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公开(公告)号：US08835376B2
公开(公告)日：2014-09-16
申请号：US13120146
申请日：2009-09-24
申请人： Zhigang Shen , Jimmy Sung Lai Yun , Jun Hu , Nital Arvind Jugade , Jiyao Zhang , Wenhao Chen , Zhe Wang , Lingyan Gao , William Glover , Jian Feng Chen
发明人： Zhigang Shen , Jimmy Sung Lai Yun , Jun Hu , Nital Arvind Jugade , Jiyao Zhang , Wenhao Chen , Zhe Wang , Lingyan Gao , William Glover , Jian Feng Chen
IPC分类号： A61K38/02 , A61K31/216 , A61K31/513 , A61K31/546 , A61K38/13 , A61K31/357 , A61K31/57 , A61K31/7052 , A61K31/277 , A61K31/197 , A61K47/38 , A61K47/24 , B01J2/06 , A61K9/16 , A61K9/20 , A61K9/14 , B01J19/00
CPC分类号： A61K9/14 , A61K9/1623 , A61K9/1652 , A61K9/1694 , A61K9/2077 , B01J2/06 , B01J19/0093 , B01J2219/00788 , B01J2219/00889
摘要： A process for making particles for delivery of drug nanoparticles is disclosed herein. The process comprises the steps of (a) forming a suspension of drug nanoparticles by mixing a precipitant solution with an anti-solvent solution under micro-mixing environment, where the formed nanoparticles have a narrow particle size distribution; (b) providing an excipient to at least one of the precipitant solution, the anti-solvent solution and the suspension of drug nanoparticles, the excipient being selected to maintain said drug nanoparticles in a dispersed state when in liquid form; and (c) drying the suspension of drug nanoparticles containing the excipient therein to remove solvent therefrom, wherein removal of the solvent causes the excipient to solidify and thereby form micro-sized matrix particles, each micro-sized particle being comprised of drug nanoparticles dispersed in a solid matrix of the excipient.
摘要翻译： 本文公开了用于制备用于递送药物纳米颗粒的颗粒的方法。 该方法包括以下步骤：（a）通过在微混合环境下将沉淀剂溶液与抗溶剂溶液混合形成药物纳米颗粒的悬浮液，其中所形成的纳米颗粒具有窄的粒度分布; （b）向沉淀剂溶液，抗溶剂溶液和药物纳米颗粒的悬浮液中的至少一种提供赋形剂，所述赋形剂被选择为当液体形式时将所述药物纳米颗粒维持在分散状态; 和（c）干燥其中含有赋形剂的药物纳米颗粒的悬浮液以从其中除去溶剂，其中去除溶剂导致赋形剂固化，从而形成微尺寸的基质颗粒，每个微尺寸颗粒由分散在 赋形剂的固体基质。
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公开(公告)号：US20070190557A1
公开(公告)日：2007-08-16
申请号：US11657399
申请日：2007-01-24
申请人： William Glover
发明人： William Glover
CPC分类号： C12Q1/6869 , C12Q2565/601 , C12Q2563/137
摘要： Systems and methods of identifying, sequencing and/or detecting nucleic acid polymers, as well as related components (e.g., substrates, software and the like) are disclosed.
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公开(公告)号：US20060024717A1
公开(公告)日：2006-02-02
申请号：US11181392
申请日：2005-07-14
申请人： William Glover
发明人： William Glover
CPC分类号： G01N23/00 , C12Q1/6816 , C12Q1/6869 , G01N23/22 , C12Q2565/601 , C12Q2565/518 , C12Q2563/137
摘要： Systems and methods of identifying, sequencing and/or detecting nucleic acid polymers, as well as related components (e.g., substrates, software and the like) are disclosed.
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公开(公告)号：US20060024716A1
公开(公告)日：2006-02-02
申请号：US11181389
申请日：2005-07-14
申请人： William Glover
发明人： William Glover
IPC分类号： C12Q1/68
CPC分类号： G01N23/00 , C12Q1/6816 , C12Q1/6869 , G01N23/22 , C12Q2565/601 , C12Q2565/518 , C12Q2563/137
摘要： Systems and methods of identifying, sequencing and/or detecting nucleic acid polymers, as well as related components (e.g., substrates, software and the like) are disclosed.
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公开(公告)号：US5720364A
公开(公告)日：1998-02-24
申请号：US656259
申请日：1996-05-28
IPC分类号： B66B9/08
CPC分类号： B66B9/0838
摘要： A stairlift comprises a carriage for movement along a fixed rail the angle of inclination of which varies along its length. A seat is pivotally mounted to the carriage and an actuating device is used for turning the seat relative to the carriage. A control device of the stairlift responds to the position of the carriage along its rail and the stored data representing the desired angle between the seat and carriage at different positions along the rail, to control the actuating device so as to maintain the seat substantially level as the carriage moves along the rail.
摘要翻译： PCT No.PCT / GB95 / 00012 Sec。 371日期：1996年5月28日 102（e）日期1996年5月28日PCT提交1995年1月5日PCT公布。 WO95 / 18763 PCT出版物 日期1995年7月13日楼梯升降机包括沿着固定轨道移动的滑架，倾斜角度沿其长度变化。 座椅可枢转地安装到托架上，并且致动装置用于相对于托架转动座椅。 楼梯升降机的控制装置响应于滑架沿其轨道的位置，并且存储的数据表示座椅与托架之间在沿着轨道的不同位置处的所需角度，以控制致动装置，从而将座椅基本上保持为 马车沿轨道移动。
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6.发明申请Nano-scale ligand arrays on substrates for particle beam instruments and related methods 审中-公开用于粒子束仪器和相关方法的纳米级配体阵列公开(公告)号：US20070134699A1
公开(公告)日：2007-06-14
申请号：US11595819
申请日：2006-11-09
申请人： William Glover , Scott McCallister
发明人： William Glover , Scott McCallister
CPC分类号： H01J37/20 , B01J19/0046 , B01J2219/00432 , B01J2219/00436 , B01J2219/00497 , B01J2219/005 , B01J2219/00511 , B01J2219/00515 , B01J2219/0052 , B01J2219/00527 , B01J2219/00536 , B01J2219/00572 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00639 , B01J2219/00641 , B01J2219/00644 , B01J2219/00648 , B01J2219/00659 , B01J2219/00675 , B01J2219/00677 , B01J2219/00689 , B01J2219/00707 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01J2219/00743 , B01L3/508 , B82Y30/00 , C12Q1/6834 , H01J2237/2004
摘要： Substrates and arrays that can be used for biological analysis with particle beam instruments are provided. In one embodiment, a substrate for an array is constructed and arranged to be used for imaging samples with a particle beam instrument such as a transmission electron microscope. The substrate can include one or more ligands (e.g., nucleic acids, polypeptides, oligosaccharides, and synthetic polymers) which may form an array. Corresponding changes in labeling chemistry can allow for ligands, binding partners and other relevant materials to be identifiable, quantitatable, and even sequenceable via modified forms of electron microscopy. In certain embodiments, the array dimensions are on the order of nanometers per functional region rather than micrometers as in certain conventional arrays. With these dimensions, smaller amounts of sample material can be used and more accurate genetic analyses performed. These smaller substrate dimensions may also give rise to dramatically reduced production costs, amongst other advantages. The transparency of the substrate, due to thinness, material type and other factors, may provide a suitable contrast ratio of the labeled molecules against the substrate that result in higher quality readings and lower cost analysis than some conventional techniques.
摘要翻译： 提供了可用于使用粒子束仪器进行生物分析的底物和阵列。 在一个实施例中，用于阵列的衬底被构造和布置成用于用诸如透射电子显微镜的粒子束仪器对样品成像。 底物可以包括可以形成阵列的一种或多种配体（例如，核酸，多肽，寡糖和合成聚合物）。 标记化学的相应变化可以允许配体，结合配偶体和其他相关材料通过电子显微镜的修改形式被识别，定量，甚至可顺序。 在某些实施例中，如在某些常规阵列中，阵列尺寸在每个功能区域的纳米数量级上而不是微米级。 通过这些尺寸，可以使用较少量的样品材料并进行更准确的遗传分析。 除了其它优点之外，这些较小的基板尺寸也可能导致显着降低的生产成本。 衬底的透明度由于薄度，材料类型和其他因素，可以提供标记分子与衬底的合适的对比度，其导致比一些常规技术更高质量的读数和更低的成本分析。
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公开(公告)号：US4857240A
公开(公告)日：1989-08-15
申请号：US229838
申请日：1988-08-08
申请人： Thom Kearnes , Joel Wennerstrom , William Glover
发明人： Thom Kearnes , Joel Wennerstrom , William Glover
IPC分类号： A61L9/12
CPC分类号： A61L9/122 , Y10S261/65 , Y10S261/88
摘要： The fragrance dispenser of this invention incorporates a service life indicator for the battery along with a fragrance pack having a service life equal to the service life of the battery, such that both the battery and fragrance pack can be easily and simultaneously maintained.
摘要翻译： 本发明的香料分配器包括电池的使用寿命指示器以及具有等于电池使用寿命的使用寿命的香水包，使得电池和香料包可以容易地并且同时地保持。
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公开(公告)号：US4464883A
公开(公告)日：1984-08-14
申请号：US327451
申请日：1981-12-04
申请人： William Glover
发明人： William Glover
CPC分类号： B65B23/10 , B65B9/067 , B65B2009/063
摘要： A wrapping material of the horizontal form, fill and seal type has, positioned between a horizontal tube former which forms a web of wrapping material into a tube with a longitudinal bottom joint and an infeed conveyor which advances articles to be wrapped at regular intervals towards the tube former, a platform on which the articles are temporarily supported until pushed off it into the tube former by succeeding articles delivered by the infeed conveyor.
摘要翻译： 水平形式，填充和密封类型的包装材料定位在水平管形成器之间，水平管形成器形成具有纵向底部接头的管中的包裹材料卷材和将待包裹的物品以规则间隔向着 管形成器，其中物品被暂时支撑的平台，直到通过由进料输送机传送的后续物品推入管形成器中。
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公开(公告)号：US4073116A
公开(公告)日：1978-02-14
申请号：US738281
申请日：1976-11-03
申请人： William Glover
发明人： William Glover
CPC分类号： B65B51/306 , B29C66/4312 , B29C66/4322 , B29C66/934 , B29C66/93431 , B29C66/93441 , B29C66/93451 , B65B51/26 , B65B9/067 , B29C65/18 , B29C66/83513
摘要： A wrapping machine comprises a tube former for a forming a web of wrapping material into a tube with a longitudinal seal, a variable speed feeding mechanism for feeding the web continuously to the tube former, an infeed conveyor for feeding articles in succession into the tube former so that they become entubed in the tube of wrapping material, and crimping dies situated beyond the tube former which are operative to form transverse seals in the tube of wrapping material between the articles. The machine includes an adjustable modulating device for matching the speed of movement of the dies to substantially the speed of advance of the tube during formation of the transverse seals. An adjustable control mechanism is provided for so controlling the dies that they will form, by appropriate adjustment, transverse seals at either every revolution, during alternate revolutions only, or during every 3rd, 4th . . . or nth revolutions of a constant speed driving shaft.
摘要翻译： 一种包装机包括一个用于将包裹材料卷材成型为具有纵向密封件的管子的管形成器，用于将织物连续地供给到管坯的可变速进给机构，用于将制品连续送入管形成器的进料输送机 使得它们被包裹在包裹材料的管中，以及位于管形成器之外的压接模具，其可操作以在物品之间的包裹材料管中形成横向密封。 该机器包括可调节的调节装置，用于在横向密封件的形成期间将模具的运动速度与管的前进速度基本上相匹配。 提供了可调节的控制机构，用于通过适当的调整来控制它们将形成的模具，每转一次，仅在交替转动期间，或在每3至4个期间进行横向密封。 。 。 或恒速驱动轴的第n转。
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公开(公告)号：US2512931A
公开(公告)日：1950-06-27
申请号：US76658847
申请日：1947-08-06
申请人： WILLIAM GLOVER
发明人： WILLIAM GLOVER
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