公开(公告)号：US20120018912A1

公开(公告)日：2012-01-26

申请号：US13259291

申请日：2010-03-18

申请人： Zhirong Chen ,  Jianfeng Chen ,  Hong Yin ,  Hong Zhao ,  Dan Qiu ,  Lifang Shi ,  Jiandong Li ,  Guangwen Chu ,  Lei Shao

发明人： Zhirong Chen ,  Jianfeng Chen ,  Hong Yin ,  Hong Zhao ,  Dan Qiu ,  Lifang Shi ,  Jiandong Li ,  Guangwen Chu ,  Lei Shao

IPC分类号： B29B9/12

CPC分类号： B01J13/043 ,  A23K20/179 ,  A23L5/44 ,  A23L33/10 ,  A23L33/105 ,  A23P10/30 ,  A23V2002/00 ,  A61K8/0241 ,  A61K8/11 ,  A61K8/31 ,  A61K8/35 ,  A61K31/01 ,  A61K31/122 ,  A61K2800/412 ,  A61Q19/00 ,  C09B61/00 ,  C09B67/0097 ,  A23V2250/211 ,  A23V2200/224

摘要： A method of preparing nano-dispersed high-all-trans-carotenoid microcapsules is provided, comprising: preparing 10-20% carotenoid suspension by milling the high-all trans-carotenoid crystals with dichloromethane until the particle size thereof is in the range of 2-5 μm, then supplying the suspension together with preheated dichloromethane of another pass into a dissolving tank to obtain a solution of 0.5-2%; delivering the solution together with ethanol or isopropanol into a crystallization device having high gravity rotating packed bed simultaneously and continuously, and then into a wiped-film evaporator for desolvation until the solid content is 10-20%, then a transparent alcohol dispersion of carotenoid is obtained; mashing the alcohol dispersion together with an aqueous solution containing an antioxidant and protective colloid and spray drying to obtain nano-dispersed high-all-trans-carotenoid microcapsules. As the crystals are nano-dispersed and the content of trans-isomer is more than 90%, the carotenoid microcapsules of present inventions exhibit high bioavailability.

摘要翻译： 提供了一种制备纳米分散高全反式类胡萝卜素微胶囊的方法，包括：通过用二氯甲烷研磨高全反式类胡萝卜素晶体制备10-20％的类胡萝卜素悬浮液，直到其粒径在2 -5μm，然后将悬浮液与另一道次的预热二氯甲烷一起供入溶解槽中，得到0.5-2％的溶液; 将溶液与乙醇或异丙醇一起输送到具有高重力旋转填充床的结晶装置中，同时且连续地进行，然后进入擦膜蒸发器进行去溶剂化直到固体含量为10-20％，然后将类胡萝卜素的透明醇分散体 获得; 将醇分散体与含有抗氧化剂和保护胶体的水溶液一起糖化并喷雾干燥，得到纳米分散的高全反式类胡萝卜素微胶囊。 由于晶体是纳米分散的并且反式异构体的含量大于90％，本发明的类胡萝卜素微胶囊显示出高的生物利用度。

公开(公告)号：US08540908B2

公开(公告)日：2013-09-24

申请号：US13259291

申请日：2010-03-18

申请人： Zhirong Chen ,  Jianfeng Chen ,  Hong Yin ,  Hong Zhao ,  Dan Qiu ,  Lifang Shi ,  Jiandong Li ,  Guangwen Chu ,  Lei Shao

发明人： Zhirong Chen ,  Jianfeng Chen ,  Hong Yin ,  Hong Zhao ,  Dan Qiu ,  Lifang Shi ,  Jiandong Li ,  Guangwen Chu ,  Lei Shao

IPC分类号： B01J13/04

CPC分类号： B01J13/043 ,  A23K20/179 ,  A23L5/44 ,  A23L33/10 ,  A23L33/105 ,  A23P10/30 ,  A23V2002/00 ,  A61K8/0241 ,  A61K8/11 ,  A61K8/31 ,  A61K8/35 ,  A61K31/01 ,  A61K31/122 ,  A61K2800/412 ,  A61Q19/00 ,  C09B61/00 ,  C09B67/0097 ,  A23V2250/211 ,  A23V2200/224

摘要： A method of preparing nano-dispersed high-all-trans-carotenoid microcapsules is provided, comprising: preparing 10-20% carotenoid suspension by milling the high-all trans-carotenoid crystals with dichloromethane until the particle size thereof is in the range of 2-5 μm, then supplying the suspension together with preheated dichloromethane of another pass into a dissolving tank to obtain a solution of 0.5-2%; delivering the solution together with ethanol or isopropanol into a crystallization device having high gravity rotating packed bed simultaneously and continuously, and then into a wiped-film evaporator for desolvation until the solid content is 10-20%, then a transparent alcohol dispersion of carotenoid is obtained; mashing the alcohol dispersion together with an aqueous solution containing an antioxidant and protective colloid and spray drying to obtain nano-dispersed high-all-trans-carotenoid microcapsules. As the crystals are nano-dispersed and the content of trans-isomer is more than 90%, the carotenoid microcapsules of present inventions exhibit high bioavailability.

摘要翻译： 提供了一种制备纳米分散高全反式类胡萝卜素微胶囊的方法，包括：通过用二氯甲烷研磨高全反式类胡萝卜素晶体制备10-20％的类胡萝卜素悬浮液，直到其粒径在2 -5μm，然后将悬浮液与另一道次的预热二氯甲烷一起供入溶解槽中，得到0.5-2％的溶液; 将溶液与乙醇或异丙醇一起输送到具有高重力旋转填充床的结晶装置中，同时且连续地进行，然后进入擦膜蒸发器进行去溶剂化直到固体含量为10-20％，然后将类胡萝卜素的透明醇分散体 获得; 将醇分散体与含有抗氧化剂和保护胶体的水溶液一起糖化并喷雾干燥，得到纳米分散的高全反式类胡萝卜素微胶囊。 由于晶体是纳米分散的并且反式异构体的含量大于90％，本发明的类胡萝卜素微胶囊显示出高的生物利用度。

公开(公告)号：US09173818B2

公开(公告)日：2015-11-03

申请号：US13980126

申请日：2011-03-25

申请人： Hong Yin ,  Jianfeng Chen ,  Zhirong Chen ,  Jiexin Wang ,  Yong Qi ,  Hong Zhao ,  Lifang Shi ,  Dan Qiu

发明人： Hong Yin ,  Jianfeng Chen ,  Zhirong Chen ,  Jiexin Wang ,  Yong Qi ,  Hong Zhao ,  Lifang Shi ,  Dan Qiu

IPC分类号： A61J3/07 ,  A61K9/00 ,  B29B9/12 ,  A61K9/16 ,  A61K9/50 ,  A61K31/07 ,  A61K9/51

CPC分类号： A61J3/07 ,  A61K9/1652 ,  A61K9/1694 ,  A61K9/5036 ,  A61K9/5089 ,  A61K9/5161 ,  A61K31/07

摘要： A method for continuously preparing stable-type vitamin A microcapsules is disclosed. The method comprises the following steps: adding vitamin A crystals and an antioxidant into a crystal melter continuously according to a certain ratio under the protection of nitrogen to prepare vitamin A melting oil containing the antioxidant; pumping the above melting oil into a high gravity rotary packed bed emulsifier with a liquid distributor by a pump, and pumping aqueous solution containing gellable modified starch into the above high gravity rotary packed bed emulsifier after deoxidation treatment to obtain vitamin A emulsion at the outlet of the high gravity rotary packed bed emulsifier; and atomizing and spraying the emulsion continuously in a cooled starch bed for granulating, and performing fluidization drying and gelation treatment in a fluidized bed by taking nitrogen as a drying medium to obtain the stable-type vitamin A microcapsules. Above method has the advantage of capability of continuous production, and has good embedding effect due to adopting the gellable modified starch, granulating and gelation treatment, thus the product has good storage stability.

摘要翻译： 公开了连续制备稳定型维生素A微胶囊的方法。 该方法包括以下步骤：在氮保护下，以一定的比例将维生素A晶体和抗氧化剂连续添加到晶体熔化器中，制备含有抗氧化剂的维生素A熔融油; 通过泵将上述熔融油泵送到具有液体分配器的高重力旋转填充床乳化剂中，并且在脱氧处理之后将含有可凝胶改性淀粉的水溶液泵送到上述高重力旋转填充床乳化剂中以在出口处获得维生素A乳液 高重力旋转填充床乳化剂; 并在冷却的淀粉床中连续雾化和喷雾乳液进行造粒，并通过以氮气作为干燥介质在流化床中进行流化干燥和凝胶化处理，得到稳定型维生素A微胶囊。 上述方法具有连续生产能力的优点，由于采用可凝胶改性淀粉，造粒和凝胶化处理，具有良好的包埋效果，因此产品具有良好的储存稳定性。

公开(公告)号：US20140001662A1

公开(公告)日：2014-01-02

申请号：US13980126

申请日：2011-03-25

申请人： Hong Yin ,  Jianfeng Chen ,  Zhirong Chen ,  Jiexin Wang ,  Yong Qi ,  Hong Zhao ,  Lifang Shi ,  Dan Qiu

发明人： Hong Yin ,  Jianfeng Chen ,  Zhirong Chen ,  Jiexin Wang ,  Yong Qi ,  Hong Zhao ,  Lifang Shi ,  Dan Qiu

IPC分类号： A61J3/07

CPC分类号： A61J3/07 ,  A61K9/1652 ,  A61K9/1694 ,  A61K9/5036 ,  A61K9/5089 ,  A61K9/5161 ,  A61K31/07

摘要： A method for continuously preparing stable-type vitamin A microcapsules is disclosed. The method comprises the following steps: adding vitamin A crystals and an antioxidant into a crystal melter continuously according to a certain ratio under the protection of nitrogen to prepare vitamin A melting oil containing the antioxidant; pumping the above melting oil into a high gravity rotary packed bed emulsifier with a liquid distributor by a pump, and pumping aqueous solution containing gellable modified starch into the above high gravity rotary packed bed emulsifier after deoxidation treatment to obtain vitamin A emulsion at the outlet of the high gravity rotary packed bed emulsifier; and atomizing and spraying the emulsion continuously in a cooled starch bed for granulating, and performing fluidization drying and gelation treatment in a fluidized bed by taking nitrogen as a drying medium to obtain the stable-type vitamin A microcapsules. Above method has the advantage of capability of continuous production, and has good embedding effect due to adopting the gellable modified starch, granulating and gelation treatment, thus the product has good storage stability.

摘要翻译： 公开了连续制备稳定型维生素A微胶囊的方法。 该方法包括以下步骤：在氮保护下，以一定的比例将维生素A晶体和抗氧化剂连续添加到晶体熔化器中，制备含有抗氧化剂的维生素A熔融油; 通过泵将上述熔融油泵送到具有液体分配器的高重力旋转填充床乳化剂中，并且在脱氧处理之后将含有可凝胶改性淀粉的水溶液泵送到上述高重力旋转填充床乳化剂中以在出口处获得维生素A乳液 高重力旋转填充床乳化剂; 并在冷却的淀粉床中连续雾化和喷雾乳液进行造粒，并通过以氮气作为干燥介质在流化床中进行流化干燥和凝胶化处理，得到稳定型维生素A微胶囊。 上述方法具有连续生产能力的优点，由于采用可凝胶改性淀粉，造粒和凝胶化处理，具有良好的包埋效果，因此产品具有良好的储存稳定性。

公开(公告)号：US20080249261A1

公开(公告)日：2008-10-09

申请号：US11873056

申请日：2007-10-16

申请人： Jiansheng Ding ,  Jianfeng Chen ,  Hongke Zhang ,  Haikui Zou ,  Weiqi Hua ,  Pengyuan Zhang ,  Shuchang Sun ,  Guangwen Chu ,  Limin Xu

发明人： Jiansheng Ding ,  Jianfeng Chen ,  Hongke Zhang ,  Haikui Zou ,  Weiqi Hua ,  Pengyuan Zhang ,  Shuchang Sun ,  Guangwen Chu ,  Limin Xu

IPC分类号： C08F2/01

CPC分类号： C08G73/0266 ,  C08L79/02

摘要： The present invention provides a method of preparing polymethylene-polyphenyl-polyamine (briefly referred to as polyamine, DAM), in which a high gravity rotating bed is used as the mixing reactor of formaldehyde and aniline hydrochloride, the mixing solution of aniline hydrochloride and circulation solution and the formaldehyde are fed into the high gravity rotating bed reactor proportionally to carry out mixing and condensation reaction under a condition of a very high gravity; the materials leaving the high gravity rotating bed reactor is introduced into a stirred vessel to proceed with the pre-condensation reaction and obtain a condensation solution; and the process steps of heating, molecular rearrangement, neutralization, water washing and purification, etc. are completed to obtain the refined DAM. With the method according to the present invention, the main by-products is obviously reduced in the condensation process, the phenomenon of deposit attaching to the inner walls of circulation pipes and heat exchanger and blockage are prevented in the condensation process, the impurity content is low in the refined DAM, and the subsequent product MDI has a lighter color, the product quality is stable and may be improved to a certain extent.

摘要翻译： 本发明提供了使用高重力旋转床作为甲醛和苯胺盐酸盐的混合反应器的多亚甲基 - 多苯基多胺（简称为多胺，DAM）的制备方法，盐酸苯胺和循环的混合溶液 溶液和甲醛按比例进料到高重力旋转床反应器中，以在非常高的重力条件下进行混合和缩合反应; 将离开高重力旋转床反应器的材料引入搅拌容器中以进行预缩合反应并获得缩合溶液; 完成加热，分子重排，中和，水洗净化等工艺步骤，得到精制DAM。 根据本发明的方法，冷凝过程中主要副产物明显减少，在冷凝过程中防止了附着在循环管内壁和热交换器上的沉积现象，堵塞现象，杂质含量为 精炼DAM低，后续产品MDI颜色较浅，产品质量稳定，可在一定程度上提高。

公开(公告)号：US20050019248A1

公开(公告)日：2005-01-27

申请号：US10624944

申请日：2003-07-21

申请人： Jianfeng Chen ,  Xiaolin Liu ,  Zhigang Shen ,  Guangwen Chu

发明人： Jianfeng Chen ,  Xiaolin Liu ,  Zhigang Shen ,  Guangwen Chu

IPC分类号： B01J8/10 ,  C01G23/00 ,  C01G23/04

CPC分类号： B82Y30/00 ,  B01J8/10 ,  B01J2219/00006 ,  C01G23/006 ,  C01P2002/72 ,  C01P2004/04 ,  C01P2004/62 ,  C01P2004/64 ,  C01P2006/40

摘要： The invention relates to a process for the preparation of fine barium titanate (BaTiO3) powders. The process comprises introducing an aqueous solution (I) containing salts of barium and titanium, and an aqueous basic solution (II) containing an inorganic or organic base separately and simultaneously into a high-gravity reactor with the high-gravity level of 1.25G to 12,500G and performing the reaction of the solution (I) with the solution (II) at a temperature of from 60 to 100° C. The solution (I) is preheated to a temperature ranging from 60° C. to 65° C. and the solution (II) is preheated to a temperature ranging from 60° C. to 100° C. respectively prior to the reaction, in which the Ba/Ti molar ratio in the solution (I) is more than 1 and the concentration of the base in the solution (II) is such that the reaction mixture is maintained at a constant OH− concentration, preferably a pH value of about 14. The reaction product is separated by filtering and washed with deionized water to remove the impurity ions and excessive barium ions, and then dried to obtain BaTiO3 powders. Said powders consist essentially of crystalline, primary particles having a uniform particle size ranging from 5 to 200 nm, an approximately spherical morphology and a high sintering activity.

摘要翻译： 本发明涉及一种制备精细钛酸钡（BaTiO3）粉末的方法。 该方法包括将含有钡和钛的盐的水溶液（I）和含有无机或有机碱的碱性水溶液（II）分别并入同时进入高重力水平为1.25G的高重力反应器中 12,500G，并在60〜100℃的温度下进行溶液（I）与溶液（II）的反应。将溶液（I）预热至60℃至65℃的温度。 并且溶液（II）分别在反应之前预热至60℃至100℃的温度，其中溶液（I）中的Ba / Ti摩尔比大于1，浓度 溶液（II）中的碱使得反应混合物保持恒定的OH - 浓度，优选pH值为约14.反应产物通过过滤分离并用去离子水洗涤以除去杂质离子 和过量的钡离子，然后干燥得到BaTiO3粉末 呃 所述粉末基本上由具有5至200nm的均匀粒度的晶体初级粒子，近似球形的形态和高烧结活性组成。

公开(公告)号：US20120037232A1

公开(公告)日：2012-02-16

申请号：US13263833

申请日：2010-04-09

申请人： Zhigang Shen ,  Jimmy Sunglai Yun ,  Jianfeng Chen ,  Guangwen Chu

发明人： Zhigang Shen ,  Jimmy Sunglai Yun ,  Jianfeng Chen ,  Guangwen Chu

IPC分类号： F15D1/00 ,  F16L9/18

CPC分类号： B01F15/065 ,  B01F11/0266 ,  B01F13/0067 ,  B01F13/1027 ,  B01J19/0093 ,  B01J2219/00788 ,  B01J2219/00889 ,  B22F2998/00 ,  Y10T137/0318

摘要： A microchannel double pipe device comprises a channel for inner nozzle (4), a channel for outer nozzle (5) and a mechanical probe (8). The channel for outer nozzle (5) concentrically surrounds the channel for inner nozzle (4), and the channel for inner nozzle (4) concentrically surrounds the mechanical probe (8). Constricted at the outlet of the channel for inner nozzle (4), the channel for inner nozzle (4) extends to form an inner nozzle core (9). Constricted at the outlet of the channel for outer nozzle (5), the channel for outer nozzle (5) extends to form an outer nozzle core (10). The outer nozzle core (10) essentially concentrically surrounds the inner nozzle core (9), and the outlets of the inner nozzle core (9) and the outer nozzle core (10) are at the same level essentially. The mechanical probe (8) is configured to intermittently empty the inner nozzle core (9). The device can be used for microcosmic mixing and reaction, especially suitable for continuous preparation of inorganic, organic or medicine particles with nanostructure or micron-structure using liquid-liquid precipitation method.

摘要翻译： 微通道双管装置包括用于内部喷嘴（4）的通道，用于外部喷嘴（5）的通道和机械探针（8）。 外喷嘴（5）的通道同心地围绕用于内喷嘴（4）的通道，内喷嘴（4）的通道同心地围绕机械探头（8）。 在内喷嘴（4）的通道的出口处被限制，内喷嘴（4）的通道延伸以形成内喷嘴芯（9）。 在外喷嘴（5）的通道的出口处受限，外喷嘴（5）的通道延伸以形成外喷嘴芯（10）。 外喷嘴芯（10）基本上同心地围绕内喷嘴芯（9），并且内喷嘴芯（9）和外喷嘴芯（10）的出口基本上处于相同的水平。 机械探针（8）构造成间歇地排空内部喷嘴芯（9）。 该装置可用于微观混合和反应，特别适用于使用液 - 液沉淀法连续制备具有纳米结构或微米结构的无机，有机或药物颗粒。

公开(公告)号：US07893301B2

公开(公告)日：2011-02-22

申请号：US11873056

申请日：2007-10-16

申请人： Jiansheng Ding ,  Jianfeng Chen ,  Hongke Zhang ,  Haikui Zou ,  Weiqi Hua ,  Pengyuan Zhang ,  Shuchang Sun ,  Guangwen Chu ,  Limin Xu

发明人： Jiansheng Ding ,  Jianfeng Chen ,  Hongke Zhang ,  Haikui Zou ,  Weiqi Hua ,  Pengyuan Zhang ,  Shuchang Sun ,  Guangwen Chu ,  Limin Xu

IPC分类号： C07C211/00

CPC分类号： C08G73/0266 ,  C08L79/02

摘要： The present invention provides a method of preparing polymethylene-polyphenyl-polyamine (briefly referred to as polyamine, DAM), in which a high gravity rotating bed is used as the mixing reactor of formaldehyde and aniline hydrochloride, the mixing solution of aniline hydrochloride and circulation solution and the formaldehyde are fed into the high gravity rotating bed reactor proportionally to carry out mixing and condensation reaction under a condition of a very high gravity; the materials leaving the high gravity rotating bed reactor is introduced into a stirred vessel to proceed with the pre-condensation reaction and obtain a condensation solution; and the process steps of heating, molecular rearrangement, neutralization, water washing and purification, etc. are completed to obtain the refined DAM. With the method according to the present invention, the main by-products is obviously reduced in the condensation process, the phenomenon of deposit attaching to the inner walls of circulation pipes and heat exchanger and blockage are prevented in the condensation process, the impurity content is low in the refined DAM, and the subsequent product MDI has a lighter color, the product quality is stable and may be improved to a certain extent.

摘要翻译： 本发明提供了使用高重力旋转床作为甲醛和苯胺盐酸盐的混合反应器的多亚甲基 - 多苯基多胺（简称为多胺，DAM）的制备方法，盐酸苯胺和循环的混合溶液 溶液和甲醛按比例进料到高重力旋转床反应器中，以在非常高的重力条件下进行混合和缩合反应; 将离开高重力旋转床反应器的材料引入搅拌容器中以进行预缩合反应并获得缩合溶液; 完成加热，分子重排，中和，水洗净化等工艺步骤，得到精制DAM。 根据本发明的方法，冷凝过程中主要副产物明显减少，在冷凝过程中防止了附着在循环管内壁和热交换器上的沉积现象，堵塞现象，杂质含量为 精炼DAM低，后续产品MDI颜色较浅，产品质量稳定，可在一定程度上提高。

公开(公告)号：US09802848B2

公开(公告)日：2017-10-31

申请号：US13496872

申请日：2009-09-17

申请人： Hongke Zhang ,  Weiqi Hua ,  Xiaogao Liu ,  Zhenhua Zhao ,  Shuchang Sun ,  Jiansheng Ding ,  Jianfeng Chen ,  Pengyuan Zhang ,  Haikui Zou ,  Guangwen Chu ,  Limin Xu

发明人： Hongke Zhang ,  Weiqi Hua ,  Xiaogao Liu ,  Zhenhua Zhao ,  Shuchang Sun ,  Jiansheng Ding ,  Jianfeng Chen ,  Pengyuan Zhang ,  Haikui Zou ,  Guangwen Chu ,  Limin Xu

IPC分类号： C02F1/26 ,  C02F9/00 ,  C01D3/16 ,  C01D3/18 ,  C02F1/20 ,  C02F1/28 ,  C02F1/38 ,  C02F1/72 ,  C02F1/74 ,  C02F103/36

CPC分类号： C02F9/00 ,  C01D3/16 ,  C01D3/18 ,  C02F1/20 ,  C02F1/265 ,  C02F1/283 ,  C02F1/38 ,  C02F1/72 ,  C02F1/74 ,  C02F2103/36

摘要： The invention relates to a method of circular use of waste brine produced in the manufacture process of MDI, comprising the following steps: (1) the waste brine produced in the manufacture process of MDI is subjected to a high-gravity extraction and then to a column extraction, wherein said waste brine contains aniline, diaminodiphenylmethane and polyamine; (2) the waste brine from step (1) is transmitted to a stripping tower for steam stripping; (3) the waste brine from the stripping tower of step (2) and a chemical oxidant are transmitted to an oxidation reactor to which air is blown for aeration; (4) the waste brine after the treatment of step (3) is transmitted to an absorption tower for absorption. The invention makes the salt water have TOC of less than 8 ppm and TN of less than 2.5 ppm and achieves regeneration of resources in the waste brine such as sodium chloride and water and the like for circular use.

公开(公告)号：US09156015B2

公开(公告)日：2015-10-13

申请号：US13263833

申请日：2010-04-09

申请人： Zhigang Shen ,  Jimmy Sunglai Yun ,  Jianfeng Chen ,  Guangwen Chu

发明人： Zhigang Shen ,  Jimmy Sunglai Yun ,  Jianfeng Chen ,  Guangwen Chu

IPC分类号： B01F5/04 ,  B01F15/06 ,  B01F11/02 ,  B01F13/00 ,  B01F13/10 ,  B01J19/00

CPC分类号： B01F15/065 ,  B01F11/0266 ,  B01F13/0067 ,  B01F13/1027 ,  B01J19/0093 ,  B01J2219/00788 ,  B01J2219/00889 ,  B22F2998/00 ,  Y10T137/0318

摘要： A microchannel double pipe device comprises a channel for inner nozzle (4), a channel for outer nozzle (5) and a mechanical probe (8). The channel for outer nozzle (5) concentrically surrounds the channel for inner nozzle (4), and the channel for inner nozzle (4) concentrically surrounds the mechanical probe (8). Constricted at the outlet of the channel for inner nozzle (4), the channel for inner nozzle (4) extends to form an inner nozzle core (9). Constricted at the outlet of the channel for outer nozzle (5), the channel for outer nozzle (5) extends to form an outer nozzle core (10). The outer nozzle core (10) essentially concentrically surrounds the inner nozzle core (9), and the outlets of the inner nozzle core (9) and the outer nozzle core (10) are at the same level essentially. The mechanical probe (8) is configured to intermittently empty the inner nozzle core (9). The device can be used for microcosmic mixing and reaction, especially suitable for continuous preparation of inorganic, organic or medicine particles with nanostructure or micron-structure using liquid-liquid precipitation method.

摘要翻译： 微通道双管装置包括用于内部喷嘴（4）的通道，用于外部喷嘴（5）的通道和机械探针（8）。 外喷嘴（5）的通道同心地围绕用于内喷嘴（4）的通道，内喷嘴（4）的通道同心地围绕机械探头（8）。 在内喷嘴（4）的通道的出口处被限制，内喷嘴（4）的通道延伸以形成内喷嘴芯（9）。 在外喷嘴（5）的通道的出口处受限，外喷嘴（5）的通道延伸以形成外喷嘴芯（10）。 外喷嘴芯（10）基本上同心地围绕内喷嘴芯（9），并且内喷嘴芯（9）和外喷嘴芯（10）的出口基本上处于相同的水平。 机械探针（8）构造成间歇地排空内部喷嘴芯（9）。 该装置可用于微观混合和反应，特别适用于使用液 - 液沉淀法连续制备具有纳米结构或微米结构的无机，有机或药物颗粒。