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1.发明申请COMPOSITIONS ENRICHED IN PHENOLIC COMPOUNDS AND METHODS FOR PRODUCING THE SAME 审中-公开苯酚化合物中的组合物及其生产方法公开(公告)号：US20080207770A1
公开(公告)日：2008-08-28
申请号：US11948622
申请日：2007-11-30
申请人： Gerald T. GOURDIN , Steven L. Richheimer , Michael S. Tempesta , David T. Bailey , Rebecca L. Nichols , F. Joseph Daugherty , Delano R. Freeberg
发明人： Gerald T. GOURDIN , Steven L. Richheimer , Michael S. Tempesta , David T. Bailey , Rebecca L. Nichols , F. Joseph Daugherty , Delano R. Freeberg
CPC分类号： C07H17/00 , A61K31/352 , A61K31/70 , A61K36/185 , A61K36/35 , A61K36/38 , A61K36/45 , A61K36/48 , A61K36/63 , A61K36/73 , A61K36/734 , A61K36/752 , A61K36/81 , A61K36/87 , C07D311/62 , Y02A50/393 , A61K2300/00
摘要： Provided are processes for the preparation of compositions enriched in phenolic compounds from a crude plant extract. One process includes a novel column purification step using a polymer resin that releasably adsorbs the phenolic compounds but does not retain polar non-phenolic compounds, wherein the resin comprises aromatic rings substituted with one or more electron-withdrawing groups. This invention also includes compositions enriched in phenolic compounds. This invention encompasses methods of using the phenolic-enriched compositions for treating warm-blooded animals, including humans, infected with paramyxovaridae such as respiratory syncytial virus, orthomyoxovaridae such as influenza A, B, and C, parainfluenza, Herpes viruses such as HSV-1 and HSV-2, and Flaviviruses such as West Nile Virus, and for treating inflammation such as caused by arthritis, stress and digestive disease. The compositions are also useful as meat additives to inhibit food-borne pathogens.
摘要翻译： 提供了从粗植物提取物制备富含酚类化合物的组合物的方法。 一种方法包括使用可释放地吸附酚类化合物但不保留极性非酚类化合物的聚合物树脂的新型柱纯化步骤，其中树脂包含被一个或多个吸电子基团取代的芳环。 本发明还包括富含酚类化合物的组合物。 本发明包括使用富含酚的组合物治疗感染副粘病毒例如呼吸道合胞病毒，正义霉病如甲型流感A，乙型和丙型流感病毒，副流感病毒，疱疹病毒如HSV-1的温血动物包括人的方法 和HSV-2和黄病毒如西尼罗病毒，并用于治疗由关节炎，压力和消化疾病引起的炎症。 组合物还可用作抑制食源性病原体的肉添加剂。
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2.发明授权公开(公告)号：US07306815B2
公开(公告)日：2007-12-11
申请号：US10764231
申请日：2004-01-23
申请人： Gerald T. Gourdin , Steven L. Richheimer , Michael S. Tempesta , David T. Bailey , Rebecca L. Nichols , F. Joseph Daugherty , Delano R. Freeberg
发明人： Gerald T. Gourdin , Steven L. Richheimer , Michael S. Tempesta , David T. Bailey , Rebecca L. Nichols , F. Joseph Daugherty , Delano R. Freeberg
IPC分类号： A61K36/00 , A61K36/45 , C07H17/00 , C07D311/00
CPC分类号： C07H17/00 , A61K31/352 , A61K31/70 , A61K36/185 , A61K36/35 , A61K36/38 , A61K36/45 , A61K36/48 , A61K36/63 , A61K36/73 , A61K36/734 , A61K36/752 , A61K36/81 , A61K36/87 , C07D311/62 , Y02A50/393 , A61K2300/00
摘要： Provided are processes for the preparation of compositions enriched in phenolic compounds from a crude plant extract. One process includes a novel column purification step using a polymer resin that releasably adsorbs the phenolic compounds but does not retain polar non-phenolic compounds, wherein the resin comprises aromatic rings substituted with one or more electron-withdrawing groups. This invention also includes compositions enriched in phenolic compounds. This invention encompasses methods of using the phenolic-enriched compositions for treating warm-blooded animals, including humans, infected with paramyxovaridae such as respiratory syncytial virus, orthomyoxovaridae such as influenza A, B, and C, parainfluenza, Herpes viruses such as HSV-1 and HSV-2, and Flaviviruses such as West Nile Virus, and for treating inflammation such as caused by arthritis, stress and digestive disease. The compositions are also useful as meat additives to inhibit food-borne pathogens.
摘要翻译： 提供了从粗植物提取物制备富含酚类化合物的组合物的方法。 一种方法包括使用可释放地吸附酚类化合物但不保留极性非酚类化合物的聚合物树脂的新型柱纯化步骤，其中树脂包含被一个或多个吸电子基团取代的芳环。 本发明还包括富含酚类化合物的组合物。 本发明包括使用富含酚的组合物治疗感染副粘病毒例如呼吸道合胞病毒，正义霉病如甲型流感A，乙型和丙型流感病毒，副流感病毒，疱疹病毒如HSV-1的温血动物包括人的方法 和HSV-2和黄病毒如西尼罗病毒，并用于治疗由关节炎，压力和消化疾病引起的炎症。 组合物还可用作抑制食源性病原体的肉添加剂。
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公开(公告)号：US06960360B2
公开(公告)日：2005-11-01
申请号：US10302264
申请日：2002-11-22
申请人： Gerald T. Gourdin , Steven L. Richheimer , Michael S. Tempesta , David T. Bailey , Rebecca L. Nichols , F. Joseph Daugherty , Delano R. Freeberg
发明人： Gerald T. Gourdin , Steven L. Richheimer , Michael S. Tempesta , David T. Bailey , Rebecca L. Nichols , F. Joseph Daugherty , Delano R. Freeberg
IPC分类号： A61K31/352 , A61K31/70 , A61K36/185 , A61K36/35 , A61K36/45 , A61K36/73 , A61K36/736 , A61K36/87 , C07D311/62 , A61K35/78 , A61K47/00 , C07H17/00 , C07D311/04
CPC分类号： A61K31/352 , A61K31/70 , A61K36/185 , A61K36/35 , A61K36/45 , A61K36/73 , A61K36/736 , A61K36/87 , C07D311/62 , Y02A50/393 , A61K2300/00
摘要： This invention provides a process for the preparation of compositions enriched in total phenols from a crude plant extract. The process includes a novel column purification step using a brominated polystyrene resin. This invention also includes compositions enriched in total phenols. The enriched compositions are characterized as containing monomeric, oligomeric and polymeric phenols and having HPLC chromatograms substantially as set forth in FIGS. 10-13. This invention encompasses methods of using the total phenol-enriched compositions for treating warm-blooded animals, including humans, infected with paramyxovaridae such as respiratory syncytial virus, orthomyoxovaridae such as influenza A, B, and C, parainfluenza, Herpes viruses such as HSV-1 and HSV-2, and Flaviviruses such as West Nile Virus, and for treating inflammation such as caused by arthritis, stress and digestive disease.
摘要翻译： 本发明提供了一种从粗植物提取物制备富含总酚的组合物的方法。 该方法包括使用溴化聚苯乙烯树脂的新型柱纯化步骤。 本发明还包括富含总酚的组合物。 富集的组合物的特征在于含有单体，低聚和聚合酚，并且具有基本如图1和2所述的HPLC色谱图。 10-13。 本发明包括使用全氟酚组合物治疗感染副粘病毒如呼吸道合胞病毒，正义霉菌科如A，B和C型流感的副流感病毒，疱疹病毒如HSV- 1和HSV-2，以及黄病毒如西尼罗病毒，并用于治疗由关节炎，应激和消化疾病引起的炎症。
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公开(公告)号：US20080199548A1
公开(公告)日：2008-08-21
申请号：US11890788
申请日：2007-08-07
申请人： Gerald T. Gourdin , Steven L. Richheimer , Michael S. Tempesta , David T. Bailey , Rebecca L. Nichols , F. Joseph Daugherty , Delano R. Freeberg
发明人： Gerald T. Gourdin , Steven L. Richheimer , Michael S. Tempesta , David T. Bailey , Rebecca L. Nichols , F. Joseph Daugherty , Delano R. Freeberg
CPC分类号： A61K31/352 , A61K31/70 , A61K36/185 , A61K36/35 , A61K36/45 , A61K36/73 , A61K36/736 , A61K36/87 , C07D311/62 , Y02A50/393 , A61K2300/00
摘要： A product made by a process which results in compositions enriched in total phenols includes purification steps not involving the addition of bisulfite ions. The enriched compositions are characterized as containing monomeric, oligomeric and polymeric phenols, total phenol concentration >12% and exhibiting in vitro COX-2 inhibitory activity enhanced by a factor of at least 2.5 over a standard aspirin dose of 660 μg/mL.
摘要翻译： 通过产生富含总酚的组合物的方法制备的产品包括不涉及加入亚硫酸氢盐离子的纯化步骤。 富集的组合物的特征在于含有单体，低聚和聚合物酚，总苯酚浓度> 12％，体外COX-2抑制活性比标准阿司匹林剂量为660mug / mL增加至少2.5倍。
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公开(公告)号：US07682637B2
公开(公告)日：2010-03-23
申请号：US11890788
申请日：2007-08-07
申请人： Gerald T. Gourdin , Steven L. Richheimer , Michael S. Tempesta , David T. Bailey , Rebecca L. Nichols , F. Joseph Daugherty , Delano R. Freeberg
发明人： Gerald T. Gourdin , Steven L. Richheimer , Michael S. Tempesta , David T. Bailey , Rebecca L. Nichols , F. Joseph Daugherty , Delano R. Freeberg
CPC分类号： A61K31/352 , A61K31/70 , A61K36/185 , A61K36/35 , A61K36/45 , A61K36/73 , A61K36/736 , A61K36/87 , C07D311/62 , Y02A50/393 , A61K2300/00
摘要： A product made by a process which results in compositions enriched in total phenols includes purification steps not involving the addition of bisulfite ions. The enriched compositions are characterized as containing monomeric, oligomeric and polymeric phenols, total phenol concentration >12% and exhibiting in vitro COX-2 inhibitory activity enhanced by a factor of at least 2.5 over a standard aspirin dose of 660 μg/mL.
摘要翻译： 通过产生富含总酚的组合物的方法制备的产品包括不涉及加入亚硫酸氢盐离子的纯化步骤。 富集的组合物的特征在于含有单体，低聚和聚合物酚，总苯酚浓度> 12％，体外COX-2抑制活性比标准阿司匹林剂量为660μg/ mL增加至少2.5倍。
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公开(公告)号：US07462370B2
公开(公告)日：2008-12-09
申请号：US11750906
申请日：2007-05-18
申请人： David T. Bailey , Delano R. Freeberg , Dennis Gertenbach , Gerald T. Gourdin , Steven L. Richheimer , Michael S. Tempesta , F. Joseph Daugherty
发明人： David T. Bailey , Delano R. Freeberg , Dennis Gertenbach , Gerald T. Gourdin , Steven L. Richheimer , Michael S. Tempesta , F. Joseph Daugherty
IPC分类号： A61K36/45
CPC分类号： C07D311/62 , A23L33/105 , A61K31/352 , A61K36/074 , A61K36/185 , A61K36/29 , A61K36/31 , A61K36/35 , A61K36/39 , A61K36/45 , A61K36/73 , A61K36/736 , A61K36/81 , A61K36/87 , A61K36/899 , A61K2300/00
摘要： This invention provides compositions enriched for anthocyanins and methods of preparation thereof from a crude plant extract. The method of preparation includes a novel column purification step using a brominated polystyrene resin.
摘要翻译： 本发明提供富含花青素的组合物及其制备方法。 制备方法包括使用溴化聚苯乙烯树脂的新型柱纯化步骤。
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公开(公告)号：US06780442B2
公开(公告)日：2004-08-24
申请号：US09943158
申请日：2001-08-30
申请人： David T. Bailey , Delano R. Freeberg , Dennis Gertenbach , Gerald T. Gourdin , Steven L. Richheimer , Michael S. Tempesta , F. Joseph Daugherty
发明人： David T. Bailey , Delano R. Freeberg , Dennis Gertenbach , Gerald T. Gourdin , Steven L. Richheimer , Michael S. Tempesta , F. Joseph Daugherty
IPC分类号： A61K3578
CPC分类号： C07D311/62 , A23L33/105 , A61K31/352 , A61K36/074 , A61K36/185 , A61K36/29 , A61K36/31 , A61K36/35 , A61K36/39 , A61K36/45 , A61K36/73 , A61K36/736 , A61K36/81 , A61K36/87 , A61K36/899 , A61K2300/00
摘要： This invention includes both a one-column process and a two-column process for the preparation of compositions enriched for anthocyanins from a crude plant extract. Both processes include a novel column purification step using a brominated polystyrene resin. This invention also includes extracts enriched for anthocyanins.
摘要翻译： 本发明包括用于从粗植物提取物制备富含花青素的组合物的单柱方法和双柱方法。 两种方法都包括使用溴化聚苯乙烯树脂的新型柱纯化步骤。 本发明还包括富含花青素的提取物。
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公开(公告)号：US20090099373A1
公开(公告)日：2009-04-16
申请号：US12262000
申请日：2008-10-30
申请人： David T. BAILEY , Delano R. Freeberg , Dennis Gertenbach , Gerald T. Gourdin , Steven L. Richheimer , Michael S. Tempesta , F. Joseph Daugherty
发明人： David T. BAILEY , Delano R. Freeberg , Dennis Gertenbach , Gerald T. Gourdin , Steven L. Richheimer , Michael S. Tempesta , F. Joseph Daugherty
IPC分类号： C07D311/00
CPC分类号： C07D311/62 , A23L33/105 , A61K31/352 , A61K36/074 , A61K36/185 , A61K36/29 , A61K36/31 , A61K36/35 , A61K36/39 , A61K36/45 , A61K36/73 , A61K36/736 , A61K36/81 , A61K36/87 , A61K36/899 , A61K2300/00
摘要： This invention provides compositions enriched for anthocyanins and methods of preparation thereof from a crude plant extract. The method of preparation includes a novel column purification step using a brominated polystyrene resin.
摘要翻译： 本发明提供富含花青素的组合物及其制备方法。 制备方法包括使用溴化聚苯乙烯树脂的新型柱纯化步骤。
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公开(公告)号：US11246846B2
公开(公告)日：2022-02-15
申请号：US16167323
申请日：2018-10-22
IPC分类号： A61K31/194 , A61K31/198 , A61K9/00 , A23L33/175 , A23L29/00 , A61K47/10 , A61K47/32 , A61K47/40 , A23L33/18 , A61K45/06
摘要： The present invention relates to formulations of certain amino acids, peptides and similar molecules in combination with trisodium citrate exhibiting improved bioavailability and enhanced uptake across digestive mucosa. The present invention relates particularly to formulation of trisodium citrate in combinations with leucine, iso-leucine, valine, arginine, sarcosine, glutathione, carnosine, glucosamine, creatine, protein hydrolysates and/or gamma-aminobutyric acid exhibiting improved uptake across digestive mucosa. More particularly, the improved uptake across digestive mucosa takes place across intestinal, esophageal and/or stomach mucosa.
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10.发明申请ENTERIC COATED, SOLUBLE CREATINE AND POLYETHYLENE GLYCOL COMPOSITION FOR ENHANCED SKELETAL UPTAKE OF ORAL CREATINE 审中-公开肠衣包衣，可溶性成分和聚乙烯甘油组合物，用于增强口腔成份的肌肉摄取公开(公告)号：US20080306159A1
公开(公告)日：2008-12-11
申请号：US12133228
申请日：2008-06-04
IPC分类号： A61K31/198
CPC分类号： A61K9/2866 , A61K9/1641 , A61K9/282 , A61K9/286 , A61K31/198
摘要： An oral creatine formulation includes soluble creatine and polyethylene glycol, coated with an enteric coating. The most preferred soluble creatine is creatine HCl. The most preferred polyethylene glycols have an average molecular weight of from 3150 to 3685, although for particular formulation formulations and particular uses, the average molecular weight polyethylene glycols may range from 190 to 9000.
摘要翻译： 口服肌酸制剂包括用肠溶衣包衣的可溶性肌酸和聚乙二醇。 最优选的可溶性肌酸是肌酸HCl。 最优选的聚乙二醇的平均分子量为3150至3685，但是对于特定的配制剂和具体用途，平均分子量的聚乙二醇可以在190-9000之间。
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