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1.发明公开公开(公告)号：US20240354599A1
公开(公告)日：2024-10-24
申请号：US18304594
申请日：2023-04-21
发明人： Hao-Wei Chen , Chung-Yao Kao , Jung-Ting Lee , Yu-Chen Chen
摘要： A method for determining a probability of a kidney stone in a subject being a uric-acid (UA) stone includes steps of: establishing, by using a machine learning algorithm, a prediction model based on a plurality of training data sets that are related to a plurality of patients, each of the plurality of training data sets at least including an estimated glomerular filtration rate (eGFR) and a value of urine pH; and feeding an input variable set into the prediction model so as to obtain the probability of the kidney stone in the subject being a UA stone. The input variable set is related to the subject and including an eGFR and a value of urine pH of the subject.
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公开(公告)号：US20240352097A1
公开(公告)日：2024-10-24
申请号：US18637905
申请日：2024-04-17
发明人： Day-Yu CHAO , Yen-Hsu Chen , Wen-Hung Wang
CPC分类号： C07K16/1081 , A61P31/14 , A61K2039/505 , C07K2317/565 , C07K2317/76
摘要： The present disclosure provides a neutralizing antibody for flaviviruses, a production method, a method of treating or preventing a flaviviruses infection in a subject, and the use thereof.
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公开(公告)号：US12098463B2
公开(公告)日：2024-09-24
申请号：US17583714
申请日：2022-01-25
发明人： Chun-Hu Chen , Ren-Huai Jhang , Chang-Ying Yang
IPC分类号： C23C18/12
CPC分类号： C23C18/1216 , C23C18/1295
摘要： A method for manufacturing an amorphous multielement metal oxide hydroxide film includes: A liquid mixture is formed by dissolving an oxidizing agent selected from a group consisting of potassium permanganate, potassium chromate, potassium dichromate and potassium ferrate, and a reducing agent in a solvent. The oxidizing agent forms an oxometallate anion having a first metal atom with a first valence number. The reducing agent forms a metal cation having a second metal atom with a third valence number. An amorphous multielement metal oxide hydroxide film is deposited on a substrate by soaking the substrate in the liquid mixture. The amorphous multielement metal oxide hydroxide film includes a multielement metal oxide hydroxide having the first metal atom with a second valence smaller than the first valence number and the second metal atom with a fourth valence number larger than the third valence number.
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公开(公告)号：US12092872B2
公开(公告)日：2024-09-17
申请号：US17933487
申请日：2022-09-20
发明人： Yung-Jr Hung , Tzu-Hsiang Yen
IPC分类号： G02B6/293
CPC分类号： G02B6/29355 , G02B6/2938
摘要： A waveguide division multiplexer and demultiplexer includes a first-stage Mach-Zehnder interferometer (MZI) and two second-stage MZIs. The first-stage MZI includes two input ends and two output ends, in which one of the inputs is configured to receive an input optical beam with a first center wavelength and a second center wavelength, and the output ends are configured to respectively transmit first-stage output optical beams respectively with the first center wavelength and the second center wavelength. One input terminals of the second-stage MZI are configured to respectively receive the first-stage output optical beams, and one output terminals of the second-stage MZI are configured to transmit second-stage output optical beams with the first and second center wavelengths, respectively. Each second-stage MZI is configured in cross-state condition.
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5.发明公开公开(公告)号：US20240276240A1
公开(公告)日：2024-08-15
申请号：US18143704
申请日：2023-05-05
发明人： Chao-Kai WEN , Feng-Ji CHEN , Tzu-Hao HUANG , De-Ming CHIAN , Chuan-Yuan WANG
IPC分类号： H04W24/02 , H04L43/065
CPC分类号： H04W24/02 , H04L43/065
摘要： A method for signal optimization between a user equipment and a reconfigurable intelligence surface includes a phase optimization step having: generating at least one modified phase combination in the state that a performance index of a current phase combination is smaller than a preset performance threshold value; evaluating whether a corresponding performance index of the modified phase combination is not smaller than the preset performance threshold value or evaluating whether the performance index of the modified phase combination is larger than the corresponding performance index of the current phase combination, to determine an optimized phase combination, enabling a corresponding performance index to be not smaller than the preset performance threshold value or not smaller than the performance index of any modified phase combination in the phase optimization step; and replacing the current phase combination by the optimized phase combination to form an updated current phase combination.
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公开(公告)号：US20240199632A1
公开(公告)日：2024-06-20
申请号：US18517497
申请日：2023-11-22
申请人： National Health Research Institutes , National Sun Yat-Sen University , National Museum of Marine Biology and Aquarium
发明人： Lun Kelvin Tsou , Guang-Hao Niu , Hsing-Pang Hsieh , Mingzi Zhang , Zhi-Hong Wen , Ping-Jyun Sung
IPC分类号： C07D493/04 , C07D307/935 , C07D413/04
CPC分类号： C07D493/04 , C07D307/935 , C07D413/04
摘要： Disclosed are compounds compound of Formula (I):
Each variable is defined herein. Also included are pharmaceutical compositions containing such a compound and a method of treating an inflammatory condition.-
7.发明公开公开(公告)号：US20230372405A1
公开(公告)日：2023-11-23
申请号：US18351018
申请日：2023-07-12
发明人： Zhi-Hong Wen , Ping-Jyun Sung , Han-Chun Hung , Chun-Hong Chen , Yu-Chia Chang
IPC分类号： A61K35/614 , A61K8/96
CPC分类号： A61K35/614 , A61K8/965 , A61K2236/331
摘要： The present invention relates to a coral composite extract, a composition including the same and a method of producing the same. The coral composite extract includes at least two briarane-type diterpenoid compounds from corals of Briareum violaceum, B. excavatum and B. stechei, thereby being applied as an effective ingredient of a skin external use composition, a cosmetic composition and a medicinal composition.
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公开(公告)号：US20230333235A1
公开(公告)日：2023-10-19
申请号：US17879987
申请日：2022-08-03
发明人： Fu-Kang Wang , Ju-Yin Shih
CPC分类号： G01S13/581 , G01S7/295 , G01S7/40
摘要： A real number sine/cosine wave basis function transform circuit includes a window segmentation element, a first transform element, a second transform element and a root-sum-square (RSS) element. The window segmentation element is provided to segment an in-phase output signal and a quadrature output signal to output an in-phase window signal and a quadrature window signal. The first and second transform elements are provided to transform the in-phase window signal and the quadrature window signal using a real number sine/cosine wave basis function to obtain a first transformed signal and a second transformed signal, respectively. The RSS element is provided to calculate an RSS value of the first and second transformed signals and output a real number sine/cosine wave basis function transformed signal.
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公开(公告)号：US11780877B2
公开(公告)日：2023-10-10
申请号：US17954929
申请日：2022-09-28
发明人： Po-Chiao Lin , Chih-Hung Chou
CPC分类号： C07K1/1077 , C07K16/00
摘要： The present invention provides a method of sugar-guided modifying a glycosylated polypeptide. First, a boronic acid group of a probe molecule and a sugar group of the glycosylated polypeptide form a first covalent bond. Next, an alkyne group of a modifying group and an azide group of the probe molecule form a second covalent bond by adding a promoter. As a result, the modifying group can be close to the glycosylated polypeptide. Then, the modifying group can bind to a nucleophilic residue that is near the sugar group, through a nucleophilic addition reaction. The method of the present invention can selectively modify a given site with the guidance of the sugar group.
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公开(公告)号：US20230238079A1
公开(公告)日：2023-07-27
申请号：US18146571
申请日：2022-12-27
发明人： Jim Jinn-Chyuan Sheu , Chung Chang , Bo-Chen Lin , Li-Yun Yang , You-Jun Lai
摘要： The present invention relates to a method and a kit, a computer-implemented method and a system for in vitro predicting survival time of an individual with bladder cancer after surgery from an individual's biological sample. Expression levels of a target gene combination of in vitro aggressive bladder cancer specimen of a patient are detected, and the target gene combination includes at least two of PPT2, ARMH4, P4HB, SLC1A6 and ARID3A, a fragment, a homologue, a variant and a derivative thereof. Next, the expression levels are respectively compared with the reference expression levels of a reference database, and converted to a risk score sum, thereby predicting an averaged survival time of a patient having aggressive bladder cancer after surgery, and being beneficially applied to a kit and a computer-implemented method for in vitro predicting survival time of patient with most aggressive types of bladder cancer after surgery.
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