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29 条记录 (耗时 0.026 秒)

    Plant growth regulating compositions
    1.
    发明授权
    Plant growth regulating compositions 失效
    植物生长调节成分

    公开(公告)号：US4310348A

    公开(公告)日：1982-01-12

    申请号：US166975

    申请日：1980-07-09

    申请人： Zoltan Budai ,  Ferenc Jurak ,  Attila Kis-tamas ,  Aranka Lay nee Konya ,  Tibor Mezei ,  Zoltan Vig ,  Terez Zubovits nee Kristof

    发明人： Zoltan Budai ,  Ferenc Jurak ,  Attila Kis-tamas ,  Aranka Lay nee Konya ,  Tibor Mezei ,  Zoltan Vig ,  Terez Zubovits nee Kristof

    IPC分类号： A01N33/24 ,  A01N35/10 ,  C07C249/04 ,  C07C251/44 ,  A01N33/02

    CPC分类号： A01N35/10

    摘要： Racemic or optionally active 2-(propargyloxyimino)-1,7,7-trimethyl-bicyclo[2,2,1]heptane of the formula (I) ##STR1## or a mixture of these isomers is prepared by reacting a racemic or optically active 1,7,7-trimethyl-bicyclo[2,2,1]heptane derivative of the general formula (II), ##STR2## wherein Y stands for oxygen atom, sulfur atom or oxime group, with a propyne derivative of the general formula (III),R--CH.sub.2 --C.tbd.CH (III)whereinR stands for halogen atom or aminooxy group, with the proviso that if Y represents oxime group, R may stand only for halogen, and if R represents aminooxy group, Y may stand only for oxygen or sulfur atom.The resulting product is new and possesses strong plant growth promoting and insecticidal effects.This is a division of application Ser. No. 065,156, filed Aug. 9, 1979, now U.S. Pat. No. 4,244,888, Jan. 13, 1981.

    摘要翻译： 式（I）的外消旋或任选活性的2-（炔丙氧基亚氨基）-1,7,7-三甲基 - 双环[2,2,1]庚烷或其混合物或这些异构体的混合物通过使 外消旋或光学活性的通式（II）的17,7-三甲基 - 双环[2,2,1]庚烷衍生物，其中Y代表氧原子，硫原子或肟基，其中 通式（III）的丙炔衍生物，其中R代表卤素原子或氨基氧基的R-CH 2 -C 3 CHCH（III），条件是如果Y表示肟基，则R可以仅为卤素，如果 R表示氨基氧基，Y可以仅为氧或硫原子。

    Plant growth regulating and insecticidal compositions
    2.
    发明授权
    Plant growth regulating and insecticidal compositions 失效
    植物生长调节和杀虫组合物

    公开(公告)号：US4244888A

    公开(公告)日：1981-01-13

    申请号：US65156

    申请日：1979-08-09

    申请人： Zoltan Budai ,  Ferenc Jurak ,  Attila Kis-Tamas ,  Aranka Lay nee Konya ,  Tibor Mezei ,  Zoltan Vig ,  Terez Zubovits nee Kristof

    发明人： Zoltan Budai ,  Ferenc Jurak ,  Attila Kis-Tamas ,  Aranka Lay nee Konya ,  Tibor Mezei ,  Zoltan Vig ,  Terez Zubovits nee Kristof

    IPC分类号： A01N33/24 ,  A01N35/10 ,  C07C249/04 ,  C07C251/44 ,  C07C131/02

    CPC分类号： A01N35/10

    摘要： Racemic or optically active 2-(propargyloxyimino)-1,7,7-trimethyl-bicyclo[2,2,1]heptane of the formula (I) ##STR1## or a mixture of these isomers is prepared by reacting a racemic or optically active 1,7,7-trimethyl-bicyclo[2,2,1]heptane derivative of the general formula (II), ##STR2## wherein Y stands for oxygen atom, sulfur atom or oxime group, with a propyne derivative of the general formula (III),R--CH.sub.2 --C.tbd.CH (III) whereinR stands for halogen atom or aminooxy group, with the proviso that if Y represents oxime group, R may stand only for halogen, and if R represents aminooxy group, Y may stand only for oxygen or sulfur atom.The resulting product is new and possesses strong plant growth promoting and insecticidal effects.

    摘要翻译： 式（I）的外消旋或光学活性的2-（炔丙氧基亚氨基）-1,7,7-三甲基 - 双环[2,2,1]庚烷或其混合物可以通过使 外消旋或光学活性的通式（II）的17,7-三甲基 - 双环[2,2,1]庚烷衍生物，其中Y代表氧原子，硫原子或肟基，其中 通式（III）的丙炔衍生物，其中R代表卤素原子或氨基氧基的R-CH 2 -C 3 CHCH（III），条件是如果Y表示肟基，则R可以仅为卤素，如果 R表示氨基氧基，Y可以仅为氧或硫原子。 产生的产品是新的，具有很强的植物生长促进和杀虫作用。

    Bicyclo(2.2.1)heptane oximes used for plant growth regulating
    4.
    发明授权
    Bicyclo(2.2.1)heptane oximes used for plant growth regulating 失效
    用于植物生长调节的双环（2.2.1）庚烷肟

    公开(公告)号：US4425158A

    公开(公告)日：1984-01-10

    申请号：US322675

    申请日：1981-11-18

    申请人： Zoltan Budai ,  Attila Kis-Tamas ,  Tibor Mezei ,  Aranka Lay nee Konya ,  Zoltan Vigh ,  Agnes Sokorai nee Janki

    发明人： Zoltan Budai ,  Attila Kis-Tamas ,  Tibor Mezei ,  Aranka Lay nee Konya ,  Zoltan Vigh ,  Agnes Sokorai nee Janki

    IPC分类号： A01N33/24 ,  A01N33/04 ,  A01N35/10 ,  A01P21/00 ,  C07C251/44 ,  C07C251/50

    CPC分类号： A01N35/10

    摘要： The invention relates to new bicyclo(2.2.1)heptane derivatives of the general formula I ##STR1## wherein R represents a C.sub.1-12 alkyl group optionally substituted by a lower alkoxy group, a C.sub.2-4 alkenyl group or a phenyl-(lower alkyl) group optionally substituted on the phenyl ring by one or more lower alkoxy groups or halogen atoms.The invention relates further to plant growth regulating compositions comprising as active agent 0.001 to 95% by weight of a racemic and/or optically active compound of the general formula I, wherein R has the above defined meanings, along with a conventional organic or inorganic, solid and/or liquid carrier and/or filler and/or diluent and/or surfactant.The invention encompasses also the preparation of the compounds of the general formula I which comprises reacting a racemic or optically active compound of the general formula II ##STR2## wherein Y is an oxygen or sulfur atom or an oxim group, with a compund of the general formula IIIR - XwhereinR is as defined above, andX represents a leaving group, preferably a halogen atom, a sulfonyloxy or an aminooxy group, with the proviso that when using a compound of the general formula II, in which Y is an oxim group, X is other than aminooxy group,in the presence of a basic condensing agent, and optionally resolving the racemic compound of the general formula I obtained into its optically active antipodes.

    摘要翻译： 本发明涉及通式I的新的双环（2.2.1）庚烷衍生物，其中R表示任选被低级烷氧基，C 2-4链烯基或苯基 - （ 低级烷基）基团，其任选在苯环上被一个或多个低级烷氧基或卤素原子取代。 本发明进一步涉及植物生长调节组合物，其包含作为活性剂0.001至95重量％的通式I的外消旋和/或旋光活性化合物，其中R具有上述定义的含义，以及常规的有机或无机， 固体和/或液体载体和/或填料和/或稀释剂和/或表面活性剂。 本发明还包括通式I的化合物的制备，其包括使通式II的外消旋或旋光活性化合物其中Y是氧或硫原子或肟基，与下列化合物反应： 通式III R-X其中R如上定义，X​​表示离去基团，优选卤素原子，磺酰氧基或氨基氧基，条件是当使用通式II的化合物时，其中Y为 肟基，X不是氨基氧基，在碱性缩合剂的存在下，并且任选地将所得通式I的外消旋化合物拆分成其光学活性对映体。

    Pharmaceutical compositions with antianginal activity
    5.
    发明授权
    Pharmaceutical compositions with antianginal activity 失效
    具有抗心绞痛活性的药物组合物

    公开(公告)号：US4621101A

    公开(公告)日：1986-11-04

    申请号：US751623

    申请日：1985-07-02

    申请人： Zoltan Budai ,  Tibor Mezei ,  Aranka Lay nee Konya ,  Lujza Petocz ,  Katalin Grasser ,  Zsuzsanna Orr

    发明人： Zoltan Budai ,  Tibor Mezei ,  Aranka Lay nee Konya ,  Lujza Petocz ,  Katalin Grasser ,  Zsuzsanna Orr

    IPC分类号： A61K31/15 ,  A61P43/00 ,  C07C251/38

    CPC分类号： C07C251/58 ,  C07C2101/14 ,  C07C2101/18

    摘要： The invention relates to pharmaceutical compositions possessing valuable antianginal activity. These compositions show higher activity and more favorable therapeutic indices than the reference compound Prenylamine. Preparation of different kinds of pharmaceutical compositions, such as tablets, dragees, capsules and injectable solutions, containing compounds of general formula (I) ##STR1## or their acid addition salts as active ingredients, is disclosed, wherein in formula (I)R is phenyl or 4-chlorophenyl;R.sup.1 and R.sup.2 each represent hydrogen, methyl or isopropyl;R.sup.3 and R.sup.4 are hydrogen, or together form a chemical bond;n is an integer from 4 to 6;A means trimethylene, if n is 4 or 6; or ethylene, if n is 5.

    摘要翻译： 本发明涉及具有有价值的抗心绞痛活性的药物组合物。 这些组合物显示比参考化合物Prenylamine更高的活性和更有利的治疗指数。 公开了含有通式（I）化合物或其酸加成盐作为活性成分的不同种类的药物组合物如片剂，硫化物，胶囊和可注射溶液的制备，其中在式（I）中R是 苯基或4-氯苯基; R1和R2各自表示氢，甲基或异丙基; R3和R4是氢，或一起形成化学键; n为4-6的整数; 如果n为4或6，则表示三亚甲基; 或乙烯，如果n为5。

    Novel oxime ethers
    6.
    发明授权
    Novel oxime ethers 失效
    新型肟醚

    公开(公告)号：US4077999A

    公开(公告)日：1978-03-07

    申请号：US749399

    申请日：1976-12-10

    申请人： Zoltan Budai ,  Aranka Lay nee Konya ,  Tibor Mezei ,  Katalin Grasser ,  Eniko Szirt nee Kiszelly ,  Ibolya Kosoczky ,  Lujza E. Petocz

    发明人： Zoltan Budai ,  Aranka Lay nee Konya ,  Tibor Mezei ,  Katalin Grasser ,  Eniko Szirt nee Kiszelly ,  Ibolya Kosoczky ,  Lujza E. Petocz

    IPC分类号： C07C251/58 ,  C07D295/088 ,  C07C131/02 ,  C07C131/04

    CPC分类号： C07D295/088 ,  C07C251/58 ,  C07C2101/08 ,  C07C2101/16 ,  C07C2101/18

    摘要： The invention relates to novel oxime ethers of the formula I ##STR1## wherein R stands for a phenyl group which may be substituted by a halogen atom or by one or more C.sub.1 -C.sub.4 alkoxy, hydroxyl, nitro or di(C.sub.1 -C.sub.3 alkyl)amino groups,R.sup.1 and R.sup.2 denote each a hydrogen atom or together a valence bond,A denotes a C.sub.2 -C.sub.4 straight or branched-chain alkylene group,N denotes an integer from 3 to 10, andR.sup.3 and R.sup.4 denote a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group, furthermore to acid addition salts and quaternary ammonium salts thereof. These new compounds are biologically active, and possess primarily local analgesic, spasmolytic, nicotine-lethality inhibiting, tetrabenazine-antagonistic and tetra-cor-spasm inhibiting effects.

    摘要翻译： 本发明涉及式I（I）的新型肟醚，其中R代表可被卤素原子取代的苯基或一个或多个C 1 -C 4烷氧基，羟基，硝基或二（C1- C 3烷基）氨基，R 1和R 2各自表示氢原子或价键一起，A表示C 2 -C 4直链或支链亚烷基，N DENOTES AN INTEGER为3〜10，R 3和R 4表示氢 原子或C1-C4烷基，此外还涉及其酸加成盐和季铵盐。 这些新化合物具有生物活性，主要具有局部镇痛，解痉，尼古丁致死抑制，四苯并嗪拮抗和四痉挛抑制作用。

    Oxime ethers and pharmaceutical compositions containing the same
    8.
    发明授权
    Oxime ethers and pharmaceutical compositions containing the same 失效
    肟醚和含有它的药物组合物

    公开(公告)号：US4395413A

    公开(公告)日：1983-07-26

    申请号：US162674

    申请日：1980-06-24

    申请人： Zoltan Budai ,  Aranka Lay nee Konya ,  Tibor Mezei ,  Lujza Petocz ,  Katalin Grasser ,  Ibolya Kosoczky ,  Eniko Szirt nee Kiszelly ,  Peter Gorog

    发明人： Zoltan Budai ,  Aranka Lay nee Konya ,  Tibor Mezei ,  Lujza Petocz ,  Katalin Grasser ,  Ibolya Kosoczky ,  Eniko Szirt nee Kiszelly ,  Peter Gorog

    IPC分类号： A61K31/15 ,  A61K31/495 ,  A61P25/04 ,  C07C67/00 ,  C07C239/00 ,  C07C249/10 ,  C07C251/58 ,  C07D295/02 ,  C07D295/088 ,  C07D295/08

    CPC分类号： C07D295/088 ,  Y10S514/926 ,  Y10S514/927

    摘要： The invention relates to novel oxime ethers of the general formula /I/ and acid addition salts and quaternary ammonium derivatives thereof, ##STR1## wherein A represents a C.sub.2-6 straight or branched alkylene chain,R and R.sup.1 each represent a C.sub.1-6 alkyl group or they form together with the adjacent nitrogen atom a heterocyclic ring containing 4 to 7 carbon atoms and optionally a further hetero atom, i.e. an oxygen, sulfur or nitrogen atom, and said ring may be optionally substituted by a C.sub.1-3 alkyl, phenyl or benzyl group,R.sup.2 and R.sup.3 each denote a hydrogen atom or together form a valency bond,R.sup.4 denotes a C.sub.1-10 alkyl or C.sub.2-10 alkenyl group, andn denotes an integer from 3 to 7.The compounds of the general formula /I/ are prepared according to the invention by reacting a cycloalkane derivative of the general formula /II/ ##STR2## wherein R.sup.2, R.sup.3, R.sup.4 and n have the same meaning as above, whereasY denotes an oxygen or sulphur atom or a .dbd.N--OH group with an aminoalkyl derivative of the general formula /III/ ##STR3## wherein R, R.sup.1 and A have the same meaning as stated above andZ means a halogen atom or a H.sub.2 N--O-- group or a salt thereof in the presence of a basic condensing agent.The new compounds of the general formula /I/ possess valuable nicotine-lethality inhibiting, local anaesthetic, analgesic effects, which are, in case of certain compounds, complemented by anti-hypertensive, maximum electroshock and tetracorspasm inhibiting, ulcus inhibiting and motility inhibiting effects, and can be applied to advantage in the therapy.

    摘要翻译： 本发明涉及通式I I的新型肟醚及其酸加成盐和季铵衍生物，其中A表示C2-6直链或支链亚烷基链，R和R1各自表示C1 -6烷基，或者它们与相邻的氮原子一起与含有4至7个碳原子的杂环和任选的另外的杂原子（即氧，硫或氮原子）一起形成，并且所述环可以任选地被C 1-3 烷基，苯基或苄基，R2和R3各自表示氢原子或一起形成价键，R4表示C1-10烷基或C2-10烯基，n表示3至7的整数。 根据本发明通过使通式/ II / IMAGE / II /的环烷烃衍生物与其中R2，R3，R4和n具有与上述相同的含义反应制备通式/ I / I，而Y表示氧或 硫原子或a =具有氨基烷基衍生物的N-OH基团 通式/ III / / III /其中R，R 1和A具有与上述相同的含义，Z表示在碱性缩合剂存在下的卤素原子或H 2 N-O-基或其盐。 新型化合物/ I /具有有价值的尼古丁杀伤力抑制，局部麻醉，止痛作用，在某些化合物的情况下，补充有抗高血压，最大电休克和四疣抑制作用，抑制溃疡和运动抑制作用 ，并且可以在治疗中有利地应用。