公开(公告)号：US20200254137A1

公开(公告)日：2020-08-13

申请号：US16089610

申请日：2017-03-31

申请人： Polyganics IP B.V.

发明人： Martin Franke Tooren ,  Dirk Erik Muller ,  Justin Van Der Veen

IPC分类号： A61L24/04 ,  A61L24/00 ,  A61L31/06 ,  A61L31/14 ,  C08G18/10 ,  C08G18/34 ,  C08G18/73

摘要： The invention is directed to a biodegradable tissue-adhesive polyurethane polymer comprising at least one amorphous segment and at least one polyurethane segment, wherein at least one of said polyurethane segment comprises a tissue-reactive functional group. A further aspect of the invention is directed to biodegradable tissue-adhesive medical devices, based on the polyurethane polymer, having the structure of a sheet, foam, stent, tube or gel. The polyurethane polymer and the device can be used in medical application.

公开(公告)号：US20220185958A1

公开(公告)日：2022-06-16

申请号：US17437600

申请日：2020-03-11

申请人： Polyganics IP B.V.

发明人： Martin Franke Tooren

IPC分类号： C08G65/333 ,  C08G69/16 ,  A61L24/04 ,  A61L24/00

摘要： The invention is directed to a tissue-adhesive multi-arm polymer comprising a core from which polymeric arms extent, which polymeric arms are substituted with a hydroxyl-substituted aromatic group based on compounds such as dopamine, L-DOPA, D-DOPA, tyramine, noradrenaline and/or serotonin. In addition, the invention is directed to a caprolactam blocked hydroxyl-substituted aromatic compound, suitable for the preparation of the tissue-adhesive multi-arm polymer and to the method for the preparation of the tissue-adhesive multi-arm polymer.

公开(公告)号：US11633517B2

公开(公告)日：2023-04-25

申请号：US16089582

申请日：2017-03-31

申请人： Polyganics IP B.V.

发明人： Martin Franke Tooren ,  Dirk Erik Muller ,  Konstantin Igorovitch Denisov

IPC分类号： A61L27/18 ,  A61L27/50 ,  A61L27/58 ,  A61L27/60 ,  C08G18/73 ,  C08G18/42 ,  C08G18/44 ,  C08G18/75 ,  C08G18/77 ,  C08G18/24 ,  C08J9/28 ,  C08L75/06 ,  C08G18/10 ,  C08G18/32

摘要： The invention is directed to biomedical polyurethanes. The invention is particularly directed to biomedical polyurethanes with improved biodegradability and to an improved preparation of the biomedical polyurethanes. In particular the present invention provides a biomedical polyurethane having the formula (A-B-C-B)n, wherein A denotes a polyol, B denotes a diisocyanate moiety, C denotes a diol component and n denotes the number of recurring units, and wherein the B-C-B segment is bioresorbable.

公开(公告)号：US11129920B2

公开(公告)日：2021-09-28

申请号：US16089610

申请日：2017-03-31

申请人： Polyganics IP B.V.

发明人： Martin Franke Tooren ,  Dirk Erik Muller ,  Justin Van Der Veen

IPC分类号： C09J175/06 ,  A61L24/04 ,  C08G18/34 ,  A61L24/00 ,  A61L31/06 ,  A61L31/14 ,  C08G18/10 ,  C08G18/73

摘要： The invention is directed to a biodegradable tissue-adhesive polyurethane polymer comprising at least one amorphous segment and at least one polyurethane segment, wherein at least one of said polyurethane segment comprises a tissue-reactive functional group. A further aspect of the invention is directed to biodegradable tissue-adhesive medical devices, based on the polyurethane polymer, having the structure of a sheet, foam, stent, tube or gel. The polyurethane polymer and the device can be used in medical application.

公开(公告)号：US10850004B2

公开(公告)日：2020-12-01

申请号：US15555245

申请日：2016-03-07

申请人： Polyganics IP B.V.

发明人： Pieter van den Berg ,  Hans Wicher Kuijper ,  Leendert Willem Schwab ,  Mariëtta Johanna Olga Elizabeth Bertleff ,  Harmen Hendrikus de Vries

IPC分类号： A61B90/00 ,  A61L27/18 ,  A61L27/58 ,  A61L27/38

摘要： The invention is directed to a nerve cap for covering a nerve stump, comprising a tubular body with a closed end and an open end and essentially consisting of biodegradable polymeric material to prevent or treat symptoms caused by neuroma. The polymeric material preferably comprises a poly(DL-lactide-co-ε-caprolactone) copolymer obtained by the copolymerizaton of DL-lactide and ε-caprolactone, which copolymer has a lactide content of 51-75 mol %.

公开(公告)号：US11801325B2

公开(公告)日：2023-10-31

申请号：US16651431

申请日：2018-10-01

申请人： Polyganics IP B.V.

发明人： Martin Franke Tooren ,  Justin Van Der Veen ,  Dirk Erik Muller

IPC分类号： A61L24/04 ,  C08L71/02

CPC分类号： A61L24/046 ,  C08L71/02

摘要： The invention is directed to a multi-arm tissue-adhesive polymer wherein at least six or more arms each comprise a reactive functional group that can form a urethane or a urea bond with an amine group present in tissue, as well as to the use thereof for sealing or closing of tissue and use in a medical treatment of a human or animal body. In a further aspect, the invention is directed to a method for the preparation of said multi-arm tissue-adhesive polymer.

公开(公告)号：US11779679B2

公开(公告)日：2023-10-10

申请号：US17204093

申请日：2021-03-17

申请人： Polyganics IP B.V.

发明人： Leendert Willem Schwab ,  Konstantin Igorovitch Denisov ,  Martin Franke Tooren ,  Theodorus Petrus Cornelis Van Doormaal

IPC分类号： A61L24/00 ,  A61L24/04

CPC分类号： A61L24/043 ,  A61L24/0015 ,  A61L24/0031 ,  A61L24/0036 ,  A61L24/0042 ,  A61L24/0094 ,  A61L2430/34 ,  A61L24/0094 ,  C08L67/04 ,  A61L24/043 ,  C08L67/04 ,  A61L24/043 ,  C08L71/02 ,  A61L24/0094 ,  C08L71/02

摘要： The invention is directed to a tissue-adhesive polymer blend comprising a bioresorbable carrier polymer and a bioresorbable synthetic tissue-reactive polymer as well as to a tissue-adhesive device for sealing dura mater comprising said tissue-adhesive polymer blend.

公开(公告)号：US11160900B2

公开(公告)日：2021-11-02

申请号：US16651475

申请日：2018-10-01

申请人： Polyganics IP B.V.

发明人： Martin Franke Tooren ,  Justin Van Der Veen ,  Dirk Erik Muller ,  Don Theo Hertsig ,  Harmen Hendrikus de Vries ,  Romke Stephan Rudolf Ribbels

IPC分类号： A61L24/04 ,  A61L24/00 ,  C08L67/04 ,  C08L69/00 ,  C08L75/04

摘要： The invention is directed to a biodegradable tissue-adhesive device for sealing tissue, said device comprising a tissue-adhesive layer which comprises a blend of a tissue-reactive polymer and a biodegradable carrier polyurethane according to the formula of A-B-C-Bn, wherein A denotes a polyol, B denotes a diisocyanate moiety, C denotes a diol component and n denotes the number of recurring units, and wherein the B-C-B segment is bioresorbable.

公开(公告)号：US20210213158A1

公开(公告)日：2021-07-15

申请号：US17204093

申请日：2021-03-17

申请人： Polyganics IP B.V.

发明人： Leendert Willem Schwab ,  Konstantin Igorovitch Denisov ,  Martin Franke Tooren ,  Theodorus Petrus Cornelis Van Doormaal

IPC分类号： A61L24/04 ,  A61L24/00

摘要： The invention is directed to a tissue-adhesive polymer blend comprising a bioresorbable carrier polymer and a bioresorbable synthetic tissue-reactive polymer as well as to a tissue-adhesive device for sealing dura mater comprising said tissue-adhesive polymer blend.

公开(公告)号：US20230302194A1

公开(公告)日：2023-09-28

申请号：US18188571

申请日：2023-03-23

申请人： Polyganics IP B.V.

发明人： Martin Franke Tooren ,  Dirk Erik Muller ,  Konstantin Igorovitch Denisov

IPC分类号： A61L27/18 ,  A61L27/58 ,  A61L27/50 ,  A61L27/60 ,  C08G18/42 ,  C08G18/73

CPC分类号： A61L27/18 ,  A61L27/507 ,  A61L27/58 ,  A61L27/60 ,  C08G18/42 ,  C08G18/73 ,  A61L2430/06 ,  A61L2430/32

摘要： The invention is directed to biomedical polyurethanes. The invention is particularly directed to biomedical polyurethanes with improved biodegradability and to an improved preparation of the biomedical polyurethanes. In particular the present invention provides a biomedical polyurethane having the formula (A-B-C-B)n, wherein A denotes a polyol, B denotes a diisocyanate moiety, C denotes a diol component and n denotes the number of recurring units, and wherein the B-C-B segment is bioresorbable.