公开(公告)号：US11576603B2

公开(公告)日：2023-02-14

申请号：US16846551

申请日：2020-04-13

申请人： Biosense Webster (Israel) Ltd. ,  Stichting voor de Technische Wetenschappen ,  Technische Universiteit Delft

发明人： Shmuel Auerbach ,  Wouter A Serdijn ,  Samprajani Rout

IPC分类号： A61B5/316 ,  A61B5/00 ,  A61B5/30 ,  A61B5/369 ,  H03M7/30

摘要： An apparatus includes data acquisition circuitry and a processor. The data acquisition circuitry is configured to acquire multiple signals using multiple respective electrodes of an array of electrodes coupled to one of an organ of a patient and tissue or a cell culture. The processor is configured to hold a definition of a mixed-norm that is defined as a function of relative positions of the electrodes in the array, and jointly compress the multiple signals in a compressed-sensing (CS) process that minimizes the mixed-norm.

公开(公告)号：US11326100B2

公开(公告)日：2022-05-10

申请号：US16926548

申请日：2020-07-10

申请人： Stichting Voor De Technische Wetenschappen ,  Universite De Berne

发明人： Pieter Dorenbos ,  Karl Krämer ,  Mikhail Alekhin

IPC分类号： C09K11/77 ,  G01T1/20 ,  G01T1/202

摘要： The disclosure relates to a scintillator and a radiation detector including the scintillator. The scintillator includes a scintillator material. In an embodiment, the scintillator material can include a metal halide doped with Eu2+ and co-doped with Sm2+. The metal halide can include at least one halogen selected from Br, Cl, and I. In an embodiment, the metal halide can include at least one element selected from alkaline-earth metals, rare-earth elements, Al, Ga, and the alkali metals selected from Li, Na, Rb, Cs. In a particular embodiment, co-doping with Sm2+ can shift the scintillation light emission peak to a region of the emission spectrum having a low self-absorbance of the scintillator material.

公开(公告)号：US20220091278A1

公开(公告)日：2022-03-24

申请号：US17603540

申请日：2020-03-27

申请人： Technische Universiteit Delft ,  Stichting voor de Technische Wetenschappen

发明人： Christiaan Christoffel Johan Tiberius ,  Gerardus Johannes Maria Janssen ,  Jeroen Koelemij

IPC分类号： G01S19/32 ,  G01S11/08 ,  G01S19/24 ,  H04W56/00

摘要： A method is disclosed for determining a signal's time of arrival at a receiver device, the signal being transmitted by a transmitter device to the receiver device. The method comprises correlating the signal as transmitted by the transmitter device and the signal as received by the receiver device with each other. The signal comprises in its frequency spectrum a first signal component spanning a first frequency range, a second signal component spanning a second frequency range and a third signal 5 component spanning a third frequency range. The first frequency range and second frequency range are separated by a first intermediate frequency range that does not contain a signal component of the signal. The second frequency range and third frequency range are separated by a second intermediate frequency range that does not contain a signal component of the signal. The method further comprises, based on the performed correlation, determining said time of arrival.

公开(公告)号：US11187818B2

公开(公告)日：2021-11-30

申请号：US16735768

申请日：2020-01-07

申请人： Stichting Voor De Technische Wetenschappen ,  Universite De Berne

发明人： Pieter Dorenbos ,  Karl W. Kramer

IPC分类号： G01T1/202 ,  G21K4/00 ,  C09K11/77 ,  G01T1/20

摘要： A scintillation crystal can include Ln(1-y)REyX3, wherein Ln represents a rare earth element, RE represents a different rare earth element, y has a value in a range of 0 to 1, and X represents a halogen. In an embodiment, the scintillation crystal is doped with a Group 1 element, a Group 2 element, or a mixture thereof, and the scintillation crystal is formed from a melt having a concentration of such elements or mixture thereof of at least approximately 0.02 wt. %. In another embodiment, the scintillation crystal can have unexpectedly improved proportionality and unexpectedly improved energy resolution properties. In a further embodiment, a radiation detection apparatus can include the scintillation crystal, a photosensor, and an electronics device. Such a radiation detection apparatus can be useful in a variety of applications.

公开(公告)号：US10119966B2

公开(公告)日：2018-11-06

申请号：US15610398

申请日：2017-05-31

申请人： STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN

发明人： Waltherus Jacobus Wilhelmus Van Venrooij ,  Jan Wouter Drijfhout ,  Martinus Adrianus Maria Van Boekel ,  Gerardus Jozef Maria Pruijn

IPC分类号： G01N33/50 ,  G01N33/564 ,  C07K7/08 ,  C07K14/47 ,  C07K7/64 ,  C07K7/52

摘要： Peptides useful in determining the presence of autoantibodies in patients suffering from rheumatoid arthritis are disclosed.

公开(公告)号：US09732354B2

公开(公告)日：2017-08-15

申请号：US14399673

申请日：2013-05-24

申请人： Wageningen Universiteit ,  Stichting voor de Technische Wetenschappen

发明人： Bart Pierre Hélène Joseph Thomma ,  Koste Abdissa Yadeta

IPC分类号： C12N15/82 ,  C07K14/415 ,  C07K16/16 ,  C12Q1/68

CPC分类号： C12N15/8282 ,  C07K14/415 ,  C07K16/16 ,  C12N15/8281 ,  C12Q1/6895 ,  C12Q2600/13 ,  C12Q2600/156

摘要： The invention relates to a new gene that is able to provide plants with resistance against pathogens, more preferably Verticillium, Ralstonia or Fusarium. Said gene is typical for Brassicaceae and encodes for a proteins having a sequence as depicted in FIG. 7 or FIG. 2A. Also provided are methods for enhancing the pathogen resistance of plants, wherein said plants preferably are Brassicaceae, but wherein the resistance also is functional in other plants. Further provided are host cells with a nucleotide construct encoding said protein.

公开(公告)号：US20140336069A1

公开(公告)日：2014-11-13

申请号：US14286878

申请日：2014-05-23

申请人： STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN

发明人： Waltherus Jacobus Wilhelmus VAN VENROOIJ ,  Jan Wouter DRIJFHOUT ,  Martinus Adrianus Maria VAN BOEKEL ,  Gerardus Jozef Maria PRUIJN

IPC分类号： G01N33/564 ,  C07K7/64 ,  C07K7/08

CPC分类号： G01N33/564 ,  C07K7/08 ,  C07K7/52 ,  C07K7/64 ,  C07K14/4713 ,  G01N2410/00 ,  G01N2800/102 ,  Y10S435/973 ,  Y10S435/975 ,  Y10S530/806

摘要： Peptides useful in determining the presence of autoantibodies in patients suffering from rheumatoid arthritis are disclosed.

摘要翻译： 公开了可用于确定患有类风湿性关节炎的患者中存在自身抗体的肽。

公开(公告)号：US08772448B2

公开(公告)日：2014-07-08

申请号：US11834557

申请日：2007-08-06

申请人： Waltherus Jacobus Wilhelmus Van Venrooij ,  Gerardus Antonius Schellekens ,  Jozef Maria Hendrik Raats ,  Rene Michael Antonius Hoet

发明人： Waltherus Jacobus Wilhelmus Van Venrooij ,  Gerardus Antonius Schellekens ,  Jozef Maria Hendrik Raats ,  Rene Michael Antonius Hoet

IPC分类号： G01N33/53 ,  A61K38/00 ,  C07K5/00

CPC分类号： G01N33/6893 ,  C07K14/47 ,  C07K14/4713 ,  C07K16/18 ,  G01N33/564 ,  G01N2333/46 ,  G01N2800/10 ,  G01N2800/102 ,  G01N2800/24

摘要： The invention relates to a peptide derived from an antigen recognized by autoantibodies, which peptide is reactive with autoimmune antibodies from a patient suffering from rheumatoid arthritis. The peptide according to the invention possesses a modified arginine residue. The invention also relates to antibodies against the peptide and a method of detecting autoimmune antibodies.

摘要翻译： 本发明涉及由自身抗体识别的抗原衍生的肽，该肽与患有类风湿性关节炎的患者的自身免疫抗体反应。 根据本发明的肽具有修饰的精氨酸残基。 本发明还涉及针对肽的抗体和检测自身免疫抗体的方法。

公开(公告)号：US20130071428A1

公开(公告)日：2013-03-21

申请号：US13635384

申请日：2011-03-15

申请人： Ferdinand Antonius Ossendorp ,  Cornelis Joseph Maria Melief ,  Jan Wouter Drijfhout

发明人： Ferdinand Antonius Ossendorp ,  Cornelis Joseph Maria Melief ,  Jan Wouter Drijfhout

IPC分类号： A61K39/08 ,  C07K17/02 ,  C07K7/08 ,  C07K14/33

CPC分类号： C07K17/02 ,  A61K39/00 ,  A61K39/385 ,  A61K39/40 ,  A61K2039/6037 ,  A61K2039/627 ,  C07K7/08 ,  C07K14/33 ,  C07K16/1282 ,  A61K2300/00

摘要： The present invention relates to conjugates comprising a peptide of at least 10 amino acid residues comprising the amino acid sequence GITELKKL for induction of potent humoral and cellular immune responses when administered to subjects having antibodies against tetanus toxoid. In one embodiment the invention relates to a prophylactic and therapeutic vaccine and in a further embodiment the invention relates to the treatment or prevention of cancer or an infectious disease.

摘要翻译： 本发明涉及包含至少10个氨基酸残基的肽的缀合物，其包含氨基酸序列GITELKKL，用于在施用于具有抗破伤风类毒素抗体的受试者时诱导有效的体液和细胞免疫应答。 在一个实施方案中，本发明涉及预防和治疗性疫苗，并且在进一步的实施方案中，本发明涉及癌症或感染性疾病的治疗或预防。

公开(公告)号：US08308643B2

公开(公告)日：2012-11-13

申请号：US10790618

申请日：2004-03-01

申请人： Antonius Franciscus Wilhelmus van der Steen ,  Christoffel Leendert de Korte ,  Frits Mastik ,  Johannes Antonius Schaar

发明人： Antonius Franciscus Wilhelmus van der Steen ,  Christoffel Leendert de Korte ,  Frits Mastik ,  Johannes Antonius Schaar

IPC分类号： A61B8/14 ,  A61B8/00 ,  A61B8/12

CPC分类号： A61B8/485 ,  A61B8/0891 ,  A61B8/12

摘要： A method for generating hardness information of tissue subject to a varying pressure. The method comprises receiving signals from the tissue from a sensor for measuring the deformation of the tissue in a measuring plane defined by the sensor, which sensor, during a varying pressure exerted on the tissue, is moved along the tissue in a direction transverse to the measuring plane; identifying strain of the tissue from the resulting signals; and relating the strain to elasticity and/or hardness parameters of the tissue. The method may comprise the step of displaying elasticity and/or hardness parameters of a tissue surface or tissue volume part extending practically parallel to the direction of motion of the sensor.

摘要翻译： 用于产生经受变化压力的组织的硬度信息的方法。 该方法包括从传感器接收来自组织的信号，用于测量由传感器限定的测量平面中组织的变形，该传感器在施加在组织上的变化压力期间沿着组织沿横向于 测量面 从所得信号中鉴定组织的应变; 并将该应变与组织的弹性和/或硬度参数联系起来。 该方法可以包括显示实质上平行于传感器的运动方向延伸的组织表面或组织体积部分的弹性和/或硬度参数的步骤。