公开(公告)号：US12091702B2

公开(公告)日：2024-09-17

申请号：US16708417

申请日：2019-12-09

Applicant: BIOMERIEUX, INC.

Inventor： Grégory Strubel ,  Maud Arsac ,  Denis Desseree ,  Pierre-Jean Cotte-Pattat ,  Pierre Mahe

IPC: C12Q1/04 ,  C12Q1/6872 ,  G01N33/483 ,  G01N33/68 ,  G06F18/2411 ,  G06F18/2413 ,  G06F18/2415 ,  G06V20/69 ,  G16B40/00 ,  G16B40/10 ,  G16B40/20 ,  H01J49/00 ,  H01J49/26

CPC classification number: C12Q1/04 ,  C12Q1/6872 ,  G01N33/483 ,  G01N33/6848 ,  G06F18/2411 ,  G06F18/2413 ,  G06F18/24155 ,  G06V20/698 ,  G16B40/00 ,  G16B40/10 ,  G16B40/20 ,  H01J49/0036 ,  H01J49/26

Abstract: An identification by mass spectrometry of a microorganism from among reference microorganisms represented by reference data sets includes: determining a set of data of the microorganism according to a spectrum; for each reference microorganism, calculating a distance between the determined and reference sets; and calculating a probability ƒ(m) according to relation





f
⁡

(
m
)


=


pN
⁡

(


m
|
μ

,
σ

)




pN
⁡

(


m
|
μ

,
σ

)


+


(

1
-
p

)

⁢

N
⁡

(


m
|

μ
_


,

σ
_


)









where: m is the distance calculated for the reference microorganism; N(m|μ,σ) is the value, for m, of a random variable modeling the distance between a reference microorganism to be identified and the reference microorganism, when the microorganism is the reference microorganism; N(m|μ,σ) is the value, for m, of a random variable modeling the distance between a microorganism to be identified and the reference microorganism, when the microorganism is not the reference microorganism; and p is a scalar in the range from 0 to 1.

公开(公告)号：US20140343864A1

公开(公告)日：2014-11-20

申请号：US14361885

申请日：2012-11-30

Applicant: bioMerieux, Inc.

Inventor： Grégory Strubel ,  Maud Arsac ,  Denis Desseree ,  Pierre-Jean Cotte-Pattat ,  Pierre Mahe

IPC: H01J49/00 ,  G01N33/483

CPC classification number: H01J49/0036 ,  C12Q1/04 ,  G01N33/483 ,  G01N33/6848 ,  G06K9/00147 ,  G06K9/6269 ,  G06K9/627 ,  G06K9/6278 ,  H01J49/26

Abstract: An identification by mass spectrometry of a microorganism from among reference microorganisms represented by reference data sets includes: determining a set of data of the microorganism according to a spectrum; for each reference microorganism, calculating a distance between the determined and reference sets; and calculating a probability f(m) according to relation f  ( m ) = pN  ( m  μ , σ ) pN  ( m  μ , σ ) + ( 1 - p )  N  ( m  μ _ , σ _ ) where: m is the distance calculated for the reference microorganism; N(m|μ,σ) is the value, for m, of a random variable modeling the distance between a reference microorganism to be identified and the reference microorganism, when the microorganism is the reference microorganism; N(m| μ, σ) is the value, for m, of a random variable modeling the distance between a microorganism to be identified and the reference microorganism, when the microorganism is not the reference microorganism; and p is a scalar in the range from 0 to 1.

Abstract translation: 通过参考数据组所表示的参考微生物中的微生物的质谱鉴定包括：根据光谱确定微生物的一组数据; 对于每个参考微生物，计算所确定的和参考组之间的距离; 并且根据关系式（m）= pN（mμ，＆sgr;）pN（mμ，＆sgr）+（1-p）N（mμ）计算概率f（m） _，＆sgr; _）其中：m是参考微生物计算的距离; 当微生物是参照微生物时，N（m |μ，＆sgr;）是m的值，用于建立待鉴定的参考微生物与参照微生物之间的距离的随机变量; N（m |μ，＆sgr;）是当微生物不是参照微生物时，随机变量建模待鉴定微生物与参照微生物之间的距离的m值; p是0到1范围内的标量。

公开(公告)号：US10546735B2

公开(公告)日：2020-01-28

申请号：US14361885

申请日：2012-11-30

Applicant: bioMerieux, Inc.

Inventor： Grégory Strubel ,  Maud Arsac ,  Denis Desseree ,  Pierre-Jean Cotte-Pattat ,  Pierre Mahe

IPC: H01J49/00 ,  G01N33/483 ,  H01J49/26

Abstract: An identification by mass spectrometry of a microorganism from among reference microorganisms represented by reference data sets includes: determining a set of data of the microorganism according to a spectrum; for each reference microorganism, calculating a distance between the determined and reference sets; and calculating a probability f(m) according to relation f ⁡ ( m ) = pN ⁡ ( m ❘ μ , σ ) pN ⁡ ( m ❘ μ , σ ) + ( 1 - p ) ⁢ N ⁡ ( m ❘ μ _ , σ _ ) where: m is the distance calculated for the reference microorganism; N(m|μ,σ) is the value, for m, of a random variable modeling the distance between a reference microorganism to be identified and the reference microorganism, when the microorganism is the reference microorganism; N(m|μ,σ) is the value, for m, of a random variable modeling the distance between a microorganism to be identified and the reference microorganism, when the microorganism is not the reference microorganism; and p is a scalar in the range from 0 to 1.