公开(公告)号：US20240209067A1

公开(公告)日：2024-06-27

申请号：US18425919

申请日：2024-01-29

申请人： MEDIMMUNE, LLC ,  HUMABS BIOMED SA

发明人： Ebony BENJAMIN ,  Nicole KALLEWAARD-LELAY ,  Josephine Mary MCAULIFFE ,  Frances PALMER-HILL ,  Leslie WACHTER ,  Andy YUAN ,  Qing ZHU ,  Davide CORTI ,  Antonio LANZAVECCHIA ,  Barbara GUARINO ,  Anna DEMARCO

IPC分类号： C07K16/10 ,  A61K31/13 ,  A61K31/215 ,  A61K31/7012 ,  A61K39/00 ,  A61K39/395 ,  A61K39/42 ,  A61K45/06 ,  C12P21/00 ,  G01N33/569 ,  G01N33/577

CPC分类号： C07K16/1018 ,  A61K31/13 ,  A61K31/215 ,  A61K31/7012 ,  A61K39/3955 ,  A61K39/42 ,  A61K45/06 ,  C12P21/005 ,  G01N33/56983 ,  G01N33/577 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/622 ,  C07K2317/624 ,  C07K2317/626 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92 ,  G01N2333/11

摘要： The invention relates to antibodies and binding fragments thereof that are capable of binding to influenza A virus hemagglutinin and neutralizing at least one group 1 subtype and at least 1 group 2 subtype of influenza A virus.

公开(公告)号：US20240132587A1

公开(公告)日：2024-04-25

申请号：US18481725

申请日：2023-10-04

申请人： MEDIMMUNE, LLC

发明人： ALLISON MARIE BARRETT ,  ZACHARY THOMAS BRITTON ,  SHANNON BREEN ,  ROSA CARRASCO ,  CHUNNING YANG ,  GORDON MOODY ,  AMANDA HATKE

IPC分类号： C07K16/28 ,  A61K39/00 ,  A61P35/00 ,  C07K14/705 ,  C07K14/71 ,  C07K14/725 ,  C07K14/73 ,  C12N5/0783 ,  C12N15/86

CPC分类号： C07K16/28 ,  A61K39/4631 ,  A61K39/464402 ,  A61P35/00 ,  C07K14/7051 ,  C07K14/70514 ,  C07K14/70517 ,  C07K14/70521 ,  C07K14/71 ,  C12N5/0636 ,  C12N15/86 ,  C07K2317/622 ,  C07K2319/03 ,  C12N2740/15043

摘要： This disclosure relates to compositions and methods for treating cancer using chimeric antigen receptor T cells and/or antigen binding domains targeting CLDN18.2.

公开(公告)号：US11932682B2

公开(公告)日：2024-03-19

申请号：US17507482

申请日：2021-10-21

申请人： MEDIMMUNE, LLC ,  HUMABS BIOMED SA

发明人： Ebony Benjamin ,  Nicole Kallewaard-LeLay ,  Josephine Mary McAuliffe ,  Frances Palmer-Hill ,  Leslie Wachter ,  Andy Yuan ,  Qing Zhu ,  Davide Corti ,  Antonio Lanzavecchia ,  Barbara Guarino ,  Anna DeMarco

IPC分类号： A61K31/13 ,  A61K31/215 ,  A61K31/7012 ,  A61K39/395 ,  A61K39/42 ,  A61K45/06 ,  C07K16/10 ,  C12P21/00 ,  G01N33/569 ,  G01N33/577 ,  A61K39/00

CPC分类号： C07K16/1018 ,  A61K31/13 ,  A61K31/215 ,  A61K31/7012 ,  A61K39/3955 ,  A61K39/42 ,  A61K45/06 ,  C12P21/005 ,  G01N33/56983 ,  G01N33/577 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/622 ,  C07K2317/624 ,  C07K2317/626 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92 ,  G01N2333/11 ,  A61K39/3955 ,  A61K2300/00 ,  A61K31/215 ,  A61K2300/00 ,  A61K31/7012 ,  A61K2300/00 ,  A61K31/13 ,  A61K2300/00

摘要： The invention relates to antibodies and binding fragments thereof that are capable of binding to influenza A virus hemagglutinin and neutralizing at least one group 1 subtype and at least 1 group 2 subtype of influenza A virus.

公开(公告)号：US20240076357A1

公开(公告)日：2024-03-07

申请号：US18463736

申请日：2023-09-08

申请人： MEDIMMUNE, LLC ,  HUMABS BIOMED SA

发明人： Nicole KALLEWAARD-LELAY ,  Qing ZHU ,  Ebony BENJAMIN ,  Leslie WACHTER ,  Andy YUAN ,  Josephine Mary MCAULIFFE ,  Davide CORTI ,  Antonio LANZAVECCHIA

IPC分类号： C07K16/10 ,  A61P31/16 ,  G01N33/569

CPC分类号： C07K16/1018 ,  A61P31/16 ,  G01N33/56983 ,  A61K2039/505

摘要： The invention relates to antibodies and antigen binding fragments thereof that are capable of binding to influenza B virus hemagglutinin (HA) and neutralizing influenza B virus in two phylogenetically distinct lineages. In one embodiment, the antibody or antigen binding fragment is capable of binding to influenza B virus hemagglutinin and neutralizing influenza B virus in Yamagata and Victoria lineages.

公开(公告)号：US11912782B2

公开(公告)日：2024-02-27

申请号：US17215479

申请日：2021-03-29

申请人： MedImmune, LLC

发明人： Krista Kinneer ,  Reena Varkey ,  Xiaodong Xiao ,  Elaine M. Hurt ,  David Tice

IPC分类号： C07K16/30 ,  C07K16/28 ,  A61K47/68 ,  A61P35/00 ,  A61K31/202 ,  A61K31/4741 ,  A61K31/551 ,  A61K31/7048 ,  C12N15/62 ,  A61K39/00

CPC分类号： C07K16/3061 ,  A61K31/202 ,  A61K31/4741 ,  A61K31/551 ,  A61K31/7048 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6867 ,  A61P35/00 ,  C07K16/2878 ,  C12N15/62 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/73 ,  C07K2317/77 ,  C07K2317/92

摘要： The disclosure is directed to an antibody-drug conjugate (ADC) comprising a monoclonal antibody, or an antigen-binding fragment thereof, directed against B-cell maturation antigen (BCMA) conjugated to a cytotoxin. The disclosure also provides compositions comprising the antibody-drug conjugate and methods of killing multiple myeloma cells (including multiple myeloma stems cells) that express BCMA by contacting multiple myeloma cells with the ADC.

公开(公告)号：US20230420081A1

公开(公告)日：2023-12-28

申请号：US18367923

申请日：2023-09-13

申请人： MEDIMMUNE, LLC

发明人： Li Yu ,  Harry Yang ,  Mohammed Dar ,  Lorin Roskos ,  Jean-Charles Soria ,  Charles Ferte ,  Wei Zhao ,  Aline Gendrin Brokmann ,  Jolyon Faria ,  Pralay Mukhopadhyay ,  Ikbel Achour

IPC分类号： G16B40/20 ,  G16B5/20 ,  G06N20/20 ,  G16H50/20 ,  G16H50/50 ,  G16H50/30 ,  G06N5/01

CPC分类号： G16B40/20 ,  G16B5/20 ,  G06N20/20 ,  G16H50/20 ,  G16H50/50 ,  G16H50/30 ,  G06N5/01 ,  G16H20/40

摘要： Methods for determining treatments for cancer patients are disclosed.

公开(公告)号：US20230381311A1

公开(公告)日：2023-11-30

申请号：US18177387

申请日：2023-03-02

申请人： MedImmune, LLC

发明人： Sajal M. PATEL ,  Swapnil K. PANSARE

IPC分类号： A61K39/395 ,  A61K47/26 ,  A61K9/08 ,  A61K9/19 ,  C07K16/00 ,  C07K14/00 ,  A61K38/00 ,  A61K47/18

CPC分类号： A61K39/39591 ,  A61K47/26 ,  A61K9/08 ,  A61K9/19 ,  C07K16/00 ,  C07K14/00 ,  A61K38/00 ,  A61K47/183 ,  A61K39/00

摘要： The present invention relates to improved pharmaceutical compositions that contain high concentrations of one or more protein biomolecule(s). In particular, the invention relates to pharmaceutical compositions that include an optimized ratio of protein biomolecule to an amorphous stabilizing compound or compounds, especially a sugar, such as sucrose, trehalose, glucose, lactose or sorbitol, or mixtures thereof, or one or more amino acid molecules such as arginine, alanine, glycine, lysine or proline, or derivatives and salts thereof, or mixtures thereof. The inclusion of such amorphous stabilizing compound(s), at such optimized ratio, provides acceptable long-term stability of the protein biomolecule, and facilitates shorter lyophilization time, more specifically shorter drying time, even more specifically shorter primary drying time.

公开(公告)号：US11759526B2

公开(公告)日：2023-09-19

申请号：US16615582

申请日：2018-05-25

申请人： MedImmune, LLC ,  The Regents Of The University Of California

发明人： Ronald James Christie ,  Changshou Gao ,  Andre Henri St. Amant ,  Javier Read de Alaniz

IPC分类号： A61K47/68 ,  A61K47/69 ,  C07C271/22 ,  C07D207/46

CPC分类号： A61K47/6811 ,  A61K47/6889 ,  A61K47/6923 ,  C07C271/22 ,  C07D207/46 ,  C07C2601/10 ,  C07C2602/50

摘要： The present invention provides a bioconjugation method and compounds for use therein. The bioconjugation method comprises the step of conjugating a biological molecule containing a first unsaturated functional group with a payload comprising a second unsaturated functional group, wherein the first and second unsaturated functional groups are complementary to each other such that conjugation is a reaction of said functional groups via a Diels-Alder reaction which forms a cyclohexene ring.

公开(公告)号：US11661449B2

公开(公告)日：2023-05-30

申请号：US17451955

申请日：2021-10-22

申请人： MedImmune, LLC

发明人： Nancy Ulbrandt ,  Nicole Kallewaard-Lelay ,  Andy Q. Yuan ,  Bettina Richter

IPC分类号： C07K16/10 ,  A61K39/00

CPC分类号： C07K16/1027 ,  A61K2039/505 ,  C07K2317/34 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/90

摘要： This application provides antibodies and functional equivalents thereof which are capable of specifically binding RSV, as well as means and methods for producing them.

公开(公告)号：US11608375B2

公开(公告)日：2023-03-21

申请号：US17060711

申请日：2020-10-01

申请人： MedImmune, LLC

发明人： Nabendu Pore ,  Martin J. Borrok, III ,  Emil F. Michelotti ,  David A. Tice ,  Robert E. Hollingsworth ,  Chien-Ying Chang ,  Partha Chowdhury

IPC分类号： C07K16/00 ,  C07K16/28 ,  A61K47/68 ,  G01N33/574 ,  A61K39/00

摘要： This disclosure provides ASCT2-binding molecules, e.g., anti-ASCT2 antibodies, and antigen-binding fragments thereof. In certain aspects, the ASCT2-binding molecules are conjugated to cytotoxic drugs, e.g., ASCT2 antibody-drug conjugates (ADCs). In certain aspects, the anti-ASCT2 antibodies and fragments thereof can be hybridoma-derived murine monoclonal antibodies, and humanized versions thereof. In certain aspects, the ASCT2-binding molecules bind specifically to cells expressing ASCT2, and in some instances, are internalized into the cells. In addition, this disclosure provides compositions and methods for diagnosing and treating diseases or disorders characterized by ASCT2 overexpression, e.g., certain types of cancer. In a particular embodiment, the disclosure provides methods for treating cancer using ASCT2 ADCs.