公开(公告)号：US06372844B1

公开(公告)日：2002-04-16

申请号：US09536677

申请日：2000-03-28

申请人： Hosei Shinoda ,  Yukiko Asou ,  Hiroaki Tamatani

发明人： Hosei Shinoda ,  Yukiko Asou ,  Hiroaki Tamatani

IPC分类号： C08L5108

CPC分类号： C08L67/02 ,  C08L69/00 ,  C08L101/00 ,  C08L2666/20

摘要： There are here disclosed a resin composition comprising a block or a graft copolymer (A) having a polyamino acid as a hydrophilic segment (a-1), and a degradable polymer as a hydrophobic segment (a-2), and a resin (B); and a method of accelerating the hydrolysis of a resin and inhibiting the heat deterioration thereof by mixing this copolymer (A) with the resin (B).

摘要翻译： 这里公开了包含具有聚氨基酸作为亲水性链段（a-1）的嵌段或接枝共聚物（A）和作为疏水链段（a-2）的可降解聚合物和树脂（B）的树脂组合物 ）; 和通过将该共聚物（A）与树脂（B）混合来加速树脂的水解并抑制其热劣化的方法。

公开(公告)号：US06372880B1

公开(公告)日：2002-04-16

申请号：US09219452

申请日：1998-12-23

申请人： Hosei Shinoda ,  Yukiko Asou ,  Hiroaki Tamatani

发明人： Hosei Shinoda ,  Yukiko Asou ,  Hiroaki Tamatani

IPC分类号： C08G6344

CPC分类号： C08G73/1092 ,  A61K9/1641 ,  C08G73/16

摘要： A copolymer having a weight-average molecular weight of 1,000 to 100,000 which comprises, as repeating structure units, both of a succinimide unit represented by the structural formula (1) and a hydroxycarboxylic acid unit represented by the structural formula (2) wherein R is a methyl group or a hydrogen atom, and a process for preparing a copolymer which comprises a polymerization step of heating a mixture of aspartic acid and a cyclic ester compound.

摘要翻译： 一种重均分子量为1,000〜100,000的共聚物，其包含由结构式（1）表示的琥珀酰亚胺单元和由结构式（2）表示的羟基羧酸单元作为重复结构单元，其中R为 甲基或氢原子，以及制备共聚物的方法，其包括加热天冬氨酸和环状酯化合物的混合物的聚合步骤。

公开(公告)号：US06342241B1

公开(公告)日：2002-01-29

申请号：US09488707

申请日：2000-01-21

申请人： Yukiko Asou ,  Hosei Shinoda ,  Hiroaki Tamatani

发明人： Yukiko Asou ,  Hosei Shinoda ,  Hiroaki Tamatani

IPC分类号： A61F1300

CPC分类号： A61K47/34 ,  A61K9/0024

摘要： A medical composition is here disclosed which comprises a hydroxy acid-based oligomer (A) and a drug (B), wherein the hydroxy acid-based oligomer (A) is an oligomer in which the carboxylic acid-terminals are at least partially esterified, and the oligomer (A) has a function of becoming pH 5 to 8 when administered into an organism, and the oligomer (A) shows fluidity at 25° C. This composition sustainedly releases the drug (B) to deliver it into an organism by a syringe or the like, and scarcely gives rise to irritation, inflammation or the like.

摘要翻译： 这里公开了包含羟基酸类低聚物（A）和药物（B）的医药组合物，其中羟基酸类低聚物（A）是其中羧酸末端至少部分酯化的低聚物， 并且低聚物（A）在施用于生物体时具有变为pH5〜8的功能，低聚物（A）在25℃下显示出流动性。该组合物持续释放药物（B），以通过 注射器等，几乎不引起刺激，炎症等。

公开(公告)号：US06419951B1

公开(公告)日：2002-07-16

申请号：US09985874

申请日：2001-11-06

申请人： Hosei Shinoda ,  Yukiko Asou ,  Hiroaki Tamatani

发明人： Hosei Shinoda ,  Yukiko Asou ,  Hiroaki Tamatani

IPC分类号： A61K952

CPC分类号： C08G73/1092 ,  A61K9/1641 ,  C08G73/16

摘要： A sustained releasing drug which includes an effective component and a copolymer having a weight-average molecular weight of 1,000 to 100,000 which comprises, as repeating structure units, both of a succinimide unit represented by the structural formula (1) and a hydroxycarboxylic acid unit represented by the structural formula (2) wherein R is a methyl group or a hydrogen atom, and a process for preparing a copolymer which comprises a polymerization step of heating a mixture of aspartic acid and a cyclic ester compound.

摘要翻译： 一种持续释放药物，其包含有效成分和重均分子量为1,000〜100,000的共聚物，其包含作为重复结构单元的由结构式（1）表示的琥珀酰亚胺单元和表示的结构式（1）所示的羟基羧酸单元 通过其中R是甲基或氢原子的结构式（2），以及包括加热天冬氨酸和环状酯化合物的混合物的聚合步骤的共聚物的制备方法。

公开(公告)号：US5686066A

公开(公告)日：1997-11-11

申请号：US723247

申请日：1996-09-30

申请人： Yukiko Harada ,  Hosei Shinoda ,  Makoto Sukegawa ,  Hiroaki Tamatani

发明人： Yukiko Harada ,  Hosei Shinoda ,  Makoto Sukegawa ,  Hiroaki Tamatani

IPC分类号： A61K8/88 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q5/06 ,  A61Q5/10 ,  A61Q19/00 ,  A61Q19/10 ,  C08G73/06 ,  C08G73/10 ,  C08F283/06 ,  A61K7/11 ,  C08L77/04 ,  C08G68/48

CPC分类号： C08G73/1092 ,  A61K8/88 ,  A61Q19/00 ,  A61Q5/00 ,  A61Q5/06 ,  A61Q5/10 ,  C08G73/0611 ,  A61Q19/10 ,  A61Q5/02 ,  Y10S424/01 ,  Y10S424/02

摘要： Disclosed are polymers (polyaspartic acid Zwitterionic derivatives) containing, in the molecule, 1 mol % or more of at least one repeating unit selected from the group consisting of repeating units represented by the following formulas (1) and (2). ##STR1## These polymers are useful in the preparation of hair-treating compositions and cosmetic compositions having excellent hairdressing properties and good biocompatibility.

摘要翻译： 公开了在分子中含有1摩尔％以上的选自由下式（1）和（2）表示的重复单元的至少一个重复单元的聚合物（聚天冬氨酸两性离子衍生物）。 可用于制备具有优异的美发特性和良好生物相容性的头发处理组合物和化妆品组合物。

公开(公告)号：US5247013A

公开(公告)日：1993-09-21

申请号：US902794

申请日：1992-06-26

申请人： Hosei Shinoda ,  Masami Ohtaguro ,  Shigeru Iimuro

发明人： Hosei Shinoda ,  Masami Ohtaguro ,  Shigeru Iimuro

IPC分类号： C08G63/06 ,  C08G63/664

CPC分类号： C08G63/664 ,  C08G63/06

摘要： A biocompatible polyester which has improved hydrolyzability obtained by bonding saccharide to the structure of a polymer consisting of a glycolic acid unit and/or a lactic acid unit, and a process for Preparing the biocompatible polyester are disclosed.

摘要翻译： 公开了具有改善的水解性的生物相容性聚酯，其通过将糖键合到由乙醇酸单元和/或乳酸单元组成的聚合物的结构上而获得，并且制备生物相容性聚酯的方法。

公开(公告)号：US5223546A

公开(公告)日：1993-06-29

申请号：US870336

申请日：1992-04-17

申请人： Kenji Morita ,  Kohichi Uchiki ,  Hosei Shinoda

发明人： Kenji Morita ,  Kohichi Uchiki ,  Hosei Shinoda

IPC分类号： B29C44/56 ,  C08J9/06 ,  C08J9/12

CPC分类号： B29C44/5672 ,  B29C44/5627 ,  C08J9/06 ,  C08J9/103 ,  C08J9/12 ,  C08J2367/04

摘要： A degradable polymer network obtained by adding from 0.2 to 10 parts by weight of a foaming agent to 100 parts by weight of a polylactic acid-base resin composition comprising from 80 to 100% by weight of polylactic acid or a lactic acid-hydroxycarboxylic acid copolymer and from 0 to 20% by weight of a plasticizer, conducting melt-foaming extrusion of resulting mixture, and opening the foam cells in the extrudate. The high polymer network is characterized in suitable flexibility and hydrolyzability and thus useful as a material for absorbing oils and body fluids, screens for sunlight, heat-insulating materials, filter media and packaging materials; and does not accumulate as industrial wastes because of hydrolyzability in the natural environment, even though abandoned after use.

公开(公告)号：US4859763A

公开(公告)日：1989-08-22

申请号：US216371

申请日：1988-07-08

申请人： Hiroshi Takayanagi ,  Tadashi Kobayashi ,  Takayoshi Masuda ,  Hosei Shinoda

发明人： Hiroshi Takayanagi ,  Tadashi Kobayashi ,  Takayoshi Masuda ,  Hosei Shinoda

IPC分类号： C08G63/06 ,  A61K9/20 ,  A61K9/22 ,  C08G63/08 ,  C08G63/78 ,  C08G63/82 ,  C08G63/85

CPC分类号： A61K9/204 ,  C08G63/08 ,  C08G63/823

摘要： A process for copolymerizing lactide and glycolide by using a specific amount of stannous octoate as a catalyst in the presence of a polymerization regulator at temperature of 200.degree.-230.degree. C. to prepare dl-lactic acid-glycolic acid-copolymers which contain 50-60 mol % of a dl-lactic acid unit and 40-50 mol % of a glycolic acid unit and have inherent viscosity of 0.4-0.6 in chloroform.

公开(公告)号：USRE34984E

公开(公告)日：1995-06-27

申请号：US224301

申请日：1994-04-07

申请人： Toshio Kitao ,  Yoshiharu Kimura ,  Hideki Yamane ,  Hiroki Nakata ,  Hosei Shinoda

发明人： Toshio Kitao ,  Yoshiharu Kimura ,  Hideki Yamane ,  Hiroki Nakata ,  Hosei Shinoda

IPC分类号： A61L31/04 ,  C08L77/00 ,  C08G69/48

CPC分类号： A61L31/041 ,  C08L77/00 ,  Y10S525/937

摘要： The present invention provides a nylon composition having increased hydrolyzability which is obtained by physically mixing 100 parts by weight of a nylon with 1 to 50 parts by weight of at least one polymer selected from the group consisting of polylactic acid, polyglycolic acid and a copolymer containing 50 mol % or more of a lactic acid unit or a glycolic acid unit as a repeating unit in its chain; and a method for increasing the hydrolyzability of a nylon by preparing such a composition. High hydrolyzability can be imparted to the nylon inherently having extremely low hydrolyzability without impairing its original mechanical strength. Therefore, various molded articles made from the nylon can be hydrolyzed under natural circumstances, and thus the wastes are not stored.

公开(公告)号：US5405887A

公开(公告)日：1995-04-11

申请号：US249994

申请日：1994-05-27

申请人： Kenji Morita ,  Kohichi Uchiki ,  Hosei Shinoda

发明人： Kenji Morita ,  Kohichi Uchiki ,  Hosei Shinoda

IPC分类号： C08J5/18 ,  D02J1/06 ,  C08J9/00

CPC分类号： C08J5/18 ,  C08J2367/04

摘要： A breathable, hydrolyzable, porous film having long-term stability in mechanical properties which is obtained by the process comprising adding from 40 to 250 parts by weight of a finely-powdered filler having an average particle size of from 0.3 to 4 .mu.m to 100 parts by weight of a polylactic acid-based resin composition comprising from 80 to 95% by weight of polylactic acid or a lactic acid-hydroxycarboxylic acid copolymer and from 5 to 20% by weight of a plasticizer comprising a citric acid ester, melting and film-forming the resultant mixture, and successively stretching the thus-obtained film 1.1 times or more at least in the direction of the axis; and which is consequently useful as a material for leakproof films of sanitary materials such as a paper diaper and packaging materials, and does not accumulate as wastes because of hydrolyzability in the natural environment in the case of being abandoned after use.

摘要翻译： 一种透气的，可水解的多孔膜，其具有机械性能的长期稳定性，该膜通过该方法获得，该方法包括将40至250重量份的平均粒度为0.3至4μm至100的细粉末填料 重量份的包含80至95重量％的聚乳酸或乳酸 - 羟基羧酸共聚物的聚乳酸类树脂组合物和5至20重量％的包含柠檬酸酯的增塑剂，熔融和膜 形成所得混合物，并且至少沿轴线方向依次将如此得到的膜拉伸1.1倍以上; 因此可用作纸尿布和包装材料等卫生材料的防漏膜的材料，并且由于在使用后放弃的情况下由于自然环境中的水解性而不会作为废物积聚。