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    Hybrid valve apparatus and method for fluid handling
    1.
    发明申请
    Hybrid valve apparatus and method for fluid handling 有权
    用于流体处理的混合阀装置和方法

    公开(公告)号：US20050129584A1

    公开(公告)日：2005-06-16

    申请号：US11034389

    申请日：2005-01-11

    申请人： James Johnson ,  Neil Picha ,  Mitchel Doktycz

    发明人： James Johnson ,  Neil Picha ,  Mitchel Doktycz

    IPC分类号： B01J19/00 ,  B67D7/02 ,  C12M1/00 ,  C40B60/14 ,  G01N1/00 ,  G01N1/14 ,  G01N35/10 ,  G01N37/00 ,  B32B27/04

    CPC分类号： G01N35/1097 ,  B01J19/0046 ,  B01J2219/00315 ,  B01J2219/00394 ,  B01J2219/00412 ,  B01J2219/00605 ,  B01J2219/00659 ,  C40B60/14 ,  F16K11/0743 ,  F16K99/0001 ,  F16K99/0013 ,  F16K99/0028 ,  F16K2099/0084 ,  G01N1/14 ,  G01N2035/1041 ,  Y10T137/86863 ,  Y10T137/87249 ,  Y10T436/2575

    摘要： A hybrid valve apparatus for use with an aspiration actuator and a dispensing actuator to transfer fluid from a reservoir to a test site on a substrate surface. The hybrid valve includes a valve assembly movable between an aspiration condition and a dispensing condition, and a manifold device coupled to the valve assembly. The manifold device includes a fluid aspiration conduit having a first aspiration port in fluid communication with the aspiration actuator. On an opposite end of the aspiration conduit is a second aspiration port in selective fluid communication with the valve assembly to selectively aspirate a liquid sample slug from the reservoir into a discrete sample path when the valve assembly is in the aspiration condition. The manifold device further includes a fluid dispensing conduit having a first dispensing port in fluid communication with the dispensing actuator, and a second dispensing port in selective fluid communication with the valve assembly. When the valve assembly is in the dispensing condition, the sample path is fluidly coupled to the dispensing actuator to selectively dispense at least one droplet of the liquid sample slug therefrom, while simultaneously being out of fluid communication with the aspiration actuator. In contrast, in the aspiration condition, the sample path is in fluid communication with the aspiration actuator, while being out of fluid communication with the dispensing actuator.

    摘要翻译： 一种用于吸入致动器和分配致动器的混合阀装置，用于将流体从储存器传送到衬底表面上的测试位置。 所述混合阀包括可在抽吸条件和分配状态之间移动的阀组件以及联接到所述阀组件的歧管装置。 歧管装置包括具有与抽吸致动器流体连通的第一抽吸端口的流体抽吸导管。 在抽吸导管的另一端是与阀组件选择性流体连通的第二抽吸端口，以便当阀组件处于抽吸状态时，将液体样品块从储存器中选择性地吸入离散的样品路径。 歧管装置还包括具有与分配致动器流体连通的第一分配端口和与阀组件选择性流体连通的第二分配端口的流体分配管道。 当阀组件处于分配状态时，样品路径流体地联接到分配致动器，以选择性地从其中分配液体样品块的至少一个液滴，同时与抽吸致动器脱离流体连通。 相反，在抽吸条件下，样品路径与抽吸致动器流体连通，同时不与分配致动器流体连通。

    Transparent solid-state structure for diagnostics of fluorescently labeled biomolecules
    4.
    发明申请
    Transparent solid-state structure for diagnostics of fluorescently labeled biomolecules 审中-公开
    用于诊断荧光标记生物分子的透明固态结构

    公开(公告)号：US20060054903A1

    公开(公告)日：2006-03-16

    申请号：US10942660

    申请日：2004-09-16

    申请人： Mitchel Doktycz ,  Robert Warmack

    发明人： Mitchel Doktycz ,  Robert Warmack

    IPC分类号： H01L33/00 ,  H01L31/12 ,  H01L27/15 ,  H01L29/161 ,  H01L31/153

    CPC分类号： G01N21/648 ,  G01N21/6428 ,  G01N21/6452

    摘要： Fluorescence modification, meaning either fluorescence enhancement or fluorescence diminishment, is obtained in a transparent layer structure comprised of a substrate, a dielectric layer and a fluorophore-labeled biomolecule layer. A metal particle layer is positioned in the layer structure a distance of 200-500 nm from the fluorophore-labeled biomolecule layer. Separation distances between 200 and 500 nanometers can be used to enhance or diminish fluorescence. All of the layers may be made transparent so that microscopic viewing of the fluorescence is possible from either side of the layer structure.

    摘要翻译： 在由基底，电介质层和荧光团标记的生物分子层构成的透明层结构中获得荧光改性，即荧光增强或荧光减弱。 金属颗粒层位于层结构中距离荧光团标记的生物分子层的距离为200-500nm。 200至500纳米之间的分离距离可用于增强或减少荧光。 所有层可以制成透明的，从而可以从层结构的任一侧显微观察荧光。

    Coupled spring system for measuring molecular forces
    5.
    发明申请
    Coupled spring system for measuring molecular forces 审中-公开
    用于测量分子力的耦合弹簧系统

    公开(公告)号：US20060059984A1

    公开(公告)日：2006-03-23

    申请号：US10947799

    申请日：2004-09-23

    申请人： Mitchel Doktycz ,  David Allison

    发明人： Mitchel Doktycz ,  David Allison

    IPC分类号： G01L1/04

    CPC分类号： G01Q60/42

    摘要： A coupled spring system is applied to dynamic force spectroscopy measurements. A microcantilever-mounted probe acts as a first spring, and a supported micromachined membrane acts as a second spring. The coupled spring system provides a system spring constant that is lower than either spring individually. By probing different regions of the membrane, the spring constant of the system can be varied.

    摘要翻译： 耦合的弹簧系统被应用于动态力谱测量。 安装有微型悬臂梁的探头用作第一弹簧，支撑的微加工膜作为第二弹簧。 联接的弹簧系统提供比每个弹簧单独地低的系统弹簧常数。 通过探测膜的不同区域，可以改变系统的弹簧常数。