##STR1## wherein R.sup.1 means an aliphatic hydrocarbon group having 9-25 carbon atoms, A and B denote specific groups respectively, R.sup.6 and R.sup.7 are individually an aliphatic hydrocarbon group having 10-26 carbon atoms, and R.sup.8 denotes a group --CH.sub.2 CH.sub.2 OH, --CH.sub.2 COOH or --COCH.sub.3.
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