公开(公告)号：US20230047436A1

公开(公告)日：2023-02-16

申请号：US17934200

申请日：2022-09-22

申请人： ZEON CORPORATION

发明人： Naoya ICHIMURA

IPC分类号： C07K7/06 ,  G01N33/545 ,  G01N33/543

摘要： A modified peptide or a modified polypeptide has the amino acid sequence of Thr-Val-Asp-Ser-Cys-Leu-Thr (SEQ ID NO: 1) and adhesiveness to a norbornene-based polymer. A ratio of the total number of amino acids constituting the modified peptide or the modified polypeptide to the number of oligopeptides consisting of the amino acid sequence of SEQ ID NO: 1 contained in the modified peptide or the modified polypeptide is 7 or more and 80 or less. The number of oligopeptides consisting of the amino acid sequence of SEQ ID NO: 1 is 1.

公开(公告)号：US20190002830A1

公开(公告)日：2019-01-03

申请号：US16063376

申请日：2016-12-21

申请人： ZEON CORPORATION

发明人： Naoya ICHIMURA

IPC分类号： C12N5/077

摘要： The invention is a method for promoting differentiation of cultured cells, including bringing a norbornene-based addition polymer formed article into contact with cells being cultured, and a cultured cell differentiation-promoting agent including a norbornene-based addition polymer formed article. The invention provides a method that can further promote the differentiation of cultured cells, and a cultured cell differentiation-promoting agent that may suitably be used for the method.

公开(公告)号：US20240199694A1

公开(公告)日：2024-06-20

申请号：US18415933

申请日：2024-01-18

申请人： ZEON CORPORATION

发明人： Naoya ICHIMURA

IPC分类号： C07K7/06 ,  G01N33/543 ,  G01N33/545

CPC分类号： C07K7/06 ,  G01N33/54353 ,  G01N33/545

摘要： An oligopeptide has the amino acid sequence of Thr-Val-Asp-Ser-Cys-Leu-Thr (SEQ ID NO: 1) with addition or insertion of a (poly)peptide to the oligopeptide, or substitution of a (poly)peptide for a part of amino acids of the oligopeptide.

公开(公告)号：US20170121679A1

公开(公告)日：2017-05-04

申请号：US15318357

申请日：2015-06-24

申请人： ZEON CORPORATION

发明人： Naoya ICHIMURA ,  Takaaki HIRANO

IPC分类号： C12N5/071

CPC分类号： C12N5/0629 ,  B32B27/00 ,  C08G61/08 ,  C08G2261/3324 ,  C08G2261/418 ,  C08G2261/724 ,  C12M23/10 ,  C12M23/20 ,  C12M35/08 ,  C12N15/09 ,  C12N2533/00

摘要： The present invention is a method that can promote the differentiation of cultured cells, and a cultured cell differentiation promoter that may suitably be used for the method. The differentiation of cultured cells is induced by bringing an alicyclic structure-containing polymer formed article into contact with cells that are being cultured.

公开(公告)号：US20190331671A1

公开(公告)日：2019-10-31

申请号：US16467171

申请日：2017-12-21

申请人： ZEON CORPORATION

发明人： Naoya ICHIMURA

IPC分类号： G01N33/545 ,  C07K7/06

摘要： Provided is a method for efficiently searching a peptide library for an oligopeptide that can be bound to the end of a protein or peptide of interest. Further, provided is an efficient and highly safe immunoassay.

公开(公告)号：US20180355309A1

公开(公告)日：2018-12-13

申请号：US15776912

申请日：2016-12-12

申请人： ZEON CORPORATION

发明人： Kazuki KUSABIRAKI ,  Naoya ICHIMURA

IPC分类号： C12N5/00

CPC分类号： C12N5/0068 ,  C12N2509/00 ,  C12N2533/30

摘要： The invention is a method for culturing adherent cells, culturing the adherent cells in a liquid medium in an alicyclic structure-containing polymer culture vessel, releasing the cells from the culture vessel by liquid flow without adding a protease, and suspending the cultured cells in a liquid medium. The cells can be easily released by a small force such as pipetting because the cells adhere loosely to the alicyclic structure-containing polymer culture vessel.

公开(公告)号：US20170130203A1

公开(公告)日：2017-05-11

申请号：US15318955

申请日：2015-06-24

申请人： ZEON CORPORATION

发明人： Naoya ICHIMURA ,  Takaaki HIRANO

IPC分类号： C12N5/071 ,  C12N5/00 ,  C12P21/00

CPC分类号： C12N5/0682 ,  C12M25/14 ,  C12N5/0068 ,  C12N5/10 ,  C12N2533/30 ,  C12P21/00

摘要： The present invention is a method for culturing adherent cells that can allow adherent cells to survive and grow even in a suspended state, a culture vessel that is formed using an alicyclic structure-containing polymer, and includes a liquid medium, and adherent cells that survive in the liquid medium in a suspended state, and a method for producing a protein. The adhesive cells can be grown in a method for culturing adherent cells comprising bringing adherent cells into contact with an alicyclic structure-containing polymer formed article to grow the adherent cells in a state in which the adherent cells are suspended in a liquid medium.