公开(公告)号：US08835376B2

公开(公告)日：2014-09-16

申请号：US13120146

申请日：2009-09-24

申请人： Zhigang Shen ,  Jimmy Sung Lai Yun ,  Jun Hu ,  Nital Arvind Jugade ,  Jiyao Zhang ,  Wenhao Chen ,  Zhe Wang ,  Lingyan Gao ,  William Glover ,  Jian Feng Chen

发明人： Zhigang Shen ,  Jimmy Sung Lai Yun ,  Jun Hu ,  Nital Arvind Jugade ,  Jiyao Zhang ,  Wenhao Chen ,  Zhe Wang ,  Lingyan Gao ,  William Glover ,  Jian Feng Chen

IPC分类号： A61K38/02 ,  A61K31/216 ,  A61K31/513 ,  A61K31/546 ,  A61K38/13 ,  A61K31/357 ,  A61K31/57 ,  A61K31/7052 ,  A61K31/277 ,  A61K31/197 ,  A61K47/38 ,  A61K47/24 ,  B01J2/06 ,  A61K9/16 ,  A61K9/20 ,  A61K9/14 ,  B01J19/00

CPC分类号： A61K9/14 ,  A61K9/1623 ,  A61K9/1652 ,  A61K9/1694 ,  A61K9/2077 ,  B01J2/06 ,  B01J19/0093 ,  B01J2219/00788 ,  B01J2219/00889

摘要： A process for making particles for delivery of drug nanoparticles is disclosed herein. The process comprises the steps of (a) forming a suspension of drug nanoparticles by mixing a precipitant solution with an anti-solvent solution under micro-mixing environment, where the formed nanoparticles have a narrow particle size distribution; (b) providing an excipient to at least one of the precipitant solution, the anti-solvent solution and the suspension of drug nanoparticles, the excipient being selected to maintain said drug nanoparticles in a dispersed state when in liquid form; and (c) drying the suspension of drug nanoparticles containing the excipient therein to remove solvent therefrom, wherein removal of the solvent causes the excipient to solidify and thereby form micro-sized matrix particles, each micro-sized particle being comprised of drug nanoparticles dispersed in a solid matrix of the excipient.

摘要翻译： 本文公开了用于制备用于递送药物纳米颗粒的颗粒的方法。 该方法包括以下步骤：（a）通过在微混合环境下将沉淀剂溶液与抗溶剂溶液混合形成药物纳米颗粒的悬浮液，其中所形成的纳米颗粒具有窄的粒度分布; （b）向沉淀剂溶液，抗溶剂溶液和药物纳米颗粒的悬浮液中的至少一种提供赋形剂，所述赋形剂被选择为当液体形式时将所述药物纳米颗粒维持在分散状态; 和（c）干燥其中含有赋形剂的药物纳米颗粒的悬浮液以从其中除去溶剂，其中去除溶剂导致赋形剂固化，从而形成微尺寸的基质颗粒，每个微尺寸颗粒由分散在 赋形剂的固体基质。

公开(公告)号：US20110306539A1

公开(公告)日：2011-12-15

申请号：US13120146

申请日：2009-09-24

申请人： Zhigang Shen ,  Jimmy Sung Lai Yun ,  Jun Hu ,  Arvind Jugade ,  Jiyao Zhang ,  Wenhao Chen ,  Zhe Wang ,  Lingyan Gao ,  Jian Feng Chen

发明人： Zhigang Shen ,  Jimmy Sung Lai Yun ,  Jun Hu ,  Arvind Jugade ,  Jiyao Zhang ,  Wenhao Chen ,  Zhe Wang ,  Lingyan Gao ,  Jian Feng Chen

IPC分类号： A61K38/02 ,  A61K31/216 ,  A61K31/513 ,  A61K31/546 ,  A61K38/13 ,  A61K31/357 ,  A61K31/57 ,  A61K31/7052 ,  A61K31/277 ,  A61K31/197 ,  A61K47/38 ,  A61K47/24 ,  A61K47/26 ,  A61K47/10 ,  A61P29/00 ,  A61K47/32 ,  A61P31/04 ,  A61P33/02 ,  A61P7/02 ,  A61P3/10 ,  A61P25/24 ,  A61P25/08 ,  A61P31/10 ,  A61P9/12 ,  A61P35/00 ,  A61P25/06 ,  A61P33/00 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P11/14 ,  A61P31/12 ,  A61P17/00 ,  A61P1/00 ,  A61P23/00 ,  A61P7/04 ,  A61P23/02 ,  A61P9/08 ,  A61K31/56

CPC分类号： A61K9/14 ,  A61K9/1623 ,  A61K9/1652 ,  A61K9/1694 ,  A61K9/2077 ,  B01J2/06 ,  B01J19/0093 ,  B01J2219/00788 ,  B01J2219/00889

摘要： A process for making particles for delivery of drug nanoparticles is disclosed herein. The process comprises the steps of (a) forming a suspension of drug nanoparticles by mixing a precipitant solution with an anti-solvent solution under micro-mixing environment, where the formed nanoparticles have a narrow particle size distribution; (b) providing an excipient to at least one of the precipitant solution, the anti-solvent solution and the suspension of drug nanoparticles, the excipient being selected to maintain said drug nanoparticles in a dispersed state when in liquid form; and (c) drying the suspension of drug nanoparticles containing the excipient therein to remove solvent therefrom, wherein removal of the solvent causes the excipient to solidify and thereby form micro-sized matrix particles, each micro-sized particle being comprised of drug nanoparticles dispersed in a solid matrix of the excipient.

摘要翻译： 本文公开了用于制备用于递送药物纳米颗粒的颗粒的方法。 该方法包括以下步骤：（a）通过在微混合环境下将沉淀剂溶液与抗溶剂溶液混合形成药物纳米颗粒的悬浮液，其中所形成的纳米颗粒具有窄的粒度分布; （b）向沉淀剂溶液，抗溶剂溶液和药物纳米颗粒的悬浮液中的至少一种提供赋形剂，所述赋形剂被选择为当液体形式时将所述药物纳米颗粒维持在分散状态; 和（c）干燥其中含有赋形剂的药物纳米颗粒的悬浮液以从其中除去溶剂，其中去除溶剂导致赋形剂固化，从而形成微尺寸的基质颗粒，每个微尺寸颗粒由分散在 赋形剂的固体基质。

公开(公告)号：US20100028236A1

公开(公告)日：2010-02-04

申请号：US12443942

申请日：2007-10-02

申请人： Zhigang Shen ,  Jiyao Zhang ,  Giawen Sim ,  Jimmy Sung Lai Yun ,  Jianfeng Chen

发明人： Zhigang Shen ,  Jiyao Zhang ,  Giawen Sim ,  Jimmy Sung Lai Yun ,  Jianfeng Chen

IPC分类号： C01F17/00 ,  C01G3/02 ,  C01G23/04 ,  C01G25/02 ,  C01G9/02 ,  C01G49/02 ,  C01G9/08 ,  B01J19/00

CPC分类号： C01B17/20 ,  B01F7/00558 ,  B01J8/10 ,  B01J19/1806 ,  B01J2219/00006 ,  B82Y30/00 ,  C01B19/007 ,  C01F17/0043 ,  C01G3/02 ,  C01G9/02 ,  C01G9/08 ,  C01G19/02 ,  C01G23/0536 ,  C01G25/02 ,  C01G49/06 ,  C01G49/08 ,  C01P2002/72 ,  C01P2004/04 ,  C01P2004/52 ,  C01P2004/64 ,  Y10S977/773

摘要： There is disclosed a process of making nano-sized or micro-sized precipitate particles. The process comprising the steps of mixing, in a reaction zone, a metal salt solution with a precipitant solution to form a precipitate, said precipitate being at least one of a metal chalcogenide, metal hydroxide and metal oxide; and applying a shear force to said mixing solutions in said reaction zone during said mixing step, wherein said shear force and the conditions within said reaction zone form said nano-sized or micro-sized precipitate particles.

摘要翻译： 公开了制备纳米尺寸或微尺寸沉淀颗粒的方法。 该方法包括在反应区中将金属盐溶液与沉淀剂溶液混合以形成沉淀物的步骤，所述沉淀物是金属硫族化物，金属氢氧化物和金属氧化物中的至少一种; 以及在所述混合步骤期间对所述反应区中的所述混合溶液施加剪切力，其中所述剪切力和所述反应区内的条件形成所述纳米尺寸或微尺寸的沉淀颗粒。

公开(公告)号：US07985388B2

公开(公告)日：2011-07-26

申请号：US12443942

申请日：2007-10-02

申请人： Zhigang Shen ,  Jiyao Zhang ,  Giawen Sim ,  Jimmy Sung Lai Yun ,  Jianfeng Chen

发明人： Zhigang Shen ,  Jiyao Zhang ,  Giawen Sim ,  Jimmy Sung Lai Yun ,  Jianfeng Chen

IPC分类号： B01J14/00 ,  C01B13/14 ,  C01B17/00 ,  C01B19/00

CPC分类号： C01B17/20 ,  B01F7/00558 ,  B01J8/10 ,  B01J19/1806 ,  B01J2219/00006 ,  B82Y30/00 ,  C01B19/007 ,  C01F17/0043 ,  C01G3/02 ,  C01G9/02 ,  C01G9/08 ,  C01G19/02 ,  C01G23/0536 ,  C01G25/02 ,  C01G49/06 ,  C01G49/08 ,  C01P2002/72 ,  C01P2004/04 ,  C01P2004/52 ,  C01P2004/64 ,  Y10S977/773

摘要： There is disclosed a process of making nano-sized or micro-sized precipitate particles. The process comprising the steps of mixing, in a reaction zone, a metal salt solution with a precipitant solution to form a precipitate, said precipitate being at least one of a metal chalcogenide, metal hydroxide and metal oxide; and applying a shear force to said mixing solutions in said reaction zone during said mixing step, wherein said shear force and the conditions within said reaction zone form said nano-sized or micro-sized precipitate particles.

摘要翻译： 公开了制备纳米尺寸或微尺寸沉淀颗粒的方法。 该方法包括在反应区中将金属盐溶液与沉淀剂溶液混合以形成沉淀物的步骤，所述沉淀物是金属硫族化物，金属氢氧化物和金属氧化物中的至少一种; 以及在所述混合步骤期间对所述反应区中的所述混合溶液施加剪切力，其中所述剪切力和所述反应区内的条件形成所述纳米尺寸或微尺寸的沉淀颗粒。

公开(公告)号：US20060020130A1

公开(公告)日：2006-01-26

申请号：US11187555

申请日：2005-07-22

申请人： Jianfeng Chen ,  Jie Zhong ,  Zhigang Shen ,  Jiyao Zhang

发明人： Jianfeng Chen ,  Jie Zhong ,  Zhigang Shen ,  Jiyao Zhang

IPC分类号： C07D501/00 ,  A61K9/14

CPC分类号： C07D501/00

摘要： A novel process for the preparation of amorphous cefuroxime axetil particles and the amorphous cefuroxime axetil particles therefrom are disclosed in the invention. Specifically, the invention is implemented by means of antisolvent recrystallization to prepare the cefuroxime axetil in an amorphous form; particularly, the amorphous ultrafine or even nanosized cefuroxime axetil with a controllable particle size and a narrow particle size distribution. The cefuroxime axetil according to the invention can used to enhance bioavailability, since it is in an amorphous form and has a controllable particle size and a narrow particle size distribution.

公开(公告)号：US07507813B2

公开(公告)日：2009-03-24

申请号：US11187555

申请日：2005-07-22

申请人： Jianfeng Chen ,  Jie Zhong ,  Zhigang Shen ,  Jiyao Zhang

发明人： Jianfeng Chen ,  Jie Zhong ,  Zhigang Shen ,  Jiyao Zhang

IPC分类号： C07D501/34

CPC分类号： C07D501/00

摘要： A novel process for the preparation of amorphous cefuroxime axetil particles and the amorphous cefuroxime axetil particles therefrom are disclosed in the invention. Specifically, the invention is implemented by means of antisolvent recrystallization to prepare the cefuroxime axetil in an amorphous form; particularly, the amorphous ultrafine or even nanosized cefuroxime axetil with a controllable particle size and a narrow particle size distribution. The cefuroxime axetil according to the invention can used to enhance bioavailability, since it is in an amorphous form and has a controllable particle size and a narrow particle size distribution.

摘要翻译： 在本发明中公开了一种用于制备无定形头孢呋辛酯颗粒和无定形头孢呋辛酯颗粒的新方法。 具体地说，本发明是通过抗溶剂重结晶实现的，以制备无定形形式的头孢呋辛酯; 特别是具有可控粒度和窄粒度分布的无定形超细或甚至纳米尺寸的头孢呋辛酯。 根据本发明的头孢呋辛酯可用于提高生物利用度，因为其为无定形形式并且具有可控的粒度和窄的粒度分布。