公开(公告)号：US10722262B2

公开(公告)日：2020-07-28

申请号：US16152632

申请日：2018-10-05

申请人： Flowcardia, Inc.

发明人： Henry Nita

IPC分类号： A61B17/22 ,  A61B17/32 ,  A61B17/00

摘要： A method of assembling an ultrasound catheter includes providing an elongated catheter body having a proximal end, a distal end, and at least one lumen extending longitudinally therethrough; coupling a proximal housing to the proximal end of the elongated catheter body, the proximal housing having a distal bore; inserting an ultrasound transmission member through the lumen of the catheter body; positioning a sonic connector on the proximal end of the ultrasound transmission member for connecting the ultrasound transmission member to a separate ultrasound generating device at a connection location, the sonic connector having a proximal section and a front portion, the proximal portion provided for connection to the separate ultrasound generating device; connecting the front portion of the sonic connector to the proximal end of the ultrasound transmission member; and retaining an absorber inside the distal bore of the proximal housing wherein the absorber substantially surrounds the ultrasound transmission member.

公开(公告)号：US10238895B2

公开(公告)日：2019-03-26

申请号：US14415126

申请日：2013-08-01

申请人： FLOWCARDIA, INC.

发明人： Jeff Sarge ,  Michael A. Summers

IPC分类号： A61N7/02 ,  A61B17/22 ,  A61B17/32 ,  A61B17/00 ,  A61N7/00

摘要： An ultrasonic system operable at high drive frequencies and/or in pulsed operation is disclosed. The system may be used in a procedure to treat an occluded blood vessel. The system can be used to transmit ultrasonic energy from an ultrasonic transducer to a distal end of an ultrasonic transmission device. The ultrasonic device may operate at a resonant frequency. The resonant frequency can be determined prior to using the device and/or during use. The ultrasonic device may operate in a range of frequencies at or near resonance. Operational parameters including, for example, reflected vibrations, temperature, and/or user input can be used by the system to adjust the driving waveform.

公开(公告)号：US10111680B2

公开(公告)日：2018-10-30

申请号：US15001103

申请日：2016-01-19

申请人： FlowCardia, Inc.

发明人： Henry Nita

IPC分类号： A61B17/20 ,  A61B17/32 ,  A61B17/22 ,  A61B17/00

摘要： An ultrasound system has a catheter including an elongate flexible catheter body having at least one lumen extending longitudinally therethrough. The catheter further includes an ultrasound transmission member extending longitudinally through the lumen of the catheter body, the ultrasound transmission member having a proximal end connectable to a separate ultrasound generating device and a distal end coupled to the distal end of the catheter body. The distal end of the catheter body is deflectable. The ultrasound system also includes a sonic connector that connects the ultrasound transmission member to an ultrasound transducer. The ultrasound system also provides a method for reverse irrigation and removal of particles.

公开(公告)号：US09282984B2

公开(公告)日：2016-03-15

申请号：US11398385

申请日：2006-04-05

申请人： Henry Nita

发明人： Henry Nita

IPC分类号： A61B17/32 ,  A61B17/22 ,  A61B17/00

CPC分类号： A61B17/22012 ,  A61B2017/00477 ,  A61B2017/22001 ,  A61B2017/22082 ,  A61B2217/007

摘要： An ultrasound system has a catheter including an elongate flexible catheter body having at least one lumen extending longitudinally therethrough. An ultrasound transmission wire extends longitudinally through the lumen of the catheter body, and has a proximal region, a distal region, and an intermediate region between the proximal region and the distal region. A sonic connector is connected to the proximal region of the ultrasound transmission wire, and a distal head is positioned at the distal end of the catheter body and coupled to the distal region of the ultrasound transmission wire. The proximal region of the ultrasound transmission wire has a larger diameter than the intermediate region, the intermediate region is continuously tapered with a progressively decreasing diameter from its proximal end to its distal end, and the distal region has a greater diameter than the distal end of the intermediate region.

摘要翻译： 超声系统具有导管，其包括细长的柔性导管主体，其具有纵向延伸通过其延伸的至少一个内腔。 超声波传输线纵向延伸通过导管主体的内腔，并具有近端区域，远端区域和近端区域与远端区域之间的中间区域。 声音连接器连接到超声波传输线的近侧区域，远侧头部位于导管主体的远端并且耦合到超声波传输线的远端区域。 超声波传输线的近端区域具有比中间区域更大的直径，中间区域从其近端到其远端以直径逐渐减小的方式连续渐缩，并且远端区域具有比远端更远的直径 中间区域。

公开(公告)号：US08679049B2

公开(公告)日：2014-03-25

申请号：US13551424

申请日：2012-07-17

申请人： Henry Nita

发明人： Henry Nita

IPC分类号： A61B17/32 ,  A61H1/00 ,  A61B8/14

CPC分类号： A61F2/95 ,  A61B8/13 ,  A61B17/22012 ,  A61B17/32002 ,  A61B17/320068 ,  A61B18/1492 ,  A61B18/18 ,  A61B18/1815 ,  A61B18/24 ,  A61B34/20 ,  A61B2017/00252 ,  A61B2017/003 ,  A61B2017/00867 ,  A61B2018/00404 ,  A61B2018/00994 ,  A61B2018/1861 ,  A61B2090/376 ,  A61B2090/3983 ,  A61N7/00

摘要： In a method for re-entry from extraluminal space into the central lumen of a vessel, a guidewire is advanced into the extraluminal space of the vessel, and then a directional catheter is advanced over the guidewire through the extraluminal space. Thereafter, the guidewire is removed from the directional catheter, an ultrasound device is placed through the directional catheter, and the ultrasound device is advanced through the extraluminal space into the central lumen and then activated.

摘要翻译： 在从腔内空间重新进入血管的中心腔的方法中，将导丝推进到血管的腔内空间中，然后将定向导管穿过导管穿过管腔内空间。 此后，将导丝从定向导管中取出，通过定向导管放置超声波装置，超声波装置通过腔内空间前进到中心腔，然后被激活。

公开(公告)号：US20140081288A1

公开(公告)日：2014-03-20

申请号：US14090926

申请日：2013-11-26

申请人： FlowCardia, Inc.

发明人： Henry Nita ,  Jeff Sarge ,  Richard Spano

IPC分类号： A61B17/22

CPC分类号： A61B17/22004 ,  A61B17/22012 ,  A61B17/2251 ,  A61B2017/00477 ,  A61B2017/22014

摘要： Ultrasound catheter devices and methods provide enhanced disruption of blood vessel obstructions. Generally, an ultrasound catheter device includes an elongate flexible catheter body with one or more lumens, an ultrasound transmission member extending longitudinally through the catheter body lumen and a distal head coupled with the transmission member and positioned adjacent the distal end of the catheter body for disrupting occlusions. A proximal housing of the catheter device may include one or more features for dissipating heat from the ultrasound transmission wire, such as a fluid inlet aperture for passage of fluid, use of heat conductive materials in the proximal housing, surface features to increase the housing's surface area, heat conductive members disposed adjacent the transmission member and the like. Various irrigation fluids may be used, such as cooled, oxygen supersaturated or lubricious fluids.

摘要翻译： 超声导管装置和方法提供增强的血管阻塞的破坏。 通常，超声导管装置包括具有一个或多个管腔的细长柔性导管主体，纵向延伸穿过导管体腔的超声传递构件和与传播构件联接并远离导管主体的远端定位的远端头，用于破坏 闭塞。 导管装置的近侧壳体可以包括用于从超声波传输线散发热量的一个或多个特征，例如用于流体通过的流体入口孔，在近侧壳体中使用导热材料，表面特征以增加壳体的表面 区域，布置在传输构件附近的导热构件等。 可以使用各种冲洗流体，例如冷却的，氧过饱和的或润滑的流体。

公开(公告)号：US08668709B2

公开(公告)日：2014-03-11

申请号：US12036870

申请日：2008-02-25

申请人： Henry Nita ,  Jeff Sarge

发明人： Henry Nita ,  Jeff Sarge

IPC分类号： A61B17/32 ,  A61B5/00

CPC分类号： A61B17/3207 ,  A61B17/22004 ,  A61B17/2202 ,  A61B17/320068 ,  A61B2017/00243 ,  A61B2017/22014 ,  A61B2017/308 ,  A61M25/0054

摘要： Ultrasound catheter devices and methods provide enhanced disruption of blood vessel obstructions. Ultrasound catheter devices generally include an elongate flexible catheter body with one or more lumens, an ultrasound transmission member extending longitudinally through the catheter body lumen and a distal head coupled with the transmission member and positioned adjacent the distal end of the catheter body for disrupting occlusions. Improved features of ultrasound catheters include catheter bodies and ultrasound transmission members with increasing distal flexibility, guidewire tubes allowing contact between a guidewire and an ultrasound transmission member, distal heads with improved guidewire lumens, and torquable proximal housings for enhancing disruption of blood vessel occlusions.

摘要翻译： 超声导管装置和方法提供增强的血管阻塞的破坏。 超声导管装置通常包括具有一个或多个管腔的细长柔性导管主体，纵向延伸穿过导管体腔的超声波传播构件和与传播构件联接并远离导管主体的远端定位以阻止闭塞的远端头部。 超声导管的改进的特征包括具有越来越远的柔性的导管体和超声传递构件，允许导丝和超声波传递构件之间接触的导丝管，具有改进的导丝腔的远端头部以及用于增强血管闭塞的破坏的扭转近端壳体。

公开(公告)号：US08506519B2

公开(公告)日：2013-08-13

申请号：US11879170

申请日：2007-07-16

申请人： Henry Nita

发明人： Henry Nita

IPC分类号： A61B17/20

CPC分类号： A61B17/2202

摘要： An ultrasound system has a catheter including an elongate flexible catheter body having a main lumen extending longitudinally therethrough. The catheter further includes an ultrasound transmission member extending longitudinally through the main lumen of the catheter body, the ultrasound transmission member having a proximal end connectable to an ultrasound generating device and a distal end coupled to the distal end of the catheter body. The catheter further includes a bent distal head or shaped a distal end of the catheter body to improve steerability.

摘要翻译： 超声系统具有导管，其包括细长的柔性导管主体，其具有纵向延伸通过其延伸的主腔。 导管还包括纵向延伸穿过导管主体的主腔的超声波传播构件，超声波传播构件具有可连接到超声波产生装置的近端和耦合到导管主体的远端的远端。 导管还包括弯曲的远端头部或成形为导管主体的远端，以提高导向性。

公开(公告)号：US20120283743A1

公开(公告)日：2012-11-08

申请号：US13548982

申请日：2012-07-13

申请人： Henry Nita

发明人： Henry Nita

IPC分类号： A61B17/225

CPC分类号： A61B17/22012 ,  A61B90/39 ,  A61B2017/22014 ,  A61B2017/22038 ,  A61B2017/22039 ,  A61B2017/22089 ,  A61M25/0068 ,  A61M25/0069 ,  A61M25/0082

摘要： An ultrasound catheter has an elongate flexible catheter body having a lumen extending longitudinally therethrough, and an ultrasound transmission member extending longitudinally through the lumen of the catheter body. The ultrasound transmission member has a proximal end that is coupled to a separate ultrasound generating device, and a distal tip that is attached to the distal end of the ultrasound transmission member and which is located at the distal end of the catheter body. The distal tip has at least one dimensional step. The ultrasound transmission member is directly attached to the catheter body and/or to a guidewire tube, either directly or via an attachment device. The catheter has an additional radiopaque marker positioned on the distal end the catheter.

摘要翻译： 超声导管具有细长的柔性导管本体，其具有纵向穿过其延伸的内腔，以及纵向延伸穿过导管主体的内腔的超声波传递构件。 超声波传输构件具有连接到单独的超声波产生装置的近端和附接到超声波传播构件的远端并且位于导管主体的远端处的远侧末端。 远端尖端具有至少一维的步骤。 超声波传输构件直接或经由附接装置直接附接到导管主体和/或导丝管。 该导管具有位于导管远端的另外的不透射线的标记。

公开(公告)号：US20120238946A1

公开(公告)日：2012-09-20

申请号：US13441829

申请日：2012-04-06

申请人： Henry Nita ,  Jeff Sarge ,  Simon Nguyen

发明人： Henry Nita ,  Jeff Sarge ,  Simon Nguyen

IPC分类号： A61M37/00

CPC分类号： A61B17/22012 ,  A61B2017/00141 ,  A61B2017/00154 ,  A61B2017/00292 ,  A61B2017/003 ,  A61B2017/00331 ,  A61B2017/00526 ,  A61B2017/22011 ,  A61B2017/22014 ,  A61B2017/22015 ,  A61B2017/320072 ,  A61M25/0009 ,  A61M25/001 ,  A61M25/0041

摘要： Ultrasound catheter devices and methods provide enhanced disruption of blood vessel obstructions. Generally, ultrasound catheters include an elongate flexible catheter body with one or more lumens, an ultrasound transmission member extending longitudinally through the catheter body lumen and, in some embodiments, a guidewire tube extending through the lumen. A distal head for disrupting occlusions is coupled with the distal end of the ultrasound transmission member and is positioned adjacent the distal end of the catheter body. Some embodiments include improved features such as a bend in the catheter body for enhancing positioning and/or advancement of the catheter.