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公开(公告)号：US20050250126A1
公开(公告)日：2005-11-10
申请号：US11015546
申请日：2004-12-16
申请人： Zeren Gao , Paul Sheppard , Brian Fox , James Holloway , Stephen Jaspers , Mark Appleby
发明人： Zeren Gao , Paul Sheppard , Brian Fox , James Holloway , Stephen Jaspers , Mark Appleby
IPC分类号： C07H21/04 , C07K14/525 , C07K14/705 , C07K16/24 , C07K16/28 , C12P21/02 , C12P21/06 , C12Q1/68
CPC分类号： C07K14/525 , C07K16/2875 , C07K2317/34
摘要： Novel tumor necrosis factor ligand polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides may be used within methods relating to immune response, and may also be used in the development of immuno-regulatory therapeutics. Also provided are antibodies, binding proteins, agonists and antagonists of the ligand polypeptides.
摘要翻译： 公开了新型肿瘤坏死因子配体多肽，编码多肽的多核苷酸，以及相关的组合物和方法。 多肽可用于与免疫应答相关的方法中，并且也可用于开发免疫调节治疗。 还提供了配体多肽的抗体，结合蛋白，激动剂和拮抗剂。
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公开(公告)号：US20050255496A1
公开(公告)日：2005-11-17
申请号：US11013247
申请日：2004-12-15
申请人： Zeren Gao , Paul Sheppard , Brian Fox , James Holloway , Stephen Jaspers
发明人： Zeren Gao , Paul Sheppard , Brian Fox , James Holloway , Stephen Jaspers
IPC分类号： C07H21/04 , C07K14/525 , C07K14/715 , C07K16/24 , C12N15/09 , C12P21/02 , C12Q1/68 , G01N33/68
CPC分类号： C07K14/525 , A61K2039/505 , C07K14/7151 , C07K16/241 , C07K2317/34 , C07K2319/30 , C12Q1/6883 , C12Q2600/158 , G01N33/6863 , G01N2500/00
摘要： Novel tumor necrosis factor ligand polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides may be used within methods relating to immune response, and may also be used in the development of immuno-regulatory therapeutics. Also provided are antibodies, binding proteins, agonists and antagonists of the ligand polypeptides.
摘要翻译： 公开了新型肿瘤坏死因子配体多肽，编码多肽的多核苷酸，以及相关的组合物和方法。 多肽可用于与免疫应答相关的方法中，并且也可用于开发免疫调节治疗。 还提供了配体多肽的抗体，结合蛋白，激动剂和拮抗剂。
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公开(公告)号：US20050255560A1
公开(公告)日：2005-11-17
申请号：US10994820
申请日：2004-11-22
申请人： Zeren Gao , Paul Sheppard , Brian Fox , James Holloway , Stephen Jaspers
发明人： Zeren Gao , Paul Sheppard , Brian Fox , James Holloway , Stephen Jaspers
CPC分类号： C07K16/2875 , A61K38/00 , C07K14/525 , C07K2317/34
摘要： Novel tumor necrosis factor ligand polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides may be used within methods relating to immune response, and may also be used in the development of immuno-regulatory therapeutics. Also provided are antibodies, binding proteins, agonists and antagonists of the ligand polypeptides.
摘要翻译： 公开了新型肿瘤坏死因子配体多肽，编码多肽的多核苷酸，以及相关的组合物和方法。 多肽可用于与免疫应答相关的方法中，并且也可用于开发免疫调节治疗。 还提供了配体多肽的抗体，结合蛋白，激动剂和拮抗剂。
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公开(公告)号：US20050256041A1
公开(公告)日：2005-11-17
申请号：US10967527
申请日：2004-10-18
申请人： Brian Fox , James Holloway , Paul Sheppard , Stacey Dillon
发明人： Brian Fox , James Holloway , Paul Sheppard , Stacey Dillon
IPC分类号： A61K38/00 , A61K38/17 , C07H21/04 , C07K14/715 , C12N15/09
CPC分类号： C07K14/7151 , A61K38/00
摘要： Novel tumor necrosis factor receptor (TNFR) polypeptides, polynucleotides encoding the polypeptides, antibodies and related compositions and methods are disclosed. The polypeptides may be used for detecting ligand, as well as agonists and antagonists. The polypeptides, polynucleotides and antibodies may also be used in methods that modulate tumor growth, metastasis, and immunity such as separating resting from stimulated immune cells.
摘要翻译： 公开了新型肿瘤坏死因子受体（TNFR）多肽，编码多肽的多核苷酸，抗体及相关组合物和方法。 多肽可用于检测配体，以及激动剂和拮抗剂。 多肽，多核苷酸和抗体也可以用于调节肿瘤生长，转移和免疫的方法，例如从刺激的免疫细胞分离休息。
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公开(公告)号：US20070298037A1
公开(公告)日：2007-12-27
申请号：US11556854
申请日：2006-11-06
申请人： Brian Fox , James Holloway , Paul Sheppard , Stacey Dillon
发明人： Brian Fox , James Holloway , Paul Sheppard , Stacey Dillon
IPC分类号： A61K39/395 , A61K38/17 , A61P1/00 , A61P17/06 , A61P25/00
CPC分类号： C07K14/7151 , A61K38/1793 , A61K2039/505 , C07K16/2878 , C07K2317/71 , C07K2319/30 , C07K2319/32 , C07K2319/40
摘要： Novel tumor necrosis factor receptor (TNFR) polypeptides, polynucleotides encoding the polypeptides, antibodies and related compositions and methods are disclosed. The polypeptides may be used for detecting ligand, as well as agonists and antagonists. The polypeptides, polynucleotides and antibodies may also be used in methods that modulate tumor growth, metastasis, and immunity such as separating resting from stimulated immune cells.
摘要翻译： 公开了新型肿瘤坏死因子受体（TNFR）多肽，编码多肽的多核苷酸，抗体及相关组合物和方法。 多肽可用于检测配体，以及激动剂和拮抗剂。 多肽，多核苷酸和抗体也可以用于调节肿瘤生长，转移和免疫的方法，例如从刺激的免疫细胞分离休息。
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公开(公告)号：US20070053903A1
公开(公告)日：2007-03-08
申请号：US11433269
申请日：2006-05-12
申请人： Zeren Gao , Brian Fox , Steven Levin , Frederick Ramsdell , Edward Howard , Janine Bilsborough
发明人： Zeren Gao , Brian Fox , Steven Levin , Frederick Ramsdell , Edward Howard , Janine Bilsborough
CPC分类号： C07K14/47 , A61K38/00 , C07K16/2827 , C07K2317/73 , C07K2319/00 , C07K2319/30
摘要： The invention provides pHHLA2 co-receptor polypeptides and functional fragments, antibodies to same, isolated polynucleotides encoding same, vectors containing the polynucleotides, cells containing the vectors. Methods of making and using these co-stimulatory pHHLA2 co-receptors molecules are also disclosed.
摘要翻译： 本发明提供pHHLA2辅助受体多肽和功能片段，对相同的编码相同的分离的多核苷酸的抗体，含有多核苷酸的载体，含有载体的细胞。 还公开了制备和使用这些共刺激性pHHLA2共受体分子的方法。
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公开(公告)号：US20080081786A1
公开(公告)日：2008-04-03
申请号：US11868170
申请日：2007-10-05
申请人： Paul Sheppard , Brian Fox , Kevin Klucher , David Taft , Wayne Kindsvogel
发明人： Paul Sheppard , Brian Fox , Kevin Klucher , David Taft , Wayne Kindsvogel
CPC分类号： C07K14/715 , A61K38/20 , A61K38/21 , C07K14/56 , C07K16/24 , C07K16/2866 , C07K2317/76 , C12Q2600/158 , Y02A50/473
摘要： The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
摘要翻译： 本发明涉及与氨基酸序列水平上与干扰素-α最密切相关的zcyto20，zcyto21，zcyto22，zycto24和zcyto25蛋白的多核苷酸和多肽分子。 该蛋白家族的受体是II类细胞因子受体。 本发明包括减少病毒感染和增加单核细胞计数的方法。 本发明还包括针对zcyto20多肽的抗体，以及产生多核苷酸和多肽的方法。
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公开(公告)号：US20070042468A1
公开(公告)日：2007-02-22
申请号：US11548023
申请日：2006-10-10
申请人： Paul Sheppard , Scott Presnell , Brian Fox , Teresa Gilbert , Betty Haldeman , Francis Grant
发明人： Paul Sheppard , Scott Presnell , Brian Fox , Teresa Gilbert , Betty Haldeman , Francis Grant
CPC分类号： C07K14/47 , C07K14/52 , C07K2319/00
摘要： The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
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公开(公告)号：US20070254340A1
公开(公告)日：2007-11-01
申请号：US11539093
申请日：2006-10-05
申请人： Paul Sheppard , Brian Fox , Kevin Klucher , David Taft , Wayne Kindsvogel
发明人： Paul Sheppard , Brian Fox , Kevin Klucher , David Taft , Wayne Kindsvogel
IPC分类号： C12P21/00
CPC分类号： C07K14/715 , A61K38/20 , A61K38/21 , C07K14/56 , C07K16/24 , C07K16/2866 , C07K2317/76 , C12Q2600/158 , Y02A50/473
摘要： The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
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公开(公告)号：US20070048841A1
公开(公告)日：2007-03-01
申请号：US11548056
申请日：2006-10-10
申请人： Paul Sheppard , Scott Presnell , Brian Fox , Teresa Gilbert , Betty Haldeman , Francis Grant
发明人： Paul Sheppard , Scott Presnell , Brian Fox , Teresa Gilbert , Betty Haldeman , Francis Grant
CPC分类号： C07K14/47 , C07K14/52 , C07K2319/00
摘要： The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
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