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公开(公告)号：US20230055210A1
公开(公告)日：2023-02-23
申请号：US17970819
申请日：2022-10-21
申请人： Phenolics, LLC
IPC分类号： A61K31/664 , A61K31/205 , A61K47/40 , A61K9/50 , A61K47/10 , A61K9/00
摘要： Formulations of creatine, preferably phosphocreatine and most preferably disodium phosphocreatine, combined with cyclodextrin exhibit improved uptake across digestive mucosa, including intestinal, esophageal, and stomach mucosa. In particular, the formulations of the present invention are designed for protection of the creatine as they come in contact with gastric juices so as to allow thereafter for unexpectedly improved site-specific intestinal release.
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公开(公告)号：US20080199548A1
公开(公告)日：2008-08-21
申请号：US11890788
申请日：2007-08-07
申请人： Gerald T. Gourdin , Steven L. Richheimer , Michael S. Tempesta , David T. Bailey , Rebecca L. Nichols , F. Joseph Daugherty , Delano R. Freeberg
发明人： Gerald T. Gourdin , Steven L. Richheimer , Michael S. Tempesta , David T. Bailey , Rebecca L. Nichols , F. Joseph Daugherty , Delano R. Freeberg
CPC分类号： A61K31/352 , A61K31/70 , A61K36/185 , A61K36/35 , A61K36/45 , A61K36/73 , A61K36/736 , A61K36/87 , C07D311/62 , Y02A50/393 , A61K2300/00
摘要： A product made by a process which results in compositions enriched in total phenols includes purification steps not involving the addition of bisulfite ions. The enriched compositions are characterized as containing monomeric, oligomeric and polymeric phenols, total phenol concentration >12% and exhibiting in vitro COX-2 inhibitory activity enhanced by a factor of at least 2.5 over a standard aspirin dose of 660 μg/mL.
摘要翻译： 通过产生富含总酚的组合物的方法制备的产品包括不涉及加入亚硫酸氢盐离子的纯化步骤。 富集的组合物的特征在于含有单体，低聚和聚合物酚，总苯酚浓度> 12％，体外COX-2抑制活性比标准阿司匹林剂量为660mug / mL增加至少2.5倍。
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3.发明申请COMPOSITIONS ENRICHED IN PHENOLIC COMPOUNDS AND METHODS FOR PRODUCING THE SAME 审中-公开苯酚化合物中的组合物及其生产方法公开(公告)号：US20080207770A1
公开(公告)日：2008-08-28
申请号：US11948622
申请日：2007-11-30
申请人： Gerald T. GOURDIN , Steven L. Richheimer , Michael S. Tempesta , David T. Bailey , Rebecca L. Nichols , F. Joseph Daugherty , Delano R. Freeberg
发明人： Gerald T. GOURDIN , Steven L. Richheimer , Michael S. Tempesta , David T. Bailey , Rebecca L. Nichols , F. Joseph Daugherty , Delano R. Freeberg
CPC分类号： C07H17/00 , A61K31/352 , A61K31/70 , A61K36/185 , A61K36/35 , A61K36/38 , A61K36/45 , A61K36/48 , A61K36/63 , A61K36/73 , A61K36/734 , A61K36/752 , A61K36/81 , A61K36/87 , C07D311/62 , Y02A50/393 , A61K2300/00
摘要： Provided are processes for the preparation of compositions enriched in phenolic compounds from a crude plant extract. One process includes a novel column purification step using a polymer resin that releasably adsorbs the phenolic compounds but does not retain polar non-phenolic compounds, wherein the resin comprises aromatic rings substituted with one or more electron-withdrawing groups. This invention also includes compositions enriched in phenolic compounds. This invention encompasses methods of using the phenolic-enriched compositions for treating warm-blooded animals, including humans, infected with paramyxovaridae such as respiratory syncytial virus, orthomyoxovaridae such as influenza A, B, and C, parainfluenza, Herpes viruses such as HSV-1 and HSV-2, and Flaviviruses such as West Nile Virus, and for treating inflammation such as caused by arthritis, stress and digestive disease. The compositions are also useful as meat additives to inhibit food-borne pathogens.
摘要翻译： 提供了从粗植物提取物制备富含酚类化合物的组合物的方法。 一种方法包括使用可释放地吸附酚类化合物但不保留极性非酚类化合物的聚合物树脂的新型柱纯化步骤，其中树脂包含被一个或多个吸电子基团取代的芳环。 本发明还包括富含酚类化合物的组合物。 本发明包括使用富含酚的组合物治疗感染副粘病毒例如呼吸道合胞病毒，正义霉病如甲型流感A，乙型和丙型流感病毒，副流感病毒，疱疹病毒如HSV-1的温血动物包括人的方法 和HSV-2和黄病毒如西尼罗病毒，并用于治疗由关节炎，压力和消化疾病引起的炎症。 组合物还可用作抑制食源性病原体的肉添加剂。
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4.发明申请公开(公告)号：US20050266104A1
公开(公告)日：2005-12-01
申请号：US11179771
申请日：2005-07-12
申请人： Gerald Gourdin , Steven Richheimer , Michael Tempesta , David Bailey , Rebecca Nichols , F. Daugherty , Delano Freeberg
发明人： Gerald Gourdin , Steven Richheimer , Michael Tempesta , David Bailey , Rebecca Nichols , F. Daugherty , Delano Freeberg
IPC分类号： A61K31/352 , A61K31/70 , A61K36/185 , A61K36/35 , A61K36/45 , A61K36/73 , A61K36/736 , A61K36/87 , C07D311/62 , A61K35/78
CPC分类号： A61K31/352 , A61K31/70 , A61K36/185 , A61K36/35 , A61K36/45 , A61K36/73 , A61K36/736 , A61K36/87 , C07D311/62 , Y02A50/393 , A61K2300/00
摘要： This invention provides a process for the preparation of compositions enriched in total phenols from a crude plant extract. The process includes a novel column purification step using a brominated polystyrene resin. This invention also includes compositions enriched in total phenols. The enriched compositions are characterized as containing monomeric, oligomeric and polymeric phenols and having HPLC chromatograms substantially as set forth in FIGS. 10-13. This invention encompasses methods of using the total phenol-enriched compositions for treating warm-blooded animals, including humans, infected with paramyxovaridae such as respiratory syncytial virus, orthomyoxovaridae such as influenza A, B, and C, parainfluenza, Herpes viruses such as HSV-1 and HSV-2, and Flaviviruses such as West Nile Virus, and for treating inflammation such as caused by arthritis, stress and digestive disease.
摘要翻译： 本发明提供了一种从粗植物提取物制备富含总酚的组合物的方法。 该方法包括使用溴化聚苯乙烯树脂的新型柱纯化步骤。 本发明还包括富含总酚的组合物。 富集的组合物的特征在于含有单体，低聚和聚合酚，并且具有基本如图1和2所述的HPLC色谱图。 10 - 13。 本发明包括使用全氟酚组合物治疗感染副粘病毒如呼吸道合胞病毒，正义霉菌如甲型流感A，B和C型副流感，疱疹病毒如HSV- 1和HSV-2，以及黄病毒如西尼罗病毒，并用于治疗由关节炎，应激和消化疾病引起的炎症。
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公开(公告)号：US20220338519A1
公开(公告)日：2022-10-27
申请号：US17716525
申请日：2022-04-08
申请人： Phenolics, LLC
IPC分类号： A23L33/105 , A23L33/175
摘要： Oral supplements containing phenolic compounds such as those present in Vaccinium and/or Sambucus, as well as other genera are enriched in total phenols and combined with either organic acid sodium salts and/or phosphocreatine salts are shown to have enhanced absorption properties. When taken together in an oral supplement, the particular phenolic compound(s) found in such extracts and in other genera containing significant quantities of total phenols are believed to enhance the activity of the phosphocreatine salts in a synergistic manner and result in enhancement of physical activity as well as provide recovery from inflammation.
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公开(公告)号：US20070269536A1
公开(公告)日：2007-11-22
申请号：US11750906
申请日：2007-05-18
申请人： David Bailey , Delano Freeberg , Dennis Gertenbach , Gerald Gourdin , Steven Richheimer , Michael Tempesta , F. Daugherty
发明人： David Bailey , Delano Freeberg , Dennis Gertenbach , Gerald Gourdin , Steven Richheimer , Michael Tempesta , F. Daugherty
IPC分类号： A61K36/45
CPC分类号： C07D311/62 , A23L33/105 , A61K31/352 , A61K36/074 , A61K36/185 , A61K36/29 , A61K36/31 , A61K36/35 , A61K36/39 , A61K36/45 , A61K36/73 , A61K36/736 , A61K36/81 , A61K36/87 , A61K36/899 , A61K2300/00
摘要： This invention provides compositions enriched for anthocyanins and methods of preparation thereof from a crude plant extract. The method of preparation includes a novel column purification step using a brominated polystyrene resin.
摘要翻译： 本发明提供富含花青素的组合物及其制备方法。 制备方法包括使用溴化聚苯乙烯树脂的新型柱纯化步骤。
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公开(公告)号：US06960360B2
公开(公告)日：2005-11-01
申请号：US10302264
申请日：2002-11-22
申请人： Gerald T. Gourdin , Steven L. Richheimer , Michael S. Tempesta , David T. Bailey , Rebecca L. Nichols , F. Joseph Daugherty , Delano R. Freeberg
发明人： Gerald T. Gourdin , Steven L. Richheimer , Michael S. Tempesta , David T. Bailey , Rebecca L. Nichols , F. Joseph Daugherty , Delano R. Freeberg
IPC分类号： A61K31/352 , A61K31/70 , A61K36/185 , A61K36/35 , A61K36/45 , A61K36/73 , A61K36/736 , A61K36/87 , C07D311/62 , A61K35/78 , A61K47/00 , C07H17/00 , C07D311/04
CPC分类号： A61K31/352 , A61K31/70 , A61K36/185 , A61K36/35 , A61K36/45 , A61K36/73 , A61K36/736 , A61K36/87 , C07D311/62 , Y02A50/393 , A61K2300/00
摘要： This invention provides a process for the preparation of compositions enriched in total phenols from a crude plant extract. The process includes a novel column purification step using a brominated polystyrene resin. This invention also includes compositions enriched in total phenols. The enriched compositions are characterized as containing monomeric, oligomeric and polymeric phenols and having HPLC chromatograms substantially as set forth in FIGS. 10-13. This invention encompasses methods of using the total phenol-enriched compositions for treating warm-blooded animals, including humans, infected with paramyxovaridae such as respiratory syncytial virus, orthomyoxovaridae such as influenza A, B, and C, parainfluenza, Herpes viruses such as HSV-1 and HSV-2, and Flaviviruses such as West Nile Virus, and for treating inflammation such as caused by arthritis, stress and digestive disease.
摘要翻译： 本发明提供了一种从粗植物提取物制备富含总酚的组合物的方法。 该方法包括使用溴化聚苯乙烯树脂的新型柱纯化步骤。 本发明还包括富含总酚的组合物。 富集的组合物的特征在于含有单体，低聚和聚合酚，并且具有基本如图1和2所述的HPLC色谱图。 10-13。 本发明包括使用全氟酚组合物治疗感染副粘病毒如呼吸道合胞病毒，正义霉菌科如A，B和C型流感的副流感病毒，疱疹病毒如HSV- 1和HSV-2，以及黄病毒如西尼罗病毒，并用于治疗由关节炎，应激和消化疾病引起的炎症。
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公开(公告)号：US20210361731A1
公开(公告)日：2021-11-25
申请号：US17326125
申请日：2021-05-20
申请人： Phenolics, LLC
IPC分类号： A61K36/45 , A61K31/14 , A61K31/155 , A61K33/00 , A61K9/00 , A23L33/105 , A23L29/00
摘要： The oral supplements of the present invention utilize phenolic compounds in combination with creatine, choline, and trisodium citrate, wherein when taken together result in enhanced cellular permeation in comparison to cellular permeation in the absence of the other compounds of the combination leading to improved brain and/or physical functioning.
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公开(公告)号：US07682637B2
公开(公告)日：2010-03-23
申请号：US11890788
申请日：2007-08-07
申请人： Gerald T. Gourdin , Steven L. Richheimer , Michael S. Tempesta , David T. Bailey , Rebecca L. Nichols , F. Joseph Daugherty , Delano R. Freeberg
发明人： Gerald T. Gourdin , Steven L. Richheimer , Michael S. Tempesta , David T. Bailey , Rebecca L. Nichols , F. Joseph Daugherty , Delano R. Freeberg
CPC分类号： A61K31/352 , A61K31/70 , A61K36/185 , A61K36/35 , A61K36/45 , A61K36/73 , A61K36/736 , A61K36/87 , C07D311/62 , Y02A50/393 , A61K2300/00
摘要： A product made by a process which results in compositions enriched in total phenols includes purification steps not involving the addition of bisulfite ions. The enriched compositions are characterized as containing monomeric, oligomeric and polymeric phenols, total phenol concentration >12% and exhibiting in vitro COX-2 inhibitory activity enhanced by a factor of at least 2.5 over a standard aspirin dose of 660 μg/mL.
摘要翻译： 通过产生富含总酚的组合物的方法制备的产品包括不涉及加入亚硫酸氢盐离子的纯化步骤。 富集的组合物的特征在于含有单体，低聚和聚合物酚，总苯酚浓度> 12％，体外COX-2抑制活性比标准阿司匹林剂量为660μg/ mL增加至少2.5倍。
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公开(公告)号：US20090099373A1
公开(公告)日：2009-04-16
申请号：US12262000
申请日：2008-10-30
申请人： David T. BAILEY , Delano R. Freeberg , Dennis Gertenbach , Gerald T. Gourdin , Steven L. Richheimer , Michael S. Tempesta , F. Joseph Daugherty
发明人： David T. BAILEY , Delano R. Freeberg , Dennis Gertenbach , Gerald T. Gourdin , Steven L. Richheimer , Michael S. Tempesta , F. Joseph Daugherty
IPC分类号： C07D311/00
CPC分类号： C07D311/62 , A23L33/105 , A61K31/352 , A61K36/074 , A61K36/185 , A61K36/29 , A61K36/31 , A61K36/35 , A61K36/39 , A61K36/45 , A61K36/73 , A61K36/736 , A61K36/81 , A61K36/87 , A61K36/899 , A61K2300/00
摘要： This invention provides compositions enriched for anthocyanins and methods of preparation thereof from a crude plant extract. The method of preparation includes a novel column purification step using a brominated polystyrene resin.
摘要翻译： 本发明提供富含花青素的组合物及其制备方法。 制备方法包括使用溴化聚苯乙烯树脂的新型柱纯化步骤。
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