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    High molecular weight primary aliphatic alcohols obtained from natural products and uses thereof
    9.
    发明授权
    High molecular weight primary aliphatic alcohols obtained from natural products and uses thereof 有权
    由天然产物获得的高分子量伯脂肪醇及其用途

    公开(公告)号：US07141611B2

    公开(公告)日：2006-11-28

    申请号：US10622249

    申请日：2003-07-18

    申请人： William R. Gamble ,  Zhengjie Liu ,  David T. Bailey ,  Pedro P. Perez ,  Dean P. Stull ,  Steven L. Richheimer ,  Rebecca L. Nichols ,  Rod Lenoble

    发明人： William R. Gamble ,  Zhengjie Liu ,  David T. Bailey ,  Pedro P. Perez ,  Dean P. Stull ,  Steven L. Richheimer ,  Rebecca L. Nichols ,  Rod Lenoble

    IPC分类号： A61K31/045 ,  C07C29/76 ,  C07C29/28 ,  C07C29/86

    CPC分类号： C07C29/76 ,  C07C29/86 ,  C07C31/125 ,  C07C33/025

    摘要： This invention provides an isolated mixture of higher molecular weight primary aliphatic alcohols having 20, 22, 24, 26, 27, 28, 30, 32 and 34 carbon atoms and having enhanced purity. This invention also provides a process for obtaining the alcohol mixture by extracting a natural product with organic solvents with or without saponification of the natural product. The alcohol mixture is useful in pharmaceutical compositions, foodstuffs and dietary supplements and is effective for lowering total cholesterol and LDL-cholesterol and increasing HDL-cholesterol levels and therefore is effective in treating hypercholesterolemia. The composition may be used to reduce the risk of coronary heart disease, to inhibit the atherosclerotic process (platelet hyperaggregability, ischemia and thrombosis), and can be used as an anti-inflammatory and anti-thrombotic agent. The composition also possesses neurotrophic properties and is useful for improving male sexual activity.

    摘要翻译： 本发明提供了具有20,22,24,26,27,28,30,32和34个碳原子的较高分子量伯脂肪醇的分离混合物，并且具有增强的纯度。 本发明还提供了一种通过在天然产物皂化或不皂化的情况下用有机溶剂萃取天然产物来获得醇混合物的方法。 酒精混合物可用于药物组合物，食品和膳食补充剂中，并有效降低总胆固醇和低密度脂蛋白胆固醇并增加HDL-胆固醇水平，因此有效治疗高胆固醇血症。 该组合物可用于降低冠心病的风险，抑制动脉粥样硬化过程（血小板超聚集，缺血和血栓形成），并可用作抗炎和抗血栓形成剂。 该组合物还具有神经营养性质，可用于改善男性的性活动。

    High purity carnosic acid from rosemary and sage extracts by pH-controlled precipitation
    10.
    发明授权
    High purity carnosic acid from rosemary and sage extracts by pH-controlled precipitation 失效
    通过pH控制沉淀，从迷迭香和鼠尾草提取物中提取高纯度的鼠尾草酸

    公开(公告)号：US5859293A

    公开(公告)日：1999-01-12

    申请号：US892046

    申请日：1997-07-14

    申请人： David T. Bailey ,  Steven L. Richheimer ,  Virginia R. Bank ,  Benjamin T. King

    发明人： David T. Bailey ,  Steven L. Richheimer ,  Virginia R. Bank ,  Benjamin T. King

    IPC分类号： A23L3/3472 ,  A23L3/3508 ,  C07C63/34

    CPC分类号： A23L3/3472 ,  A23L3/3508

    摘要： A process for the extraction and isolation of concentrated carnosic acid from plant matter of the Labiatae family including contacting the plant matter with a water-miscible solvent to form a plant extract and adjusting the pH of the plant extract to a level between 7 and 10 while adding water in an amount sufficient to cause precipitation of impurities while retaining the carnosic acid salt in solution. The impurities are separated and the remaining aqueous solution is acidified to precipitate a highly purified carnosic acid product which is essentially odorless, flavorless and colorless.

    摘要翻译： 从Labiatae家族的植物物质提取和分离浓缩的鼠尾草酸的方法，包括将植物物质与水混溶性溶剂接触以形成植物提取物并将植物提取物的pH调节至7至10的水平，同时 加入足够量的水以引起杂质沉淀，同时保留溶液中的鼠尾草酸盐。 分离杂质，将剩余的水溶液酸化以沉淀基本上无臭，无味和无色的高度纯化的肌肉酸产物。