公开(公告)号：US20180105477A1

公开(公告)日：2018-04-19

申请号：US15565133

申请日：2016-11-29

申请人： ZHEJIANG NHU COMPANY LTD. ,  SHANDONG NHU PHARMACEUTICAL CO., LTD. ,  ZHEJIANG UNIVERSITY

发明人： YOUGUI ZHOU ,  MING YU ,  JINTAO YUAN ,  LEI ZHAO ,  XIANDONG ZHU ,  GUANGXIONG YU ,  WEIWEI SU ,  WEIKANG SHAO ,  XINGXING SHI ,  YIN ZHANG ,  MING FENG ,  ZHIRONG CHEN ,  HAORAN LI ,  YUHONG ZHANG

IPC分类号： C07B53/00 ,  B01J31/02 ,  B01J23/46 ,  C07C45/62 ,  C07C47/21 ,  C07C47/225 ,  C07C47/232 ,  C07C49/21 ,  C07C49/217 ,  C07D307/46 ,  C07D333/22

CPC分类号： C07B53/00 ,  B01J23/462 ,  B01J23/464 ,  B01J23/468 ,  B01J31/02 ,  B01J31/0237 ,  C07C45/62 ,  C07C47/21 ,  C07C47/225 ,  C07C47/232 ,  C07C49/21 ,  C07C49/217 ,  C07C67/303 ,  C07C201/12 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/10 ,  C07D307/46 ,  C07D333/22 ,  Y02P20/584 ,  C07C205/44 ,  C07C47/02 ,  C07C47/19 ,  C07C47/198 ,  C07C47/23 ,  C07C69/716 ,  C07C47/24 ,  C07C49/403 ,  C07C47/277 ,  C07C49/175 ,  C07C49/213 ,  C07C49/215 ,  C07C49/427

摘要： The present invention discloses a method for preparing optically active carbonyl compound, comprising the following steps: under the catalysis of chiral amine salt and transition metal catalysts, with hydrogen and catalytic amount of dihydropyridine compound as hydrogen source, use α, β-unsaturated aldehydes or α, β-unsaturated troponoid compounds to conduct asymmetric catalytic reaction to obtain the optically active carbonyl compound. This method comes in moderate reaction condition, simple operation, and catalytic amount of dihydropyridine compounds usage, the target product is easy to be separated and purified from the reaction system, and the metal catalyst can be recycled, it is economical.