公开(公告)号：US08735439B2

公开(公告)日：2014-05-27

申请号：US12594186

申请日：2009-04-29

Applicant: Kye Shin Park ,  Eun Hee Lee ,  Hyo Jun Kim

Inventor： Kye Shin Park ,  Eun Hee Lee ,  Hyo Jun Kim

IPC: C07D487/22

CPC classification number: C07D487/22 ,  A61K41/0071 ,  A61K47/551 ,  C07D519/00

Abstract: The present invention relates to a novel chlorin e6-folic acid conjugate, a preparation method thereof, and a pharmaceutical composition for the treatment of cancer comprising the same, and more particularly, to a novel compound prepared by linking chlorin e6 to folic acid, which effectively produces singlet oxygen in various media and has much better tumor selectivity than the known porphyrin-based photosensitizers, thereby being used effectively in photodynamic therapy for malignant tumors, a preparation method thereof, and a pharmaceutical composition for photodynamic treatment of solid tumors comprising the compound as an active ingredient.

Abstract translation: 本发明涉及一种新的二氢卟吩e6-叶酸结合物，其制备方法和用于治疗癌症的药物组合物，特别涉及通过将二氢卟酚e6连接到叶酸而制备的新型化合物，其中 有效地在各种培养基中产生单线态氧，并且具有比已知的基于卟啉的光敏剂更好的肿瘤选择性，从而有效地用于恶性肿瘤的光动力学治疗，其制备方法和用于光动力治疗实体瘤的药物组合物，包括化合物 作为活性成分。

公开(公告)号：US11327079B2

公开(公告)日：2022-05-10

申请号：US16627710

申请日：2018-12-12

Applicant: Diatech Korea Co., Ltd.

Inventor： Kye Shin Park ,  Joon Sang Park ,  Eun Hee Lee ,  Dong Hwi Hwang ,  In Jung Ji ,  Jae Woo Roh ,  Jin Sung Ahn ,  Eun-Jeong Yoon ,  Ji Hye Ko

IPC: G01N33/68 ,  C12N9/86 ,  C12Q1/34 ,  C12Q1/04 ,  C12Q1/06

Abstract: The present invention relates to a method of directly detecting, using a mass-spectrometry method, whether a microorganism contained in a sample is resistant to antibiotics, and a kit for detection used therewith. More particularly, the present invention relates to a method and kit for directly detecting an antibiotic hydrolase secreted by a microorganism resistant to antibiotics, thereby directly determining whether the microorganism is resistant to antibiotics. According to the present invention, it is possible to very simply and immediately confirm whether a specific strain is resistant to antibiotics in the field. In particular, a complicated pretreatment process such as proteolysis is not performed, and a complicated identification process of calibrating and then combining the obtained results is not performed. Accordingly, it is possible to realize a method of easily confirming whether antibiotic resistance occurs in just a dozen minutes, compared to a conventional technology in which it takes several days to confirm whether antibiotic resistance occurs, and a simple diagnostic kit used therewith.

公开(公告)号：US20120059018A1

公开(公告)日：2012-03-08

申请号：US12594186

申请日：2009-04-29

Applicant: Kye Shin Park ,  Eun Hee Lee ,  Hyo Jun Kim

Inventor： Kye Shin Park ,  Eun Hee Lee ,  Hyo Jun Kim

IPC: A61K31/519 ,  A61P35/00 ,  C07D487/22

CPC classification number: C07D487/22 ,  A61K41/0071 ,  A61K47/551 ,  C07D519/00

Abstract: The present invention relates to a novel chlorin e6-folic acid conjugate, a preparation method thereof, and a pharmaceutical composition for the treatment of cancer comprising the same, and more particularly, to a novel compound prepared by linking chlorin e6 to folic acid, which effectively produces singlet oxygen in various media and has much better tumor selectivity than the known porphyrin-based photosensitizers, thereby being used effectively in photodynamic therapy for malignant tumors, a preparation method thereof, and a pharmaceutical composition for photodynamic treatment of solid tumors comprising the compound.

Abstract translation: 本发明涉及一种新的二氢卟吩e6-叶酸结合物，其制备方法和用于治疗癌症的药物组合物，特别涉及通过将二氢卟酚e6连接到叶酸而制备的新型化合物，其中 有效地在各种培养基中产生单线态氧，并且具有比已知的基于卟啉的光敏剂更好的肿瘤选择性，从而有效地用于恶性肿瘤的光动力学治疗，其制备方法和用于光动力治疗实体瘤的药物组合物，其包含化合物 。

公开(公告)号：US20120035180A1

公开(公告)日：2012-02-09

申请号：US12594180

申请日：2009-04-29

Applicant: Kye Shin Park ,  Eun Hee Lee ,  Hyo Jun Kim

Inventor： Kye Shin Park ,  Eun Hee Lee ,  Hyo Jun Kim

IPC: A61K31/519 ,  A61P35/00

CPC classification number: A61K31/395 ,  A61K31/519 ,  A61K31/722 ,  A61K41/0071 ,  A61K47/551 ,  A61K2300/00

Abstract: The present invention relates to a pharmaceutical composition for the treatment of cancer comprising a chlorin e6-folic acid conjugate compound and chitosan, and more particularly, to a pharmaceutical composition for photodynamic therapy of solid tumors comprising the novel chlorin e6-folic acid conjugate compound or a pharmaceutically acceptable salt thereof and chitosan, in which the novel compound is prepared by linking chlorin e6 to folic acid, and effectively produces singlet oxygen in various media and has much better tumor selectivity than the known porphyrin-based photosensitizers, thereby being used effectively in photodynamic treatment for malignant tumors.

Abstract translation: 本发明涉及用于治疗癌症的药物组合物，其包含二氢卟吩e6-叶酸结合化合物和壳聚糖，更具体地，涉及一种用于实体瘤的光动力疗法的药物组合物，其包含新的二氢卟吩e6-叶酸结合物或 其药学上可接受的盐和壳聚糖，其中通过将二氢卟酚e6连接到叶酸来制备新化合物，并且在各种培养基中有效产生单线态氧并且具有比已知的基于卟啉的光敏剂更好的肿瘤选择性，从而有效地用于 恶性肿瘤的光动力治疗。

公开(公告)号：US20210318332A1

公开(公告)日：2021-10-14

申请号：US16627710

申请日：2018-12-12

Applicant: Diatech Korea Co., Ltd.

Inventor： Kye Shin PARK ,  Joon Sang PARK ,  Eun Hee LEE ,  Dong Hwi HWANG ,  In Jung JI ,  Jae WOO ROH ,  Jin Sung AHN ,  Eun-Jeong YOON ,  Ji Hye KO

IPC: G01N33/68 ,  C12Q1/34 ,  C12Q1/04 ,  C12Q1/06 ,  C12N9/86

Abstract: The present invention relates to a method of directly detecting, using a mass-spectrometry method, whether a microorganism contained in a sample is resistant to antibiotics, and a kit for detection used therewith. More particularly, the present invention relates to a method and kit for directly detecting an antibiotic hydrolase secreted by a microorganism resistant to antibiotics, thereby directly determining whether the microorganism is resistant to antibiotics. According to the present invention, it is possible to very simply and immediately confirm whether a specific strain is resistant to antibiotics in the field. In particular, a complicated pretreatment process such as proteolysis is not performed, and a complicated identification process of calibrating and then combining the obtained results is not performed. Accordingly, it is possible to realize a method of easily confirming whether antibiotic resistance occurs in just a dozen minutes, compared to a conventional technology in which it takes several days to confirm whether antibiotic resistance occurs, and a simple diagnostic kit used therewith.

公开(公告)号：US08673653B2

公开(公告)日：2014-03-18

申请号：US12937139

申请日：2009-04-10

Applicant: Hyung-Soon Park ,  Sang-Wan So ,  Woon-Seok Yeo ,  Soo-Jae Lee ,  Jung-Rok Lee ,  Ju-Hee o Lee ,  Kwang-Pyo Kim

Inventor： Hyung-Soon Park ,  Sang-Wan So ,  Woon-Seok Yeo ,  Soo-Jae Lee ,  Jung-Rok Lee ,  Ju-Hee o Lee ,  Kwang-Pyo Kim

IPC: G01N33/553

CPC classification number: G01N33/553 ,  G01N33/585 ,  G01N33/6848 ,  G01N2458/15 ,  H01J49/00 ,  Y10T436/24

Abstract: Provided is a novel method for amplifying mass spectrometric signals. A novel method for detecting signals of a target molecule includes: allowing a sample, which comprises a target molecule, to contact a gold particle having a surface modified to selectively bind the target molecule, allowing a low molecular weight molecule engrafted to the gold particle generate mass spectrometric signals after the interaction, e.g., binding, between the gold particle and the target molecule, and amplifying the mass spectrometric signals to generate much mass spectrometric signals of the low molecular weight molecule even when trace amounts of the target molecule are present. An assay system using the method and the gold particle prepared in the method are provided. The method amplifies signals of the target molecule without pretreatment of a sample, making it possible to measure the target molecule simply and precisely.

Abstract translation: 提供了一种扩增质谱信号的新方法。 用于检测靶分子信号的新方法包括：允许包含目标分子的样品接触具有修饰以选择性结合靶分子的表面的金颗粒，允许移植到金颗粒的低分子量分子产生 即使存在痕量的目标分子，即使在金颗粒与靶分子之间的相互作用之后的质谱信号，也可以扩增质谱信号以产生低分子量分子的大量质谱信号。 提供了使用该方法的测定系统和该方法中制备的金颗粒。 该方法在不预处理样品的情况下放大靶分子的信号，使得可以简单且准确地测量目标分子。