公开(公告)号：US20110005305A1

公开(公告)日：2011-01-13

申请号：US12517946

申请日：2007-12-06

申请人： Zhi Xu ,  Rakesh Bose ,  James M. Anderson

发明人： Zhi Xu ,  Rakesh Bose ,  James M. Anderson

IPC分类号： G01N30/28

CPC分类号： G01N30/84 ,  G01N30/74 ,  G01N2030/8447 ,  G01N2030/847 ,  G01N2030/8494

摘要： A flow controller for use with a liquid chromatography detector. The flow controller includes a flow channel comprising an inlet portion, a control channel portion in communication with the inlet portion, and an outlet portion in communication with said control channel portion. The control channel portion has a cross-sectional area smaller than a cross-sectional area of a drift tube of the liquid chromatography detector for channeling the flow of droplets through the smaller cross-sectional area. The flow controller is shaped and sized to reduce pressure fluctuations and turbulence in the droplet stream of the liquid chromatography detector.

摘要翻译： 用于液相色谱检测器的流量控制器。 流量控制器包括流动通道，其包括入口部分，与入口部分连通的控制通道部分和与所述控制通道部分连通的出口部分。 控制通道部分的横截面积小于液相色谱检测器的漂移管的横截面面积，用于将液滴流通过较小的横截面积。 流量控制器的形状和尺寸可以减小液相色谱检测器液滴流中的压力波动和湍流。

公开(公告)号：US08397553B2

公开(公告)日：2013-03-19

申请号：US12517946

申请日：2007-12-06

申请人： Zhi Xu ,  Rakesh Bose ,  James M. Anderson

发明人： Zhi Xu ,  Rakesh Bose ,  James M. Anderson

IPC分类号： G01N1/00

CPC分类号： G01N30/84 ,  G01N30/74 ,  G01N2030/8447 ,  G01N2030/847 ,  G01N2030/8494

摘要： A flow controller for use with a liquid chromatography detector. The flow controller includes a flow channel comprising an inlet portion, a control channel portion in communication with the inlet portion, and an outlet portion in communication with said control channel portion. The control channel portion has a cross-sectional area smaller than a cross-sectional area of a drift tube of the liquid chromatography detector for channeling the flow of droplets through the smaller cross-sectional area. The flow controller is shaped and sized to reduce pressure fluctuations and turbulence in the droplet stream of the liquid chromatography detector.

摘要翻译： 用于液相色谱检测器的流量控制器。 流量控制器包括流动通道，其包括入口部分，与入口部分连通的控制通道部分和与所述控制通道部分连通的出口部分。 控制通道部分的横截面积小于液相色谱检测器的漂移管的横截面面积，用于将液滴流通过较小的横截面积。 流量控制器的形状和尺寸可以减小液相色谱检测器液滴流中的压力波动和湍流。

公开(公告)号：US20130006071A1

公开(公告)日：2013-01-03

申请号：US13610256

申请日：2012-09-11

申请人： Zhi Xu

发明人： Zhi Xu

IPC分类号： A61B5/1455

CPC分类号： A61B5/14532 ,  A61B5/1455 ,  A61B5/6826 ,  A61B5/6838 ,  A61B5/7225 ,  A61B2562/0238 ,  A61B2576/00 ,  G06F19/00

摘要： Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. This includes utilizing at least one light source configured to strike a target area of a sample, utilizing at least one light filter positioned to receive light transmitted through the target area of the sample from the at least one light source, utilizing at least one light detector positioned to receive light from the at least one light source and filtered by the at least one light filter, and to generate an output signal, having a time dependent current, which is indicative of the power of light detected, receiving the output signal from the at least one light detector with a processor, calculating the attenuance attributable to blood with a ratio factor based on the received output signal, and determining a blood glucose level based on the calculated attenuance.

摘要翻译： 公开了基于光谱数据非生物地测量生物样品中的血糖水平的系统和方法。 这包括利用至少一个光源，其被配置成撞击样品的目标区域，利用至少一个光过滤器，其定位成通过至少一个光检测器接收透射来自所述至少一个光源的样品的目标区域的光 定位成从所述至少一个光源接收光并被所述至少一个滤光器滤波，并且产生具有时间相关电流的输出信号，所述时间相关电流指示所检测的光的功率，从所述至少一个光滤波器接收来自所述至少一个光滤波器的输出信号 具有处理器的至少一个光检测器，基于所接收的输出信号以比例因子计算归因于血液的衰减，以及基于所计算的衰减来确定血糖水平。

公开(公告)号：US20130006070A1

公开(公告)日：2013-01-03

申请号：US13610140

申请日：2012-09-11

申请人： Zhi Xu

发明人： Zhi Xu

IPC分类号： A61B5/1455

CPC分类号： A61B5/14532 ,  A61B5/1455 ,  A61B5/6826 ,  A61B5/6838 ,  A61B5/7225 ,  A61B2562/0238 ,  A61B2576/00 ,  G06F19/00

摘要： Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. This includes utilizing at least one light source configured to strike a target area of a sample, utilizing at least one light filter positioned to receive light transmitted through the target area from the at least one light source, utilizing at least one light detector positioned to receive light from the at least one light source and filtered by the at least one light filter, and to generate an output signal, having a time dependent current, which is indicative of the power of light detected, receiving the output signal from the at least one light detector with a processor and based on the received output signal, calculating the attenuance attributable to blood in a sample with a signal-to-noise ratio of at least 20-to-1; and determining a blood glucose level.

摘要翻译： 公开了基于光谱数据非生物地测量生物样品中的血糖水平的系统和方法。 这包括利用构造成撞击样品的目标区域的至少一个光源，利用至少一个光过滤器，其定位成从至少一个光源接收透射通过目标区域的光，利用至少一个光检测器定位成接收 来自所述至少一个光源的光并由所述至少一个滤光器滤波，并且产生输出信号，所述输出信号具有指示所检测的光的功率的时间相关电流，所述输出信号从所述至少一个光滤波器接收所述输出信号 光检测器，具有处理器并基于接收的输出信号，计算信噪比至少为20比1的样品中归因于血液的衰减; 并确定血糖水平。

公开(公告)号：US07961305B2

公开(公告)日：2011-06-14

申请号：US12256028

申请日：2008-10-22

申请人： Zhi Xu ,  Robert D. Rosenthal

发明人： Zhi Xu ,  Robert D. Rosenthal

IPC分类号： G01N33/48

CPC分类号： G01N21/474 ,  A61B5/0059 ,  A61B5/14532 ,  A61B5/1455 ,  G01N2201/0633

摘要： Embodiments of the invention relate to an internal reflection light funnel, including an internal reflection cone having a first diameter at an entrance end and a second diameter at an exit end, the first diameter being greater than the second diameter; and a light source embedded within the cone. The funnel has a half angle of less than about 25 degrees.

摘要翻译： 本发明的实施例涉及一种内反射光漏斗，其包括在入射端具有第一直径且在出射端具有第二直径的内反射锥体，第一直径大于第二直径; 以及嵌入锥体内的光源。 漏斗的半角小于约25度。

公开(公告)号：US07809418B2

公开(公告)日：2010-10-05

申请号：US12245298

申请日：2008-10-03

申请人： Zhi Xu

发明人： Zhi Xu

IPC分类号： A61B5/1455

CPC分类号： G01N21/359 ,  A61B5/14532 ,  A61B5/1455 ,  G01N21/474

摘要： Embodiments of the invention relate to an apparatus including a light source to generate a plurality of light beams with each of the plurality of light beams having a different wavelength range. The apparatus also includes a light funnel to direct the plurality of light beams to the target area, an aperture to direct the plurality of light beams emitting from the target area to a lens, the lens configured to collect the light beams emitting from the target area. Further, the apparatus includes a detector including a plurality of light-sensing devices each configured to detect a light beam and configured to generate an output signal indicative of an intensity of light detected and a processor for determining the blood characteristic as a function of each generated output signal.

摘要翻译： 本发明的实施例涉及一种包括用于产生多个光束的光源的装置，其中多个光束中的每一个具有不同的波长范围。 该装置还包括一个光漏斗，用于将多个光束引导到目标区域，一个孔径，用于将从目标区域发射的多个光束引导到透镜，该透镜被配置成收集从目标区域发射的光束 。 此外，该装置包括检测器，其包括多个光感测装置，每个光感测装置被配置为检测光束并且被配置为产生指示所检测到的光的强度的输出信号，以及用于根据每个生成的功能确定血液特性的处理器 输出信号。

公开(公告)号：US20100002229A1

公开(公告)日：2010-01-07

申请号：US12325890

申请日：2008-12-01

申请人： David W. Larsen ,  Zhi Xu

发明人： David W. Larsen ,  Zhi Xu

IPC分类号： G01N21/53

CPC分类号： G01N30/74 ,  G01N21/0303 ,  G01N21/53 ,  G01N2030/847 ,  G01N2030/8494 ,  G01N2201/0642 ,  G01N21/47

摘要： The invention concerns high sensitivity light scattering detection and its application to evaporative light scattering detection in liquid chromatography. The exemplary embodiment includes a detection cell to accept particles suspended in a gas stream and permit a polarized light beam to pass through a trajectory of the particles and gas stream. A sample light detector is disposed to detect light scattered in the detection cell. A light trap accepts the polarized beam after it passes through the detection cell. The light trap includes an elongated housing through which the polarized beam passes, and light absorptive material within the elongated housing. An absorptive filter is aligned such that the angle of incidence of the light beam upon the filter approximates Brewster's angle and the electric field vector of the beam is aligned with the plane of incidence between the beam and the filter. Other embodiments of the invention provide increased light collection. Embodiments of the invention include temperature-controlled entrance and exit ports that control particle trajectory. Embodiments of the invention include a reference cell disposed between a detection cell and a light trap, and the reference cell includes lensing and a spherical mirror to direct light toward a reference light detector. The reference light detector provides a reference signal that may be used with noise cancellation circuitry, operating in either voltage or current mode, to reduce light source noise in the sample signal.

摘要翻译： 本发明涉及高灵敏度光散射检测及其在液相色谱中的蒸发光散射检测中的应用。 该示例性实施例包括接收悬浮在气流中的颗粒并允许偏振光束通过颗粒和气流的轨迹的检测单元。 设置采样光检测器以检测在检测单元中散射的光。 光阱在其通过检测单元之后接受偏振光束。 光阱包括通过偏振光束通过的细长壳体和细长壳体内的光吸收材料。 对准吸收滤光器，使得光束在滤光片上的入射角近似于布鲁斯特角，并且光束的电场矢量与光束与滤光片之间的入射平面对准。 本发明的其它实施例提供增加的光收集。 本发明的实施例包括控制粒子轨迹的温度控制的入口和出口。 本发明的实施例包括设置在检测单元和光阱之间的参考单元，并且参考单元包括透镜和球面镜，以将光引向参考光检测器。 参考光检测器提供可用于噪声消除电路的参考信号，其以电压或电流模式工作，以减少采样信号中的光源噪声。

公开(公告)号：US20090247843A1

公开(公告)日：2009-10-01

申请号：US12407999

申请日：2009-03-20

申请人： Zhi Xu

发明人： Zhi Xu

IPC分类号： A61B5/1455

CPC分类号： A61B5/1455 ,  A61B5/14532

摘要： A method and system for detecting glucose in a biological sample is disclosed. This includes illuminating a biological sample with a light source, collecting transmitted, transflected or reflected light from the sample with a detector, generating spectral data of one or more components in the sample other than glucose in a spectral data analysis device, and analyzing the spectral data of the one or more components, sufficient to provide a glucose measurement from the spectral data of the one or more components other than glucose with the spectral data analysis device.

摘要翻译： 公开了一种用于检测生物样品中的葡萄糖的方法和系统。 这包括用光源照射生物样品，用检测器收集来自样品的透射的，透过的或反射的光，在光谱数据分析装置中产生除了葡萄糖之外的样品中的一个或多个成分的光谱数据，并分析光谱 所述一个或多个组件的数据足以从所述光谱数据分析装置提供葡萄糖以外的一种或多种组分的光谱数据进行葡萄糖测量。

公开(公告)号：US07268881B2

公开(公告)日：2007-09-11

申请号：US10780278

申请日：2004-02-17

申请人： David W. Larsen ,  Zhi Xu

发明人： David W. Larsen ,  Zhi Xu

IPC分类号： G01N21/00

CPC分类号： G01N30/74 ,  G01N21/0303 ,  G01N21/53 ,  G01N2030/847 ,  G01N2030/8494 ,  G01N2201/0642 ,  G01N21/47

摘要： The invention concerns high sensitivity light scattering detection and its application to evaporative light scattering detection in liquid chromatography. The exemplary embodiment includes a detection cell to accept particles suspended in a gas stream and permit a polarized light beam to pass through a trajectory of the particles and gas stream. A sample light detector is disposed to detect light scattered in the detection cell. A light trap accepts the polarized beam after it passes through the detection cell. The light trap includes an elongated housing through which the polarized beam passes, and light absorptive material within the elongated housing. An absorptive filter is aligned such that the angle of incidence of the light beam upon the filter approximates Brewster's angle and the electric field vector of the beam is aligned with the plane of incidence between the beam and the filter. Other embodiments of the invention provide increased light collection. Embodiments of the invention include temperature-controlled entrance and exit ports that control particle trajectory. Embodiments of the invention include a reference cell disposed between a detection cell and a light trap, and the reference cell includes lensing and a spherical mirror to direct light toward a reference light detector. The reference light detector provides a reference signal that may be used with noise cancellation circuitry, operating in either voltage or current mode, to reduce light source noise in the sample signal.

摘要翻译： 本发明涉及高灵敏度光散射检测及其在液相色谱中的蒸发光散射检测中的应用。 该示例性实施例包括接收悬浮在气流中的颗粒并允许偏振光束通过颗粒和气流的轨迹的检测单元。 设置采样光检测器以检测在检测单元中散射的光。 光阱在其通过检测单元之后接受偏振光束。 光阱包括通过偏振光束通过的细长壳体和细长壳体内的光吸收材料。 对准吸收滤光器，使得光束在滤光片上的入射角近似于布鲁斯特角，并且光束的电场矢量与光束与滤光片之间的入射平面对准。 本发明的其它实施例提供增加的光收集。 本发明的实施例包括控制粒子轨迹的温度控制的入口和出口。 本发明的实施例包括设置在检测单元和光阱之间的参考单元，并且参考单元包括透镜和球面镜，以将光引向参考光检测器。 参考光检测器提供可用于噪声消除电路的参考信号，其以电压或电流模式工作，以减少采样信号中的光源噪声。

公开(公告)号：US20050179904A1

公开(公告)日：2005-08-18

申请号：US10780278

申请日：2004-02-17

申请人： David Larsen ,  Zhi Xu

发明人： David Larsen ,  Zhi Xu

IPC分类号： G01N21/00 ,  G01N21/03 ,  G01N21/53 ,  G01N30/74 ,  G01N30/84

CPC分类号： G01N30/74 ,  G01N21/0303 ,  G01N21/53 ,  G01N2030/847 ,  G01N2030/8494 ,  G01N2201/0642 ,  G01N21/47

摘要： The invention concerns high sensitivity light scattering detection and its application to evaporative light scattering detection in liquid chromatography. The exemplary embodiment includes a detection cell to accept particles suspended in a gas stream and permit a polarized light beam to pass through a trajectory of the particles and gas stream. A sample light detector is disposed to detect light scattered in the detection cell. A light trap accepts the polarized beam after it passes through the detection cell. The light trap includes an elongated housing through which the polarized beam passes, and light absorptive material within the elongated housing. An absorptive filter is aligned such that the angle of incidence of the light beam upon the filter approximates Brewster's angle and the electric field vector of the beam is aligned with the plane of incidence between the beam and the filter. Other embodiments of the invention provide increased light collection. Embodiments of the invention include temperature-controlled entrance and exit ports that control particle trajectory. Embodiments of the invention include a reference cell disposed between a detection cell and a light trap, and the reference cell includes lensing and a spherical mirror to direct light toward a reference light detector. The reference light detector provides a reference signal that may be used with noise cancellation circuitry, operating in either voltage or current mode, to reduce light source noise in the sample signal.

摘要翻译： 本发明涉及高灵敏度光散射检测及其在液相色谱中的蒸发光散射检测中的应用。 该示例性实施例包括接收悬浮在气流中的颗粒并允许偏振光束通过颗粒和气流的轨迹的检测单元。 设置采样光检测器以检测在检测单元中散射的光。 光阱在其通过检测单元之后接受偏振光束。 光阱包括通过偏振光束通过的细长壳体和细长壳体内的光吸收材料。 对准吸收滤光器，使得光束在滤光片上的入射角近似于布鲁斯特角，并且光束的电场矢量与光束与滤光片之间的入射平面对准。 本发明的其它实施例提供增加的光收集。 本发明的实施例包括控制粒子轨迹的温度控制的入口和出口。 本发明的实施例包括设置在检测单元和光阱之间的参考单元，并且参考单元包括透镜和球面镜，以将光引向参考光检测器。 参考光检测器提供可用于噪声消除电路的参考信号，其以电压或电流模式工作，以减少采样信号中的光源噪声。