-
1.发明授权公开(公告)号：US08110662B2
公开(公告)日：2012-02-07
申请号：US11869267
申请日：2007-10-09
申请人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Otsuka , Jun-Ichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki , Shin-Ichi Funahashi , Shoji Miyata , Kenji Sobue , Kenichiro Hayashi
发明人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Otsuka , Jun-Ichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki , Shin-Ichi Funahashi , Shoji Miyata , Kenji Sobue , Kenichiro Hayashi
CPC分类号： C07K16/18 , A61K38/00 , A61K2039/505 , A61K2039/53 , C07K14/47 , C07K14/4702 , C12N2799/021
摘要： A cDNA fragment participating in the maintenance of smooth muscle differentiation was isolated using a culture system of chicken gizzard smooth muscle cells, the differential display method and the subtracted hybridization method. Using the obtained cDNA sequence as a query, cDNA sequences of Helix Research Institute (Japanese Patent Application No. 2000-118776) were retrieved, and thus, a novel gene “C-NT2RP3001495” was obtained. The protein encoded by this gene has two WW domains that participate in protein interactions in the N-terminal domain. Evidence suggests that this protein binds to other proteins, and thus regulates the intracellular signal transduction, gene expression, and so on, thereby participating in the maintenance of the differentiation of smooth muscle cells. This protein and compounds regulating the expression thereof are markedly useful in developing drugs for various diseases associated with abnormality in the maintenance of smooth muscle cell differentiation.
摘要翻译： 使用鸡ard平滑肌细胞培养系统，差异显示法和减法杂交法分离参与维持平滑肌分化的cDNA片段。 使用获得的cDNA序列作为查询，检索Helix研究所的cDNA序列（日本专利申请2000-118776），从而得到新的基因“C-NT2RP3001495”。 由该基因编码的蛋白质具有参与N末端结构域中的蛋白质相互作用的两个WW结构域。 证据表明，该蛋白质与其他蛋白质结合，从而调节细胞内信号转导，基因表达等，从而参与维持平滑肌细胞的分化。 该蛋白质和调节其表达的化合物在开发用于维持平滑肌细胞分化异常的各种疾病的药物中显着有用。
-
公开(公告)号：US07560541B2
公开(公告)日：2009-07-14
申请号：US11767852
申请日：2007-06-25
申请人： Takao Isogai , Tomoyasu Sugiyama , Tetsuji Otsuki , Ai Wakamatsu , Hiroyuki Sato , Shizuko Ishii , Jun-ichi Yamamoto , Yuuko Isono , Yuri Hio , Kaoru Otsuka , Keiichi Nagai , Ryotaro Irie , Ichiro Tamechika , Naohiko Seki , Tsutomu Yoshikawa , Motoyuki Otsuka , Kenji Nagahari , Yasuhiko Masuho
发明人： Takao Isogai , Tomoyasu Sugiyama , Tetsuji Otsuki , Ai Wakamatsu , Hiroyuki Sato , Shizuko Ishii , Jun-ichi Yamamoto , Yuuko Isono , Yuri Hio , Kaoru Otsuka , Keiichi Nagai , Ryotaro Irie , Ichiro Tamechika , Naohiko Seki , Tsutomu Yoshikawa , Motoyuki Otsuka , Kenji Nagahari , Yasuhiko Masuho
CPC分类号： G01N33/566 , C07K14/47 , G01N2500/00
摘要： Novel full-length cDNAs are provided. cDNA derived from human have been isolated. The full-length nucleotide sequences of the cDNA and amino acid sequences encoded by the nucleotide sequences have been determined. Because the cDNA of the present invention are full-length and contain the translation start site, they provide information useful for analyzing the functions of the polypeptide.
摘要翻译： 提供新的全长cDNA。 已经分离了源自人的cDNA。 已经确定了由核苷酸序列编码的cDNA和氨基酸序列的全长核苷酸序列。 因为本发明的cDNA是全长的并含有翻译起始位点，所以它们提供了可用于分析多肽功能的信息。
-
公开(公告)号：US20090311748A1
公开(公告)日：2009-12-17
申请号：US12502157
申请日：2009-07-13
申请人： Takao Isogai , Tomoyasu Sugiyama , Tetsuji Otsuki , Ai Wakamatsu , Hiroyuki Sato , Shizuko Ishii , Jun-ichi Yamamoto , Yuuko Isono , Yuri Hio , Kaoru Otsuka , Keiichi Nagai , Ryotaro Irie , Ichiro Tamechika , Naohiko Seki , Tsutomu Yoshikawa , Motoyuki Otsuka , Kenji Nagahari , Yasuhiko Masuho
发明人： Takao Isogai , Tomoyasu Sugiyama , Tetsuji Otsuki , Ai Wakamatsu , Hiroyuki Sato , Shizuko Ishii , Jun-ichi Yamamoto , Yuuko Isono , Yuri Hio , Kaoru Otsuka , Keiichi Nagai , Ryotaro Irie , Ichiro Tamechika , Naohiko Seki , Tsutomu Yoshikawa , Motoyuki Otsuka , Kenji Nagahari , Yasuhiko Masuho
CPC分类号： G01N33/566 , C07K14/47 , G01N2500/00
摘要： Novel full-length cDNAs are provided.cDNA derived from human have been isolated. The full-length nucleotide sequences of the cDNA and amino acid sequences encoded by the nucleotide sequences have been determined. Because the cDNA of the present invention are full-length and contain the translation start site, they provide information useful for analyzing the functions of the polypeptide.
摘要翻译： 提供新的全长cDNA。 已经分离了源自人的cDNA。 已经确定了由核苷酸序列编码的cDNA和氨基酸序列的全长核苷酸序列。 因为本发明的cDNA是全长的并含有翻译起始位点，所以它们提供了可用于分析多肽功能的信息。
-
4.发明申请公开(公告)号：US20080069826A1
公开(公告)日：2008-03-20
申请号：US11869267
申请日：2007-10-09
申请人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Otsuka , Jun-Ichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki , Shin-Ichi Funahashi , Shoji Miyata , Kenji Sobue , Kenichiro Hayashi
发明人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Otsuka , Jun-Ichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki , Shin-Ichi Funahashi , Shoji Miyata , Kenji Sobue , Kenichiro Hayashi
CPC分类号： C07K16/18 , A61K38/00 , A61K2039/505 , A61K2039/53 , C07K14/47 , C07K14/4702 , C12N2799/021
摘要： A cDNA fragment participating in the maintenance of smooth muscle differentiation was isolated using a culture system of chicken gizzard smooth muscle cells, the differential display method and the subtracted hybridization method. Using the obtained cDNA sequence as a query, cDNA sequences of Helix Research Institute (Japanese Patent Application No. 2000-118776) were retrieved, and thus, a novel gene “C-NT2RP3001495” was obtained. The protein encoded by this gene has two WW domains that participate in protein interactions in the N-terminal domain. Evidence suggests that this protein binds to other proteins, and thus regulates the intracellular signal transduction, gene expression, and so on, thereby participating in the maintenance of the differentiation of smooth muscle cells. This protein and compounds regulating the expression thereof are markedly useful in developing drugs for various diseases associated with abnormality in the maintenance of smooth muscle cell differentiation.
摘要翻译： 使用鸡ard平滑肌细胞培养系统，差异显示法和减法杂交法分离参与维持平滑肌分化的cDNA片段。 使用获得的cDNA序列作为查询，检索Helix研究所的cDNA序列（日本专利申请2000-118776），从而得到新的基因“C-NT2RP3001495”。 由该基因编码的蛋白质具有参与N末端结构域中的蛋白质相互作用的两个WW结构域。 证据表明，该蛋白质与其他蛋白质结合，从而调节细胞内信号转导，基因表达等，从而参与维持平滑肌细胞的分化。 该蛋白质和调节其表达的化合物在开发用于维持平滑肌细胞分化异常的各种疾病的药物中显着有用。
-
公开(公告)号：US07193069B2
公开(公告)日：2007-03-20
申请号：US10108260
申请日：2002-03-28
申请人： Takao Isogai , Tomoyasu Sugiyama , Tetsuji Otsuki , Ai Wakamatsu , Hiroyuki Sato , Shizuko Ishii , Jun-ichi Yamamoto , Yuuko Isono , Yuri Hio , Kaoru Otsuka , Keiichi Nagai , Ryotaro Irie , Ichiro Tamechika , Naohiko Seki , Tsutomu Yoshikawa , Motoyuki Otsuka , Kenji Nagahari , Yasuhiko Masuho
发明人： Takao Isogai , Tomoyasu Sugiyama , Tetsuji Otsuki , Ai Wakamatsu , Hiroyuki Sato , Shizuko Ishii , Jun-ichi Yamamoto , Yuuko Isono , Yuri Hio , Kaoru Otsuka , Keiichi Nagai , Ryotaro Irie , Ichiro Tamechika , Naohiko Seki , Tsutomu Yoshikawa , Motoyuki Otsuka , Kenji Nagahari , Yasuhiko Masuho
IPC分类号： C07H21/04
CPC分类号： G01N33/566 , C07K14/47 , G01N2500/00
摘要： Novel full-length cDNAs are provided.2443 cDNA derived from human have been isolated. The full-length nucleotide sequences of the cDNA and amino acid sequences encoded by the nucleotide sequences have been determined. Because the cDNA of the present invention are full-length and contain the translation start site, they provide information useful for analyzing the functions of the polypeptide.
摘要翻译： 提供新的全长cDNA。 已经分离出来自人的2443 cDNA。 已经确定了由核苷酸序列编码的cDNA和氨基酸序列的全长核苷酸序列。 因为本发明的cDNA是全长的并含有翻译起始位点，所以它们提供了可用于分析多肽功能的信息。
-
公开(公告)号：US20060105376A1
公开(公告)日：2006-05-18
申请号：US11293697
申请日：2005-12-05
申请人： Takao Isogai , Tomoyasu Sugiyama , Tetsuji Otsuki , Ai Wakamatsu , Hiroyuki Sato , Shizuko Ishii , Jun-ichi Yamamoto , Yuuko Isono , Yuri Hio , Kaoru Otsuka , Keiichi Nagai , Ryotaro Irie , Ichiro Tamechika , Naohiko Seki , Tsutomu Yoshikawa , Motoyuki Otsuka , Kenji Nagahari , Yasuhiko Masuho
发明人： Takao Isogai , Tomoyasu Sugiyama , Tetsuji Otsuki , Ai Wakamatsu , Hiroyuki Sato , Shizuko Ishii , Jun-ichi Yamamoto , Yuuko Isono , Yuri Hio , Kaoru Otsuka , Keiichi Nagai , Ryotaro Irie , Ichiro Tamechika , Naohiko Seki , Tsutomu Yoshikawa , Motoyuki Otsuka , Kenji Nagahari , Yasuhiko Masuho
CPC分类号： G01N33/566 , C07K14/47 , G01N2500/00
摘要： Novel full-length cDNAs are provided. 2443 cDNA derived from human have been isolated. The full-length nucleotide sequences of the cDNA and amino acid sequences encoded by the nucleotide sequences have been determined. Because the cDNA of the present invention are full-length and contain the translation start site, they provide information useful for analyzing the functions of the polypeptide.
摘要翻译： 提供新的全长cDNA。 已经分离出来自人的2443 cDNA。 已经确定了由核苷酸序列编码的cDNA和氨基酸序列的全长核苷酸序列。 因为本发明的cDNA是全长的并含有翻译起始位点，所以它们提供了可用于分析多肽功能的信息。
-
公开(公告)号：US20070020637A1
公开(公告)日：2007-01-25
申请号：US10760320
申请日：2004-01-21
申请人： Takao Isogai , Tomoyasu Sugiyama , Tetsuji Otsuki , Al Wakamatsu , Hiroyuki Sato , Shizuko Ishii , Junichi Yamamoto , Yuko Isono , Keiichi Nagai , Ryotaro Irie
发明人： Takao Isogai , Tomoyasu Sugiyama , Tetsuji Otsuki , Al Wakamatsu , Hiroyuki Sato , Shizuko Ishii , Junichi Yamamoto , Yuko Isono , Keiichi Nagai , Ryotaro Irie
CPC分类号： C07K14/47
摘要： Novel full-length cDNAs are provided. 2,495 cDNA derived from human have been isolated. The full-length nucleotide sequences of the cDNA and amino acid sequences encoded by the nucleotide sequences have been determined. Because the cDNA of the present invention are full-length and contain the translation start site, they provide information useful for analyzing the functions of the polypeptide.
摘要翻译： 提供新的全长cDNA。 已经分离出来自人的2,495个cDNA。 已经确定了由核苷酸序列编码的cDNA和氨基酸序列的全长核苷酸序列。 因为本发明的cDNA是全长的并含有翻译起始位点，所以它们提供了可用于分析多肽功能的信息。
-
公开(公告)号：US20050250144A1
公开(公告)日：2005-11-10
申请号：US11109156
申请日：2005-04-19
申请人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Otsuka , Jun-Ichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki , Shin-Ichi Funahashi , Chiaki Senoo , Jin-Ichi Nezu
发明人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Otsuka , Jun-Ichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki , Shin-Ichi Funahashi , Chiaki Senoo , Jin-Ichi Nezu
IPC分类号： A61K38/00 , C07K14/47 , C12N1/15 , C12N1/19 , C12N1/21 , C12N15/12 , C12Q1/68 , C07H21/04 , C12N9/12 , C12N9/16 , C12N15/09 , C12P21/06
CPC分类号： C07K14/4702 , A61K38/00 , A61K2039/505 , A61K2039/53 , C07K14/47 , C12N2799/021
摘要： Selection of clones having the kinase and/or phosphatase-like structure from clones which had been isolated and the structures thereof had been determined in the Helix Research Institute (helix clones; Japanese Patent Application No. 2000-183767) was conducted. Two novel genes were provided by carrying out homology search for all the helix clones by using the amino acid sequences of known kinases and phosphatases as queries. The genes are expected to be involved in intracellular signal transduction. The physiological functions of the inventive genes can be tested by using reporter gene assay systems capable of detecting signal transduction. The proteins of the present invention are useful as target molecules in drug discovery and in the development of new pharmaceuticals.
摘要翻译： 已经在螺旋研究所（螺旋克隆，日本专利申请2000-183767）中确定了已经分离的克隆的克隆和/或磷酸酶样结构的克隆及其结构的选择。 通过使用已知的激酶和磷酸酶的氨基酸序列作为查询，通过对所有螺旋克隆进行同源性检索来提供两个新基因。 这些基因预期参与细胞内信号转导。 可以通过使用能够检测信号转导的报告基因测定系统来测试本发明基因的生理功能。 本发明的蛋白质可用作药物发现和开发新药物中的靶分子。
-
公开(公告)号：US20080032304A1
公开(公告)日：2008-02-07
申请号：US11767852
申请日：2007-06-25
申请人： Takao Isogai , Tomoyasu Sugiyama , Tetsuji Otsuki , Ai Wakamatsu , Hiroyuki Sato , Shizuko Ishii , Jun-ichi Yamamoto , Yuuko Isono , Yuri Hio , Kaoru Otsuka , Keiichi Nagai , Ryotaro Irie , Ichiro Tamechika , Naohiko Seki , Tsutomu Yoshikawa , Motoyuki Otsuka , Kenji Nagahari , Yasuhiko Masuho
发明人： Takao Isogai , Tomoyasu Sugiyama , Tetsuji Otsuki , Ai Wakamatsu , Hiroyuki Sato , Shizuko Ishii , Jun-ichi Yamamoto , Yuuko Isono , Yuri Hio , Kaoru Otsuka , Keiichi Nagai , Ryotaro Irie , Ichiro Tamechika , Naohiko Seki , Tsutomu Yoshikawa , Motoyuki Otsuka , Kenji Nagahari , Yasuhiko Masuho
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04 , C07K14/46 , C07K16/18 , G01N33/566 , C12N1/00 , C12N15/63 , C12P19/34
CPC分类号： G01N33/566 , C07K14/47 , G01N2500/00
摘要： cDNA derived from human have been isolated. The full-length nucleotide sequences of the cDNA and amino acid sequences encoded by the nucleotide sequences have been determined. Because the cDNA of the present invention are full-length and contain the translation start site, they provide information useful for analyzing the functions of the polypeptide.
摘要翻译： 已经分离了源自人的cDNA。 已经确定了由核苷酸序列编码的cDNA和氨基酸序列的全长核苷酸序列。 因为本发明的cDNA是全长的并含有翻译起始位点，所以它们提供了可用于分析多肽功能的信息。
-
10.发明授权公开(公告)号：US07279558B2
公开(公告)日：2007-10-09
申请号：US11051410
申请日：2005-02-04
申请人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Otsuka , Jun-Ichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki , Shin-Ichi Funahashi , Shoji Miyata , Kenji Sobue , Kenichiro Hayashi
发明人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Koji Hayashi , Kaoru Otsuka , Jun-Ichi Yamamoto , Shizuko Ishii , Tomoyasu Sugiyama , Ai Wakamatsu , Keiichi Nagai , Tetsuji Otsuki , Shin-Ichi Funahashi , Shoji Miyata , Kenji Sobue , Kenichiro Hayashi
CPC分类号： C07K16/18 , A61K38/00 , A61K2039/505 , A61K2039/53 , C07K14/47 , C07K14/4702 , C12N2799/021
摘要： A cDNA fragment participating in the maintenance of smooth muscle differentiation was isolated using a culture system of chicken gizzard smooth muscle cells, the differential display method and the subtracted hybridization method. Using the obtained cDNA sequence as a query, cDNA sequences of Helix Research Institute (Japanese Patent Application No. 2000-118776) were retrieved, and thus, a novel gene “C-NT2RP3001495” was obtained. The protein encoded by this gene has two WW domains that participate in protein interactions in the N-terminal domain. Evidence suggests that this protein binds to other proteins, and thus regulates the intracellular signal transduction, gene expression, and so on, thereby participating in the maintenance of the differentiation of smooth muscle cells. This protein and compounds regulating the expression thereof are markedly useful in developing drugs for various diseases associated with abnormality in the maintenance of smooth muscle cell differentiation.
摘要翻译： 使用鸡ard平滑肌细胞培养系统，差异显示法和减法杂交法分离参与维持平滑肌分化的cDNA片段。 使用获得的cDNA序列作为查询，检索Helix研究所的cDNA序列（日本专利申请2000-118776），从而得到新的基因“C-NT2RP3001495”。 由该基因编码的蛋白质具有参与N末端结构域中的蛋白质相互作用的两个WW结构域。 证据表明，该蛋白质与其他蛋白质结合，从而调节细胞内信号转导，基因表达等，从而参与维持平滑肌细胞的分化。 该蛋白质和调节其表达的化合物在开发用于维持平滑肌细胞分化异常的各种疾病的药物中显着有用。
-
-
-
-
-
-
-
-
-
搜索结果
18 条记录 (耗时 0.078 秒)
