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公开(公告)号：US08315691B2
公开(公告)日：2012-11-20
申请号：US12238809
申请日：2008-09-26
IPC分类号： A61B6/00
CPC分类号： A61N5/1037 , A61N5/1039 , A61N5/1049 , A61N5/1067 , A61N2005/1059 , A61N2005/1061
摘要： The invention provides a non-invasive system and method for treatment of the heart. In a first aspect, a method for treatment of an anatomical site related to arrhythmogenesis of a heart of a patient comprises creating a target shape encompassing the anatomical site, directing particle beam radiation or x-ray radiation from outside the patient toward the target shape wherein one or more doses of radiation ablates the target shape and disregarding at least one orientation of cardiac motion while creating the target shape or directing the particle beam or both.
摘要翻译： 本发明提供了一种用于治疗心脏的非侵入性系统和方法。 在第一方面，一种用于治疗与患者心脏的心律失常相关的解剖部位的方法包括产生包围解剖部位的靶形状，将粒子束辐射或从患者外部的X射线辐射引向目标形状，其中 一个或多个剂量的辐射消除了目标形状并且忽略了心脏运动的至少一个取向，同时产生目标形状或引导粒子束或二者。
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公开(公告)号：US20090080610A1
公开(公告)日：2009-03-26
申请号：US12238809
申请日：2008-09-26
CPC分类号： A61N5/1037 , A61N5/1039 , A61N5/1049 , A61N5/1067 , A61N2005/1059 , A61N2005/1061
摘要： The invention provides a non-invasive system and method for treatment of the heart. In a first aspect, a method for treatment of an anatomical site related to arrhythmogenesis of a heart of a patient comprises creating a target shape encompassing the anatomical site, directing particle beam radiation or x-ray radiation from outside the patient toward the target shape wherein one or more doses of radiation ablates the target shape and disregarding at least one orientation of cardiac motion while creating the target shape or directing the particle beam or both.
摘要翻译： 本发明提供了一种用于治疗心脏的非侵入性系统和方法。 在第一方面，一种用于治疗与患者心脏的心律失常相关的解剖部位的方法包括产生包围解剖部位的靶形状，将粒子束辐射或从患者外部的X射线辐射引向目标形状，其中 一个或多个剂量的辐射消除了目标形状并且忽略了心脏运动的至少一个取向，同时产生目标形状或引导粒子束或二者。
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公开(公告)号：US08805481B2
公开(公告)日：2014-08-12
申请号：US13619545
申请日：2012-09-14
IPC分类号： A61B6/00
CPC分类号： A61N5/1037 , A61N5/1039 , A61N5/1049 , A61N5/1067 , A61N2005/1059 , A61N2005/1061
摘要： The invention provides a non-invasive system and method for treatment of the heart. In a first aspect, a method for treatment of an anatomical site related to arrhythmogenesis of a heart of a patient comprises creating a target shape encompassing the anatomical site, directing particle beam radiation or x-ray radiation from outside the patient toward the target shape wherein one or more doses of radiation ablates the target shape and disregarding at least one orientation of cardiac motion while creating the target shape or directing the particle beam or both.
摘要翻译： 本发明提供了一种用于治疗心脏的非侵入性系统和方法。 在第一方面，一种用于治疗与患者心脏的心律失常相关的解剖部位的方法包括产生包围解剖部位的靶形状，将粒子束辐射或从患者外部的X射线辐射引向目标形状，其中 一个或多个剂量的辐射消除了目标形状并且忽略了心脏运动的至少一个取向，同时产生目标形状或引导粒子束或二者。
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公开(公告)号：US20130131426A1
公开(公告)日：2013-05-23
申请号：US13619545
申请日：2012-09-14
IPC分类号： A61N5/10
CPC分类号： A61N5/1037 , A61N5/1039 , A61N5/1049 , A61N5/1067 , A61N2005/1059 , A61N2005/1061
摘要： The invention provides a non-invasive system and method for treatment of the heart. In a first aspect, a method for treatment of an anatomical site related to arrhythmogenesis of a heart of a patient comprises creating a target shape encompassing the anatomical site, directing particle beam radiation or x-ray radiation from outside the patient toward the target shape wherein one or more doses of radiation ablates the target shape and disregarding at least one orientation of cardiac motion while creating the target shape or directing the particle beam or both.
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5.发明申请Heart Treatment Kit, System, and Method for Radiosurgically Alleviating Arrhythmia 有权心脏治疗套件，系统和放射外科缓解心律失常的方法公开(公告)号：US20130131425A1
公开(公告)日：2013-05-23
申请号：US13619509
申请日：2012-09-14
申请人： Thilaka Sumanaweera , Ed Gardner , Oliver Blanck , Tao Cai , Darrin Uecker , Patrick Maguire
发明人： Thilaka Sumanaweera , Ed Gardner , Oliver Blanck , Tao Cai , Darrin Uecker , Patrick Maguire
IPC分类号： A61N5/10
CPC分类号： A61N5/1037 , A61B5/0422 , A61B5/7207 , A61B5/7289 , A61B6/03 , A61B6/037 , A61B6/503 , A61B6/504 , A61B8/0883 , A61B8/0891 , A61B90/39 , A61B2034/2051 , A61B2034/2063 , A61N5/1039 , A61N5/1049 , A61N5/1067 , A61N5/1077 , A61N2005/1061
摘要： Radiosurgical treatments of tissues of the heart mitigate arrhythmias and treat other tumerous and non-tumerous disease using an implanted fiducial positioned in or near the heart using cardiac catheterization techniques. The fiducials may be implanted after diagnostic and planning images of the target tissues have been acquired. Fiducial implantation may take place the day of a scheduled radiosurgical treatment. Techniques to accommodate post-planning fiducial implantation may include registration of the implanted fiducial location with the treatment plan, and active fiducials may limit collateral imaging radiation exposure while enhancing tracking accuracy.
摘要翻译： 心脏组织的放射外科治疗可以使用心脏导管插入技术使用位于心脏或心脏附近的植入基准来减轻心律失常并治疗其他肿瘤和非肿瘤性疾病。 可以在诊断和植入目标组织的图像之后植入基准。 基准植入可能是在进行放射外科治疗的当天进行的。 适应规划后基准植入的技术可以包括植入的基准位置与治疗计划的对齐，并且活动的基准可以限制旁路成像辐射暴露，同时增强跟踪精度。
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公开(公告)号：US20080177280A1
公开(公告)日：2008-07-24
申请号：US11971725
申请日：2008-01-09
申请人： John Adler , Thilaka Sumanaweera , Patrick Maguire
发明人： John Adler , Thilaka Sumanaweera , Patrick Maguire
IPC分类号： A61B19/00
CPC分类号： A61N5/1049 , A61B5/1135 , A61B34/10 , A61B34/30 , A61B90/10 , A61B90/36 , A61B2017/00243 , A61B2017/00703 , A61B2034/301 , A61B2090/101 , A61B2090/363 , A61B2090/364 , A61N5/1037 , A61N5/1067 , A61N5/1068 , A61N2005/1062
摘要： Radiosurgical treatment of tissues of the heart to mitigate arrhythmias such as atrial fibrillation or the like. Radiosurgical targeting of the relatively rapid movement of heart tissues may be enhanced by generating a moving model volume using a time-sequence of three dimensional acquired tissue volumes. A digitally reconstructed radiograph (DRR) may be generated from the model at a desired cardiac and/or respiration motion phase and compared to an X-ray or the like taken immediately before or during treatment. When a series of radiation beams will be directed to a heart tissue to alleviate an arrhythmia, the treatment system may alter the radiation beam series in response to the type of the arrhythmia.
摘要翻译： 放射外科治疗心脏组织以减轻心律失常如心房颤动等。 可以通过使用三维获取的组织体积的时间序列产生移动模型体积来增强心脏组织相对快速运动的放射外科手术。 可以在期望的心脏和/或呼吸运动阶段从模型生成数字重建的放射照片（DRR），并与在治疗之前或治疗期间采集的X射线等进行比较。 当一系列辐射束被引导到心脏组织以减轻心律失常时，治疗系统可以响应于心律失常的类型改变辐射束序列。
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7.发明申请公开(公告)号：US20090257557A1
公开(公告)日：2009-10-15
申请号：US12404881
申请日：2009-03-16
申请人： Thilaka Sumanaweera , Patrick Maguire , Ed Gardner , Jay West
发明人： Thilaka Sumanaweera , Patrick Maguire , Ed Gardner , Jay West
CPC分类号： A61N5/1049 , A61N5/1037 , A61N5/1067 , A61N2005/1059 , A61N2005/1061
摘要： Method and systems are disclosed for radiating a moving target inside a heart. The method includes acquiring sequential volumetric representations of an area of the heart and defining a target tissue region and/or a radiation sensitive structure region in 3D for a first of the representations. The target tissue region and/or radiation sensitive structure region are identified for another of the representations by an analysis of the area of the heart from the first representation and the other representation. Radiation beams to the target tissue region are fired in response to the identified target tissue region and/or radiation sensitive structure region from the other representation.
摘要翻译： 公开了用于在心脏内辐射移动目标的方法和系统。 该方法包括获取心脏区域的顺序体积表示，并且针对第一表示定义3D的目标组织区域和/或辐射敏感结构区域。 通过从第一表示和其他表示的心脏区域的分析来识别目标组织区域和/或辐射敏感结构区域以用于另一个表示。 响应于来自其他表示的识别的目标组织区域和/或辐射敏感结构区域，对目标组织区域的辐射束被点燃。
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8.发明授权Heart treatment kit, system, and method for radiosurgically alleviating arrhythmia 有权心脏治疗套件，系统和放射外科减轻心律失常的方法公开(公告)号：US08784290B2
公开(公告)日：2014-07-22
申请号：US12838113
申请日：2010-07-16
申请人： Thilaka Sumanaweera , Ed Gardner , Oliver Blanck , Tao Cai , Darrin Uecker , Patrick Maguire
发明人： Thilaka Sumanaweera , Ed Gardner , Oliver Blanck , Tao Cai , Darrin Uecker , Patrick Maguire
IPC分类号： A61N5/00
CPC分类号： A61N5/1037 , A61B5/0422 , A61B5/7207 , A61B5/7289 , A61B6/03 , A61B6/037 , A61B6/503 , A61B6/504 , A61B8/0883 , A61B8/0891 , A61B90/39 , A61B2034/2051 , A61B2034/2063 , A61N5/1039 , A61N5/1049 , A61N5/1067 , A61N5/1077 , A61N2005/1061
摘要： Radiosurgical treatments of tissues of the heart mitigate arrhythmias and treat other tumerous and non-tumerous disease using an implanted fiducial positioned in or near the heart using cardiac catheterization techniques. The fiducials may be implanted after diagnostic and planning images of the target tissues have been acquired. Fiducial implantation may take place the day of a scheduled radiosurgical treatment. Techniques to accommodate post-planning fiducial implantation may include registration of the implanted fiducial location with the treatment plan, and active fiducials may limit collateral imaging radiation exposure while enhancing tracking accuracy.
摘要翻译： 心脏组织的放射外科治疗可以使用心脏导管插入技术使用位于心脏或心脏附近的植入基准来减轻心律失常并治疗其他肿瘤和非肿瘤性疾病。 可以在诊断和植入目标组织的图像之后植入基准。 基准植入可能是在进行放射外科治疗的当天进行的。 适应规划后基准植入的技术可以包括植入的基准位置与治疗计划的对齐，并且活动的基准可以限制旁路成像辐射暴露，同时增强跟踪精度。
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公开(公告)号：US20110166408A1
公开(公告)日：2011-07-07
申请号：US12838308
申请日：2010-07-16
申请人： Thilaka Sumanaweera , Ed Gardner , Oliver Blanck , Tao Cai , Darrin Uecker , Patrick Maguire
发明人： Thilaka Sumanaweera , Ed Gardner , Oliver Blanck , Tao Cai , Darrin Uecker , Patrick Maguire
CPC分类号： A61N5/1039 , A61B6/032 , A61B6/503 , A61B6/5211 , A61B34/10 , A61B2034/104 , A61B2034/105 , A61B2034/107 , A61N5/103 , G06T15/08 , G06T19/20 , G06T2210/41
摘要： A system that generates a three-dimensional model of a tissue surface, for example the inner surface of the heart from two-dimensional image data slices. On this surface, one or more pattern lines are drawn, e.g., by a physician using a user interface, to designate desired lesion(s) on the surface. From the pattern lines, a three-dimensional volume for a lesion can be determined using known constraints. Advantageously, the series of boundaries generated by the three-dimensional volume may be projected back onto the individual CT scans, which then may be transferred to a standard radiosurgical planning tool. A dose cloud may also be projected on the model to aid in evaluating a plan.
摘要翻译： 生成组织表面的三维模型的系统，例如来自二维图像数据切片的心脏的内表面。 在该表面上，例如由医生使用用户界面绘制一个或多个图案线，以在表面上指定所需的损伤。 从图案线可以使用已知的约束来确定损伤的三维体积。 有利地，由三维体积产生的一系列边界可以被投射回到单独的CT扫描上，然后可以将它们转移到标准的放射外科规划工具。 也可以在模型上投射剂量云以帮助评估计划。
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公开(公告)号：US20080177279A1
公开(公告)日：2008-07-24
申请号：US11971399
申请日：2008-01-09
IPC分类号： A61B19/00
CPC分类号： A61N5/1049 , A61B34/10 , A61B34/20 , A61B34/30 , A61B90/10 , A61B90/36 , A61B2017/00044 , A61B2017/00243 , A61B2017/00703 , A61B2034/105 , A61B2034/107 , A61B2034/2055 , A61B2034/301 , A61B2090/101 , A61B2090/363 , A61B2090/364 , A61B2090/376 , A61B2090/3762 , A61B2090/378 , A61B2090/3945 , A61N5/1067 , A61N2005/1058
摘要： A method and system are disclosed for radiosurgical treatment of moving tissues of the heart, including acquiring at least one volume of the tissue and acquiring at least one ultrasound data set, image or volume of the tissue using an ultrasound transducer disposed at a position. A similarity measure is computed between the ultrasound image or volume and the acquired volume or a simulated ultrasound data set, image or volume. A robot is configured in response to the similarity measure and the position of the transducer, and a radiation beam is fired from the configured robot.
摘要翻译： 公开了一种用于放射外科治疗心脏移动组织的方法和系统，包括获取组织的至少一个体积并且使用设置在位置处的超声换能器获取组织的至少一个超声数据集，图像或体积。 在超声图像或体积与所获取的体积或模拟的超声数据集，图像或体积之间计算相似性度量。 响应于相似性测量和换能器的位置来配置机器人，并且从配置的机器人发射辐射束。
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