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公开(公告)号：US20230011269A1
公开(公告)日：2023-01-12
申请号：US17808390
申请日：2022-06-23
发明人： Joanne REILAND WAKEMAN , Colin ROWLINGS , Sha LIU , Gerry BURKE , Christian VON CORSWANT , Christer TANNERGREN , Johan HJÄRTSTAM
IPC分类号： A61K9/20 , A61K9/14 , A61K9/00 , A61K9/48 , A61K9/50 , A61K31/426 , A61K31/4418 , A61K45/06
摘要： The present invention relates to pharmaceutical compositions containing 2-((3-(4-cyanonaphthalen-1-yl)pyridine-4-yl)thio)-2-methylpropanoic acid or a pharmaceutically acceptable salt (hereinafter referred to as the “Agent”), more particularly to orally deliverable compositions containing the Agent; to the use of said compositions as a medicament; and to processes for the preparation of said compositions.
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公开(公告)号：US20210171466A1
公开(公告)日：2021-06-10
申请号：US17123380
申请日：2020-12-16
发明人： Samedy OUK , Esmir GUNIC , Jean-Michel VERNIER , Chixu CHEN
IPC分类号： C07D213/70 , C07D239/38 , C07D241/18 , C07D401/04 , C07D403/04 , C07D405/04 , C07D417/04 , A61K31/426 , A61K31/4418 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/4725 , A61K31/4965 , A61K31/497 , A61K31/502 , A61K31/505 , A61K31/506 , A61K31/519 , A61K45/06 , C07D401/10 , C07D403/10 , C07D405/10 , C07D417/10
摘要： Described herein are compounds useful in the modulation of blood uric acid levels, formulations containing them and methods of using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid.
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公开(公告)号：US10266493B2
公开(公告)日：2019-04-23
申请号：US13703890
申请日：2011-06-15
申请人： Samedy Ouk , Esmir Gunic , Jean-Michel Vernier , Chixu Chen
发明人： Samedy Ouk , Esmir Gunic , Jean-Michel Vernier , Chixu Chen
IPC分类号： C07D213/70 , A61K31/497 , C07D403/10 , C07D405/10 , A61K31/426 , A61K31/4418 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/4725 , A61K31/4965 , A61K31/519 , A61K31/502 , A61K31/505 , A61K31/506 , C07D417/10 , A61K45/06 , C07D401/10 , C07D417/04 , C07D405/04 , C07D403/04 , C07D401/04 , C07D241/18 , C07D239/38
摘要： Described herein are compounds useful in the modulation of blood uric acid levels, formulations containing them and methods of using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid.
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公开(公告)号：US09216179B2
公开(公告)日：2015-12-22
申请号：US13704192
申请日：2011-06-14
申请人： Jeffrey Miner , Jean-Luc Girardet , Barry D. Quart
发明人： Jeffrey Miner , Jean-Luc Girardet , Barry D. Quart
IPC分类号： A61K31/41 , A61K31/425 , A61K31/519 , A61K31/4196 , A61K31/426 , A61K45/06
CPC分类号： A61K31/426 , A61K31/4196 , A61K31/519 , A61K45/06 , A61K2300/00
摘要： Sodium 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetate is described. In addition, pharmaceutical compositions and uses of such compositions for the treatment of a variety of diseases and conditions are described.
摘要翻译： 描述2-（5-溴-4-（4-环丙基萘-1-基）-4H-1,2,4-三唑-3-基硫基）乙酸钠。 此外，描述了这些组合物的药物组合物和用途，用于治疗各种疾病和病症。
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公开(公告)号：US08808742B2
公开(公告)日：2014-08-19
申请号：US12937630
申请日：2009-04-14
IPC分类号： A61K31/18 , A61K9/28 , A61K31/56 , A61K31/519 , A61P35/00 , A61P35/02 , A61P19/02 , A61P25/00 , A61P29/00
CPC分类号： A61K47/38 , A61K9/146 , A61K9/4858 , A61K9/4866 , A61K31/18 , A61K47/02 , A61K47/20
摘要： This invention relates to compositions, methods for preparing the compositions and methods for treating or preventing diseases, comprising administering the compositions.
摘要翻译： 本发明涉及组合物，制备组合物的方法和治疗或预防疾病的方法，包括给药组合物。
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公开(公告)号：US20140080783A1
公开(公告)日：2014-03-20
申请号：US14082681
申请日：2013-11-18
发明人： Mark CHAPMAN
IPC分类号： A61K31/18 , A61K31/5377 , A61K31/7068 , A61N5/00 , A61K31/4188 , A61K31/436 , A61K45/06 , A61K31/517 , A61K31/185
CPC分类号： A61K31/18 , A61K31/185 , A61K31/4188 , A61K31/436 , A61K31/517 , A61K31/5377 , A61K31/7064 , A61K31/7068 , A61K45/06 , A61N5/00 , A61K2300/00
摘要： The present invention relates to the field of oncology and provides compositions and methods for treating specific cancers, including non small cell lung cancer, breast cancer, thyroid cancer, pancreatic cancer, colon cancer, melanoma, hepatoma and adenocarcinoma. Particularly, compositions and methods involving administration, either simultaneously or sequentially, of pharmaceutical combinations comprising (S)—N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide with other compounds, to patients suffering from cancer are described.
摘要翻译： 本发明涉及肿瘤学领域，并提供用于治疗特定癌症的组合物和方法，包括非小细胞肺癌，乳腺癌，甲状腺癌，胰腺癌，结肠癌，黑素瘤，肝癌和腺癌。 特别地，包括同时或依次施用包含（S）-N-（3,4-二氟-2-（2-氟-4-碘苯基氨基）-6-甲氧基苯基）-1-（ 2,3-二羟基丙基）环丙烷-1-磺酰胺与其他化合物对患有癌症的患者进行了描述。
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公开(公告)号：US20130296345A1
公开(公告)日：2013-11-07
申请号：US13879373
申请日：2010-10-15
申请人： Barry D. Quart
发明人： Barry D. Quart
IPC分类号： A61K31/4196 , A61K31/426 , A61K31/519
CPC分类号： A61K31/4196 , A61K31/426 , A61K31/519 , A61K2300/00 , A61P13/12 , A61P19/02
摘要： Provided herein are methods of treating gout, treating hyperuricemia, lowering serum uric acid, or the like with compounds of formula (I) have the following structure Further, provided herein are compositions comprising a compound of formula (I).
摘要翻译： 本文提供了用式（I）化合物治疗痛风，治疗高尿酸血症，降低血清尿酸等的方法具有以下结构。此外，本文提供了包含式（I）化合物的组合物。
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8.发明授权Polymorphic forms of 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid and uses thereof 有权2-（5-溴-4-（4-环丙基萘-1-基）-4H-1,2,4-三唑-3-基硫基）乙酸的多晶型及其用途公开(公告)号：US08546436B2
公开(公告)日：2013-10-01
申请号：US13339283
申请日：2011-12-28
IPC分类号： A61K31/41 , A61K31/44 , A61K31/56 , C07D249/00
CPC分类号： A61K31/4196 , A61K31/426 , A61K31/519 , A61K31/522 , C07D249/06 , C07D249/12
摘要： Crystalline polymorph forms of 2-(5-bromo-4-(4-cyclopropyl naphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid are described. Pharmaceutical compositions and the uses of such compounds, compound forms, and compositions for the treatment of a variety of diseases and conditions are also presented.
摘要翻译： 描述2-（5-溴-4-（4-环丙基萘-1-基）-4H-1,2,4-三唑-3-基硫基）乙酸的结晶多晶型形式。 还提出了药物组合物以及这些化合物，化合物形式和组合物用于治疗各种疾病和病症的用途。
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9.发明授权Preparation of (R)-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide and (S)-N-3,4-difluoro-2(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide 有权（R）-N-（3,4-二氟-2-（2-氟-4-碘苯基氨基）-6-甲氧基苯基）-1-（2,3-二羟基丙基）环丙烷-1-磺酰胺和（S） -N-3,4-二氟-2（2-氟-4-碘苯基氨基）-6-甲氧基苯基）-1-（2,3-二羟基丙基）环丙烷-1-磺酰胺公开(公告)号：US08513443B2
公开(公告)日：2013-08-20
申请号：US13386519
申请日：2010-07-10
IPC分类号： C07D317/10
CPC分类号： C07C303/38 , C07C317/18 , C07C2601/02 , C07D317/18 , C07D317/26 , C07C311/28
摘要： The present invention relates to the preparation of (R)—N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide and (S)—N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide.
摘要翻译： 本发明涉及制备（R）-N-（3,4-二氟-2-（2-氟-4-碘苯基氨基）-6-甲氧基苯基）-1-（2,3-二羟基丙基）环丙烷-1 - 磺酰胺和（S）-N-（3,4-二氟-2-（2-氟-4-碘苯基氨基）-6-甲氧基苯基）-1-（2,3-二羟丙基）环丙烷-1-磺酰胺。
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公开(公告)号：US20130203779A1
公开(公告)日：2013-08-08
申请号：US13857108
申请日：2013-04-04
发明人： Samedy Ouk , Esmir Gunic , Jean-Michel Vernier
IPC分类号： A61K31/4418 , A61K31/519 , A61K31/426 , C07D213/70
CPC分类号： C07D213/70 , A61K31/426 , A61K31/4418 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/4725 , A61K31/4965 , A61K31/497 , A61K31/502 , A61K31/505 , A61K31/506 , A61K31/519 , A61K45/06 , C07D239/38 , C07D241/18 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/10 , C07D417/04 , C07D417/10
摘要： Described herein are compounds useful in the modulation of blood uric acid levels, formulations containing them and methods of using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid.
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