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公开(公告)号：US08304223B2
公开(公告)日：2012-11-06
申请号：US12532347
申请日：2008-03-11
申请人： Uwe Bornscheuer , Anke Hummel , Dominique Böttcher , Elke Brüsehaber , Kai Doderer , Harald Trauthwein
发明人： Uwe Bornscheuer , Anke Hummel , Dominique Böttcher , Elke Brüsehaber , Kai Doderer , Harald Trauthwein
IPC分类号： C12N9/18
CPC分类号： C12N9/18 , C12P7/02 , C12P7/42 , C12P7/62 , C12P41/004
摘要： The invention relates to novel mutants of γPLE, to vehicles containing the same and to their use in the production of enantiomer-enriched alcohols, carboxylic acids and esters.
摘要翻译： 本发明涉及γPLE的新颖突变体，其涉及含有该突变体的载体及其在制备富含对映异构体的醇，羧酸和酯的用途。
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公开(公告)号：US08017354B2
公开(公告)日：2011-09-13
申请号：US12504785
申请日：2009-07-17
摘要： The present invention relates to a microorganism which comprises at least one copy of a polynucleic acid sequence which is foreign to the host and which encodes a protein having an enzymic activity, and comprises a chaperone system which assists the expression of the protein in the form of an active enzyme, and to a method for producing a protein having esterase activity using such a microorganism.
摘要翻译： 本发明涉及一种微生物，其包含至少一个拷贝的多核酸序列，该多核酸序列对于宿主而言是外源的，并且编码具有酶活性的蛋白质，并且包括辅助蛋白质表达形式的伴侣系统 活性酶，以及使用这样的微生物生产具有酯酶活性的蛋白质的方法。
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公开(公告)号：US20230167472A9
公开(公告)日：2023-06-01
申请号：US16764476
申请日：2018-11-16
申请人： ENZYMICALS AG , UNIVERSITÄT ROSTOCK
IPC分类号： C12P13/00 , C12P7/40 , C07C211/63 , C07C57/30
CPC分类号： C12P13/005 , C12P7/40 , C07C211/63 , C07C57/30
摘要： Described herein is a method for preparing an amino salt compound, the method including: i) providing a carbonyl compound; ii) reacting the carbonyl compound provided according to (i) in the presence of a transaminase with ii-a) at least one primary amine; and ii-b) at least one carboxylic acid; thereby obtaining a mixture including an at least partially crystallized amino salt compound including a cation and a carboxylate anion based on the at least one carboxylic acid added according to (ii-b). Also described herein is an amino salt compound obtained or obtainable by the method and to the amino salt compound, and a composition including a) an amine of general formula (IIa); and b) at least one carboxylic acid of general formula (III).
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公开(公告)号：US20220162654A1
公开(公告)日：2022-05-26
申请号：US16764476
申请日：2018-11-16
申请人： ENZYMICALS AG , UNIVERSITÄT ROSTOCK
IPC分类号： C12P13/00 , C12P7/40 , C07C211/63 , C07C57/30
摘要： Described herein is a method for preparing an amino salt compound, the method including: i) providing a carbonyl compound; ii) reacting the carbonyl compound provided according to (i) in the presence of a transaminase with ii-a) at least one primary amine; and ii-b) at least one carboxylic acid; thereby obtaining a mixture including an at least partially crystallized amino salt compound including a cation and a carboxylate anion based on the at least one carboxylic acid added according to (ii-b). Also described herein is an amino salt compound obtained or obtainable by the method and to the amino salt compound, and a composition including a) an amine of general formula (IIa); and b) at least one carboxylic acid of general formula (III).
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公开(公告)号：US12018303B2
公开(公告)日：2024-06-25
申请号：US16764476
申请日：2018-11-16
申请人： ENZYMICALS AG , UNIVERSITÄT ROSTOCK
IPC分类号： C12P13/00 , C07C57/30 , C07C211/63 , C12P7/40
CPC分类号： C12P13/005 , C07C57/30 , C07C211/63 , C12P7/40
摘要： Described herein is a method for preparing an amino salt compound, the method including: i) providing a carbonyl compound; ii) reacting the carbonyl compound provided according to (i) in the presence of a transaminase with ii-a) at least one primary amine; and ii-b) at least one carboxylic acid; thereby obtaining a mixture including an at least partially crystallized amino salt compound including a cation and a carboxylate anion based on the at least one carboxylic acid added according to (ii-b). Also described herein is an amino salt compound obtained or obtainable by the method and to the amino salt compound, and a composition including a) an amine of general formula (IIa); and b) at least one carboxylic acid of general formula (III).
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公开(公告)号：US20210155653A1
公开(公告)日：2021-05-27
申请号：US16625967
申请日：2018-06-21
申请人： Enzymicals AG
发明人： Ulf Menyes , Philipp Suss , Henrike Brundiek , Melinda Fekete
摘要： The present invention relates to a process for producing bile acid derivatives having a protected hydroxyl group in the 3 position comprising contacting a bile acid derivative having an unprotected 3-alpha-hydroxyl group with a specific lipase. The present invention further relates to a bile acid derivative obtained or obtainable by the process, to the use of the bile acid derivative obtained or obtainable by the process for producing lithocholic acid and also to a process for producing lithocholic acid and to lithocholic obtained by the process. The invention further relates to the use of lithocholic acid obtained or obtainable by the process for producing ursodeoxycholic acid or ursodeoxycholic acid derivatives.
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公开(公告)号：US20110207186A1
公开(公告)日：2011-08-25
申请号：US12532347
申请日：2008-03-11
申请人： Uwe Bornscheuer , Anke Hummel , Dominique Böttcher , Elke Brüsehaber , Kai Doderer , Harald Trauthwein
发明人： Uwe Bornscheuer , Anke Hummel , Dominique Böttcher , Elke Brüsehaber , Kai Doderer , Harald Trauthwein
CPC分类号： C12N9/18 , C12P7/02 , C12P7/42 , C12P7/62 , C12P41/004
摘要： The invention relates to novel mutants of γPLE, to vehicles containing the same and to their use in the production of enantiomer-enriched alcohols, carboxylic acids and esters.
摘要翻译： 本发明涉及γPLE的新颖突变体，其涉及含有该突变体的载体及其在制备富含对映异构体的醇，羧酸和酯的用途。
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