公开(公告)号：US08470325B2

公开(公告)日：2013-06-25

申请号：US12449543

申请日：2008-02-15

Applicant: Yukio Ando ,  Ikuro Maruyama ,  Shingo Yamada

Inventor： Yukio Ando ,  Ikuro Maruyama ,  Shingo Yamada

IPC: A61K39/395 ,  A61K39/00 ,  C07K16/24 ,  C07K16/18

CPC classification number: C07K16/24 ,  C07K2317/21 ,  C07K2317/23 ,  C07K2317/76

Abstract: Previously, it was difficult to obtain high-affinity antibodies that specifically bind to HMGB-1 but not to HMGB-2. Under this circumstance, the present inventors successfully obtained antibodies that are more reactive to HMGB-1 than to HMGB-2 by using specific peptides as an antigen. The present inventors also demonstrated that the antibodies had a HMGB-1-neutralizing activity. The present inventors administered the antibodies to amyloidosis model animals, and as a result, successfully demonstrated that the antibodies produced a significant therapeutic effect.

Abstract translation: 以前，难以获得特异性结合HMGB-1但不与HMGB-2结合的高亲和力抗体。 在这种情况下，通过使用特定的肽作为抗原，本发明人成功地获得了比HMGB-2更能反应HMGB-1的抗体。 本发明人还证明了抗体具有HMGB-1-中和活性。 本发明人给淀粉样变性模型动物施用抗体，结果证明抗体产生显着的治疗效果。

公开(公告)号：US08354107B2

公开(公告)日：2013-01-15

申请号：US12449543

申请日：2008-02-15

Applicant: Yukio Ando ,  Ikuro Maruyama ,  Shingo Yamada

Inventor： Yukio Ando ,  Ikuro Maruyama ,  Shingo Yamada

IPC: A61K39/395 ,  A61K39/00 ,  C07K16/24 ,  C07K16/18

Abstract: Previously, it was difficult to obtain high-affinity antibodies that specifically bind to HMGB-1 but not to HMGB-2. Under this circumstance, the present inventors successfully obtained antibodies that are more reactive to HMGB-1 than to HMGB-2 by using specific peptides as an antigen. The present inventors also demonstrated that the antibodies had a HMGB-1-neutralizing activity. The present inventors administered the antibodies to amyloidosis model animals, and as a result, successfully demonstrated that the antibodies produced a significant therapeutic effect.

公开(公告)号：US20110229487A1

公开(公告)日：2011-09-22

申请号：US12449543

申请日：2008-02-15

Applicant: Yukio Ando ,  Ikuro Maruyama ,  Shingo Yamada

Inventor： Yukio Ando ,  Ikuro Maruyama ,  Shingo Yamada

IPC: A61K39/395 ,  C07K16/18 ,  A61P3/00

CPC classification number: C07K16/24 ,  C07K2317/21 ,  C07K2317/23 ,  C07K2317/76

Abstract: Previously, it was difficult to obtain high-affinity antibodies that specifically bind to HMGB-1 but not to HMGB-2. Under this circumstance, the present inventors successfully obtained antibodies that are more reactive to HMGB-1 than to HMGB-2 by using specific peptides as an antigen. The present inventors also demonstrated that the antibodies had a HMGB-1-neutralizing activity. The present inventors administered the antibodies to amyloidosis model animals, and as a result, successfully demonstrated that the antibodies produced a significant therapeutic effect.

Abstract translation: 以前，难以获得特异性结合HMGB-1但不与HMGB-2结合的高亲和力抗体。 在这种情况下，通过使用特定的肽作为抗原，本发明人成功地获得了比HMGB-2更能反应HMGB-1的抗体。 本发明人还证明了抗体具有HMGB-1-中和活性。 本发明人给淀粉样变性模型动物施用抗体，结果证明抗体产生显着的治疗效果。

公开(公告)号：US20100216977A1

公开(公告)日：2010-08-26

申请号：US12449562

申请日：2008-02-15

Applicant: Kazuyoshi Kuwano ,  Naoki Hamada ,  Ikuro Maruyama ,  Shingo Yamada

Inventor： Kazuyoshi Kuwano ,  Naoki Hamada ,  Ikuro Maruyama ,  Shingo Yamada

IPC: C07K16/18

CPC classification number: C07K16/24 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/76

Abstract: An objective of the present invention is to provide effective methods for treating interstitial pulmonary diseases including interstitial pneumonia such as IPF. The present invention suggests that antibodies against HMGB-1 are effective for treating pulmonary fibrosis. Thus, the present invention provides preparations which comprise an anti-HMGB-1 antibody for treating interstitial pulmonary diseases.

Abstract translation: 本发明的目的是提供治疗间质性肺疾病（包括间质性肺炎如IPF）的有效方法。 本发明提出针对HMGB-1的抗体对于治疗肺纤维化是有效的。 因此，本发明提供了包含用于治疗间质性肺疾病的抗HMGB-1抗体的制剂。

公开(公告)号：US20100173277A1

公开(公告)日：2010-07-08

申请号：US12527159

申请日：2008-02-15

Applicant: Yohichi Yasunami ,  Ikuro Maruyama ,  Shingo Yamada

Inventor： Yohichi Yasunami ,  Ikuro Maruyama ,  Shingo Yamada

IPC: A01N1/02 ,  C07K16/18

CPC classification number: C07K16/24 ,  A61K2039/505 ,  C07K2317/76

Abstract: An objective of the present invention is to provide effective methods for suppressing rejection in organ transplantation, in particular, pancreatic islet transplantation which is useful in treating diabetes. The present invention demonstrated that antibodies against HMGB-1 suppressed the rejection in pancreatic islet transplantation and promoted the survival of grafted pancreatic islets. Thus, the present invention provides agents that comprise an anti-HMGB-1 antibody for suppressing rejection in organ transplantation.

Abstract translation: 本发明的目的是提供用于抑制器官移植排斥反应的有效方法，特别是可用于治疗糖尿病的胰岛移植。 本发明证明抗HMGB-1的抗体抑制了胰岛移植中的排斥反应，促进了移植胰岛的生存。 因此，本发明提供了包含用于抑制器官移植排斥反应的抗HMGB-1抗体的药剂。

公开(公告)号：US09206265B2

公开(公告)日：2015-12-08

申请号：US14131052

申请日：2012-04-13

Applicant: Toshiya Uozumi ,  Shingo Yamada ,  Noriaki Nakamura ,  Koichiro Hisano ,  Motoki Hosaka ,  Toshihiko Sugano

Inventor： Toshiya Uozumi ,  Shingo Yamada ,  Noriaki Nakamura ,  Koichiro Hisano ,  Motoki Hosaka ,  Toshihiko Sugano

IPC: B01J31/00 ,  B01J37/00 ,  C08F4/02 ,  C08F2/00 ,  C08F4/52 ,  C08F110/06

CPC classification number: C08F4/52 ,  C08F110/06 ,  C08F2500/04 ,  C08F2500/12 ,  C08F4/651 ,  C08F4/6576 ,  C08F4/6548 ,  C08F4/6465

Abstract: An olefin polymer that is obtained using an olefin polymerization catalyst that includes a solid catalyst component for olefin polymerization that includes titanium, magnesium, a halogen, and an ester compound (A) represented by the following formula (1): R1R2C═C(COOR3)(COOR4), an organoaluminum compound, and an optional external electron donor compound, exhibits primary properties (e.g., molecular weight distribution and stereoregularity) similar to those of an olefin polymer obtained using a solid catalyst component that includes a phthalic ester as an electron donor.

Abstract translation: 1.一种烯烃聚合物，其使用包含由下式（1）表示的钛，镁，卤素和酯化合物（A）的烯烃聚合用固体催化剂成分的烯烃聚合催化剂得到：R1R2C = C（COOR3 ）（COOR4），有机铝化合物和任选的外电子给体化合物，显示与使用包含邻苯二甲酸酯作为电子的固体催化剂组分获得的烯烃聚合物的主要性质（例如，分子量分布和立构规整性） 捐赠者。

公开(公告)号：US08562778B2

公开(公告)日：2013-10-22

申请号：US13503701

申请日：2011-10-13

Applicant: Shingo Yamada ,  Kozo Odawara

Inventor： Shingo Yamada ,  Kozo Odawara

IPC: B32B38/18 ,  B32B38/10

CPC classification number: B65H35/0013 ,  G02F1/1303 ,  H01L21/67132 ,  H05K3/323

Abstract: A tape adhering apparatus and a tape adhering method for adhering an ACF tape formed from an anisotropic conductive film to a target adhering area on a substrate are disclosed. It is an objective of the invention to provide a tape adhering apparatus and a tape adhering method that enable shortening of a time consumed by operation for adhering one cut piece of an ACF tape. According to the present invention, the separator is peeled from the cut piece of the ACF tape by letting the tape conveyor means convey the tape member in synchronism with the transfer action of the transfer base and thereafter a cut portion of the ACF tape to be next adhered is placed at the cutting position of the tape cutting means by letting the tape conveyor means continually convey the tape member in the forward conveyance direction.

Abstract translation: 公开了一种用于将由各向异性导电膜形成的ACF带粘附到基板上的目标粘合区域的带粘附装置和带粘附方法。 本发明的目的是提供一种能够缩短用于粘附ACF带的一个切割片的操作消耗的时间的带粘附装置和带粘附方法。 根据本发明，通过使带式输送机与转印底座的转印动作同步地输送带状构件，然后将ACF带的切割部分分割成下一个，从而将分离器从ACF带的切割片上剥离 通过使带式传送装置在向前传送方向上连续地传送带状构件，将粘合物放置在带切割装置的切割位置。

公开(公告)号：US08951379B2

公开(公告)日：2015-02-10

申请号：US13702139

申请日：2011-06-10

Applicant: Shingo Yamada

Inventor： Shingo Yamada

IPC: B32B37/00 ,  H05K13/04 ,  B29C63/02 ,  H01L23/00 ,  H05K3/32 ,  H01R4/04

CPC classification number: H05K13/04 ,  B29C63/02 ,  H01L24/27 ,  H01L24/29 ,  H01L24/743 ,  H01L24/83 ,  H01L2224/27436 ,  H01L2224/2929 ,  H01L2224/293 ,  H01L2224/743 ,  H01L2224/83101 ,  H01L2224/83192 ,  H01L2224/83851 ,  H01L2924/01004 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01019 ,  H01L2924/01033 ,  H01L2924/07811 ,  H01L2924/15788 ,  H01R4/04 ,  H05K3/323 ,  H05K2201/10128 ,  H05K2201/10446 ,  Y10T29/49128 ,  Y10T29/4913 ,  Y10T156/10 ,  Y10T156/1052 ,  Y10T156/1064 ,  Y10T156/1084 ,  Y10T156/1089 ,  Y10T156/1092 ,  H01L2924/00

Abstract: In the tape attaching method of cutting a tape member into conductive tape pieces and attaching the conductive tape pieces onto a plurality of attachment regions which are formed at a side edge part of a board, an attaching step in which the conductive tape pieces is attached onto the attachment region of a first press position, and a moving step, in which by driving a tape sending mechanism to perform the operation of sending the tape member while a press bonding head and a peeling unit are integrally moved relative to the board, the press bonding head is aligned with the attachment region of a second press position, and a separator is peeled from the tape member attached onto the first press position by the peeling unit during the relative movement, are repeated.

Abstract translation: 在将带状构件切割成导电性带片并将导电性带片附着在形成在基板的侧缘部的多个附着区域的带状贴附方法中，将导电性带片附着到 第一按压位置的安装区域和移动步骤，其中通过驱动带式送料机构来执行将压带结合头和剥离单元相对于板一体地移动的带状部件的操作，压力机 接合头与第二按压位置的附接区域对准，并且在相对移动期间，通过剥离单元将分离器从附接到第一按压位置的带构件上重复。

公开(公告)号：US20140221583A1

公开(公告)日：2014-08-07

申请号：US14131052

申请日：2012-04-13

Applicant: Toshiya Uozumi ,  Shingo Yamada ,  Noriaki Nakamura ,  Koichiro Hisano ,  Motoki Hosaka ,  Toshihiko Sugano

Inventor： Toshiya Uozumi ,  Shingo Yamada ,  Noriaki Nakamura ,  Koichiro Hisano ,  Motoki Hosaka ,  Toshihiko Sugano

IPC: C08F4/52

CPC classification number: C08F4/52 ,  C08F110/06 ,  C08F2500/04 ,  C08F2500/12 ,  C08F4/651 ,  C08F4/6576 ,  C08F4/6548 ,  C08F4/6465

Abstract: An olefin polymer that is obtained using an olefin polymerization catalyst that includes a solid catalyst component for olefin polymerization that includes titanium, magnesium, a halogen, and an ester compound (A) represented by the following formula (1): R1R2C═C(COOR3)(COOR4), an organoaluminum compound, and an optional external electron donor compound, exhibits primary properties (e.g., molecular weight distribution and stereoregularity) similar to those of an olefin polymer obtained using a solid catalyst component that includes a phthalic ester as an electron donor.

Abstract translation: 1.一种烯烃聚合物，其使用包含由下式（1）表示的钛，镁，卤素和酯化合物（A）的烯烃聚合用固体催化剂成分的烯烃聚合催化剂得到：R1R2C = C（COOR3 ）（COOR4），有机铝化合物和任选的外部电子给体化合物，显示与使用包含邻苯二甲酸酯作为电子的固体催化剂组分获得的烯烃聚合物的主要性质（例如分子量分布和立构规整性） 捐赠者。

公开(公告)号：US20120312461A1

公开(公告)日：2012-12-13

申请号：US13503701

申请日：2011-10-13

Applicant: Shingo Yamada ,  Kozo Odawara

Inventor： Shingo Yamada ,  Kozo Odawara

IPC: B32B38/18 ,  B32B38/10

CPC classification number: B65H35/0013 ,  G02F1/1303 ,  H01L21/67132 ,  H05K3/323

Abstract: It is an objective of the invention to provide a tape adhering apparatus and a tape adhering method that enable shortening of a time consumed by operation for adhering one cut piece of an ACF tape. After a cut piece 4S of an ACF tape 4 is pressed against and adhered to a target adhering area Sa on a substrate 2 by a press tool 22, a transfer base 14 is transferred, and a tape member Tp is then forwardly conveyed in synchronism with transfer of the transfer base 14 in such a way that the press tool 22 comes to an elevated position above the target adhering area Sa on the substrate 2 where the cut piece 4S of the ACF tape 4 is to be adhered, thereby peeling a separator Sp off from the cut piece 4S of the ACF tape 4. A tape cutting unit 24 is disposed downstream of a region Rg of, immediately below the press tool 22, of the tape member Tp conveyed by the tape conveyor unit 23 with respect to a forward conveyance direction of the tape member Tp. A cut position of the ACF tape 4 can be positioned by continual forward transfer of the tape member Tp.

Abstract translation: 本发明的目的是提供一种能够缩短用于粘附ACF带的一个切割片的操作消耗的时间的带粘附装置和带粘附方法。 在通过冲压工具22将ACF带4的切割片4S按压并附着在基板2上的目标粘合区域Sa之后，转印基底14，然后将带状构件Tp与 转印底座14的移动，使得冲压工具22到达要粘附ACF带4的切割片4S的基底2上的目标粘合区域Sa上方的升高位置，从而剥离隔离物Sp 从ACF带4的切割片4S脱离。带切割单元24设置在压带机22正下方的由带式输送机单元23相对于前方传送的带构件Tp的区域Rg的下游 带状构件Tp的输送方向。 ACF带4的切割位置可以通过带状构件Tp的不断向前传送来定位。