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    HETEROBIFUNCTIONAL INHIBITORS OF E-SELECTINS AND CXCR4 CHEMOKINE RECEPTORS
    5.
    发明申请
    HETEROBIFUNCTIONAL INHIBITORS OF E-SELECTINS AND CXCR4 CHEMOKINE RECEPTORS 审中-公开

    公开(公告)号：US20170305951A1

    公开(公告)日：2017-10-26

    申请号：US15531951

    申请日：2015-12-01

    申请人： GlycoMimetics, Inc.

    发明人： John L MAGNANI ,  Arun K. SARKAR ,  John M. PETERSON

    IPC分类号： C07H15/26

    摘要： Compounds, compositions, and methods for treatment and/or prevention of cancer and inflammatory diseases, and for releasing cells such as stem cells (e.g., bone marrow progenitor cells) into circulating blood and enhancing retention of the cells in the blood are disclosed. For example, heterobifunctional compounds that inhibit both E-selectins and CXCR4 chemokine receptors are described and pharmaceutical compositions comprising at least one of the same.

    Heterobifunctional pan-selectin inhibitors
    7.
    再颁专利
    Heterobifunctional pan-selectin inhibitors 有权
    异双功能泛选择素抑制剂

    公开(公告)号：USRE44778E1

    公开(公告)日：2014-02-25

    申请号：US13484020

    申请日：2012-05-30

    申请人： John L. Magnani ,  John T. Patton, Jr. ,  Arun K. Sarkar ,  Sergei A. Svarovsky ,  Beat Ernst

    发明人： John L. Magnani ,  John T. Patton, Jr. ,  Arun K. Sarkar ,  Sergei A. Svarovsky ,  Beat Ernst

    IPC分类号： C07H15/22

    CPC分类号： A61K31/706 ,  A61K47/549 ,  C07H15/22 ,  C07H15/26 ,  C07H17/00

    摘要： Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise particular glycomimetics alone or linked to a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).

    摘要翻译： 提供化合物和方法用于调节由选择素结合介导的体外和体内过程。 更具体地，描述了选择素调节剂及其用途，其中调节（例如，抑制或增强）选择素介导的功能的选择素调节剂单独包含特定的糖模拟物或连接到称为BASAs的化合物类别（苄基氨基磺酸 ）或称为BACAs（苄基氨基羧酸）的一类化合物的成员。

    E-SELECTIN ANTAGONISTS
    8.
    发明申请
    E-SELECTIN ANTAGONISTS 有权

    公开(公告)号：US20130331350A1

    公开(公告)日：2013-12-12

    申请号：US13822573

    申请日：2011-09-12

    申请人： Beat Ernst ,  Céline E. Weckerle ,  Jonas K. Egger

    发明人： Beat Ernst ,  Céline E. Weckerle ,  Jonas K. Egger

    IPC分类号： C07H17/02

    CPC分类号： C07H17/02 ,  C07H15/26

    摘要： Compounds, compositions and methods are provided for inhibiting in vitro and in vivo processes mediated by E-selectin binding. More specifically, particular glycomimetic compounds are described, wherein the compounds are E-selectin antagonists.

    摘要翻译： 化合物，组合物和方法用于抑制由E-选择蛋白结合介导的体外和体内过程。 更具体地，描述了特定的糖模拟化合物，其中所述化合物是E-选择蛋白拮抗剂。

    Glycomimetic inhibitors of the PA-IL lectin, PA-IIL lectin or both the lectins from pseudomonas
    9.
    发明授权
    Glycomimetic inhibitors of the PA-IL lectin, PA-IIL lectin or both the lectins from pseudomonas 有权
    来自假单胞菌的PA-IL凝集素，PA-IIL凝集素或两者的凝集素的模拟抑制剂

    公开(公告)号：US08258290B2

    公开(公告)日：2012-09-04

    申请号：US12370826

    申请日：2009-02-13

    申请人： John L Magnani ,  John T Patton, Jr. ,  Arun K Sarkar

    发明人： John L Magnani ,  John T Patton, Jr. ,  Arun K Sarkar

    IPC分类号： C07H3/08 ,  C07H3/06 ,  A61K31/702

    CPC分类号： C07H17/04 ,  C07H3/06 ,  G01N33/56911 ,  G01N2333/21

    摘要： Compositions and methods are provided related to Pseudomonas bacteria. The compositions and methods may be used for diagnosis and therapy of medical conditions involving infection with Pseudomonas bacteria. Such infections include Pseudomonas aeruginosa in the lungs of patients with cystic fibrosis. A compound useful in the present methods may be used in combination with a therapeutic agent or may be linked to a therapeutic agent. Pseudomonas bacteria may be inhibited by blocking colonization, inhibiting virulence factors, arresting growth or killing the bacteria.

    摘要翻译： 提供了与假单胞菌属相关的组合物和方法。 组合物和方法可用于诊断和治疗涉及感染假单胞菌的医学病症。 这种感染包括铜绿假单胞菌在囊性纤维化患者的肺部。 可用于本发明方法的化合物可与治疗剂组合使用或可与治疗剂连接。 通过阻断定植，抑制毒力因子，阻止生长或杀死细菌，可以抑制假单胞菌。