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公开(公告)号：US20230083885A1
公开(公告)日：2023-03-16
申请号：US17711961
申请日：2022-04-01
申请人： Praxis Biotech LLC
发明人： Gonzalo Andrés URETA DÍAZ , Brahmam PUJALA , Dayanand PANPATIL , Sebastian BERNALES , Sarvajit CHAKRAVARTY
IPC分类号： A61K31/4709 , C07K14/535 , C07K14/50 , C07D413/12 , C07D271/06 , C07D413/04 , C07D285/08 , C07D263/32 , C07D231/12 , C07D417/12 , C07D413/14 , C07D401/12 , A61K31/4245 , A61K31/538 , A61K31/497 , A61K31/433 , A61K31/421 , A61K31/415 , A01N43/82 , A01N43/84 , A01N43/56 , A01P21/00 , C12P21/00 , C12N5/071 , C12N15/86
摘要： The present disclosure relates generally to therapeutic agents that may be useful as modulators of Integrated Stress Response (ISR) pathway.
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公开(公告)号：US20230047589A1
公开(公告)日：2023-02-16
申请号：US17398862
申请日：2021-08-10
申请人： Praxis Biotech LLC
发明人： Sebastian BERNALES , Luz Marina DELGADO OYARZO , Gonzalo Esteban NÚÑEZ VASQUEZ , Gonzalo Andrés URETA DÍAZ , Brahmam PUJALA , Dayanand PANPATIL , Bhawana BHATT , Sarvajit CHAKRAVARTY
IPC分类号： C07D413/12 , C07D263/24 , C07D307/85 , C07D401/12 , C07D405/12 , C07D215/18 , C07D211/58 , C07D491/048 , C07D277/68 , C12N5/00 , C07D265/36
摘要： The present disclosure relates generally to therapeutic agents that may be useful as inhibitors of Integrated Stress Response (ISR) pathway.
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公开(公告)号：US20230028584A1
公开(公告)日：2023-01-26
申请号：US17767028
申请日：2020-10-09
申请人： Praxis Biotech LLC
发明人： Brahmam PUJALA , Balaji Dashrath SATHE , Sebastian BERNALES , Gonzalo Andrés URETA DÍAZ , Sebastian BELMAR
IPC分类号： C07D417/14 , C07D413/14
摘要： Compounds (1-2) as modulators of Activating Transcription Factor 6 (ATF6) are provided. The compounds may find use as therapeutic agents for the treatment of diseases or disorders mediated by ATF6 and may find particular use in the treatment of viral infections, neurodegenerative diseases, vascular diseases, or cancer. (Formula (1-2))
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公开(公告)号：US11230542B2
公开(公告)日：2022-01-25
申请号：US16219805
申请日：2018-12-13
申请人： Praxis Biotech LLC
发明人： Sebastian Bernales , Luz Marina Delgado Oyarzo , Gonzalo Esteban Núñez Vasquez , Gonzalo Andrés Ureta Díaz , Brahmam Pujala , Dayanand Panpatil , Bhawana Bhatt , Sarvajit Chakravarty
IPC分类号： A61K31/44 , C07D413/12 , C07D263/24 , C07D307/85 , C07D401/12 , C07D405/12 , C07D215/18 , C07D211/58 , C07D491/048 , C07D277/68 , C12N5/00 , C07D265/36 , A61P35/00 , A61P21/00 , A61P25/28
摘要： The present disclosure relates generally to therapeutic agents that may be useful as inhibitors of Integrated Stress Response (ISR) pathway.
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公开(公告)号：US20210317102A1
公开(公告)日：2021-10-14
申请号：US16899520
申请日：2020-06-11
申请人： Praxis Biotech LLC
发明人： Luz Marina DELGADO OYARZO , Gonzalo Andrés URETA DÍAZ , Brahmam PUJALA , Dayanand PANPATIL , Sebastian BERNALES , Sarvajit CHAKRAVARTY
IPC分类号： C07D401/12 , C07D471/08 , C07D235/24 , C07D211/34 , C07D405/12 , C07C235/36 , C07D215/56 , C07D307/85 , C07D213/81 , C07D241/24 , C07D407/12 , C07D265/36 , A01N43/42 , A01N43/52 , A01N43/12 , A01N43/60 , A01N47/32 , A01N37/30 , A01N37/26 , A01N43/84 , C12P21/00
摘要： The present disclosure relates generally to therapeutic agents that may be useful as inhibitors of Integrated Stress Response (ISR) pathway.
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公开(公告)号：US20220389001A1
公开(公告)日：2022-12-08
申请号：US17767031
申请日：2020-10-09
申请人： Praxis Biotech LLC
发明人： Brahmam PUJALA , Balaji Dashrath SATHE , Pooja THAKRAL , Sebastian BERNALES , Gonzalo Andrés URETA DÍAZ , Sebastian BELMAR
IPC分类号： C07D413/14
摘要： Compounds (I) as modulators of Activating Transcription Factor 6 (ATF6) are provided. The compounds may find use as therapeutic agents for the treatment of diseases or disorders mediated by ATF6 and may find particular use in the treatment of viral infections, neurodegenerative diseases, vascular diseases, or cancer.
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公开(公告)号：US20220071966A1
公开(公告)日：2022-03-10
申请号：US17398902
申请日：2021-08-10
申请人： Praxis Biotech LLC
发明人： Luz Marina DELGADO OYARZO , Gonzalo Andrés URETA DÍAZ , Brahmam PUJALA , Dayanand PANPATIL , Sebastian BERNALES , Sarvajit CHAKRAVARTY
IPC分类号： A61K31/428 , A61P21/00 , A61P25/28 , A61K31/4468 , A61K31/4525 , A61K31/4709 , A61K31/495 , A61K31/497 , A61K31/538 , C07D221/00 , C07D241/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07K16/00 , C12N5/073
摘要： The present disclosure relates generally to therapeutic agents that may be useful as inhibitors of Integrated Stress Response (ISR) pathway.
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公开(公告)号：US20230144841A1
公开(公告)日：2023-05-11
申请号：US17944963
申请日：2022-09-14
申请人： Praxis Biotech LLC
发明人： Brahmam PUJALA , Dayanand PANPATIL , Sebastian BERNALES , Sebastian BELMAR , Gonzalo Andrés URETA DÍAZ
IPC分类号： A61K31/4709 , A61K31/192 , C07D405/14 , C07D401/12 , C07D401/14 , A61P35/00
CPC分类号： A61K31/4709 , A61K31/192 , C07D405/14 , C07D401/12 , C07D401/14 , A61P35/00
摘要： Compounds and compositions for modulating fibroblast activation protein (FAP) are described. The compounds and compositions may find use as therapeutic agents for the treatment of diseases, including hyperproliferative diseases.
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公开(公告)号：US20230042881A1
公开(公告)日：2023-02-09
申请号：US17831771
申请日：2022-06-03
申请人： Praxis Biotech LLC
发明人： Gonzalo Andrés URETA DÍAZ , Brahmam PUJALA , Dayanand PANPATIL , Sebastian BERNALES , Sarvajit CHAKRAVARTY
IPC分类号： A61K31/47 , C07K1/10 , C07D215/38 , A61K31/4709 , C07D405/12 , A61K31/538 , C07D413/12 , C07D401/12 , C07D405/14 , C07D263/58 , A61K31/423 , A61K31/428 , C07D277/82 , C07D401/14 , A61K31/497 , A61K31/343 , C07D307/81 , C07D407/12 , C07D413/14 , A61K31/443 , A61K31/454 , C07D417/12 , A01N43/42 , A01N43/84 , A01N43/76 , A01N43/78 , A01N43/60 , A01N43/12 , A01N43/40 , A01P21/00 , A61P1/18 , C12N5/00
摘要： The present disclosure relates generally to therapeutic agents that may be useful as modulators of Integrated Stress Response (ISR) pathway.
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公开(公告)号：US11504364B2
公开(公告)日：2022-11-22
申请号：US16724198
申请日：2019-12-21
申请人： Praxis Biotech LLC
发明人： Brahmam Pujala , Dayanand Panpatil , Sebastian Bernales , Sebastian Belmar , Gonzalo Andrés Ureta Díaz
IPC分类号： C07D405/14 , A61K31/4709 , A61K31/192 , C07D401/12 , C07D401/14 , A61P35/00
摘要： Compounds and compositions for modulating fibroblast activation protein (FAP) are described. The compounds and compositions may find use as therapeutic agents for the treatment of diseases, including hyperproliferative diseases.
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