-
公开(公告)号：US20100256172A1
公开(公告)日：2010-10-07
申请号：US12657801
申请日：2010-01-28
申请人： Zhan Shi , Irache Visiers , Tricia J. Vos , Stepan Vyskocil
发明人： Zhan Shi , Irache Visiers , Tricia J. Vos , Stepan Vyskocil
IPC分类号： A61K31/506 , C07D401/14 , A61K31/4439 , A61P35/00 , A61P29/00 , A61P9/00 , A61P37/06
CPC分类号： A61K31/4439 , A61K31/4436 , A61K31/444 , A61K31/497 , A61K31/506 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/14
摘要： This invention provides compounds of formula I: wherein R1, R2, R3, CY, X1, X2, and X3 are as described in the specification. The compounds are inhibitors of PI3K and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
摘要翻译： 本发明提供式I化合物：其中R1，R2，R3，CY，X1，X2和X3如说明书中所述。 这些化合物是PI3K的抑制剂，因此可用于治疗增殖性，炎性或心血管疾病。
-
公开(公告)号：US08796314B2
公开(公告)日：2014-08-05
申请号：US12657801
申请日：2010-01-28
申请人： Zhan Shi , Irache Visiers , Tricia J. Vos , Stepan Vyskocil
发明人： Zhan Shi , Irache Visiers , Tricia J. Vos , Stepan Vyskocil
IPC分类号： A61K31/506 , A61K31/497 , A61K31/444 , A61K31/4439 , A61K31/4436 , C07D409/14 , C07D409/04
CPC分类号： A61K31/4439 , A61K31/4436 , A61K31/444 , A61K31/497 , A61K31/506 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/14
摘要： This invention provides compounds of formula I: wherein R1, R2, R3, CY, X1, X2, and X3 are as described in the specification. The compounds are inhibitors of PI3K and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
摘要翻译： 本发明提供式I化合物：其中R1，R2，R3，CY，X1，X2和X3如说明书中所述。 这些化合物是PI3K的抑制剂，因此可用于治疗增殖性，炎性或心血管疾病。
-
公开(公告)号：US08481550B2
公开(公告)日：2013-07-09
申请号：US13216352
申请日：2011-08-24
申请人： Christopher F. Claiborne , Stephen Critchley , Courtney A. Cullis , Steven P. Langston , Hirotake Mizutani , Edward J. Olhava , Stephane Peluso , Irache Visiers , Stepan Vyskocil , Gabriel S. Weatherhead
发明人： Christopher F. Claiborne , Stephen Critchley , Courtney A. Cullis , Steven P. Langston , Hirotake Mizutani , Edward J. Olhava , Stephane Peluso , Irache Visiers , Stepan Vyskocil , Gabriel S. Weatherhead
IPC分类号： A61K31/505 , C07D239/48
CPC分类号： C07D239/42 , A61K31/53 , C07D213/56 , C07D213/69 , C07D213/74 , C07D213/81 , C07D213/82 , C07D239/36 , C07D239/48 , C07D251/18 , C07D251/48 , C07D401/04 , C07D401/06 , C07D403/04 , C07D471/04 , C07D471/08 , C07D473/30 , C07D473/34 , C07D487/04
摘要： This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.
-
公开(公告)号：US08008307B2
公开(公告)日：2011-08-30
申请号：US11890338
申请日：2007-08-06
申请人： Christopher F. Claiborne , Stephen Critchley , Courtney Cullis , Steven P. Langston , Hirotake Mizutani , Edward J. Olhava , Stephane Peluso , Irache Visiers , Stepan Vyskocil , Gabriel S. Weatherhead
发明人： Christopher F. Claiborne , Stephen Critchley , Courtney Cullis , Steven P. Langston , Hirotake Mizutani , Edward J. Olhava , Stephane Peluso , Irache Visiers , Stepan Vyskocil , Gabriel S. Weatherhead
IPC分类号： C07D239/48 , A61K31/505
CPC分类号： C07D239/42 , A61K31/53 , C07D213/56 , C07D213/69 , C07D213/74 , C07D213/81 , C07D213/82 , C07D239/36 , C07D239/48 , C07D251/18 , C07D251/48 , C07D401/04 , C07D401/06 , C07D403/04 , C07D471/04 , C07D471/08 , C07D473/30 , C07D473/34 , C07D487/04
摘要： This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.
摘要翻译： 本发明涉及抑制E1活化酶的化合物，包含该化合物的药物组合物和使用该化合物的方法。 该化合物可用于治疗疾病，特别是细胞增殖病症，包括癌症，炎症和神经变性疾病; 和与感染和恶病质相关的炎症。
-
公开(公告)号：US20120071482A1
公开(公告)日：2012-03-22
申请号：US13216352
申请日：2011-08-24
申请人： Christopher F. Claiborne , Stephen Critchley , Courtney Cullis , Steven P. Langston , Hirotake Mizutani , Edward J. Olhava , Stephane Peluso , Irache Visiers , Stepan Vyskocil , Gabriel S. Weatherhead
发明人： Christopher F. Claiborne , Stephen Critchley , Courtney Cullis , Steven P. Langston , Hirotake Mizutani , Edward J. Olhava , Stephane Peluso , Irache Visiers , Stepan Vyskocil , Gabriel S. Weatherhead
IPC分类号： A61K31/53 , A61K31/52 , A61K31/519 , A61K31/506 , A61K31/505 , A61K31/437 , A61K31/44 , C07D251/48 , C07D487/04 , A61P35/00 , C07D401/04 , C07D239/47 , C07D471/04 , C07D211/98 , C07D473/28 , C12N9/99
CPC分类号： C07D239/42 , A61K31/53 , C07D213/56 , C07D213/69 , C07D213/74 , C07D213/81 , C07D213/82 , C07D239/36 , C07D239/48 , C07D251/18 , C07D251/48 , C07D401/04 , C07D401/06 , C07D403/04 , C07D471/04 , C07D471/08 , C07D473/30 , C07D473/34 , C07D487/04
摘要： This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.
摘要翻译： 本发明涉及抑制E1活化酶的化合物，包含该化合物的药物组合物和使用该化合物的方法。 该化合物可用于治疗疾病，特别是细胞增殖病症，包括癌症，炎症和神经变性疾病; 和与感染和恶病质相关的炎症。
-
公开(公告)号：US20080051404A1
公开(公告)日：2008-02-28
申请号：US11890338
申请日：2007-08-06
申请人： Christopher Claiborne , Stephen Critchley , Courtney Cullis , Steven Langston , Hiro Mizutani , Edward Olhava , Stephane Peluso , Irache Visiers , Stepan Vyskocil , Gabriel Weatherhead
发明人： Christopher Claiborne , Stephen Critchley , Courtney Cullis , Steven Langston , Hiro Mizutani , Edward Olhava , Stephane Peluso , Irache Visiers , Stepan Vyskocil , Gabriel Weatherhead
IPC分类号： C07D473/32 , A61K31/44 , A61K31/4965 , A61K31/519 , A61K31/52 , A61K31/522 , A61K31/53 , C12N9/99 , A61P35/00 , A61P37/00 , C07D211/92 , C07D239/24 , C07D251/48
CPC分类号： C07D239/42 , A61K31/53 , C07D213/56 , C07D213/69 , C07D213/74 , C07D213/81 , C07D213/82 , C07D239/36 , C07D239/48 , C07D251/18 , C07D251/48 , C07D401/04 , C07D401/06 , C07D403/04 , C07D471/04 , C07D471/08 , C07D473/30 , C07D473/34 , C07D487/04
摘要： This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.
摘要翻译： 本发明涉及抑制E1活化酶的化合物，包含该化合物的药物组合物和使用该化合物的方法。 该化合物可用于治疗疾病，特别是细胞增殖病症，包括癌症，炎症和神经变性疾病; 和与感染和恶病质相关的炎症。
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.031 秒)
