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公开(公告)号：US20240269273A1
公开(公告)日：2024-08-15
申请号：US18616429
申请日：2024-03-26
申请人： MedImmune, LLC
IPC分类号： A61K39/395 , A61K9/00 , A61K9/08 , A61K9/19 , A61K38/00 , A61K39/00 , A61K47/02 , A61K47/18 , A61K47/22 , A61K47/26
CPC分类号： A61K39/395 , A61K9/08 , A61K9/19 , A61K47/02 , A61K47/183 , A61K47/22 , A61K47/26 , A61K9/0019 , A61K38/00 , A61K39/00
摘要： The present invention relates to improved pharmaceutical compositions that contain high concentrations of one or more protein biomolecule(s). In particular, the invention relates to such pharmaceutical compositions that include one or more amino acid molecules, particularly arginine, alanine, glycine, lysine or proline, or derivatives and salts thereof, or mixtures thereof, as stabilizing compounds. The inclusion of such stabilizing compounds decreases reconstitution time whilst improving and/or maintaining the long-term stability of the protein biomolecule, so as to facilitate the treatment, management, amelioration and/or prevention of a disease or condition by the pharmaceutical composition. The invention particularly pertains to such pharmaceutical compositions that lack, or substantially lack, a sugar stabilizing agent.
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公开(公告)号：US20240239898A1
公开(公告)日：2024-07-18
申请号：US18559910
申请日：2022-05-09
申请人： MedImmune, LLC
发明人： Vaheh Yuni OGANESYAN , Lu SHAN
CPC分类号： C07K16/283 , A61K47/68 , C07K2317/31 , C07K2317/524 , C07K2317/526 , C07K2317/55 , C07K2317/622 , C07K2317/94
摘要： The present disclosure relates to modified FcRn binding fragments with improved half-life, specifically fusion proteins and polypeptides comprising said modified FcRn binding fragments, and methods of manufacturing said fusion proteins and their use in methods of treatment.
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公开(公告)号：US12018068B2
公开(公告)日：2024-06-25
申请号：US17397474
申请日：2021-08-09
申请人： MedImmune, LLC , Humabs BioMed SA
发明人： Qun Wang , Charles K. Stover , Meghan Pennini , Chew-shun Chang , Xiaodong Xiao , Jamese Hilliard , Gilad Kaplan , Davide Corti , Elisabetta Cameroni , Martina Beltramello
CPC分类号： C07K16/1228 , A61P31/04 , C12N15/63 , A61K31/407 , A61K38/00 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/565 , C07K2317/734 , C07K2317/76
摘要： The present disclosure provides binding proteins (e.g., antibodies or antigen binding fragments thereof) that specifically bind to Klebsiella pneumoniae O1 and induce opsonophagocytic killing of Klebsiella (e.g., Klebsiella pneumoniae). The present disclosure also provides methods of reducing Klebsiella (e.g., Klebsiella pneumoniae) or treating or preventing Klebsiella (e.g., Klebsiella pneumoniae) infection in a subject comprising administering the Klebsiella pneumoniae O1 binding proteins, (e.g., antibodies or antigen-binding fragments thereof) to the subject.
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公开(公告)号：US20240150437A1
公开(公告)日：2024-05-09
申请号：US18490743
申请日：2023-10-19
申请人： MEDIMMUNE, LLC
IPC分类号： C07K16/00 , C12Q1/6806 , C12Q1/686
CPC分类号： C07K16/005 , C12Q1/6806 , C12Q1/686 , C07K2317/622
摘要： The present invention provides a method for producing encapsulated natively-paired scFv amplicons, by encapsulating single cells in droplets, wherein the droplets further contain reagents for amplifying and sinking native pairings of heavy and light chain variable domain amplicons from single encapsulated cells; lysing the single encapsulated cells; and generating the encapsulated natively-paired scFv amplicons, wherein each scFv amplicon comprises a native pairing of heavy and light chain variable domain amplicons.
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公开(公告)号：US11971377B2
公开(公告)日：2024-04-30
申请号：US16979682
申请日：2019-03-12
发明人： Tinglu Yang , Bradley Rogers , Jifeng Zhang , Paul S. Cremer
CPC分类号： G01N25/04 , B01L7/54 , G01N25/14 , B01L3/502715 , B01L9/00 , B01L2300/042 , B01L2300/0609 , B01L2300/0627 , B01L2300/1805 , B01L2300/1816 , B01L2300/1822 , B01L2300/1894 , G01N25/02
摘要： The present invention describes a versatile, robust and environmentally controlled platform with a linear temperature gradient for massively parallel chemical or biochemical processing. This apparatus is capable of probing the phase transition behavior of macromolecules in solution, both thermodynamically and kinetically. This includes—but is not limited to—liquid/liquid phase transition behavior of antibody solutions and in situ gelation of thermo-responsive polymers. The device can be operated in a multiplex fashion using a controlled temperature gradient architecture and visualized by dark field microscopy or by other optical intensity measurements.
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公开(公告)号：US11926657B2
公开(公告)日：2024-03-12
申请号：US18054757
申请日：2022-11-11
申请人： MEDIMMUNE, LLC
发明人： Nicole Kallewaard-Lelay , Qing Zhu , Godfrey Jonah Rainey , Cuihua Gao , Srinath Kasturirangan , Changshou Gao
CPC分类号： C07K16/1018 , A61P31/16 , A61K2039/505 , A61K2039/545 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/66 , C07K2317/72 , C07K2317/74 , C07K2317/76 , C07K2317/92
摘要： Binding molecules, including bispecific antibodies that include at least two anti-influenza binding domains are disclosed, including binding molecules having a first binding domain that specifically binds influenza A virus and a second binding domain that specifically binds influenza B virus.
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公开(公告)号：US11787853B2
公开(公告)日：2023-10-17
申请号：US17499495
申请日：2021-10-12
申请人： MEDIMMUNE, LLC , HUMABS BIOMED SA
发明人： Nicole Kallewaard-Lelay , Qing Zhu , Ebony Benjamin , Leslie Wachter , Andy Yuan , Josephine Mary Mcauliffe , Davide Corti , Antonio Lanzavecchia
IPC分类号： C07K16/10 , A61P31/16 , G01N33/569 , A61K39/00
CPC分类号： C07K16/1018 , A61P31/16 , G01N33/56983 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/76 , C07K2317/92 , G01N2333/11 , G01N2469/10
摘要： The invention relates to antibodies and antigen binding fragments thereof that are capable of binding to influenza B virus hemagglutinin (HA) and neutralizing influenza B virus in two phylogenetically distinct lineages. In one embodiment, the antibody or antigen binding fragment is capable of binding to influenza B virus hemagglutinin and neutralizing influenza B virus in Yamagata and Victoria lineages.
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公开(公告)号：US20230192803A1
公开(公告)日：2023-06-22
申请号：US18046728
申请日：2022-10-14
申请人： MedImmune, LLC
IPC分类号： C07K14/705 , C12N15/86 , A61P35/04
CPC分类号： C07K14/705 , C12N15/86 , A61P35/04 , C07K2319/03 , C07K2319/30
摘要： The disclosure provides chimeric antigen receptors and antibodies that comprise antigen-binding domains that specifically bind human STEAP2, nucleotides that encode the same, cells comprising the same, and methods of using the same in the treatment of cancer (e.g., prostate cancer).
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公开(公告)号：US20230112916A1
公开(公告)日：2023-04-13
申请号：US18054757
申请日：2022-11-11
申请人： MEDIMMUNE, LLC
发明人： Nicole KALLEWAARD-LELAY , Qing ZHU , Godfrey Jonah RAINEY , Cuihua GAO , Srinath KASTURIRANGAN , Changshou GAO
摘要： Binding molecules, including bispecific antibodies that include at least two anti-influenza binding domains are disclosed, including binding molecules having a first binding domain that specifically binds influenza A virus and a second binding domain that specifically binds influenza B virus.
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公开(公告)号：US11555175B2
公开(公告)日：2023-01-17
申请号：US16679713
申请日：2019-11-11
申请人： Medimmune, LLC
发明人： Brena Williams , Jeong Lee
摘要： This application provides improved cell culture media and cell culture methods comprising N-acetylcysteine. These improved cell culture media and cell culture methods increase cell viability, cellular growth rate and/or reduce cell doubling time of cholesterol auxotrophic cells, myeloma cells, and hybridoma cells.
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