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公开(公告)号：US09504853B2
公开(公告)日：2016-11-29
申请号：US14930419
申请日：2015-11-02
申请人： CyberHeart, Inc.
发明人： Thilaka Sumanaweera , Ed Gardner , Oliver Blanck , Tao Cai , Darrin Uecker , Patrick Maguire
CPC分类号： A61N5/1039 , A61B6/032 , A61B6/503 , A61B6/5211 , A61B34/10 , A61B2034/104 , A61B2034/105 , A61B2034/107 , A61N5/103 , G06T15/08 , G06T19/20 , G06T2210/41
摘要： A system that generates a three-dimensional model of a tissue surface, for example the inner surface of the heart from two-dimensional image data slices. On this surface, one or more pattern lines are drawn, e.g., by a physician using a user interface, to designate desired lesion(s) on the surface. From the pattern lines, a three-dimensional volume for a lesion can be determined using known constraints. Advantageously, the series of boundaries generated by the three-dimensional volume may be projected back onto the individual CT scans, which then may be transferred to a standard radiosurgical planning tool. A dose cloud may also be projected on the model to aid in evaluating a plan.
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2.发明授权Heart treatment kit, system, and method for radiosurgically alleviating arrhythmia 有权心脏治疗套件，系统和放射外科减轻心律失常的方法公开(公告)号：US09320916B2
公开(公告)日：2016-04-26
申请号：US13619509
申请日：2012-09-14
申请人： Thilaka Sumanaweera , Ed Gardner , Oliver Blanck , Tao Cai , Darrin Uecker , Patrick Maguire
发明人： Thilaka Sumanaweera , Ed Gardner , Oliver Blanck , Tao Cai , Darrin Uecker , Patrick Maguire
CPC分类号： A61N5/1037 , A61B5/0422 , A61B5/7207 , A61B5/7289 , A61B6/03 , A61B6/037 , A61B6/503 , A61B6/504 , A61B8/0883 , A61B8/0891 , A61B90/39 , A61B2034/2051 , A61B2034/2063 , A61N5/1039 , A61N5/1049 , A61N5/1067 , A61N5/1077 , A61N2005/1061
摘要： Radiosurgical treatments of tissues of the heart mitigate arrhythmias and treat other tumerous and non-tumerous disease using an implanted fiducial positioned in or near the heart using cardiac catheterization techniques. The fiducials may be implanted after diagnostic and planning images of the target tissues have been acquired. Fiducial implantation may take place the day of a scheduled radiosurgical treatment. Techniques to accommodate post-planning fiducial implantation may include registration of the implanted fiducial location with the treatment plan, and active fiducials may limit collateral imaging radiation exposure while enhancing tracking accuracy.
摘要翻译： 心脏组织的放射外科治疗可以使用心脏导管插入技术使用位于心脏或心脏附近的植入基准来减轻心律失常并治疗其他肿瘤和非肿瘤性疾病。 可以在诊断和植入目标组织的图像之后植入基准。 基准植入可能是在进行放射外科治疗的当天进行的。 适应规划后基准植入的技术可以包括植入的基准位置与治疗计划的对齐，并且活动的基准可以限制旁路成像辐射暴露，同时增强跟踪精度。
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3.发明授权公开(公告)号：US08345821B2
公开(公告)日：2013-01-01
申请号：US12900717
申请日：2010-10-08
申请人： Thilaka Sumanaweera , Patrick Maguire , Ed Gardner
发明人： Thilaka Sumanaweera , Patrick Maguire , Ed Gardner
IPC分类号： G21K5/10
CPC分类号： A61N5/1067 , A61B5/0402 , A61B6/032 , A61B6/503 , A61B6/5235 , A61B6/5294 , A61N5/1031 , A61N5/1037 , A61N5/1039 , A61N5/1049 , A61N5/1068 , A61N5/1077 , A61N2005/1061
摘要： Method and systems are disclosed for radiating a moving target inside a heart. The method includes acquiring sequential volumetric representations of an area of the heart and defining a target tissue region and/or a radiation sensitive structure region in 3D for a first of the representations. The target tissue region and/or radiation sensitive structure region are identified for another of the representations by an analysis of the area of the heart from the first representation and the other representation. Radiation beams to the target tissue region are fired in response to the identified target tissue region and/or radiation sensitive structure region from the other representation.
摘要翻译： 公开了用于在心脏内辐射移动目标的方法和系统。 该方法包括获取心脏区域的顺序体积表示，并且针对第一表示定义3D的目标组织区域和/或辐射敏感结构区域。 通过从第一表示和其他表示的心脏区域的分析来识别目标组织区域和/或辐射敏感结构区域以用于另一个表示。 响应于来自其他表示的识别的目标组织区域和/或辐射敏感结构区域，对目标组织区域的辐射束被点燃。
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4.发明申请公开(公告)号：US20110137158A1
公开(公告)日：2011-06-09
申请号：US12900717
申请日：2010-10-08
申请人： Thilaka Sumanaweera , Patrick Maguire , Ed Gardner
发明人： Thilaka Sumanaweera , Patrick Maguire , Ed Gardner
IPC分类号： A61B6/00
CPC分类号： A61N5/1067 , A61B5/0402 , A61B6/032 , A61B6/503 , A61B6/5235 , A61B6/5294 , A61N5/1031 , A61N5/1037 , A61N5/1039 , A61N5/1049 , A61N5/1068 , A61N5/1077 , A61N2005/1061
摘要： Method and systems are disclosed for radiating a moving target inside a heart. The method includes acquiring sequential volumetric representations of an area of the heart and defining a target tissue region and/or a radiation sensitive structure region in 3D for a first of the representations. The target tissue region and/or radiation sensitive structure region are identified for another of the representations by an analysis of the area of the heart from the first representation and the other representation. Radiation beams to the target tissue region are fired in response to the identified target tissue region and/or radiation sensitive structure region from the other representation.
摘要翻译： 公开了用于在心脏内辐射移动目标的方法和系统。 该方法包括获取心脏区域的顺序体积表示，并且针对第一表示定义3D的目标组织区域和/或辐射敏感结构区域。 通过从第一表示和其他表示的心脏区域的分析来识别目标组织区域和/或辐射敏感结构区域以用于另一个表示。 响应于来自其他表示的识别的目标组织区域和/或辐射敏感结构区域，对目标组织区域的辐射束被点燃。
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公开(公告)号：US07645276B2
公开(公告)日：2010-01-12
申请号：US11080318
申请日：2005-03-14
CPC分类号： A61N5/10 , A61N5/1039 , A61N5/1049 , A61N5/1064 , A61N5/1084
摘要： The invention provides a non-invasive method for treatment of arrhythmia. In a first aspect, a method for treatment of atrial fibrillation in a heart of a patient comprises directing radiation from outside the patient toward one or more target treatment regions of the heart so as to inhibit the atrial fibrillation. The radiation may induce isolation of a pulmonary vein.
摘要翻译： 本发明提供了治疗心律失常的非侵入性方法。 在第一方面，用于治疗患者心脏中的心房颤动的方法包括将来自患者外部的辐射引导到心脏的一个或多个目标治疗区域，以便抑制心房颤动。 放射线可诱导肺静脉分离。
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公开(公告)号：US09968801B2
公开(公告)日：2018-05-15
申请号：US14624056
申请日：2015-02-17
申请人： CyberHeart, Inc.
CPC分类号： A61N5/1067 , A61B5/0402 , A61B6/032 , A61B6/503 , A61B6/5235 , A61B6/5294 , A61N5/1031 , A61N5/1037 , A61N5/1039 , A61N5/1049 , A61N5/1068 , A61N5/1077 , A61N2005/1061
摘要： Method and systems are disclosed for radiating a moving target inside a heart. The method includes acquiring sequential volumetric representations of an area of the heart and defining a target tissue region and/or a radiation sensitive structure region in 3D for a first of the representations. The target tissue region and/or radiation sensitive structure region are identified for another of the representations by an analysis of the area of the heart from the first representation and the other representation. Radiation beams to the target tissue region are fired in response to the identified target tissue region and/or radiation sensitive structure region from the other representation.
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7.发明申请Heart Treatment Kit, System, and Method for Radiosurgically Alleviating Arrhythmia 有权心脏治疗套件，系统和放射外科缓解心律失常的方法公开(公告)号：US20130131425A1
公开(公告)日：2013-05-23
申请号：US13619509
申请日：2012-09-14
申请人： Thilaka Sumanaweera , Ed Gardner , Oliver Blanck , Tao Cai , Darrin Uecker , Patrick Maguire
发明人： Thilaka Sumanaweera , Ed Gardner , Oliver Blanck , Tao Cai , Darrin Uecker , Patrick Maguire
IPC分类号： A61N5/10
CPC分类号： A61N5/1037 , A61B5/0422 , A61B5/7207 , A61B5/7289 , A61B6/03 , A61B6/037 , A61B6/503 , A61B6/504 , A61B8/0883 , A61B8/0891 , A61B90/39 , A61B2034/2051 , A61B2034/2063 , A61N5/1039 , A61N5/1049 , A61N5/1067 , A61N5/1077 , A61N2005/1061
摘要： Radiosurgical treatments of tissues of the heart mitigate arrhythmias and treat other tumerous and non-tumerous disease using an implanted fiducial positioned in or near the heart using cardiac catheterization techniques. The fiducials may be implanted after diagnostic and planning images of the target tissues have been acquired. Fiducial implantation may take place the day of a scheduled radiosurgical treatment. Techniques to accommodate post-planning fiducial implantation may include registration of the implanted fiducial location with the treatment plan, and active fiducials may limit collateral imaging radiation exposure while enhancing tracking accuracy.
摘要翻译： 心脏组织的放射外科治疗可以使用心脏导管插入技术使用位于心脏或心脏附近的植入基准来减轻心律失常并治疗其他肿瘤和非肿瘤性疾病。 可以在诊断和植入目标组织的图像之后植入基准。 基准植入可能是在进行放射外科治疗的当天进行的。 适应规划后基准植入的技术可以包括植入的基准位置与治疗计划的对齐，并且活动的基准可以限制旁路成像辐射暴露，同时增强跟踪精度。
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公开(公告)号：US08315691B2
公开(公告)日：2012-11-20
申请号：US12238809
申请日：2008-09-26
IPC分类号： A61B6/00
CPC分类号： A61N5/1037 , A61N5/1039 , A61N5/1049 , A61N5/1067 , A61N2005/1059 , A61N2005/1061
摘要： The invention provides a non-invasive system and method for treatment of the heart. In a first aspect, a method for treatment of an anatomical site related to arrhythmogenesis of a heart of a patient comprises creating a target shape encompassing the anatomical site, directing particle beam radiation or x-ray radiation from outside the patient toward the target shape wherein one or more doses of radiation ablates the target shape and disregarding at least one orientation of cardiac motion while creating the target shape or directing the particle beam or both.
摘要翻译： 本发明提供了一种用于治疗心脏的非侵入性系统和方法。 在第一方面，一种用于治疗与患者心脏的心律失常相关的解剖部位的方法包括产生包围解剖部位的靶形状，将粒子束辐射或从患者外部的X射线辐射引向目标形状，其中 一个或多个剂量的辐射消除了目标形状并且忽略了心脏运动的至少一个取向，同时产生目标形状或引导粒子束或二者。
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公开(公告)号：US20100137709A1
公开(公告)日：2010-06-03
申请号：US12621777
申请日：2009-11-19
CPC分类号： A61B5/04021 , A61B5/113 , A61B6/583 , A61B90/39 , A61B2017/00694 , A61B2560/0223 , A61N5/1049 , A61N5/1067 , A61N2005/1076 , G09B23/286 , G09B23/288
摘要： A target motion simulator system for use in verifying target tracking with a radiation therapy device. The system comprises a radiation detection target coupled to a first motion actuator simulating a first motion of a first tissue and a fiducial coupled to a second motion actuator simulating a second motion of a second tissue offset from the first tissue, a component of the first motion being asynchronous with the second motion. A synthetic physiological signal generator is synchronized with the component of the first motion, wherein an output signal from the generator, in combination with a sensed position of the fiducial, may be used by the radiation therapy device in tracking the target.
摘要翻译： 一种用于使用放射治疗装置验证目标跟踪的目标运动模拟器系统。 该系统包括耦合到模拟第一组织的第一运动的第一运动致动器的辐射检测目标和耦合到模拟来自第一组织的第二组织偏移的第二运动的第二运动致动器的基准，第一运动的分量 与第二动作异步。 合成生理信号发生器与第一运动的分量同步，其中来自发生器的输出信号与基准的感测位置的组合可以被放射线治疗装置用于跟踪目标。
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公开(公告)号：US20090080610A1
公开(公告)日：2009-03-26
申请号：US12238809
申请日：2008-09-26
CPC分类号： A61N5/1037 , A61N5/1039 , A61N5/1049 , A61N5/1067 , A61N2005/1059 , A61N2005/1061
摘要： The invention provides a non-invasive system and method for treatment of the heart. In a first aspect, a method for treatment of an anatomical site related to arrhythmogenesis of a heart of a patient comprises creating a target shape encompassing the anatomical site, directing particle beam radiation or x-ray radiation from outside the patient toward the target shape wherein one or more doses of radiation ablates the target shape and disregarding at least one orientation of cardiac motion while creating the target shape or directing the particle beam or both.
摘要翻译： 本发明提供了一种用于治疗心脏的非侵入性系统和方法。 在第一方面，一种用于治疗与患者心脏的心律失常相关的解剖部位的方法包括产生包围解剖部位的靶形状，将粒子束辐射或从患者外部的X射线辐射引向目标形状，其中 一个或多个剂量的辐射消除了目标形状并且忽略了心脏运动的至少一个取向，同时产生目标形状或引导粒子束或二者。
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