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1.ANTIBODIES TARGETING BONE MORPHOGENETIC PROTEIN 9 (BMP9) AND METHODS THEREFOR 审中-公开
标题翻译: 靶向骨形态蛋白9(BMP9)的抗体及其方法公开(公告)号:US20160355583A1
公开(公告)日:2016-12-08
申请号:US15165150
申请日:2016-05-26
申请人: Zijun CHEN , Sujun DENG , Yun HE , Dagang HUANG , Markus KUGLER , Qian LI , Chris Xiangyang LU , Xiao LUO , Yongqiang SHAN , Kathrin Ulrike TISSOT-DAGUETTE , Jing WU
发明人: Zijun CHEN , Sujun DENG , Yun HE , Dagang HUANG , Markus KUGLER , Qian LI , Chris Xiangyang LU , Xiao LUO , Yongqiang SHAN , Kathrin Ulrike TISSOT-DAGUETTE , Jing WU
IPC分类号: C07K16/22 , A61K45/06 , A61K39/395
CPC分类号: C07K16/22 , A61K31/155 , A61K31/355 , A61K31/4439 , A61K31/4725 , A61K31/497 , A61K31/513 , A61K31/522 , A61K31/575 , A61K31/675 , A61K31/7072 , A61K38/1875 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94 , C12N15/09 , C12N15/63 , A61K2300/00
摘要: The present invention relates to isolated antibodies and antigen-binding fragments thereof which bind human BMP9 and compositions and methods of use thereof.
摘要翻译: 本发明涉及结合人BMP9的分离的抗体及其抗原结合片段及其组合物及其使用方法。
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公开(公告)号:US20160280783A1
公开(公告)日:2016-09-29
申请号:US15180879
申请日:2016-06-13
申请人: Joy GHOSH , Mark Anthony RUTZ , Kathrin Ulrike TISSOT-DAGUETTE , Igor SPLAWSKI , Michael ROGUSKA
发明人: Joy GHOSH , Mark Anthony RUTZ , Kathrin Ulrike TISSOT-DAGUETTE , Igor SPLAWSKI , Michael ROGUSKA
IPC分类号: C07K16/26 , A61K39/395 , C07K16/22 , A61K45/06
CPC分类号: C07K16/26 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/22 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: The present invention relates to compositions and methods for the inhibition of EPO. The invention provides antibodies and antigen binding fragments thereof that bind to EPO and are able to inhibit EPO-dependent cell proliferation and/or EPO-dependent cell signaling.
摘要翻译: 本发明涉及抑制EPO的组合物和方法。 本发明提供了结合EPO并能够抑制EPO依赖性细胞增殖和/或EPO依赖性细胞信号传导的抗体及其抗原结合片段。
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公开(公告)号:US20160030594A1
公开(公告)日:2016-02-04
申请号:US14774512
申请日:2014-03-12
申请人: Tinya ABRAMS , Steven COHEN , Christie P. FANTON , Catrin FINNER , Thomas HUBER , Kathy MILLER , Siew Ho SCHLEYER , Kathrin Ulrike TISSOT-DAGUETTE
发明人: Tinya ABRAMS , Steven COHEN , Christie P. FANTON , Catrin FINNER , Thomas HUBER , Kathy MILLER , Siew Ho SCHLEYER , Kathrin Ulrike TISSOT-DAGUETTE
CPC分类号: A61K47/6803 , A61K9/0019 , A61K9/19 , A61K31/537 , A61K45/06 , A61K47/12 , A61K47/26 , A61K47/6801 , A61K47/6849 , A61K47/6855 , A61K47/6857 , A61K47/6865 , A61K47/6867 , A61K47/6889 , A61K49/00 , A61K51/103 , A61K51/1093 , A61K2039/505 , C07K16/2803 , C07K16/2863 , C07K16/32 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要: The present invention relates to anti-cKIT antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.
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