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    MICRO FLUIDICS MANIFOLD APPARATUS
    2.
    发明申请
    MICRO FLUIDICS MANIFOLD APPARATUS 审中-公开
    微型流体显示装置

    公开(公告)号：US20090074625A1

    公开(公告)日：2009-03-19

    申请号：US12326723

    申请日：2008-12-02

    申请人： James E. Johnson ,  Neil R. Picha ,  Mitchel J. Doktycz

    发明人： James E. Johnson ,  Neil R. Picha ,  Mitchel J. Doktycz

    IPC分类号： B01L3/02

    CPC分类号： G01N35/1097 ,  B01J19/0046 ,  B01J2219/00315 ,  B01J2219/00394 ,  B01J2219/00412 ,  B01J2219/00605 ,  B01J2219/00659 ,  C40B60/14 ,  F16K11/0743 ,  F16K99/0001 ,  F16K99/0013 ,  F16K99/0028 ,  F16K2099/0084 ,  G01N1/14 ,  G01N2035/1041 ,  Y10T137/86863 ,  Y10T137/87249 ,  Y10T436/2575

    摘要： A manifold device is provided for use with a valve assembly, an aspiration source and a dispensing source to transfer fluid from at least one of a plurality of fluid reservoirs to at least one test site on a substrate surface. The manifold device includes a manifold body that defines a plurality of fluid aspiration conduits, for fluid aspiration in an aspiration position, and a plurality of fluid dispensing conduits to selectively dispense at least one droplet of the corresponding liquid sample slug, in a dispensing position. In the aspiration position, the respective sample paths are out of fluid communication with the dispensing source and, in the dispensing position, the respective sample paths are out of fluid communication with the aspiration source.

    摘要翻译： 提供歧管装置，用于与阀组件，抽吸源和分配源一起使用以将流体从多个流体储存器中的至少一个流体传送到基底表面上的至少一个测试部位。 歧管装置包括歧管主体，其限定多个流体抽吸导管，用于在抽吸位置中的流体抽吸，以及多个流体分配管道，用于在分配位置中选择性地分配相应液体样品块的至少一个液滴。 在抽吸位置中，各个样品路径不与分配源流体连通，并且在分配位置中，各个样品路径不与抽吸源流体连通。

    Apparatus and method for assessing the liquid flow performances through a small dispensing orifice
    3.
    发明授权
    Apparatus and method for assessing the liquid flow performances through a small dispensing orifice 有权
    通过小分配孔评估液体流动性能的装置和方法

    公开(公告)号：US06983636B2

    公开(公告)日：2006-01-10

    申请号：US10353804

    申请日：2003-01-27

    申请人： James E. Johnson ,  Neil R. Picha ,  Craig M. Storms ,  David A. Martin

    发明人： James E. Johnson ,  Neil R. Picha ,  Craig M. Storms ,  David A. Martin

    IPC分类号： G01F25/00

    CPC分类号： B01L3/021 ,  B01L3/0268 ,  B01L2200/143 ,  B01L2200/148 ,  B01L2300/14 ,  B01L2400/02 ,  B01L2400/0487 ,  B01L2400/06 ,  B01L2400/0633 ,  B01L2400/0666 ,  G01N35/00594 ,  G01N35/00712 ,  G01N35/1002 ,  G01N35/1016 ,  G01N35/1065 ,  G01N2035/00237 ,  G01N2035/1041 ,  G01N2035/1044 ,  Y10T137/3003 ,  Y10T436/15 ,  Y10T436/2575

    摘要： A universal calibration apparatus and method to estimate the dispense output from a low volume, non-contact, liquid dispensing systems that may be applied for every hardware configuration (e.g., tube length, orifice diameter, tip design, etc), reagent solution property and environmental condition. This same calibration technique is applied to calibrate or tune these non-contact liquid dispensing systems to dispense desired volumes (in the range of about 0.050 μL to 50 μL), irrespective of the hardware configuration or the solution properties. That is, the calibration technique is not dependent on any variables, but the result (the actual dispense volume) is dependant on the variable mentioned. By actuating selected pulse widths, and measuring the resulting volume, a Calibration Profile can be generated correlating the liquid volume dispensed from the orifice to the respective pulse width of the dispensing valve thereof through calibration points. In particular, one is selected to deliver a first volume of liquid that is less than a lower base pulse width correlating to the lowest volume of the selected range of volumes of liquid, while a second pulse width is selected to deliver a second volume of liquid dispensed that is greater than an upper ceiling pulse width correlating to the highest volume of the selected range of volumes of liquid. Intermediary pulse widths are also applied, each selected to deliver a different, spaced-apart, respective intermediary low volumes of liquid dispensed from the dispensing orifice between the first volume and the second volume. Thus, applying the Calibration Profile, the pulse widths correlating to the one or more targeted discrete volumes for liquid dispensing can be extrapolated.

    摘要翻译： 一种通用校准装置和方法，用于估计可用于每个硬件配置（例如，管长度，孔直径，尖端设计等）的低体积非接触式液体分配系统的分配输出，试剂溶液性质和 环境条件。 应用相同的校准技术来校准或调谐这些非接触式液体分配系统以分配所需体积（在约0.050μm至50μm的范围内），而不考虑硬件配置或溶液性质。 也就是说，校准技术不依赖于任何变量，但结果（实际分配量）取决于所提到的变量。 通过启动所选择的脉冲宽度并测量所得到的体积，可以产生校准曲线，其将通过校准点将从孔口分配的液体体积与其分配阀的相应脉冲宽度相关联。 特别地，选择一种来输送第一体积的液体，其小于与所选择的液体体积范围的最小体积相关的较低基本脉冲宽度，而选择第二脉冲宽度以输送第二体积的液体 分配大于与所选择的液体体积范围的最大体积相关的上顶脉冲宽度。 中间脉冲宽度也被应用，每个脉冲宽度被选择以在第一容积和第二容积之间输送从分配孔分配的不同的间隔开的相应的中等体积的液体。 因此，应用校准曲线，可以外推与液体分配的一个或多个目标离散体积相关的脉冲宽度。

    Hybrid valve apparatus and method for fluid handling
    4.
    发明授权
    Hybrid valve apparatus and method for fluid handling 有权
    用于流体处理的混合阀装置和方法

    公开(公告)号：US07497995B2

    公开(公告)日：2009-03-03

    申请号：US11034389

    申请日：2005-01-11

    申请人： James E. Johnson ,  Neil R. Picha ,  Mitchel J. Doktycz

    发明人： James E. Johnson ,  Neil R. Picha ,  Mitchel J. Doktycz

    IPC分类号： B01L3/02

    CPC分类号： G01N35/1097 ,  B01J19/0046 ,  B01J2219/00315 ,  B01J2219/00394 ,  B01J2219/00412 ,  B01J2219/00605 ,  B01J2219/00659 ,  C40B60/14 ,  F16K11/0743 ,  F16K99/0001 ,  F16K99/0013 ,  F16K99/0028 ,  F16K2099/0084 ,  G01N1/14 ,  G01N2035/1041 ,  Y10T137/86863 ,  Y10T137/87249 ,  Y10T436/2575

    摘要： A hybrid valve apparatus for use with an aspiration actuator and a dispensing actuator to transfer fluid from a reservoir to a test site on a substrate surface. The hybrid valve includes a valve assembly movable between an aspiration condition and a dispensing condition, and a manifold device coupled to the valve assembly. The manifold device includes a fluid aspiration conduit having a first aspiration port in fluid communication with the aspiration actuator. On an opposite end of the aspiration conduit is a second aspiration port in selective fluid communication with the valve assembly to selectively aspirate a liquid sample slug from the reservoir into a discrete sample path when the valve assembly is in the aspiration condition. The manifold device further includes a fluid dispensing conduit having a first dispensing port in fluid communication with the dispensing actuator, and a second dispensing port in selective fluid communication with the valve assembly. When the valve assembly is in the dispensing condition, the sample path is fluidly coupled to the dispensing actuator to selectively dispense at least one droplet of the liquid sample slug therefrom, while simultaneously being out of fluid communication with the aspiration actuator. In contrast, in the aspiration condition, the sample path is in fluid communication with the aspiration actuator, while being out of fluid communication with the dispensing actuator.

    摘要翻译： 一种用于吸入致动器和分配致动器的混合阀装置，用于将流体从储存器传送到衬底表面上的测试位置。 所述混合阀包括可在抽吸条件和分配状态之间移动的阀组件以及联接到所述阀组件的歧管装置。 歧管装置包括具有与抽吸致动器流体连通的第一抽吸端口的流体抽吸导管。 在抽吸导管的另一端是与阀组件选择性流体连通的第二抽吸端口，以便当阀组件处于抽吸状态时，将液体样品块从储存器中选择性地吸入离散的样品路径。 歧管装置还包括具有与分配致动器流体连通的第一分配端口和与阀组件选择性流体连通的第二分配端口的流体分配管道。 当阀组件处于分配状态时，样品路径流体地联接到分配致动器，以选择性地从其中分配液体样品块的至少一个液滴，同时与抽吸致动器脱离流体连通。 相反，在抽吸条件下，样品路径与抽吸致动器流体连通，同时不与分配致动器流体连通。

    SYSTEM AND METHOD FOR REPETITIVE, HIGH PERFORMANCE, LOW VOLUME, NON-CONTACT LIQUID DISPENSING
    5.
    发明申请
    SYSTEM AND METHOD FOR REPETITIVE, HIGH PERFORMANCE, LOW VOLUME, NON-CONTACT LIQUID DISPENSING 审中-公开
    重复性，高性能，低体积，非接触液体分配的系统和方法

    公开(公告)号：US20070155019A1

    公开(公告)日：2007-07-05

    申请号：US11627830

    申请日：2007-01-26

    申请人： James Johnson ,  Neil Picha ,  Craig Storms ,  David Martin

    发明人： James Johnson ,  Neil Picha ,  Craig Storms ,  David Martin

    IPC分类号： G01N1/10

    CPC分类号： B01L3/021 ,  B01L3/0268 ,  B01L2200/143 ,  B01L2200/148 ,  B01L2300/14 ,  B01L2400/02 ,  B01L2400/0487 ,  B01L2400/06 ,  B01L2400/0633 ,  B01L2400/0666 ,  G01N35/00594 ,  G01N35/00712 ,  G01N35/1002 ,  G01N35/1016 ,  G01N35/1065 ,  G01N2035/00237 ,  G01N2035/1041 ,  G01N2035/1044 ,  Y10T137/3003 ,  Y10T436/15 ,  Y10T436/2575

    摘要： An apparatus and method for delivering repetitive, precision, low volume liquid dispensing from a dispensing orifice of a non-contact liquid dispensing apparatus. An elongated communication passageway of the dispensing apparatus is defined by interior walls having one end in fluid communication with a system fluid reservoir and an opposite end terminating at the dispensing orifice. A system fluid is placed in the communication passageway extending substantially continuously from the system fluid reservoir to the dispensing orifice. The system fluid reservoir is pressurized at a substantially constant back pressure, with a pressurizing gas, preferably helium, that suppresses in-gassing, and that is substantially insoluble to the system liquid. A dispensing liquid is aspirated through the dispensing orifice and into the communication passageway substantially to an interface region with the system fluid contained in the communication passageway. To effect dispensing, a rapid pressure pulse with a predetermined pulse width is applied to the system fluid, enabling substantially accurate, relatively small volume, non-contact liquid dispensing of the dispensing liquid from the dispensing orifice.

    摘要翻译： 一种用于从非接触式液体分配装置的分配孔输送重复，精确，低体积的液体分配的装置和方法。 分配装置的细长的连通通道由具有与系统流体储存器流体连通的一端和终止于分配孔的相对端的内壁限定。 系统流体被放置在从系统流体储存器到分配孔基本上连续延伸的连通通道中。 系统流体储存器以基本上恒定的背压加压，其中加压气体，优选氦气，其抑制气体放电，并且基本上不溶于系统液体。 分配液体通过分配孔被抽吸到连通通道中，基本上与包含在连通通道中的系统流体的界面区域相连。 为了实现分配，将具有预定脉冲宽度的快速压力脉冲施加到系统流体，使得能够从分配孔口实现基本准确的，相对较小体积的非接触液体分配分配液体。

    Hybrid valve apparatus and method for fluid handling
    6.
    发明申请
    Hybrid valve apparatus and method for fluid handling 有权
    用于流体处理的混合阀装置和方法

    公开(公告)号：US20050129584A1

    公开(公告)日：2005-06-16

    申请号：US11034389

    申请日：2005-01-11

    申请人： James Johnson ,  Neil Picha ,  Mitchel Doktycz

    发明人： James Johnson ,  Neil Picha ,  Mitchel Doktycz

    IPC分类号： B01J19/00 ,  B67D7/02 ,  C12M1/00 ,  C40B60/14 ,  G01N1/00 ,  G01N1/14 ,  G01N35/10 ,  G01N37/00 ,  B32B27/04

    CPC分类号： G01N35/1097 ,  B01J19/0046 ,  B01J2219/00315 ,  B01J2219/00394 ,  B01J2219/00412 ,  B01J2219/00605 ,  B01J2219/00659 ,  C40B60/14 ,  F16K11/0743 ,  F16K99/0001 ,  F16K99/0013 ,  F16K99/0028 ,  F16K2099/0084 ,  G01N1/14 ,  G01N2035/1041 ,  Y10T137/86863 ,  Y10T137/87249 ,  Y10T436/2575

    摘要： A hybrid valve apparatus for use with an aspiration actuator and a dispensing actuator to transfer fluid from a reservoir to a test site on a substrate surface. The hybrid valve includes a valve assembly movable between an aspiration condition and a dispensing condition, and a manifold device coupled to the valve assembly. The manifold device includes a fluid aspiration conduit having a first aspiration port in fluid communication with the aspiration actuator. On an opposite end of the aspiration conduit is a second aspiration port in selective fluid communication with the valve assembly to selectively aspirate a liquid sample slug from the reservoir into a discrete sample path when the valve assembly is in the aspiration condition. The manifold device further includes a fluid dispensing conduit having a first dispensing port in fluid communication with the dispensing actuator, and a second dispensing port in selective fluid communication with the valve assembly. When the valve assembly is in the dispensing condition, the sample path is fluidly coupled to the dispensing actuator to selectively dispense at least one droplet of the liquid sample slug therefrom, while simultaneously being out of fluid communication with the aspiration actuator. In contrast, in the aspiration condition, the sample path is in fluid communication with the aspiration actuator, while being out of fluid communication with the dispensing actuator.

    摘要翻译： 一种用于吸入致动器和分配致动器的混合阀装置，用于将流体从储存器传送到衬底表面上的测试位置。 所述混合阀包括可在抽吸条件和分配状态之间移动的阀组件以及联接到所述阀组件的歧管装置。 歧管装置包括具有与抽吸致动器流体连通的第一抽吸端口的流体抽吸导管。 在抽吸导管的另一端是与阀组件选择性流体连通的第二抽吸端口，以便当阀组件处于抽吸状态时，将液体样品块从储存器中选择性地吸入离散的样品路径。 歧管装置还包括具有与分配致动器流体连通的第一分配端口和与阀组件选择性流体连通的第二分配端口的流体分配管道。 当阀组件处于分配状态时，样品路径流体地联接到分配致动器，以选择性地从其中分配液体样品块的至少一个液滴，同时与抽吸致动器脱离流体连通。 相反，在抽吸条件下，样品路径与抽吸致动器流体连通，同时不与分配致动器流体连通。

    ROTARY WASH VALVE
    7.
    发明申请
    ROTARY WASH VALVE 有权
    旋转洗衣机

    公开(公告)号：US20020112767A1

    公开(公告)日：2002-08-22

    申请号：US09785914

    申请日：2001-02-16

    申请人： Innovadyne Technologies, Inc.

    发明人： James E. Johnson ,  Neil Picha ,  Jon Nichols

    IPC分类号： F16K011/074

    CPC分类号： F16K11/0743 ,  A61M39/223 ,  A61M39/225 ,  Y10T137/0424 ,  Y10T137/4259 ,  Y10T137/86501 ,  Y10T137/86509

    摘要： A wash system for a fluid handling system that permits simultaneous washing of a plurality of parallel fluid channels is disclosed. In one aspect of the invention, a specialized rotary wash valve is described. In another aspect of the invention a system which incorporates wash and selector valves is described which permits a plurality of separate fluid lines emerging from the selector valve to be washed simultaneously.

    摘要翻译： 公开了用于流体处理系统的洗涤系统，其允许同时洗涤多个平行的流体通道。 在本发明的一个方面，描述了专门的旋转洗涤阀。 在本发明的另一方面，描述了一种包括洗涤和选择阀的系统，其允许从选择阀排出的多个单独的流体管线被同时洗涤。

    Method of purging trapped gas from a system fluid contained in an actuation valve
    9.
    发明授权
    Method of purging trapped gas from a system fluid contained in an actuation valve 失效
    从包含在致动阀中的系统流体清除被捕获的气体的方法

    公开(公告)号：US07169616B2

    公开(公告)日：2007-01-30

    申请号：US10353824

    申请日：2003-01-27

    申请人： James E. Johnson ,  Neil R. Picha ,  Craig M. Storms ,  David A. Martin

    发明人： James E. Johnson ,  Neil R. Picha ,  Craig M. Storms ,  David A. Martin

    IPC分类号： G01N1/10 ,  B01L3/02 ,  F16T1/42

    CPC分类号： B01L3/021 ,  B01L3/0268 ,  B01L2200/143 ,  B01L2200/148 ,  B01L2300/14 ,  B01L2400/02 ,  B01L2400/0487 ,  B01L2400/06 ,  B01L2400/0633 ,  B01L2400/0666 ,  G01N35/00594 ,  G01N35/00712 ,  G01N35/1002 ,  G01N35/1016 ,  G01N35/1065 ,  G01N2035/00237 ,  G01N2035/1041 ,  G01N2035/1044 ,  Y10T137/3003 ,  Y10T436/15 ,  Y10T436/2575

    摘要： An apparatus and method for delivering repetitive, precision, low volume liquid dispensing from a dispensing orifice of a non-contact liquid dispensing apparatus. An elongated communication passageway of the dispensing apparatus is defined by interior walls having one end in fluid communication with a system fluid reservoir and an opposite end terminating at the dispensing orifice. A system fluid is placed in the communication passageway extending substantially continuously from the system fluid reservoir to the dispensing orifice. A relatively small volume of gaseous fluid is aspirated through the dispensing orifice, and into the communication passageway in a manner such that the gaseous fluid extends substantially continuously across the transverse cross-sectional dimension of the communication passageway. Subsequently, a dispensing liquid is aspirated through the dispensing orifice and into the communication passageway in a manner such that the relatively small volume of aspirated gaseous fluid forms a minute, unitary air gap fully enclosed between the interior walls of the communication passageway and a liquid interface between the system fluid and the dispensing liquid contained in the communication passageway. This minute air gap substantially prevents dispersion and dilution therebetween at the liquid interface. To effect dispensing, a rapid pressure pulse with a predetermined pulse width is applied to the system fluid upstream from the minute air gap, causing the pressure pulse to traverse the minute air gap to the dispensing liquid without substantial fluid compression of the minute air gap. This enables substantially accurate, relatively small volume, non-contact liquid dispensing of the dispensing liquid from the dispensing orifice.

    摘要翻译： 一种用于从非接触式液体分配装置的分配孔输送重复，精确，低体积的液体分配的装置和方法。 分配装置的细长的连通通道由具有与系统流体储存器流体连通的一端和终止于分配孔的相对端的内壁限定。 系统流体被放置在从系统流体储存器到分配孔基本上连续延伸的连通通道中。 通过分配孔吸入相对小体积的气态流体，并以这样的方式进入连通通道，使得气态流体基本上连续地延伸穿过连通通道的横截面尺寸。 随后，分配液体通过分配孔吸入并进入连通通道，使得相对较小体积的吸入气态流体形成完全封闭在连通通道的内壁之间的微小整体空气间隙和液体界面 在系统流体和包含在连通通道中的分配液体之间。 这种微小气隙基本上防止了液体界面处的分散和稀释。 为了实现分配，将具有预定脉冲宽度的快速压力脉冲施加到从微小空气间隙上游的系统流体，使得压力脉冲穿过分配液体的微小空气间隙，而不会明显地流体压缩微小气隙。 这使得能够从分配孔口实现分配液体的基本上精确的，相当小体积的非接触液体分配。