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18 条记录 (耗时 0.027 秒)

    Copolymer and process for preparing the same
    1.
    发明授权
    Copolymer and process for preparing the same 有权
    共聚物及其制备方法

    公开(公告)号：US06372880B1

    公开(公告)日：2002-04-16

    申请号：US09219452

    申请日：1998-12-23

    申请人： Hosei Shinoda ,  Yukiko Asou ,  Hiroaki Tamatani

    发明人： Hosei Shinoda ,  Yukiko Asou ,  Hiroaki Tamatani

    IPC分类号： C08G6344

    CPC分类号： C08G73/1092 ,  A61K9/1641 ,  C08G73/16

    摘要： A copolymer having a weight-average molecular weight of 1,000 to 100,000 which comprises, as repeating structure units, both of a succinimide unit represented by the structural formula (1) and a hydroxycarboxylic acid unit represented by the structural formula (2) wherein R is a methyl group or a hydrogen atom, and a process for preparing a copolymer which comprises a polymerization step of heating a mixture of aspartic acid and a cyclic ester compound.

    摘要翻译： 一种重均分子量为1,000〜100,000的共聚物，其包含由结构式（1）表示的琥珀酰亚胺单元和由结构式（2）表示的羟基羧酸单元作为重复结构单元，其中R为 甲基或氢原子，以及制备共聚物的方法，其包括加热天冬氨酸和环状酯化合物的混合物的聚合步骤。

    Medical composition of hydroxy acid-based oligomer
    2.
    发明授权
    Medical composition of hydroxy acid-based oligomer 失效
    羟基酸类低聚物的医药组成

    公开(公告)号：US06342241B1

    公开(公告)日：2002-01-29

    申请号：US09488707

    申请日：2000-01-21

    申请人： Yukiko Asou ,  Hosei Shinoda ,  Hiroaki Tamatani

    发明人： Yukiko Asou ,  Hosei Shinoda ,  Hiroaki Tamatani

    IPC分类号： A61F1300

    CPC分类号： A61K47/34 ,  A61K9/0024

    摘要： A medical composition is here disclosed which comprises a hydroxy acid-based oligomer (A) and a drug (B), wherein the hydroxy acid-based oligomer (A) is an oligomer in which the carboxylic acid-terminals are at least partially esterified, and the oligomer (A) has a function of becoming pH 5 to 8 when administered into an organism, and the oligomer (A) shows fluidity at 25° C. This composition sustainedly releases the drug (B) to deliver it into an organism by a syringe or the like, and scarcely gives rise to irritation, inflammation or the like.

    摘要翻译： 这里公开了包含羟基酸类低聚物（A）和药物（B）的医药组合物，其中羟基酸类低聚物（A）是其中羧酸末端至少部分酯化的低聚物， 并且低聚物（A）在施用于生物体时具有变为pH5〜8的功能，低聚物（A）在25℃下显示出流动性。该组合物持续释放药物（B），以通过 注射器等，几乎不引起刺激，炎症等。

    Resin composition
    3.
    发明授权
    Resin composition 有权
    树脂组成

    公开(公告)号：US06372844B1

    公开(公告)日：2002-04-16

    申请号：US09536677

    申请日：2000-03-28

    申请人： Hosei Shinoda ,  Yukiko Asou ,  Hiroaki Tamatani

    发明人： Hosei Shinoda ,  Yukiko Asou ,  Hiroaki Tamatani

    IPC分类号： C08L5108

    CPC分类号： C08L67/02 ,  C08L69/00 ,  C08L101/00 ,  C08L2666/20

    摘要： There are here disclosed a resin composition comprising a block or a graft copolymer (A) having a polyamino acid as a hydrophilic segment (a-1), and a degradable polymer as a hydrophobic segment (a-2), and a resin (B); and a method of accelerating the hydrolysis of a resin and inhibiting the heat deterioration thereof by mixing this copolymer (A) with the resin (B).

    摘要翻译： 这里公开了包含具有聚氨基酸作为亲水性链段（a-1）的嵌段或接枝共聚物（A）和作为疏水链段（a-2）的可降解聚合物和树脂（B）的树脂组合物 ）; 和通过将该共聚物（A）与树脂（B）混合来加速树脂的水解并抑制其热劣化的方法。

    Sustained releasing drug comprising copolymers and process for preparing the same
    4.
    发明授权
    Sustained releasing drug comprising copolymers and process for preparing the same 有权
    包含共聚物的缓释药物及其制备方法

    公开(公告)号：US06419951B1

    公开(公告)日：2002-07-16

    申请号：US09985874

    申请日：2001-11-06

    申请人： Hosei Shinoda ,  Yukiko Asou ,  Hiroaki Tamatani

    发明人： Hosei Shinoda ,  Yukiko Asou ,  Hiroaki Tamatani

    IPC分类号： A61K952

    CPC分类号： C08G73/1092 ,  A61K9/1641 ,  C08G73/16

    摘要： A sustained releasing drug which includes an effective component and a copolymer having a weight-average molecular weight of 1,000 to 100,000 which comprises, as repeating structure units, both of a succinimide unit represented by the structural formula (1) and a hydroxycarboxylic acid unit represented by the structural formula (2) wherein R is a methyl group or a hydrogen atom, and a process for preparing a copolymer which comprises a polymerization step of heating a mixture of aspartic acid and a cyclic ester compound.

    摘要翻译： 一种持续释放药物，其包含有效成分和重均分子量为1,000〜100,000的共聚物，其包含作为重复结构单元的由结构式（1）表示的琥珀酰亚胺单元和表示的结构式（1）所示的羟基羧酸单元 通过其中R是甲基或氢原子的结构式（2），以及包括加热天冬氨酸和环状酯化合物的混合物的聚合步骤的共聚物的制备方法。

    Cross-linked polymer
    6.
    发明授权
    Cross-linked polymer 失效
    交联聚合物

    公开(公告)号：US5986042A

    公开(公告)日：1999-11-16

    申请号：US14421

    申请日：1998-01-27

    申请人： Yoshihiro Irizato ,  Makoto Sukegawa ,  Toshio Katoh ,  Hiroaki Tamatani

    发明人： Yoshihiro Irizato ,  Makoto Sukegawa ,  Toshio Katoh ,  Hiroaki Tamatani

    IPC分类号： C08G69/48 ,  C08G73/02 ,  C08G69/10

    CPC分类号： C08G69/48 ,  C08G73/028 ,  C08G73/0293

    摘要： A cross-linked polymer containing, in its molecule, recurring units represented by the following formula (1), and having biodegradability and high water-absorbency: ##STR1## wherein R.sub.1 is a pendant group having at least one functional group selected from the group consisting of acidic groups and salts thereof, a glycino group and salts thereof, cationic groups and betaine groups; X.sub.1 is NH, NR.sub.1 ', R.sub.1 ' being an alkyl, aralkyl or aryl group, O or S; and n.sub.1 is 1 or 2.

    摘要翻译： 在其分子中含有由下式（1）表示的重复单元并且具有生物降解性和高吸水性的交联聚合物：其中R1是具有至少一个选自酸性的官能团的侧基 基团和盐，缩水甘油基及其盐，阳离子基团和甜菜碱基团; X1是NH，NR1'，R1'是烷基，芳烷基或芳基，O或S; n1为1或2。

    Production process of cross-linked polysuccinimide resin
    10.
    发明授权
    Production process of cross-linked polysuccinimide resin 有权
    交联聚琥珀酰亚胺树脂的生产工艺

    公开(公告)号：US06346569B1

    公开(公告)日：2002-02-12

    申请号：US09514954

    申请日：2000-02-28

    申请人： Yoshihiro Irizato ,  Makoto Sukegawa ,  Toshio Katoh ,  Hiroaki Tamatani ,  Akinori Nagatomo ,  Masaru Wada

    发明人： Yoshihiro Irizato ,  Makoto Sukegawa ,  Toshio Katoh ,  Hiroaki Tamatani ,  Akinori Nagatomo ,  Masaru Wada

    IPC分类号： C08J324

    CPC分类号： C08G73/1092

    摘要： A process is disclosed for producing with good productivity a cross-linked polyaspartic acid resin having biodegradability and high water absorbency. The process features inclusion of one of the following steps: (a) a polysuccinimide, which has been brought into a dispersed state by a dispersant, and a cross-linking agent are reacted to produce the cross-linked polyaspartic acid resin; (b) imide rings of a cross-linked polysuccinimide are subjected to a hydrolysis reaction while controlling a swelling degree of a resulting gel, whereby the cross-linked polyaspartic acid resin is produced; and (c) a gel of a cross-linked polysuccinimide, which has been obtained by reacting a cross-linking agent to a solution of a polysuccinimide in an organic solvent, is disintegrated to subject imide rings of the cross-linked polysuccinimide to a hydrolysis reaction, so that the cross-linked polyaspartic acid resin is produced. The process may also include one or both of the following steps as needed: (d) a gel of the cross-linked polyaspartic acid resin is washed with water and/or a water-miscible organic solvent; and (e) the polysuccinimide is produced using a basic amino acid as a cross-linking agent.

    摘要翻译： 公开了一种具有生物降解性和高吸水性的交联聚天冬氨酸树脂以高生产率生产的方法。 该方法包括以下步骤之一：（a）已经通过分散剂进入分散状态的聚琥珀酰亚胺和交联剂反应生成交联聚天冬氨酸树脂; （b）交联聚琥珀酰亚胺的酰亚胺环进行水解反应同时控制所得凝胶的溶胀度，从而制得交联聚天冬氨酸树脂; 和（c）通过使交联剂与聚琥珀酰亚胺在有机溶剂中的溶液反应而获得的交联聚琥珀酰亚胺的凝胶被分解以使交联的聚琥珀酰亚胺的酰亚胺环进行水解 反应，制成交联聚天冬氨酸树脂。 该方法还可以根据需要包括以下步骤中的一种或两种：（d）用水和/或水混溶性有机溶剂洗涤交联聚天冬氨酸树脂的凝胶; 和（e）使用碱性氨基酸作为交联剂制备聚琥珀酰亚胺。