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公开(公告)号:US10065901B2
公开(公告)日:2018-09-04
申请号:US15565133
申请日:2016-11-29
发明人: Yougui Zhou , Ming Yu , Jintao Yuan , Lei Zhao , Xiandong Zhu , Guangxiong Yu , Weiwei Su , Weikang Shao , Xingxing Shi , Yin Zhang , Ming Feng , Zhirong Chen , Haoran Li , Yuhong Zhang
IPC分类号: C07C45/62 , C07B53/00 , B01J31/02 , B01J23/46 , C07D333/22 , C07C47/225 , C07C47/232 , C07C49/21 , C07C49/217 , C07D307/46 , C07C47/21
摘要: The present invention discloses a method for preparing optically active carbonyl compound, comprising the following steps: under the catalysis of chiral amine salt and transition metal catalysts, with hydrogen and catalytic amount of dihydropyridine compound as hydrogen source, use α, β-unsaturated aldehydes or α, β-unsaturated troponoid compounds to conduct asymmetric catalytic reaction to obtain the optically active carbonyl compound. This method comes in moderate reaction condition, simple operation, and catalytic amount of dihydropyridine compounds usage, the target product is easy to be separated and purified from the reaction system, and the metal catalyst can be recycled, it is economical.
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2.
公开(公告)号:US10058849B2
公开(公告)日:2018-08-28
申请号:US15565593
申请日:2016-05-10
发明人: Ming Yu , Jintao Yuan , Haidong Yu , Weikang Shao , Yuhong Zhang
IPC分类号: B01J23/847 , C07C35/12 , C07C29/20 , C07C29/56
CPC分类号: B01J23/8472 , B01J23/835 , B01J23/847 , B01J25/02 , B01J37/06 , B01J2523/31 , B01J2523/55 , B01J2523/845 , B01J2523/847 , C07C29/20 , C07C29/56 , C07C35/12 , C07C2601/14 , C22C19/03
摘要: The present invention discloses a metal complex catalyst, its preparing method and its application in preparing D,L-menthol, the metal complex catalyst includes weight percent elements as follows: 70-85% of Ni, 8-10% of Al, 5-10% of V, and 2-10% of Co. When this metal complex catalyst is applied in preparing D,L-menthol through thymol hydrogenation, it has the characteristics of high reaction activity and quick racemization of chiral compound. Meanwhile, a certain kind of alkali added in isomerization is the key to reducing light constituent byproduct. The whole process comes in good reaction selectivity, simple preparing technology, low production cost, and environment-friendly synthetic route.
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