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13 条记录 (耗时 0.014 秒)

    Antiprotozoal compounds
    4.
    发明授权
    Antiprotozoal compounds 有权
    抗原生动物化合物

    公开(公告)号：US09475788B2

    公开(公告)日：2016-10-25

    申请号：US14919037

    申请日：2015-10-21

    申请人： Dennis Michael Godek ,  Harry Ralph Howard

    发明人： Dennis Michael Godek ,  Harry Ralph Howard

    IPC分类号： C07D405/04 ,  A61K31/4025 ,  A61P33/06 ,  C07D307/87

    CPC分类号： C07D307/87 ,  C07D405/04

    摘要： The invention is directed to a compound of formula I, a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing a compound of formula I, and a method of treatment of a disorder or condition selected from the group consisting of Human African Trypanosomiasis (HAT), Chagas disease, Leishmaniasis and malaria.

    摘要翻译： 本发明涉及式I化合物，其药学上可接受的盐，含有式I化合物的药物组合物，以及治疗选自以下的疾病或病症的方法：人非洲锥虫病（HAT）， 恰加斯病，利什曼病和疟疾。

    Histamine-3 Receptor Antagonists
    6.
    发明申请
    Histamine-3 Receptor Antagonists 审中-公开
    组胺3受体拮抗剂

    公开(公告)号：US20160237052A1

    公开(公告)日：2016-08-18

    申请号：US14624821

    申请日：2015-02-18

    申请人： Dennis Michael Godek ,  Harry Ralph Howard

    发明人： Dennis Michael Godek ,  Harry Ralph Howard

    IPC分类号： C07D307/87

    CPC分类号： C07D307/87

    摘要： The invention is directed to a compound of formula I, as defined herein, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing a compound of formula I; and a method of treatment of a disorder or condition selected from the list consisting of acute myocardial infarction; memory processes disorders; dementia; cognition disorders such as Alzheimer's disease; attention deficit disorder (ADD); attention-deficit hyperactivity disorder (ADHD); cancers such as cutaneous carcinoma, medullary thyroid carcinoma and melanoma; Meniere's disease; gastrointestinal disorders; inflammation; migraine; motion sickness; obesity; pain; septic shock; respiratory disorders (including allergic rhinitis, nasal congestion and allergic congestion) in a mammal, including a human, that may be effected by administering to said mammal a pharmacologically effective amount of a compound of formula I, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

    摘要翻译： 本发明涉及如本文定义的式I化合物或其药学上可接受的盐; 含有式I化合物的药物组合物; 以及治疗选自急性心肌梗塞的病例或病症的方法; 记忆过程障碍; 痴呆; 认知障碍如阿尔茨海默病; 注意缺陷障碍（ADD）; 注意缺陷多动障碍（ADHD）; 癌症如皮肤癌，甲状腺髓样癌和黑素瘤; 梅尼埃病; 胃肠道疾病; 炎; 偏头痛 晕车 肥胖; 疼痛; 败血性休克 包括人在内的哺乳动物的呼吸障碍（包括过敏性鼻炎，鼻塞和过敏充血），其可以通过向所述哺乳动物施用药理学有效量的式I化合物或其药学上可接受的盐，和 药用载体。