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公开(公告)号:US12280253B2
公开(公告)日:2025-04-22
申请号:US17248735
申请日:2021-02-05
Applicant: Galvani Bioelectronics Limited
Inventor: Faisal Zaidi , Sabastien Ouchouche , Paul Matteucci
Abstract: An extravascular or intravascular neural interface is disclosed comprising three C-ring portions, with at least two including an electrode, an electrode pair or an electrode array. The portions are formed of a flexible material that is configured to enable the portions to self-size to fit around or against a surface of a target vessel when the neural interface is released at a position along the target vessel. A spinal portion configured to house electrical conductors for the electrodes is connected to one or more portions. The portions may be spaced sufficient apart to permit radial expansion and contraction of a target vessel around or within which the neural interface is placed, to reduce never compression, open trench low-pressure unrestricted blood-flow, and to enhance fluid exchange with the target vessel. The portions may be arranged in a low helix angle forming at least two full turns.
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2.
公开(公告)号:US20240299737A1
公开(公告)日:2024-09-12
申请号:US18573365
申请日:2022-06-23
Applicant: GALVANI BIOELECTRONICS LIMITED
Inventor: Rizwan BASHIRULLAH , Gerald Edwin HUNSBERGER
IPC: A61N1/05
CPC classification number: A61N1/0558
Abstract: Stents for intravascular neural stimulation are disclosed herein that at least partially contact a vessel wall. The stent comprises a scaffold extending in a longitudinal direction and having an outer perimeter that at least partially contacts the wall. A pulse generator can generate electrical signals for delivery to a nerve for intravascular neural stimulation. The scaffold has mounted thereon a first set of one or more electrodes electrically coupled to the pulse generator. The stent further comprises a second set of one or more electrodes electrically coupled to the pulse generator. The second set of electrodes is unconnected to the scaffold, i.e. not directly mounted on the scaffold. Methods of implanting a stent into a vessel using a deployment catheter are disclosed herein. The stent to be implanted comprises a pulse generator, a scaffold, and a distal set of one or more electrodes electrically coupled to the pulse generator. The distal set of electrodes is unconnected to the scaffold, i.e. not directly mounted on the scaffold. The method comprises positioning a distal end of the deployment catheter at the intravascular location, advancing the stent within the deployment catheter, further advancing the stent to expose the one or more electrodes of the distal set of one or more electrodes outside of, preferably beyond the deployment catheter, providing an electrical stimulation via the exposed electrodes, and withdrawing the stent within the deployment catheter.
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公开(公告)号:USD1009265S1
公开(公告)日:2023-12-26
申请号:US29788570
申请日:2021-06-24
Applicant: GALVANI BIOELECTRONICS LIMITED
Designer: Peng Cong , Benjamin Yaffe , Morten Hansen
Abstract: FIG. 1 is a perspective view of suture tabs showing the claimed design;
FIG. 2 is a top view thereof;
FIG. 3 is a bottom view thereof;
FIG. 4 is an enlarged right side view thereof;
FIG. 5 is an enlarged left side view thereof;
FIG. 6 is a front view thereof;
FIG. 7 is a rear view thereof;
FIG. 8 is a perspective view of suture tabs showing the claimed design;
FIG. 9 is a top view thereof;
FIG. 10 is a bottom view thereof;
FIG. 11 is an enlarged right side view thereof;
FIG. 12 is an enlarged left side view thereof;
FIG. 13 is a front view thereof;
FIG. 14 is a rear view thereof;
FIG. 15 is a perspective view of suture tabs showing the claimed design;
FIG. 16 is a top view thereof;
FIG. 17 is a bottom view thereof;
FIG. 18 is an enlarged right side view thereof;
FIG. 19 is an enlarged left side view thereof;
FIG. 20 is a front view thereof; and,
FIG. 21 is a rear view thereof.
The dashed broken lines in the Figures show portions of the pair of suture tabs that form no part of the claimed design.-
公开(公告)号:US20230271010A1
公开(公告)日:2023-08-31
申请号:US18140387
申请日:2023-04-27
Applicant: Galvani Bioelectronics Limited
Inventor: Margarita J. Vervoordeldonk , Eric Irwin , Daniel John Chew , Matteo Donega , Cindy Cleypool , Isha Gupta
CPC classification number: A61N1/3606 , A61N1/0556 , A61N1/36139 , A61N1/36178 , A61N1/36135 , A61N1/3614 , A61N1/36171 , A61N2001/083
Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is adjacent to the splenic artery at a position where the splenic artery is not in direct contact with the pancreas, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating disorders, such as disorders associated with inflammation. The invention provides improved ways of reducing inflammation with minimized off-target effects, in particular surgical trauma.
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公开(公告)号:US11672972B2
公开(公告)日:2023-06-13
申请号:US15733276
申请日:2018-12-11
Applicant: Galvani Bioelectronics Limited , UCL Business PLC
Inventor: Rizwan Bashirullah , Gerald Edwin Hunsberger , Matteo Donega , Daniel Chew , David Holder , Kirill Aristovich
CPC classification number: A61N1/0556 , A61N1/36053 , A61N1/36182
Abstract: A nerve interface device including at least one cuff portion having an assembled position in which the cuff portion forms at least part of a passageway for receiving a nerve along a longitudinal axis passing through the passageway; and first and second rings of electrodes mounted on the at least one cuff portion, each ring of electrodes including a plurality of electrodes. Each electrode in the first ring has a corresponding longitudinally-aligned electrode in the second ring so as to form a plurality of pairs of electrodes spaced apart from each other along the longitudinal axis. The plurality of pairs of electrodes includes at least a first pair of electrodes, the first pair of electrodes mounted on the at least one cuff portion. The at least one cuff portion includes an asymmetric configuration about a central axis perpendicular to the longitudinal cuff axis.
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公开(公告)号:US20230142770A1
公开(公告)日:2023-05-11
申请号:US18151004
申请日:2023-01-06
Applicant: GALVANI BIOELECTRONICS LIMITED , Université Côte d 'Azur , CENTRE NATIONALE DE LA RECHERCHE SCIENTIFIQUE
Inventor: Philippe Blancou , Nicolas GLAICHENHAUS , Arun SRIDHAR
IPC: A61N1/36
CPC classification number: A61N1/36139 , A61N1/36007 , A61N1/36157 , A61N1/36171 , A61N1/37211
Abstract: Devices and methods for the stimulation of neural signalling of an apical splenic nerve, the device having a transducer for placement on or around the apical splenic nerve, and a signal generator to generate a signal that stimulates or inhibits the neural activity of the apical splenic nerve to produce a physiological response. The transducer has at least one electrode, and the signal generator is a voltage or current source. The stimulation electrical signal has a frequency of between 1 Hz and 50 Hz.
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公开(公告)号:US20230125962A1
公开(公告)日:2023-04-27
申请号:US18145780
申请日:2022-12-22
Applicant: GALVANI BIOELECTRONICS LIMITED
Inventor: Faisal ZAIDI , Sebastien OUCHOUCHE
Abstract: An extravascular neural interface is disclosed containing electrodes for neurostimulation of the vessel. The devices are housed in flexible substrates, each substrate having a spinal portion for routing leads/conductors into the device for connection to the electrodes. Extending from opposite sides of the spinal portion is a self-sizing inner flap that supports and positions the electrodes to be inward facing, i.e., extravascular designs, and one more rigid outer flap. The electrodes may be flexible multifilar coil electrodes.
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公开(公告)号:US20230041002A1
公开(公告)日:2023-02-09
申请号:US17769620
申请日:2020-10-15
Applicant: Galvani Bioelectronics Limited
Inventor: Morten Hansen , Jay Canham
Abstract: A belt-like garment is disclosed herein that addresses the need in the wireless recharging field for a holder that maintains the proximity of the recharger to the implanted device, is less bulky and better conforming to the wearer, is easy to don and doff, and prevents shifting throughout the recharging session.
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公开(公告)号:US20230017399A1
公开(公告)日:2023-01-19
申请号:US17883332
申请日:2022-08-08
Inventor: Alessandra Giarola , Yee-Hsee Hsieh , Stephen J. Lewis , Arun Sridhar
Abstract: This disclosure provides an apparatus or system for the modulation of neural activity in the cervical sympathetic chain (CSC) or superior cervical ganglion (SCG) or SCG post-ganglionic branch(es) and for the treatment of sleep apnoea, as well as methods for their use.
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10.
公开(公告)号:US20230010306A1
公开(公告)日:2023-01-12
申请号:US17785374
申请日:2020-12-15
Applicant: Galvani Bioelectronics Limited
Inventor: Rizwan Bashirullah , Gerald Edwin Hunsberger
Abstract: A stent for intravascular stimulation comprises a scaffold comprising first and second scaffold structures, each scaffold structure comprising at least one substantially annular portion. The stent further comprises one or more anodal electrodes formed from or electrically coupled to at least a substantially annular portion of the first scaffold structure and one or more cathodal electrodes electrically formed from or coupled to at least a substantially annular portion of the second scaffold structure. The stent further comprises an anodal lead electrically coupled to the first scaffold structure to form a conductive path from the one or more anodal electrodes to a generator and a cathodal lead electrically coupled to the second scaffold structure to form a conductive path from the one or more cathodal electrodes to the generator. The stent further comprises a sleeve of insulating material, wherein the scaffold structures are attached to or formed on the sleeve of insulating material and are separated from each other by a distance such that the first and second scaffold structures are electrically insulated from each other.
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