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    Balloons for medical catheters
    1.
    发明授权
    Balloons for medical catheters 失效
    医用导管气球

    公开(公告)号：US5849846A

    公开(公告)日：1998-12-15

    申请号：US476101

    申请日：1995-06-06

    申请人： Ziyun Chen ,  Tai C. Cheng ,  Jeong S. Lee ,  Ketan P. Muni ,  Udayan Patel ,  Robert P. Saltman

    发明人： Ziyun Chen ,  Tai C. Cheng ,  Jeong S. Lee ,  Ketan P. Muni ,  Udayan Patel ,  Robert P. Saltman

    IPC分类号： A61L29/00 ,  A61L29/04 ,  A61M25/00 ,  A61M25/16 ,  C08L23/02 ,  C08L67/00 ,  C08L67/02 ,  C08L77/00 ,  A61M25/10 ,  A61M29/02

    CPC分类号： A61L29/049 ,  A61M25/1029 ,  C08L67/02 ,  A61M2025/1031 ,  A61M25/0009

    摘要： A catheter and/or balloon for a medical catheter is formed from a blend of polymeric components, including a first crystalline polymeric component and a second softening polymeric component. The polymeric material can also include a third compatibilizing agent to facilitate blending the first two polymeric components together. The first polymeric component can be a polyester or a polyamide, and the second polymeric component can be a polyolefin, or an ethylene copolymer. The third polymeric component is preferably an ethylene copolymer containing a reactive group that forms a covalent bond with the first polymeric component. The polymeric material forming the balloon or catheter also can include a catalyst to catalyze a reaction between the compatibilizing ethylene copolymer and the second polymer component. The second, softening polymeric component can also include a silane coupling agent, to provide a reactive softening copolymer that bonds with the first strong polymeric component, to provide increased flexibility of catheters and balloons formed from the polymeric components. The properties of the balloon and catheter formed from the polymeric material can be enhanced by crosslinking by irradiation of the polymeric material.

    摘要翻译： 用于医疗导管的导管和/或气囊由聚合物组分的混合物形成，包括第一结晶聚合物组分和第二软化聚合物组分。 聚合物材料还可以包括第三相容剂以便于将前两个聚合物组分共混在一起。 第一聚合物组分可以是聚酯或聚酰胺，第二聚合物组分可以是聚烯烃或乙烯共聚物。 第三聚合物组分优选是含有与第一聚合物组分形成共价键的反应性基团的乙烯共聚物。 形成气囊或导管的聚合物材料还可以包括催化剂，以催化相容性乙烯共聚物和第二聚合物组分之间的反应。 第二软化聚合物组分还可以包括硅烷偶联剂，以提供与第一强聚合物组分键合的反应性软化共聚物，以提供由聚合物组分形成的导管和气囊的增加的柔性。 由聚合物材料形成的球囊和导管的性质可以通过聚合材料的照射交联来增强。

    Polymer blends for use in making medical devices including catheters and balloons for dilatation catheters
    2.
    发明授权
    Polymer blends for use in making medical devices including catheters and balloons for dilatation catheters 失效

    公开(公告)号：US5554120A

    公开(公告)日：1996-09-10

    申请号：US280764

    申请日：1994-07-25

    申请人： Ziyun Chen ,  Tai Cheng ,  Ketan Muni ,  Udayan Patel ,  Robert Saltman

    发明人： Ziyun Chen ,  Tai Cheng ,  Ketan Muni ,  Udayan Patel ,  Robert Saltman

    IPC分类号： A61L29/00 ,  A61F2/958 ,  A61L29/04 ,  A61M25/00 ,  A61M25/16 ,  C08L23/02 ,  C08L67/00 ,  C08L67/02 ,  C08L77/00 ,  A61M25/10 ,  A61M29/02

    CPC分类号： A61M25/1029 ,  A61L29/049 ,  C08L67/02 ,  A61M2025/1031 ,  A61M25/0009

    摘要： A combination of polymeric components provides desired characteristics in forming medical instruments such as catheters and balloons for dilatation catheters. For example, a balloon material is formed from a blend of polymeric components, including a first crystalline polymeric component and a second softening polymeric component. Where the first two components are generally incompatible, the balloon material can also include a third compatibilizing agent to facilitate blending the first two polymeric components together. The first polymeric component can be a branched or straight chain polyamide having a molecular weight of at least about 5000, or a polyester prepared from aromatic dicarboxylic acids having 8 to 14 carbon atoms or aliphatic dicarboxylic acids having from 2 to 12 carbon atoms, and at least one glycol having the formula HO(CH.sub.2).sub.n OH, where n is an integer from 2 to 10, neopentyl glycol and cyclohexane dimethanol. The second polymeric component can be a polyolefin, an ethylene copolymer, a polyester block copolymer, or a polyamide block copolymer. The third polymeric component is preferably an ethylene copolymer having the formula E/X/Y where E is ethylene; X is an .alpha., .beta.-ethylenically unsaturated monomer derived from at least one of alkylacrylate, alkylmethacrylate, alkyl vinyl ether, carbon monoxide, sulfur dioxide, or mixtures thereof, where the alkyl groups contain 1-12 carbon atoms; and Y is an .alpha., .beta.-ethylenically unsaturated monomer containing a reactive group that forms a covalent bond with the first polymeric component. The polymeric blend can be irradiated to enhance the properties of the balloon material, including significantly increasing burst pressures.

    Polymer blends for use in making medical devices including catheters and balloons for dilatation catheters
    4.
    发明授权
    Polymer blends for use in making medical devices including catheters and balloons for dilatation catheters 失效
    用于制造包括用于扩张导管的导管和气球的医疗装置的聚合物共混物

    公开(公告)号：US6013728A

    公开(公告)日：2000-01-11

    申请号：US856733

    申请日：1997-05-15

    申请人： Ziyun Chen ,  Tai Cheng ,  Ketan Muni ,  Udayan Patel ,  Robert Saltman

    发明人： Ziyun Chen ,  Tai Cheng ,  Ketan Muni ,  Udayan Patel ,  Robert Saltman

    IPC分类号： A61L29/00 ,  A61F2/958 ,  A61L29/04 ,  A61M25/00 ,  A61M25/16 ,  C08L23/02 ,  C08L67/00 ,  C08L67/02 ,  C08L77/00

    CPC分类号： A61M25/1029 ,  A61L29/049 ,  C08L67/02 ,  A61M2025/1031 ,  A61M25/0009

    摘要： A combination of polymeric components provides desired characteristics in forming medical instruments such as catheters and balloons for dilatation catheters. For example, a balloon material is formed from a blend of polymeric components, including a first crystalline polymeric component and a second softening polymeric component. Where the first two components are generally incompatible, the balloon material can also include a third compatibilizing agent to facilitate blending the first two polymeric components together. The first polymeric component can be a branched or straight chain polyamide having a molecular weight of at least about 5000, or a polyester prepared from aromatic dicarboxylic acids having 8 to 14 carbon atoms or aliphatic dicarboxylic acids having from 2 to 12 carbon atoms, and at least one glycol having the formula HO(CH.sub.2).sub.n OH, where n is an integer from 2 to 10, neopentyl glycol and cyclohexane dimethanol. The second polymeric component can be a polyolefin, an ethylene copolymer, a polyester block copolymer, or a polyamide block copolymer. The third polymeric component is preferably an ethylene copolymer having the formula E/X/Y where E is ethylene; X is an .alpha., .beta.-ethylenically unsaturated monomer derived from at least one of alkylacrylate, alkylmethacrylate, alkyl vinyl ether, carbon monoxide, sulfur dioxide, or mixtures thereof, where the alkyl groups contain 1-12 carbon atoms; and Y is an .alpha., .beta.-ethylenically unsaturated monomer containing a reactive group that forms a covalent bond with the first polymeric component. The polymeric blend can be irradiated to enhance the properties of the balloon material, including significantly increasing burst pressures.

    摘要翻译： 聚合物组分的组合在形成用于扩张导管的导管和气囊的医疗器械中提供期望的特性。 例如，气球材料由聚合物组分的共混物形成，包括第一结晶聚合物组分和第二软化聚合物组分。 在前两种组分通常不相容的情况下，球囊材料还可以包括第三相容剂以便于将前两个聚合物组分混合在一起。 第一聚合物组分可以是分子量为至少约5000的支链或直链聚酰胺，或由具有8至14个碳原子的芳族二羧酸或具有2至12个碳原子的脂族二羧酸制备的聚酯，以及在 至少一种具有式HO（CH 2）n OH的二醇，其中n为2-10的整数，新戊二醇和环己烷二甲醇。 第二聚合物组分可以是聚烯烃，乙烯共聚物，聚酯嵌段共聚物或聚酰胺嵌段共聚物。 第三聚合物组分优选是具有式E / X / Y的乙烯共聚物，其中E是乙烯; X是衍生自丙烯酸烷基酯，甲基丙烯酸烷基酯，烷基乙烯基醚，一氧化碳，二氧化硫或其混合物中的至少一种的α，β-烯属不饱和单体，其中烷基含有1-12个碳原子; 并且Y是含有与第一聚合物组分形成共价键的反应性基团的α，β-烯属不饱和单体。 可以照射聚合物共混物以增强球囊材料的性质，包括显着增加爆破压力。

    Polymer blends for use in making medical devices including catheters and balloons for dilation catheters
    6.
    发明授权
    Polymer blends for use in making medical devices including catheters and balloons for dilation catheters 失效
    用于制造包括用于扩张导管的导管和气囊的医疗装置的聚合物共混物

    公开(公告)号：US5747591A

    公开(公告)日：1998-05-05

    申请号：US742272

    申请日：1996-10-31

    申请人： Ziyun Chen ,  Tai Cheng ,  Ketan Muni ,  Udayan Patel ,  Robert Saltman

    发明人： Ziyun Chen ,  Tai Cheng ,  Ketan Muni ,  Udayan Patel ,  Robert Saltman

    IPC分类号： A61L29/00 ,  A61F2/958 ,  A61L29/04 ,  A61M25/00 ,  A61M25/16 ,  C08L23/02 ,  C08L67/00 ,  C08L67/02 ,  C08L77/00 ,  A61M25/10

    CPC分类号： A61M25/1029 ,  A61L29/049 ,  C08L67/02 ,  A61M2025/1031 ,  A61M25/0009

    摘要： A combination of polymeric components provides desired characteristics in forming medical instruments such as catheters and balloons for dilatation catheters. For example, a balloon material is formed from a blend of polymeric components, including a first crystalline polymeric component and a second softening polymeric component. Where the first two components are generally incompatible, the balloon material can also include a third compatibilizing agent to facilitate blending the first two polymeric components together. The first polymeric component can be a branched or straight chain polyamide having a molecular weight of at least about 5000, or a polyester prepared from aromatic dicarboxylic acids having 8 to 14 carbon atoms or aliphatic dicarboxylic acids having from 2 to 12 carbon atoms, and at least one glycol having the formula HO(CH.sub.2).sub.n OH, where n is an integer from 2 to 10, neopentyl glycol and cyclohexane dimethanol. The second polymeric component can be a polyolefin, an ethylene copolymer, a polyester block copolymer, or a polyamide block copolymer. The third polymeric component is preferably an ethylene copolymer having the formula E/X/Y where E is ethylene; X is an .alpha., .beta.-ethylenically unsaturated monomer derived from at least one of alkylacrylate, alkylmethacrylate, alkyl vinyl ether, carbon monoxide, sulfur dioxide, or mixtures thereof, where the alkyl groups contain 1-12 carbon atoms; and Y is an .alpha., .beta.-ethylenically unsaturated monomer containing a reactive group that forms a covalent bond with the first polymeric component. The polymeric blend can be irradiated to enhance the properties of the balloon material, including significantly increasing burst pressures.

    摘要翻译： 聚合物组分的组合在形成用于扩张导管的导管和气囊的医疗器械中提供期望的特性。 例如，气球材料由聚合物组分的共混物形成，包括第一结晶聚合物组分和第二软化聚合物组分。 在前两种组分通常不相容的情况下，球囊材料还可以包括第三相容剂以便于将前两个聚合物组分混合在一起。 第一聚合物组分可以是分子量为至少约5000的支链或直链聚酰胺，或由具有8至14个碳原子的芳族二羧酸或具有2至12个碳原子的脂族二羧酸制备的聚酯，以及在 至少一种具有式HO（CH 2）n OH的二醇，其中n为2-10的整数，新戊二醇和环己烷二甲醇。 第二聚合物组分可以是聚烯烃，乙烯共聚物，聚酯嵌段共聚物或聚酰胺嵌段共聚物。 第三聚合物组分优选是具有式E / X / Y的乙烯共聚物，其中E是乙烯; X是衍生自丙烯酸烷基酯，甲基丙烯酸烷基酯，烷基乙烯基醚，一氧化碳，二氧化硫或其混合物中的至少一种的α，β-烯属不饱和单体，其中烷基含有1-12个碳原子; 并且Y是含有与第一聚合物组分形成共价键的反应性基团的α，β-烯属不饱和单体。 可以照射聚合物共混物以增强球囊材料的性质，包括显着增加爆破压力。

    Polymer blends for use in making medical devices including catheters and balloons for dilatation catheters
    7.
    发明授权
    Polymer blends for use in making medical devices including catheters and balloons for dilatation catheters 失效

    公开(公告)号：US5565523A

    公开(公告)日：1996-10-15

    申请号：US481871

    申请日：1995-06-07

    申请人： Ziyun Chen ,  Tai Cheng ,  Ketan Muni ,  Udayan Patel ,  Robert Saltman

    发明人： Ziyun Chen ,  Tai Cheng ,  Ketan Muni ,  Udayan Patel ,  Robert Saltman

    IPC分类号： A61L29/00 ,  A61F2/958 ,  A61L29/04 ,  A61M25/00 ,  A61M25/16 ,  C08L23/02 ,  C08L67/00 ,  C08L67/02 ,  C08L77/00 ,  A61M25/10

    CPC分类号： A61M25/1029 ,  A61L29/049 ,  C08L67/02 ,  A61M2025/1031 ,  A61M25/0009

    摘要： A combination of polymeric components provides desired characteristics in forming medical instruments such as catheters and balloons for dilatation catheters. For example, a balloon material is formed from a blend of polymeric components, including a first crystalline polymeric component and a second softening polymeric component. Where the first two components are generally incompatible, the balloon material can also include a third compatibilizing agent to facilitate blending the first two polymeric components together. The first polymeric component can be a branched or straight chain polyamide having a molecular weight of at least about 5000, or a polyester prepared from aromatic dicarboxylic acids having 8 to 14 carbon atoms or aliphatic dicarboxylic acids having from 2 to 12 carbon atoms, and at least one glycol having the formula HO(CH.sub.2).sub.n OH, where n is an integer from 2 to 10, neopentyl glycol and cyclohexane dimethanol. The second polymeric component can be a polyolefin, an ethylene copolymer, a polyester block copolymer, or a polyamide block copolymer. The third polymeric component is preferably an ethylene copolymer having the formula E/X/Y where E is ethylene; X is an .alpha., .beta.-ethylenically unsaturated monomer derived from at least one of alkylacrylate, alkylmethacrylate, alkyl vinyl ether, carbon monoxide, sulfur dioxide, or mixtures thereof, where the alkyl groups contain 1-12 carbon atoms; and Y is an .alpha., .beta.-ethylenically unsaturated monomer containing a reactive group that forms a covalent bond with the first polymeric component. The polymeric blend can be irradiated to enhance the properties of the balloon material, including significantly increasing burst pressures.