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1.发明授权公开(公告)号：US11330806B2
公开(公告)日：2022-05-17
申请号：US15740974
申请日：2015-07-02
发明人： Jinsong Li , Yuxuan Wu , Cuiqing Zhong , Qi Yin , Zhenfei Xie , Meizhu Bai
IPC分类号： A01K67/00 , A01K67/027 , C12N15/85 , C12N15/113 , C12N15/877 , C12N5/0735 , C12N15/873
摘要： The present invention relates to an AG-haESCs in which H19 DMR and IG-DMR are knocked out, a method for preparing the AG-haESCs, and use of the AG-haESCs in constructing a genetically modified semi-cloned animal and a library of a genetically modified semi-cloned animal. The AG-haESCs is capable of obtaining characteristics resembling a round spermatid, and upon injection into an oocyte, a viable SC mouse is stably obtained. The present invention is capable of being effectively used in multi-gene genetic manipulation, advancing the acquisition of animals with multiple genetic modifications.
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公开(公告)号：US20240042026A1
公开(公告)日：2024-02-08
申请号：US18009713
申请日：2021-06-11
发明人： CHENQI XU , QIUPING ZHOU , WEI WU , XING HE , HE SUN
IPC分类号： A61K39/00 , C07K14/725 , C07K14/705 , C07K16/28 , C07K16/32 , A61P35/00 , C12N15/86
CPC分类号： A61K39/4631 , C07K14/7051 , C07K14/70521 , C07K16/2803 , C07K16/32 , A61K39/4611 , A61K39/464468 , A61K39/464412 , A61P35/00 , C12N15/86 , C07K2319/03 , C12N2740/15043
摘要： A chimeric antigen receptor, includes an extracellular domain, a transmembrane domain, and an intracellular domain, which are connected in sequence, where the extracellular domain includes an antigen recognition region and a hinge region, and one end of the intracellular domain which is connected to the transmembrane domain is connected to a CD3ε intracellular region. The chimeric antigen receptor can further improve the treatment effect of B-cell leukemia lymphoma, and reduce inflammatory cytokines generated from macrophage mononuclear cell activation by down-regulating cytokines, so that cytokine storm can be prevented in an early stage, and the risk of neurotoxicity can be reduced. The treatment effect of mesothelin high-expression solid tumors is further improved in mesothelin-positive tumor treatment, and the prevention of cytokine storm and the reduced risk of neurotoxicity can be realized at an early stage.
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公开(公告)号：US20240002855A1
公开(公告)日：2024-01-04
申请号：US18254616
申请日：2021-11-26
发明人： JingYi Hui , JinZhu Wang , Hong Zhu
IPC分类号： C12N15/113 , C07K14/82 , C07K19/00 , A61P35/00
CPC分类号： C12N15/1135 , C07K14/82 , C07K19/00 , A61P35/00 , C12N2320/33 , C12N2310/321
摘要： Provided are a nucleic acid molecule binding to an YB-1 protein and an application thereof in diagnosis, prevention and treatment of cancers. The nucleic acid molecule comprises a sequence selected from the group consisting of: (1) a nucleic acid sequence shown in N1N2N3N4AN5CN6N7N8 (SEQ ID NO: 1), wherein N1 is C, G, U, or none, N2 is A, G, U, or none, N3 is C, G, U, or none, N4 is C, G, U, or none, N5 is C or U, and each of N6, N7 and N8 is independently C, G, U, or none; and (2) a complementary sequence of (1).
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4.发明申请公开(公告)号：US20230043161A1
公开(公告)日：2023-02-09
申请号：US17789378
申请日：2020-08-28
IPC分类号： A61K38/57 , A61K35/545 , A61P1/16 , G01N33/50
摘要： The present invention provides an application of CST1 in prevention and/or treatment of liver immune dysregulation diseases. Specifically, the present invention provides an application of a CST1 gene, or a protein thereof, or a promoter thereof for preparing a composition or a preparation. The composition or the preparation is used for prevention and/or treatment of liver immune dysregulation diseases.
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公开(公告)号：US20220347226A1
公开(公告)日：2022-11-03
申请号：US17761445
申请日：2020-09-17
发明人： Yi Zeng , Daisong Wang
摘要： Provided herein are endocrine progenitor cells and organoids derived from adult islets in vitro, as well as methods for making and using the same. The compositions are useful for treating or preventing diabetes, other diseases or disorders characterized by impaired islet function, and symptoms thereof.
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公开(公告)号：US20220017599A1
公开(公告)日：2022-01-20
申请号：US17294527
申请日：2019-11-19
发明人： Jianfeng Chen , Changdong Lin
IPC分类号： C07K14/705 , C12N15/85 , C12N15/90 , C12N5/0783
摘要： A composition and method for regulating the migration of immune cells. The method for regulating the migration of immune cells comprises the step of strengthening or weakening the interaction between Hsp90 and α4 integrin in immune cells. Also provided is an immune cell capable of strengthening or weakening the interaction between Hsp90 and α4 integrin and a pharmaceutical composition thereof. The present method and pharmaceutical composition may be used to treat pathogen infections and autoimmune diseases or to kill tumor cells.
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公开(公告)号：US20210340494A1
公开(公告)日：2021-11-04
申请号：US17281161
申请日：2019-08-14
发明人： Lijian Hui , Ludi Zhang , Kun Zhang
IPC分类号： C12N5/071 , A61K35/407 , A61P1/16
摘要： Provided are a method for expanding a hepatocyte in vitro and an application thereof. A culture system is provided for reprogramming a human hepatocyte into a proliferating intermediate-state cell between a mature hepatocyte and a liver progenitor cell. The liver repopulation ability of the system was verified in animals. The method does not require the introduction of an exogenous gene into a hepatocyte, and the expansion of the hepatocyte can be realized by conventional culture. The obtained hepatocyte can be passaged, and can be cultured to maturation to obtain a functional mature human hepatocyte.
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公开(公告)号：US20240124456A1
公开(公告)日：2024-04-18
申请号：US18274889
申请日：2022-01-29
申请人： SHANGHAITECH UNIVERSITY , CENTER FOR EXCELLENCE IN MOLECULAR CELL SCIENCE, CHINESE ACADEMY OF SCIENCES
发明人： Jianjun CHENG , Sheng WANG , Huan WANG , Luyu FAN , Zhangcheng CHEN , Jing YU , Jianzhong QI , Fen NIE
IPC分类号： C07D471/14 , A61P25/18 , A61P25/24 , C07D519/00
CPC分类号： C07D471/14 , A61P25/18 , A61P25/24 , C07D519/00 , C07B2200/13
摘要： An aza-ergoline derivative and a preparation method therefor and an application thereof. The derivative has a structure as shown in formula (I). The aza-ergoline derivative has good affinity, agonistic activity or selectivity to a dopamine D2 receptor.
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9.发明公开公开(公告)号：US20240067706A1
公开(公告)日：2024-02-29
申请号：US18270917
申请日：2022-01-05
发明人： Bing Sun , Xiaoyu Sun , Chunyan Yi , Zhiyang Ling , Yaguang Zhang
IPC分类号： C07K16/10 , A61K39/00 , A61P31/14 , C12N5/0783 , G01N33/569
CPC分类号： C07K16/1003 , A61K39/4611 , A61K39/4631 , A61P31/14 , C12N5/0636 , G01N33/56983 , A61K2239/13 , A61K2239/38 , C07K2317/565 , C07K2317/622 , C12N2510/00
摘要： Disclosed are a fully human broad-spectrum neutralizing antibody against coronavirus, and the use thereof. Specifically disclosed are a fully human monoclonal antibody against an S2 region of coronavirus S protein, a nucleic acid sequence encoding the antibody, and a preparation method therefor. The antibody can effectively bind to and neutralize a variety of coronaviruses in a broad spectrum manner, and can be used for preventing and treating diseases related to coronavirus infection, such as SARS-CoV-2. Further disclosed is the potential use thereof in vaccine design.
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公开(公告)号：US20230277668A1
公开(公告)日：2023-09-07
申请号：US18017696
申请日：2021-06-11
发明人： CHENQI XU , QIUPING ZHOU , WEI WU , XINYI XU , XING HE
IPC分类号： A61K39/00 , C07K16/28 , C07K14/705 , C07K14/73 , A61P35/00
CPC分类号： A61K39/4631 , C07K16/2809 , C07K14/70521 , C07K14/70578 , C07K14/70517 , C07K14/70514 , C07K16/2803 , A61K39/4611 , A61P35/00 , C07K2317/53
摘要： A chimeric antigen receptor containing a CD3ε intracellular region with a Y/F mutation, includes an extracellular domain, a transmembrane domain, and an intracellular domain which are connected in sequence, where one end of the intracellular domain, which is connected to the transmembrane domain, is connected to the CD3ε intracellular region with the Y/F mutation, and the CD3ε intracellular region with the Y/F mutation refers to a Y/F mutant CD3ε intracellular region in which both tyrosines are mutated to phenylalanines in the ITAM of the CD3ε intracellular region. T cells modified with the chimeric antigen receptor have improved viability, decreased apoptosis level, and increased proliferation ability, and down-regulate the expression levels of cytokines IFN-γ and TNF-α.
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