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![NEAR-INFRARED NERVE-SPARING BENZO[C]PHENOXAZINE FLUOROPHORES](/abs-image/US/2024/10/24/US20240352035A1/abs.jpg.150x150.jpg)
公开(公告)号：US20240352035A1
公开(公告)日：2024-10-24
申请号：US18755492
申请日：2024-06-26
发明人： Summer L. Gibbs , Lei G. Wang , Connor W. Barth
IPC分类号： C07D498/04 , A61B5/00 , C09K11/06
CPC分类号： C07D498/04 , C09K11/06 , A61B5/0071 , A61B5/0075 , C09K2211/1033
摘要： Provided are near-infrared nerve-sparing fluorescent compounds, compositions comprising them, and methods of their use in medical procedures.
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2.发明公开公开(公告)号：US20240336972A1
公开(公告)日：2024-10-10
申请号：US18292884
申请日：2022-01-05
发明人： Wesley Yu
IPC分类号： C12Q1/6886 , A61K31/22 , A61K31/366 , A61K31/405 , A61K31/455 , A61K31/47 , A61K31/505 , A61K45/06 , A61P35/00
CPC分类号： C12Q1/6886 , A61K31/22 , A61K31/366 , A61K31/405 , A61K31/455 , A61K31/47 , A61K31/505 , A61K45/06 , A61P35/00 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158
摘要： The present disclosure provides the use of inhibitor(s) of an activity of HMG-CoA reductase (HMGCR) (a statin) to reduce and/or prevent future metastasis and prolong survival inpatients diagnosed with melanoma, for instance determined to be at high-risk of melanoma progression, such as melanoma metastasis. Also disclosed are methods for treating patients with a statin. Optionally, described methods involve measurement of a gene expression profile signature in the primary melanoma.
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公开(公告)号：US12084653B2
公开(公告)日：2024-09-10
申请号：US18160796
申请日：2023-01-27
发明人： Hiroyuki Nakai , Samuel Huang , Kei Adachi
CPC分类号： C12N15/11 , C12N7/00 , C12N15/1082 , C12N15/86 , C12N2310/11 , C12N2320/33 , C12N2750/14122 , C12N2750/14123 , C12N2750/14142 , C12N2750/14145 , C12N2830/008
摘要： Disclosed are methods for performing transcription-dependent directed evolution (TRADE) and novel AAV capsids selected using such methods.
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公开(公告)号：US12030858B2
公开(公告)日：2024-07-09
申请号：US17272015
申请日：2019-08-23
发明人： Michael Cohen , Ilsa Kirby
IPC分类号： C07D239/90 , C07D403/12 , C07D473/38
CPC分类号： C07D239/90 , C07D403/12 , C07D473/38
摘要： Provided are substituted 8-methylquinazolin-4(3H)-one compounds useful as PARP inhibitors for the treatment of cancer and asthma, as well as pharmaceutical compositions comprising them and methods for their synthesis.
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5.发明授权公开(公告)号：US11945855B2
公开(公告)日：2024-04-02
申请号：US17282455
申请日：2019-10-04
申请人： Oregon Health & Science University , The United States Government as represented by the Department of Veterans Affairs
CPC分类号： C07K14/70539 , A61K39/0008 , A61P37/06 , A61K2039/6031
摘要： Recombinant polypeptides comprising a modified DRα1 domain are provided. In some embodiments, the polypeptides include the modified DRα1 domain, an antigenic peptide, and optionally a linker sequence. Pharmaceutical compositions comprising the recombinant polypeptides, methods of treating inflammatory disease using said recombinant polypeptides or pharmaceutical compositions, and expression constructs comprising nucleic acids that encode the recombinant polypeptides are also provided.
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公开(公告)号：US11944382B2
公开(公告)日：2024-04-02
申请号：US17044559
申请日：2019-04-02
CPC分类号： A61B3/102 , A61B3/0025 , A61B5/0066
摘要： Disclosed are methods and systems correcting bulk-motion artifacts in phase-based functional OCT images. The disclosed methods and systems are based on the use of the standard deviation of the phase shift signal present in phase-based OCT imaging. When applied with functional OCT techniques such as OCT angiography, Doppler OCT, and OCT elastography, the disclosed methods provide improved image quality and decreased computational cost compared to other methods of bulk motion compensation.
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7.发明公开公开(公告)号：US20240065544A1
公开(公告)日：2024-02-29
申请号：US18455154
申请日：2023-08-24
CPC分类号： A61B3/102 , A61B5/0066 , A61B5/7203 , G06T5/002 , G06T5/009 , G06T7/0012 , G06T2207/10101 , G06T2207/20021 , G06T2207/20064 , G06T2207/20201 , G06T2207/30041
摘要： Disclosed are methods and systems for signal attenuation-compensated projection-resolved (sacPR) optical coherence tomography angiography (OCTA). The sacPR OCTA may be free of segmentation and vascular contrast enhancement. In some embodiments, projection artifacts may be suppressed with signal compensation including flow and large vessel shadow compensation for projection removal and wavelet-based compensation for noise suppression.
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公开(公告)号：USD1012285S1
公开(公告)日：2024-01-23
申请号：US29736899
申请日：2020-06-03
摘要： FIG. 1 is a front isometric view of a two-point discrimination device for a lanyard showing our new design.
FIG. 2 is a rear isometric view thereof.
FIG. 3 is a front elevation view thereof.
FIG. 4 is a rear elevation view thereof.
FIG. 5 is a right side elevation view thereof, of which the left side elevation view is a mirror image.
FIG. 6 is a top plan view thereof; and,
FIG. 7 is a bottom plan view thereof.
The broken lines in FIGS. 1-4 illustrate portions of the two-point discrimination device for a lanyard that form no part of the claimed design.-
公开(公告)号：US11866462B2
公开(公告)日：2024-01-09
申请号：US16098814
申请日：2017-05-03
发明人： Hiroyuki Nakai , Kei Adachi
IPC分类号： C12N15/86 , A61K39/23 , C07K14/005 , A61K38/00
CPC分类号： C07K14/005 , C12N15/86 , A61K38/00 , C12N2750/14122 , C12N2750/14143 , C12N2830/38
摘要： Disclosed are adeno-associated viral vectors and plasmids encoding the same. Also disclosed are methods of using adeno-associated viral vectors to deliver a protein of interest to the subject. The disclosed vectors have phenotypes including but not limited to increased retention in the blood of a subject, avoidance of the liver, and transduction of the brain and other tissues.
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公开(公告)号：US20230348378A1
公开(公告)日：2023-11-02
申请号：US18042209
申请日：2021-08-20
发明人： Dexing ZENG , Lingyi SUN , Zhonghan LI
IPC分类号： C07D207/46 , A61K51/04 , A61K51/08
CPC分类号： C07D207/46 , A61K51/0497 , A61K51/082 , A61K2121/00
摘要： Compounds are described having albumin binding groups, where said compounds can be complexed with therapeutic and/or diagnostic agents and further can include targeting functionality. When introduced into the circulatory system the compounds and complexes bind serum albumin, and thereby exhibit useful properties including enhanced circulatory half-life, improved uptake by target tissues, and improved target/nontarget ratios. These properties make the compounds and complexes useful in therapeutic and diagnostic methods.
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