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公开(公告)号：US20120195901A1
公开(公告)日：2012-08-02
申请号：US13448269
申请日：2012-04-16
IPC分类号： A61K39/395 , C12N7/01 , C12N5/10 , C12N1/15 , C12N1/21 , C12N1/19 , C12N15/63 , A61K31/66 , C07K16/00 , C07H21/04 , C07C69/52 , A61P35/00 , A61P37/02 , A61P41/00 , A61P25/28 , A61P3/04 , A61P3/10 , A61P27/02 , A61P13/12 , A61P17/00 , A61P9/00 , A61P17/02 , G01N33/566
CPC分类号： G01N33/92 , A61K2039/505 , C07K16/3076 , C07K16/44 , C07K2317/24 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/54386 , G01N33/577 , G01N2405/04
摘要： Compositions and methods for making and using anti-LPA agents, for example, monoclonal antibodies, are described.
摘要翻译： 描述了用于制备和使用抗LPA剂的组合物和方法，例如单克隆抗体。
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2.发明授权Methods of using humanized antibodies and compositions for binding sphingosine-1-phosphate 有权使用人源化抗体和用于结合鞘氨醇-1-磷酸的组合物的方法公开(公告)号：US08025877B2
公开(公告)日：2011-09-27
申请号：US12258355
申请日：2008-10-24
申请人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Williams
发明人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Williams
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K39/00
CPC分类号： C07K16/44 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to anti-S1P agents, particularly humanized monoclonal antibodies (and antigen binding fragments thereof) specifically reactive with S1P, compositions containing such antibodies (or fragments), and the use of such antibodies (or fragments), for example, to treat diseases and conditions associated with aberrant levels of S1P.
摘要翻译： 本发明涉及与S1P特异性反应的抗S1P试剂，特别是人源化单克隆抗体（及其抗原结合片段），含有此类抗体（或片段）的组合物，以及使用这种抗体（或片段），例如 治疗与S1P异常水平相关的疾病和病症。
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3.发明授权Humanized antibody compositions and methods for binding lysophosphatidic acid 失效人源化抗体组合物和结合溶血磷脂酸的方法公开(公告)号：US08604172B2
公开(公告)日：2013-12-10
申请号：US12761584
申请日：2010-04-16
申请人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Gareth Williams
发明人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Gareth Williams
IPC分类号： C12P21/08
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/44 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/70 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Compositions and methods for making and using humanized anti-LPA monoclonal antibodies, and fragments and derivatives thereof, are described.
摘要翻译： 描述了制备和使用人源化抗LPA单克隆抗体的组合物和方法及其片段和衍生物。
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4.发明授权Use of anti-sphingosine-1-phosphate antibodies in combination with chemotherapeutic agents 有权抗鞘氨醇-1-磷酸抗体与化学治疗剂的组合使用公开(公告)号：US08361465B2
公开(公告)日：2013-01-29
申请号：US12690033
申请日：2010-01-19
IPC分类号： A61K39/395 , A61K39/00 , C07K16/00 , C12P21/08
CPC分类号： C07K16/44 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K2317/24 , A61K2300/00
摘要： The present invention relates to use of anti-S1P antibodies in combination with chemotherapeutic agents for treatment and/or prevention of cancer, tumor growth, metastasis and/or growth of metastatic tumors.
摘要翻译： 本发明涉及抗S1P抗体与化学治疗剂组合用于治疗和/或预防转移性肿瘤的癌症，肿瘤生长，转移和/或生长的用途。
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5.发明授权公开(公告)号：US08222373B2
公开(公告)日：2012-07-17
申请号：US12258346
申请日：2008-10-24
申请人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Gareth Williams
发明人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Gareth Williams
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K39/00
CPC分类号： C07K16/44 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to anti-S1P agents, particularly humanized monoclonal antibodies (and antigen binding fragments thereof) specifically reactive with S1P, compositions containing such antibodies (or fragments), and the use of such antibodies (or fragments), for example, to treat diseases and conditions associated with aberrant levels of S1P.
摘要翻译： 本发明涉及与S1P特异性反应的抗S1P试剂，特别是人源化单克隆抗体（及其抗原结合片段），含有此类抗体（或片段）的组合物，以及使用这种抗体（或片段），例如 治疗与S1P异常水平相关的疾病和病症。
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公开(公告)号：US09163091B2
公开(公告)日：2015-10-20
申请号：US12406874
申请日：2009-03-18
申请人： Roger A. Sabbadini , William A. Garland , James Stephen Swaney , Rosalia Matteo , Gordon Mills , Jonathan Michael Wojciak
发明人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , James Stephen Swaney , Rosalia Matteo , Gordon Mills , Jonathan Michael Wojciak
CPC分类号： C07K16/44 , A61K2039/505 , C07K16/18 , C07K16/3076 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12Q1/6883 , C12Q1/6886 , G01N33/92
摘要： Compositions and methods for making and using anti-LPA agents, for example, monoclonal antibodies, are described. Variable domain and complementarity determining region amino acid sequences of several monoclonal antibodies against LPA are disclosed, as is a consensus anti-LPA monoclonal antibody variable domain sequence.
摘要翻译： 描述了用于制备和使用抗LPA剂的组合物和方法，例如单克隆抗体。 公开了针对LPA的几种单克隆抗体的可变结构域和互补决定区氨基酸序列，以及共有抗LPA单克隆抗体可变结构域序列。
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公开(公告)号：US20130058951A1
公开(公告)日：2013-03-07
申请号：US13695287
申请日：2011-04-29
IPC分类号： A61K39/395 , A61P27/02
CPC分类号： C07K16/18 , A61K2039/505 , A61K2039/507 , C07K16/22 , C07K2317/73 , C07K2317/76
摘要： The present invention relates to methods that involve administration of an anti-S1 P antibody or antibody fragment or derivative to a subject having or suspected of having an ocular disease or condition, including one involving choroidal neovascularization, in order to achieve a desired effect. Such effects include reducing the size of a choroidal neovascularization lesion in the eye, decreasing or resolving retinal pigment epithelial detachment, decreasing central retinal lesion thickness, and preserving or improving visual acuity. Pharmaceutical compositions comprising an anti-S1 P antibody for ocular administration are also provided. The compositions and methods are particularly useful for treating subjects having age-related macular degeneration, particularly exudative or wet age-related macular degeneration.
摘要翻译： 本发明涉及包括向有或具有眼部疾病或病症的受试者施用抗S1P抗体或抗体片段或衍生物的方法，包括涉及脉络膜新生血管形成的受试者，以获得期望的效果。 这种作用包括减少眼睛脉络膜新血管形成病变的尺寸，减少或解决视网膜色素上皮脱离，减少视网膜中央病变厚度，以及保持或改善视力。 还提供了包含用于眼部给药的抗S1P抗体的药物组合物。 组合物和方法对于治疗具有年龄相关性黄斑变性，特别是渗出性或湿性年龄相关性黄斑变性的受试者特别有用。
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公开(公告)号：US08158124B2
公开(公告)日：2012-04-17
申请号：US12129109
申请日：2008-05-29
IPC分类号： C07K16/00
CPC分类号： G01N33/92 , A61K2039/505 , C07K16/3076 , C07K16/44 , C07K2317/24 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/54386 , G01N33/577 , G01N2405/04
摘要： Compositions and methods for making and using anti-LPA agents, for example, monoclonal antibodies, are described.
摘要翻译： 描述了用于制备和使用抗LPA剂的组合物和方法，例如单克隆抗体。
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公开(公告)号：US08026342B2
公开(公告)日：2011-09-27
申请号：US12258383
申请日：2008-10-24
申请人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Gareth Williams
发明人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Gareth Williams
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K39/00
CPC分类号： C07K16/44 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to anti-S1P agents, for example, humanized monoclonal antibodies, and their uses for detection of S1P or for treatment of diseases and conditions associated with S1P.
摘要翻译： 本发明涉及抗S1P剂，例如人源化单克隆抗体及其用于检测S1P或用于治疗与S1P相关的疾病和病症的用途。
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公开(公告)号：US07829674B2
公开(公告)日：2010-11-09
申请号：US11924890
申请日：2007-10-26
申请人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Gareth Williams
发明人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Gareth Williams
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K39/00
CPC分类号： C07K16/44 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to anti-S1P agents, for example, humanized monoclonal antibodies, and their uses for detection of S1P or for treatment of diseases and conditions associated with S1P.
摘要翻译： 本发明涉及抗S1P剂，例如人源化单克隆抗体及其用于检测S1P或用于治疗与S1P相关的疾病和病症的用途。
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