公开(公告)号：US07193069B2

公开(公告)日：2007-03-20

申请号：US10108260

申请日：2002-03-28

申请人： Takao Isogai ,  Tomoyasu Sugiyama ,  Tetsuji Otsuki ,  Ai Wakamatsu ,  Hiroyuki Sato ,  Shizuko Ishii ,  Jun-ichi Yamamoto ,  Yuuko Isono ,  Yuri Hio ,  Kaoru Otsuka ,  Keiichi Nagai ,  Ryotaro Irie ,  Ichiro Tamechika ,  Naohiko Seki ,  Tsutomu Yoshikawa ,  Motoyuki Otsuka ,  Kenji Nagahari ,  Yasuhiko Masuho

发明人： Takao Isogai ,  Tomoyasu Sugiyama ,  Tetsuji Otsuki ,  Ai Wakamatsu ,  Hiroyuki Sato ,  Shizuko Ishii ,  Jun-ichi Yamamoto ,  Yuuko Isono ,  Yuri Hio ,  Kaoru Otsuka ,  Keiichi Nagai ,  Ryotaro Irie ,  Ichiro Tamechika ,  Naohiko Seki ,  Tsutomu Yoshikawa ,  Motoyuki Otsuka ,  Kenji Nagahari ,  Yasuhiko Masuho

IPC分类号： C07H21/04

CPC分类号： G01N33/566 ,  C07K14/47 ,  G01N2500/00

摘要： Novel full-length cDNAs are provided.2443 cDNA derived from human have been isolated. The full-length nucleotide sequences of the cDNA and amino acid sequences encoded by the nucleotide sequences have been determined. Because the cDNA of the present invention are full-length and contain the translation start site, they provide information useful for analyzing the functions of the polypeptide.

摘要翻译： 提供新的全长cDNA。 已经分离出来自人的2443 cDNA。 已经确定了由核苷酸序列编码的cDNA和氨基酸序列的全长核苷酸序列。 因为本发明的cDNA是全长的并含有翻译起始位点，所以它们提供了可用于分析多肽功能的信息。

公开(公告)号：US20060105376A1

公开(公告)日：2006-05-18

申请号：US11293697

申请日：2005-12-05

申请人： Takao Isogai ,  Tomoyasu Sugiyama ,  Tetsuji Otsuki ,  Ai Wakamatsu ,  Hiroyuki Sato ,  Shizuko Ishii ,  Jun-ichi Yamamoto ,  Yuuko Isono ,  Yuri Hio ,  Kaoru Otsuka ,  Keiichi Nagai ,  Ryotaro Irie ,  Ichiro Tamechika ,  Naohiko Seki ,  Tsutomu Yoshikawa ,  Motoyuki Otsuka ,  Kenji Nagahari ,  Yasuhiko Masuho

发明人： Takao Isogai ,  Tomoyasu Sugiyama ,  Tetsuji Otsuki ,  Ai Wakamatsu ,  Hiroyuki Sato ,  Shizuko Ishii ,  Jun-ichi Yamamoto ,  Yuuko Isono ,  Yuri Hio ,  Kaoru Otsuka ,  Keiichi Nagai ,  Ryotaro Irie ,  Ichiro Tamechika ,  Naohiko Seki ,  Tsutomu Yoshikawa ,  Motoyuki Otsuka ,  Kenji Nagahari ,  Yasuhiko Masuho

IPC分类号： C12Q1/68 ,  G01N33/53 ,  C07H21/04 ,  C12P21/06

CPC分类号： G01N33/566 ,  C07K14/47 ,  G01N2500/00

摘要： Novel full-length cDNAs are provided. 2443 cDNA derived from human have been isolated. The full-length nucleotide sequences of the cDNA and amino acid sequences encoded by the nucleotide sequences have been determined. Because the cDNA of the present invention are full-length and contain the translation start site, they provide information useful for analyzing the functions of the polypeptide.

摘要翻译： 提供新的全长cDNA。 已经分离出来自人的2443 cDNA。 已经确定了由核苷酸序列编码的cDNA和氨基酸序列的全长核苷酸序列。 因为本发明的cDNA是全长的并含有翻译起始位点，所以它们提供了可用于分析多肽功能的信息。

公开(公告)号：US06159489A

公开(公告)日：2000-12-12

申请号：US373480

申请日：1999-08-12

申请人： Toyohisa Sakurada ,  Hiroshi Suzuki

发明人： Toyohisa Sakurada ,  Hiroshi Suzuki

IPC分类号： A01M1/02 ,  A01M1/20 ,  A01M5/00 ,  A01M29/12 ,  A01N25/10 ,  A01N25/18 ,  A01N37/02 ,  B65D65/46 ,  A61F2/02 ,  A01N25/08 ,  A01N25/32 ,  A01N25/34 ,  A61K47/32

CPC分类号： B65D65/466 ,  A01M1/02 ,  A01M1/2005 ,  A01M1/2044 ,  A01M1/2055 ,  A01M29/12 ,  A01M5/00 ,  A01N25/10 ,  A01N25/18 ,  A01N37/02 ,  Y02W90/13

摘要： Described are a biodegradable sustained-release preparation which comprises a mixture of 99 to 10 parts by weight of an aliphatic polyester and 1 to 90 parts by weight of a modifier for the regulation of sustained releasability of an active ingredient, and the active ingredient held by said mixture; a biodegradable pheromone dispenser, wherein an aliphatic polyester is used as a sustained release layer for a pheromone contained therein as a liquid phase, said aliphatic polyester having recurring units whose ratio (I/II) of (I) the number of the carbon atoms constituting the main chain and not relating to ester linkage to (II) the number of the carbon atoms constituting the ester linkage is 2 or larger; and a biodegradable pest controlling agent which is obtained by mixing and dispersing an active ingredient and a carrier for holding said active ingredient in a biodegradable aliphatic polyester or which comprises 2 to 60 wt. % of an active ingredient, 30 to 95 wt. % of a biodegradable aliphatic polyester and 2 to 50 wt. % of a carrier for holding the active ingredient.

公开(公告)号：US20070020637A1

公开(公告)日：2007-01-25

申请号：US10760320

申请日：2004-01-21

申请人： Takao Isogai ,  Tomoyasu Sugiyama ,  Tetsuji Otsuki ,  Al Wakamatsu ,  Hiroyuki Sato ,  Shizuko Ishii ,  Junichi Yamamoto ,  Yuko Isono ,  Keiichi Nagai ,  Ryotaro Irie

发明人： Takao Isogai ,  Tomoyasu Sugiyama ,  Tetsuji Otsuki ,  Al Wakamatsu ,  Hiroyuki Sato ,  Shizuko Ishii ,  Junichi Yamamoto ,  Yuko Isono ,  Keiichi Nagai ,  Ryotaro Irie

IPC分类号： C12Q1/68 ,  C07H21/04

CPC分类号： C07K14/47

摘要： Novel full-length cDNAs are provided. 2,495 cDNA derived from human have been isolated. The full-length nucleotide sequences of the cDNA and amino acid sequences encoded by the nucleotide sequences have been determined. Because the cDNA of the present invention are full-length and contain the translation start site, they provide information useful for analyzing the functions of the polypeptide.

摘要翻译： 提供新的全长cDNA。 已经分离出来自人的2,495个cDNA。 已经确定了由核苷酸序列编码的cDNA和氨基酸序列的全长核苷酸序列。 因为本发明的cDNA是全长的并含有翻译起始位点，所以它们提供了可用于分析多肽功能的信息。

公开(公告)号：US5993843A

公开(公告)日：1999-11-30

申请号：US883746

申请日：1997-06-27

申请人： Toyohisa Sakurada ,  Hiroshi Suzuki

发明人： Toyohisa Sakurada ,  Hiroshi Suzuki

IPC分类号： A01M1/02 ,  A01M1/20 ,  A01M5/00 ,  A01M29/12 ,  A01N25/10 ,  A01N25/18 ,  A01N37/02 ,  B65D65/46 ,  A01N25/08 ,  A01N25/34

CPC分类号： B65D65/466 ,  A01M1/02 ,  A01M1/2005 ,  A01M1/2044 ,  A01M1/2055 ,  A01M29/12 ,  A01M5/00 ,  A01N25/10 ,  A01N25/18 ,  A01N37/02 ,  Y02W90/13

摘要： Described are a biodegradable sustained-release preparation which comprises a mixture of 99 to 10 parts by weight of an aliphatic polyester and 1 to 90 parts by weight of a modifier for the regulation of sustained releasability of an active ingredient, and the active ingredient held by said mixture; a biodegradable pheromone dispenser, wherein an aliphatic polyester is used as a sustained release layer for a pheromone contained therein as a liquid phase, said aliphatic polyester having recurring units whose ratio (I/II) of (I) the number of the carbon atoms constituting the main chain and not relating to ester linkage to (II) the number of the carbon atoms constituting the ester linkage is 2 or larger; and a biodegradable pest controlling agent which is obtained by mixing and dispersing an active ingredient and a carrier for holding said active ingredient in a biodegradable aliphatic polyester or which comprises 2 to 60 wt. % of an active ingredient, 30 to 95 wt. % of a biodegradable aliphatic polyester and 2 to 50 wt. % of a carrier for holding the active ingredient.

摘要翻译： 描述了一种可生物降解的缓释制剂，其包含99至10重量份的脂族聚酯和1至90重量份的调节剂用于调节活性成分的持续释放性的混合物，和由 说混合物 一种可生物降解的信息素分配器，其中使用脂肪族聚酯作为其中含有的信息素作为液相的缓释层，所述脂族聚酯具有重复单元，其比率（I）与（I）构成的碳原子数 主链不与酯键连接（II）构成酯键的碳原子数为2以上; 和通过将活性成分和用于将所述活性成分保持在生物降解性脂肪族聚酯中的载体混合分散而得到的生物降解性害虫控制剂，或者含有2〜60重量％ ％的活性成分，30至95wt。 ％的可生物降解的脂族聚酯和2至50wt。 用于保持活性成分的载体的％。

公开(公告)号：US5145775A

公开(公告)日：1992-09-08

申请号：US483823

申请日：1990-02-23

申请人： Nobutoshi Yamada ,  Norifusa Matsuo ,  Takaaki Araki

发明人： Nobutoshi Yamada ,  Norifusa Matsuo ,  Takaaki Araki

IPC分类号： C07K14/01 ,  C12N15/34 ,  C12N15/866

CPC分类号： C12N15/86 ,  C07K14/005 ,  C12N2710/14122 ,  C12N2710/14143

摘要： A polyhedrin gene of Spodoptera litura nuclear polyhedrosis virus (SlNPV C-411) has the following restriction enzyme cleavage map and about 3 kilobase pairs: ##STR1## At least a part of said polyhedrin gene can be substituted by a gene coding for a useful substance to construct a vector and a recombinant virus, and it is possible to produce a useful substance such as a peptide, protein or glycoprotein by culturing a cell infected with the recombinant virus.

公开(公告)号：US20070082345A1

公开(公告)日：2007-04-12

申请号：US11429594

申请日：2006-05-08

申请人： Toshio Ota ,  Takao Isogai ,  Tetsuo Nishikawa ,  Yuri Kawai ,  Tomoyasu Sugiyama ,  Koji Hayashi

发明人： Toshio Ota ,  Takao Isogai ,  Tetsuo Nishikawa ,  Yuri Kawai ,  Tomoyasu Sugiyama ,  Koji Hayashi

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K14/47

CPC分类号： C07K14/505 ,  C07K14/47

摘要： Novel human secretory proteins or membrane proteins, and full length cDNAs encoding the proteins are provided. 173 kinds of novel proteins and polynucleotides encoding these proteins have been isolated. The proteins of the present invention are useful as candidates for medicines or as target molecules for developing medicines. The polynucleotides of the present invention are used to produce these proteins.

摘要翻译： 提供新的人类分泌蛋白或膜蛋白，以及编码蛋白质的全长cDNA。 已经分离了173种新型蛋白质和编码这些蛋白质的多核苷酸。 本发明的蛋白质可用作药物的候选物或用作开发药物的靶分子。 本发明的多核苷酸用于制备这些蛋白质。

公开(公告)号：US07129338B1

公开(公告)日：2006-10-31

申请号：US10305278

申请日：2002-11-27

申请人： Toshio Ota ,  Takao Isogai ,  Tetsuo Nishikawa ,  Yuri Kawai ,  Tomoyasu Sugiyama ,  Koji Hayashi

发明人： Toshio Ota ,  Takao Isogai ,  Tetsuo Nishikawa ,  Yuri Kawai ,  Tomoyasu Sugiyama ,  Koji Hayashi

IPC分类号： C07H19/167 ,  C07H19/173

CPC分类号： C07K14/47 ,  C07K14/505

摘要： Human cDNA encoding a secretory or membrane protein useful as a candidate for developing medicine or as a target molecule for developing medicine. The expression level of the polynucleotide of the present invention increased in NT2 cells after retinoic acid-treatment. Accordingly, this cDNA is associated neurological disease.

摘要翻译： 编码分泌蛋白或膜蛋白的人类cDNA可用作开发药物或用作开发药物的靶分子。 在视黄酸处理后，本发明的多核苷酸的表达量在NT2细胞中增加。 因此，该cDNA与神经系统疾病相关。

公开(公告)号：US20060029945A1

公开(公告)日：2006-02-09

申请号：US11072512

申请日：2005-03-07

申请人： Takao Isogai ,  Tomoyasu Sugiyama ,  Tetsuji Otsuki ,  Ai Wakamatsu ,  Hiroyuki Sato ,  Shizuko Ishii ,  Jun-ichi Yamamoto ,  Yuuko Isono ,  Yuri Hio ,  Kaoru Otsuka ,  Keiichi Nagai ,  Ryotaro Irie ,  Ichiro Tamechika ,  Naohiko Seki ,  Tsutomu Yoshikawa ,  Motoyuki Otsuka ,  Kenji Nagahari ,  Yasuhiko Masuho

发明人： Takao Isogai ,  Tomoyasu Sugiyama ,  Tetsuji Otsuki ,  Ai Wakamatsu ,  Hiroyuki Sato ,  Shizuko Ishii ,  Jun-ichi Yamamoto ,  Yuuko Isono ,  Yuri Hio ,  Kaoru Otsuka ,  Keiichi Nagai ,  Ryotaro Irie ,  Ichiro Tamechika ,  Naohiko Seki ,  Tsutomu Yoshikawa ,  Motoyuki Otsuka ,  Kenji Nagahari ,  Yasuhiko Masuho

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K14/47 ,  C07K16/18

CPC分类号： C07K14/47

摘要： Novel full-length cDNAs are provided. 1970 cDNA derived from human have been isolated. The full-length nucleotide sequences of the cDNA and amino acid sequences encoded by the nucleotide sequences have been determined. Because the cDNA of the present invention are full-length and contain the translation start site, they provide information useful for analyzing the functions of the polypeptide.

公开(公告)号：US20070105122A1

公开(公告)日：2007-05-10

申请号：US10917503

申请日：2004-08-13

申请人： Toshio Ota ,  Takao Isogai ,  Tetsuo Nishikawa ,  Koji Hayashi ,  Kaoru Saito ,  Junichi Yamamoto ,  Shizuko Ishii ,  Tomoyasu Sugiyama ,  Ai Wakamatsu ,  Keiichi Nagai ,  Tetsuji Otsuki

发明人： Toshio Ota ,  Takao Isogai ,  Tetsuo Nishikawa ,  Koji Hayashi ,  Kaoru Saito ,  Junichi Yamamoto ,  Shizuko Ishii ,  Tomoyasu Sugiyama ,  Ai Wakamatsu ,  Keiichi Nagai ,  Tetsuji Otsuki

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705

CPC分类号： C07K14/4702 ,  A61K38/00 ,  C07K14/47

摘要： Primers for synthesizing full-length cDNAs and their use are provided. 5602 cDNA encoding a human protein has been isolated and nucleotide sequences of 5′-, and 3′-ends of the cDNA have been determined. Furthermore, primers for synthesizing the full-length cDNA have been provided to clarify the function of the protein encoded by the cDNA. The full-length cDNA of the present invention containing the translation start site provides information useful for analyzing the functions of the protein.

摘要翻译： 提供了用于合成全长cDNA的引物及其用途。 已经分离了编码人蛋白质的cDNA，已经确定了cDNA的5'和3'末端的核苷酸序列。 此外，提供了用于合成全长cDNA的引物以阐明由cDNA编码的蛋白质的功能。 含有翻译起始位点的本发明的全长cDNA提供了可用于分析蛋白质功能的信息。