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公开(公告)号：US08632845B2
公开(公告)日：2014-01-21
申请号：US12766758
申请日：2010-04-23
CPC分类号： B29C65/76 , A61F2/82 , A61F2/86 , A61F2/91 , A61F2210/0004 , A61F2210/0076 , A61F2240/001 , A61F2250/0067 , A61F2310/00389 , A61L31/14 , A61L31/148 , A61L2420/02 , B05D1/38 , B05D3/0254 , B05D3/0473 , B29C65/10 , B29K2067/046 , B29K2105/258 , B29L2031/7534
摘要： Various embodiments of methods for coating stents are described herein. Applying a composition including polymer component and solvent to a stent substrate followed by exposing the polymer component to a temperature equal to or greater than a Tg of the polymer component is disclosed. Repeating the applying and exposing one or more times to form a coating with the result that the solvent content of the coating after the final exposing step is at a level suitable for a finished stent is further disclosed.
摘要翻译： 本文描述了用于涂覆支架的方法的各种实施例。 公开了将包含聚合物组分和溶剂的组合物施用到支架基底，然后将聚合物组分暴露于等于或大于聚合物组分的Tg的温度。 重复施加和暴露一次或多次以形成涂层，结果是在最终曝光步骤之后涂层的溶剂含量处于适合成品支架的水平。
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2.发明授权Poly(ester amides) for the control of agent-release from polymeric compositions 有权用于控制聚合物组合物释放试剂的聚（酯酰胺）公开(公告)号：US08815274B2
公开(公告)日：2014-08-26
申请号：US12478693
申请日：2009-06-04
申请人： Jessica R. DesNoyer , Stephen D. Pacetti , Lothar W. Kleiner , Syed F. A. Hossainy , Yung-Ming Chen , Gordon Stewart , Gina Zhang
发明人： Jessica R. DesNoyer , Stephen D. Pacetti , Lothar W. Kleiner , Syed F. A. Hossainy , Yung-Ming Chen , Gordon Stewart , Gina Zhang
IPC分类号： A61F13/00
CPC分类号： A61L31/10 , A61L27/18 , A61L27/34 , A61L31/06 , A61L31/16 , A61L2300/416 , A61L2300/604 , C08L77/12
摘要： The present invention generally encompasses a medical article, such as a medical device or coating comprising an agent or combination of agents, wherein the agent is distributed throughout a polymeric matrix. The polymeric matrix comprises an agent and a poly(ester amide) having a design that was preselected to provide a predetermined release rate of the combination of agents from the medical article.
摘要翻译： 本发明通常包括医疗制品，例如包含试剂或试剂组合的医疗装置或涂层，其中所述试剂分布在整个聚合物基质中。 聚合物基质包含试剂和聚（酯酰胺），该聚（酯酰胺）具有预先设计以提供来自医药制品的试剂组合的预定释放速率的设计。
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3.发明授权公开(公告)号：US08661630B2
公开(公告)日：2014-03-04
申请号：US12124991
申请日：2008-05-21
CPC分类号： A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/604 , A61L2300/606 , Y10T24/258 , C08L67/04
摘要： The present invention provides a coating comprising a reservoir layer comprising a semi-crystalline polymer and a primer layer comprising an amorphous polymer on an implantable device and methods of making and using the same.
摘要翻译： 本发明提供一种包含储存层的涂层，其包含半结晶聚合物和在可植入装置上包含无定形聚合物的底漆层及其制备和使用该涂层的方法。
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公开(公告)号：US08383142B2
公开(公告)日：2013-02-26
申请号：US12723556
申请日：2010-03-12
申请人： Syed F. A. Hossainy , Stephen D. Pacetti , Keith E. Fong , Vinayak Bhat , Deborra Sanders Millare , Judy A. Guruwaiya , Daryush Mirzaee , Evgenia Mandrusov
发明人： Syed F. A. Hossainy , Stephen D. Pacetti , Keith E. Fong , Vinayak Bhat , Deborra Sanders Millare , Judy A. Guruwaiya , Daryush Mirzaee , Evgenia Mandrusov
CPC分类号： A61L27/34 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L33/0011 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/02 , A61L2420/08 , C08L29/04
摘要： Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients.
摘要翻译： 提供用于可植入装置或腔内假体（例如支架）的涂层，包括形成涂层的方法。 涂层可用于递送活性成分或活性成分的组合。
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公开(公告)号：US08048448B2
公开(公告)日：2011-11-01
申请号：US11454813
申请日：2006-06-15
CPC分类号： A61K9/5115 , A61K9/0009 , A61K9/127 , A61K41/0019 , A61K41/0028
摘要： Nano-constructs comprising nanoshells and methods of using the nano-constructs for treating or ameliorating a medical condition are provided.
摘要翻译： 提供包含纳米壳的纳米构建体和使用纳米构建体治疗或改善医学状况的方法。
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公开(公告)号：US07063884B2
公开(公告)日：2006-06-20
申请号：US11064916
申请日：2005-02-22
CPC分类号： A61F2/82 , A61F2250/0056 , A61F2250/0067 , A61L31/10 , Y10T428/13 , Y10T428/24942
摘要： A stent comprising a coating layer is disclosed. The coating layer has a hydrophobic component and a hydrophilic component, wherein a region of the coating layer on or about the outermost surface of the coating layer has a higher content or concentration of the hydrophilic component than the hydrophobic component.
摘要翻译： 公开了一种包括涂层的支架。 涂层具有疏水性成分和亲水性成分，其中涂层的最外表面上或周围的涂层的区域具有比疏水性成分更高的亲水性成分的含量或浓度。
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公开(公告)号：US06790228B2
公开(公告)日：2004-09-14
申请号：US09750595
申请日：2000-12-28
申请人： Syed F. A. Hossainy , Stephen D. Pacetti , Keith E. Fong , Vinayak Bhat , Deborra Sanders Millare , Judy A. Guruwaiya , Daryush Mirzaee , Evgenia Mandrusov
发明人： Syed F. A. Hossainy , Stephen D. Pacetti , Keith E. Fong , Vinayak Bhat , Deborra Sanders Millare , Judy A. Guruwaiya , Daryush Mirzaee , Evgenia Mandrusov
IPC分类号： A61F206
CPC分类号： A61L27/34 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L33/0011 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/02 , A61L2420/08 , C08L29/04
摘要： Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients.
摘要翻译： 提供用于可植入装置或腔内假体（例如支架）的涂层，包括形成涂层的方法。 涂层可用于递送活性成分或活性成分的组合。
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公开(公告)号：US06663662B2
公开(公告)日：2003-12-16
申请号：US09750515
申请日：2000-12-28
IPC分类号： A61F206
CPC分类号： A61F2/07 , A61F2/89 , A61F2002/075
摘要： A diffusion barrier for an implantable device, such as a stent, carrying a therapeutic or bioactive substance is disclosed. The diffusion barrier reduces the rate at which the therapeutic or bioactive substance is released from the device. The diffusion barrier can be made from a polymeric material impregnated with particles.
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9.发明授权Polymers containing poly(ester amides) and agents for use with medical articles and methods of fabricating the same 有权含聚（酯酰胺）的聚合物和用于医疗制品的试剂及其制造方法公开(公告)号：US08808723B2
公开(公告)日：2014-08-19
申请号：US12504542
申请日：2009-07-16
申请人： Stephen D. Pacetti , Charles Claude , Thierry Glauser , Jessica R. DesNoyer , Syed F. A. Hossainy
发明人： Stephen D. Pacetti , Charles Claude , Thierry Glauser , Jessica R. DesNoyer , Syed F. A. Hossainy
摘要： Polymers containing poly(ester amides) and agents for use with medical articles and methods of fabricating the same are disclosed. The medical article generally comprises an implantable substrate having a coating, and the coating contains a polymer comprising a polymeric product of a reaction comprising a polyol, a polycarboxylic acid, an amino acid and an agent.
摘要翻译： 公开了含有聚（酯酰胺）的聚合物和用于医疗制品的试剂及其制造方法。 医疗制品通常包括具有涂层的可植入基底，并且该涂层含有包含包含多元醇，多元羧酸，氨基酸和试剂的反应的聚合产物的聚合物。
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10.发明授权Primer layer coatings of a material with a high content of hydrogen bonding groups for implantable devices and a method of forming the same 有权用于可植入装置的具有高含量氢键基团的材料的底漆层涂层及其形成方法公开(公告)号：US08652501B2
公开(公告)日：2014-02-18
申请号：US13427608
申请日：2012-03-22
申请人： Syed F. A. Hossainy , Stephen D. Pacetti , Keith E. Fong , Vinayak Bhat , Deborra Sanders Millare , Judy A. Guruwaiya , Daryush Mirzaee , Evgenia Mandrusov
发明人： Syed F. A. Hossainy , Stephen D. Pacetti , Keith E. Fong , Vinayak Bhat , Deborra Sanders Millare , Judy A. Guruwaiya , Daryush Mirzaee , Evgenia Mandrusov
CPC分类号： A61L27/34 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L33/0011 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/02 , A61L2420/08 , C08L29/04
摘要： Primer coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The primer coatings can include a material with a high content of hydrogen bonding groups, such as some types of epoxy polymers and melamine formaldehydes. Coatings subsequently disposed over the primer coating can be used for the delivery of an active ingredient or a combination of active ingredients.
摘要翻译： 提供用于可植入装置或腔内假体（例如支架）的底漆涂层，包括形成涂层的方法。 底漆涂层可以包括具有高含量氢键基团的材料，例如一些类型的环氧聚合物和三聚氰胺甲醛。 随后布置在底漆涂层上的涂层可用于递送活性成分或活性成分的组合。
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