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公开(公告)号：US09284283B2
公开(公告)日：2016-03-15
申请号：US14376247
申请日：2013-02-01
发明人： Michael Taylor , Nicholas K. Terrett , William H. Connors , Cheri Snedeker , Kelley C. Shortsleeves , Benjamin A. Seigal , Stephen P. Hale , Timothy F. Briggs , Frank G. Favaloro, Jr. , Tyler J. Cipriani , Dingxue Yan , Sethu L. Alexander , Atli Thorarensen , Li Xing
IPC分类号： C07D257/10 , C07D273/00 , C07D401/12 , C07D409/14 , C07D413/12 , C07D409/12 , C07D405/12 , C07D257/02 , C07D403/12 , C07D417/12 , A61K31/4965 , A61K31/33 , A61K31/44 , A61K31/445 , A61K31/425 , A61K31/42 , A61K31/38 , A61K31/35 , A61K38/00 , A61K31/366 , C07D255/02
CPC分类号： C07D257/10 , A61K31/366 , A61K31/42 , A61K38/00 , C07D255/02 , C07D257/02 , C07D273/00 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： The invention relates generally to macrocyclic compounds of formula I and their therapeutic use. More particularly, the invention relates to macrocyclic compounds that modulate the activity of IL-17 and/or are useful in the treatment of medical conditions, such as inflammatory diseases and other IL-17-associated disorders.
摘要翻译： 本发明一般涉及式I的大环化合物及其治疗用途。 更具体地说，本发明涉及调节IL-17的活性和/或可用于治疗诸如炎性疾病和其它IL-17相关疾病的医学病症的大环化合物。
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公开(公告)号：US09605022B2
公开(公告)日：2017-03-28
申请号：US14441807
申请日：2013-11-07
摘要： There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
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公开(公告)号：US08338565B2
公开(公告)日：2012-12-25
申请号：US12544604
申请日：2009-08-20
申请人： Jinbo Lee , Julian F. Bond , Nicholas Terrett , Frank G. Favaloro, Jr. , Daniel Wang , Timothy F. Briggs , Benjamin Adam Seigal , Wei-Chuan Sun , Stephen P. Hale
发明人： Jinbo Lee , Julian F. Bond , Nicholas Terrett , Frank G. Favaloro, Jr. , Daniel Wang , Timothy F. Briggs , Benjamin Adam Seigal , Wei-Chuan Sun , Stephen P. Hale
CPC分类号： C07D273/00 , C07D257/02
摘要： Disclosed herein are macrocyclic compounds and methods for their synthesis and use. In particular, macrocyclic compounds are disclosed that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma.
摘要翻译： 本文公开了大环化合物及其合成和使用的方法。 特别地，公开了调节肿瘤坏死因子α的活性和/或可用于治疗诸如类风湿性关节炎，牛皮癣和哮喘等医学病症的大环化合物。
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4.发明授权Compositions and methods for biodetection by nucleic acid-templated chemistry 失效通过核酸模板化学生物检测的组合物和方法公开(公告)号：US08071388B2
公开(公告)日：2011-12-06
申请号：US12391898
申请日：2009-02-24
申请人： Yumei Huang , James M. Coull
发明人： Yumei Huang , James M. Coull
IPC分类号： G01N33/68 , G01N33/00 , C07D209/04 , C07D207/46 , C07D209/56 , C07H21/04 , C07C229/40
CPC分类号： C07H21/04 , C07D209/08 , C07D209/14 , C07D209/56 , C07D209/58 , C09B23/0091 , C09B23/105 , G01N33/5308 , G01N33/533 , Y10T436/143333 , Y10T436/145555
摘要： The invention provides compositions and methods for the detection of biological targets, (e.g. nucleic acids and proteins) by nucleic acid-templated chemistry, for example, by generating fluorescent polymethine dyes.
摘要翻译： 本发明提供了通过核酸模板化学，例如通过产生荧光聚甲炔染料来检测生物学靶标（例如核酸和蛋白质）的组合物和方法。
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公开(公告)号：US07968289B2
公开(公告)日：2011-06-28
申请号：US11913521
申请日：2006-05-03
CPC分类号： C12Q1/682 , C12Q1/6823 , C12Q2537/155 , C12Q2525/301 , C12Q2523/107 , C12Q2525/113
摘要： The invention provides turnover probes for use in a variety of detection assays, for example, nucleic acid detection assays. In addition, the invention provides assays, for example, nucleic acid detection assays, using such turnover probes.
摘要翻译： 本发明提供用于各种检测测定法的转换探针，例如核酸检测测定法。 此外，本发明提供了使用这种周转探针的测定法，例如核酸检测测定法。
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