公开(公告)号：US20050165108A1

公开(公告)日：2005-07-28

申请号：US10508364

申请日：2002-04-29

申请人： Shanmughasamy Rajamahendra ,  Chandrashekhar Aswathanarayanappa ,  Tom Thomas Puthiaparampil ,  Madhavan Sridharan ,  Sambasivam Ganesh

发明人： Shanmughasamy Rajamahendra ,  Chandrashekhar Aswathanarayanappa ,  Tom Thomas Puthiaparampil ,  Madhavan Sridharan ,  Sambasivam Ganesh

IPC分类号： A61P3/10 ,  A61K31/198 ,  C07B53/00 ,  C07C20060101 ,  C07C231/02 ,  C07C231/24 ,  C07C233/63 ,  C07C235/82

CPC分类号： C07C233/63 ,  C07C2601/14

摘要： The present invention relates to a novel crystalline form of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine and methods for preparing the same.

摘要翻译： 本发明涉及N-（反式-4-异丙基环己基羰基）-D-苯丙氨酸的新结晶形式及其制备方法。

公开(公告)号：US08012723B2

公开(公告)日：2011-09-06

申请号：US12686321

申请日：2010-01-12

申请人： Madhav Kulkarni ,  Surekha K. Prabhu ,  Madenahally Channabasappa Shivakumar ,  Prijyajit Sengupta ,  Sanjay Tiwari ,  Rakesh Mendhe ,  Nitin Patil ,  Laxmi Adhikary ,  Anand Khedkar ,  Ramakrishnan Melarkode ,  Ramavana Gururaja ,  Shrikumar Suryanarayan

发明人： Madhav Kulkarni ,  Surekha K. Prabhu ,  Madenahally Channabasappa Shivakumar ,  Prijyajit Sengupta ,  Sanjay Tiwari ,  Rakesh Mendhe ,  Nitin Patil ,  Laxmi Adhikary ,  Anand Khedkar ,  Ramakrishnan Melarkode ,  Ramavana Gururaja ,  Shrikumar Suryanarayan

IPC分类号： C12P17/00 ,  C12P17/16 ,  C12N1/20 ,  C12N15/00

CPC分类号： C12R1/465 ,  C12P17/188

摘要： The present invention discloses a new strain of Streptomyces sp. BICC 7522, its variants or mutants and use of the strain for the production of macrolides, process of production and purification of macrolides.

摘要翻译： 本发明公开了一种新的Streptomyces sp。 BICC 7522，其变体或突变体以及该菌株用于生产大环内酯类，大环内酯类的生产和纯化方法。

公开(公告)号：US11058768B2

公开(公告)日：2021-07-13

申请号：US15303881

申请日：2015-04-16

申请人： BIOCON LTD. ,  MYLAN GMBH

发明人： Kala Chandramouli ,  Rohan Pai

IPC分类号： A61K39/395 ,  C07K16/32 ,  A61K9/19 ,  A61K47/26 ,  A61K47/10 ,  A61K47/20 ,  A61J1/20 ,  A61J1/06 ,  A61J1/14 ,  A61K47/18 ,  A61K9/00

摘要： A stable pharmaceutical formulation comprising a protein of interest, sorbitol and polyethylene glycol (PEG). The sorbitol and protein is present in a molar ratio of 550 to 700 mole of sorbitol:1 mole of protein and the PEG to protein is present in the molar ratio of 2-50:1. The formulation optionally comprising buffer. The formulation in lyophilised form is stable for at least 4 years at 2-8° C. Also provided is a process for preparing the composition and a pharmaceutical kit comprising the same.

公开(公告)号：US20100184985A1

公开(公告)日：2010-07-22

申请号：US12686321

申请日：2010-01-12

申请人： Madhav Kulkarni ,  Surekha K. Prabhu ,  Madenahally Channabasappa Shivakumar ,  Prijyajit Sengupta ,  Sanjay Tiwari ,  Rakesh Mendhe ,  Nitin Patil ,  Laxmi Adhikary ,  Anand Khedkar ,  Ramakrishnan Melarkode ,  Ramavana Gururaja ,  Shrikumar Suryanarayan

发明人： Madhav Kulkarni ,  Surekha K. Prabhu ,  Madenahally Channabasappa Shivakumar ,  Prijyajit Sengupta ,  Sanjay Tiwari ,  Rakesh Mendhe ,  Nitin Patil ,  Laxmi Adhikary ,  Anand Khedkar ,  Ramakrishnan Melarkode ,  Ramavana Gururaja ,  Shrikumar Suryanarayan

IPC分类号： C07D491/18 ,  C12P1/04 ,  C12P17/18

CPC分类号： C12R1/465 ,  C12P17/188

摘要： The present invention discloses a new strain of Streptomyces sp. BICC 7522, its variants or mutants and use of the strain for the production of macrolides, process of production and purification of macrolides.

摘要翻译： 本发明公开了一种新的Streptomyces sp。 BICC 7522，其变体或突变体以及该菌株用于生产大环内酯类，大环内酯类的生产和纯化方法。

公开(公告)号：US07605123B2

公开(公告)日：2009-10-20

申请号：US11184528

申请日：2005-07-19

申请人： Balasingam Radhakrishnan ,  Diti Aggarwal ,  Michelle Ferro ,  Kenneth D. James ,  Navdeep B. Malkar ,  Mark A. Miller ,  Leo Pavliv ,  Karen Polowy ,  Monica Puskas ,  Nnochiri N. Ekwuribe

发明人： Balasingam Radhakrishnan ,  Diti Aggarwal ,  Michelle Ferro ,  Kenneth D. James ,  Navdeep B. Malkar ,  Mark A. Miller ,  Leo Pavliv ,  Karen Polowy ,  Monica Puskas ,  Nnochiri N. Ekwuribe

IPC分类号： A61K38/28

CPC分类号： C07K14/62 ,  A61K9/0095 ,  A61K9/2013 ,  A61K9/2018 ,  A61K33/30 ,  A61K38/00 ,  A61K38/28 ,  A61K45/06 ,  A61K47/60 ,  A61K47/69 ,  A61K2300/00

摘要： Fatty acid compositions for administration of of pharmaceutical agents, such as proteins and peptides, protein and peptide conjugates, and/or cation-polypeptide conjugate complexes. In particular, the invention provides a solid pharmaceutical composition formulated for oral administration by ingestion, having from about 0.1 to about 75% w/w fatty acid component, where the fatty acid component comprises saturated or unsaturated C4, C5, C6, C7, C8, C9, C10, C11, or C12 fatty acids and/or salts of such fatty acids; and a therapeutic agent. Further, the invention provides a liquid pharmaceutical composition formulated for oral administration by ingestion, comprising: from about 0.1 to about 10% w/v fatty acid component, where the fatty acid component comprises saturated or unsaturated C4, C5, C6, C7, C8, C9, C10, C11, or C12 fatty acids and/or salts of such fatty acids; and a therapeutic agent.

摘要翻译： 用于施用药剂例如蛋白质和肽，蛋白质和肽缀合物和/或阳离子 - 多肽缀合物复合物的脂肪酸组合物。 特别地，本发明提供了一种配制成通过摄取口服给药的固体药物组合物，其具有约0.1至约75％w / w脂肪酸组分，其中脂肪酸组分包含饱和或不饱和C4，C5，C6，C7，C8 ，C9，C10，C11或C12脂肪酸和/或这些脂肪酸的盐; 和治疗剂。 此外，本发明提供配制成通过摄取口服给药的液体药物组合物，其包含：约0.1至约10％w / v脂肪酸组分，其中脂肪酸组分包含饱和或不饱和C4，C5，C6，C7，C8 ，C9，C10，C11或C12脂肪酸和/或这些脂肪酸的盐; 和治疗剂。